Isobolographic analysis of interaction between intrathecal morphine and clonidine in the formalin test in rats

European Journal of Pharmacology

Volumn 337, Issue 1, 1997, Pages 11-17

  Przesmycki, Krzysztof ^a   Dzieciuch, Jacek A ^a   Czuczwar, Stanisław J ^a   Kleinrok, Zdzisław ^a  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

Clonidine; Formalin test; Morphine; Nociception

Indexed keywords

CLONIDINE; MORPHINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG POTENTIATION; EXPERIMENTAL MODEL; INTRATHECAL DRUG ADMINISTRATION; MOTOR PERFORMANCE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ADRENERGIC ALPHA-AGONISTS; ANALGESICS, OPIOID; ANIMALS; CLONIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FORMALDEHYDE; INJECTIONS, SPINAL; MALE; MORPHINE; PAIN MEASUREMENT; PSYCHOMOTOR PERFORMANCE; RATS; RATS, WISTAR;

EID: 0030727488     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01280-6     Document Type: Article

References (38)

1. Berenbaum M.C. What is synergy? Pharmacol. Rev. 41:1989;93-141.
2. Brignola G., Calignano A., Di Rosa M. Modulation of morphine antinociception in the mouse by endogenous nitric oxide. Br. J. Pharmacol. 113:1994;1372-1376.
3. Coderre T.J., Melzack R. The role of NMDA receptor operated calcium channels in persistent nociception after formalin-induced tissue injury. J. Neurosci. 12:1992;3671-3675.
4. Coderre T.J., Van Empel I. The utility of excitatory amino acid (EAA) antagonists as analgesic agents. I. Comparison of the antinociceptive activity of various classes of EAA antagonists in mechanical, thermal and chemical nociceptive tests. Pain. 59:1994;345-352.
5. Coderre T.J., Vaccarino A.L., Melzack R. Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection. Brain Res. 535:1990;155-158.
6. Coombs D.W., Jensen L.E., Murphy C.A. Microdose intrathecal clonidine and morphine for postoperative analgesia. Anesthesiology. 67:1987;A238.
7. Drasner K., Fields H.L. Synergy between the antinociceptive effect of intrathecal clonidine and systemic morphine in the rat. Pain. 32:1988;309-312.
8. Gordh Jr. T. Epidural clonidine for treatment of postoperative pain after thoracotomy. A double-blind placebo-controlled study. Acta Anaesthesiol. Scand. 32:1988;702-709.
9. Hylden J.L.K., Wilcox G.L. Intrathecal morphine in mice: A new technique. Eur. J. Pharmacol. 67:1980;313-316.
10. Hylden J.L.K., Wilcox G.L. Pharmacological characterization of substance P-induced nociception in mice: Modulation by opioid and noradrenergic agonists at spinal level. J. Pharmacol. Exp. Ther. 226:1983;398-404.
11. Jones B.J., Roberts D.J. The quantitative measurement of motor incoordination in naive mice using an accelerating rotarod. J. Pharm. Pharmacol. 20:1968;302-304.
12. Lee Y-W., Yaksh T.L. Analysis of drug interaction between intrathecal clonidine and MK-801 in peripheral neuropathic pain rat model. Anesthesiology. 82:1995;741-748.
13. Malmberg A.B., Yaksh T.L. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat. J. Pharm. Exp. Ther. 263:1992;136-146.
14. Malmberg A.B., Yaksh T.L. Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction. Anesthesiology. 79:1993;270-281.
15. Malmberg A.B., Yaksh T.L. Spinal nitric oxide inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats. Pain. 54:1993;291-300.
16. Meller S.T., Gebhart G.F. Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain. 52:1993;127-136.
17. Monasky M.S., Zinsmeister A.R., Stevens C.W., Yaksh T.L. Interaction of intrathecal morphine and ST-91 on antinociception in the rat: Dose-response analysis, antagonism and clearance. J. Pharmacol. Exp. Ther. 254:1990;383-392.
18. Motsch J., Graber E. Addition of clonidine enhances postoperative analgesia from epidural morphine: A double-blind study. Anesthesiology. 73:1990;1067-1073.
19. North R.A., Williams J.T., Superenant A., Christie M.J. Mu and delta opioid receptors belonging to a family of receptors that are coupled to potassium channels. Proc. Natl. Acad. Sci. USA. 84:1987;5487-5491.
20. Omote K., Kitahata L.M., Collins J.G., Nakatani K., Nakagawa I. Interaction between opiate subtype and alpha-2 adrenergic agonists in suppression of noxiously evoked activity of WDR neurones in the spinal dorsal horn. Anesthesiology. 74:1991;737-743.
21. Ossipov M.H., Suarez L.J., Spaulding T.C. Antinociceptive interactions between alpha-2 adrenergic and opiate agonists at the spinal level in rodents. Anesth. Analg. 68:1989;194-200.
22. Ossipov M.H., Harris S., Lloyd P., Messineo E. An isobolographic analysis of the antinociceptive effect of systemically and intrathecally administered combinations of clonidine and opiates. J. Pharmacol. Exp. Ther. 255:1990;1107-1116.
23. Papir-Kricheli D., Frey J., Laufer R., Gilon C., Chorev M., Selinger Z., Devor M. Behavioural effects of receptor specific substance P agonists. Pain. 31:1987;263-276.
24. Plummer J.L., Cmielewski P.L., Gourlay G.K., Owen H., Cousins M.J. Antinociceptive and motor effects of intrathecal morphine combined with intrathecal clonidine, noradrenaline, carbachol or midazolam in rats. Pain. 49:1992;145-152.
25. Przewłocki R., Machelska H., Przewłocka B. Inhibition of nitric oxide synthase enhances morphine antinociception in the rat spinal cord. Life Sci. 53:1993;1-5.
26. Roerig S.C., Fujimoto J.M. Multiplicative interaction between intrathecally and intracerebroventricularly administered mu opioid agonists but limited interactions between delta and kappa agonists for antinociception in mice. J. Pharmacol. Exp. Ther. 249:1989;762-768.
27. Solomon R.E., Gebhart G.F. Synergistic antinociceptive interactions among drugs administered to the spinal cord. Anesth. Analg. 78:1994;1164-1172.
28. 2 adrenergic antinociception in the rat spinal cord. Neurosci. Lett. 139:1992;65-68.
29. Takano Y., Yaksh T.L. Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. J. Pharmacol. Exp. Ther. 261:1992;764-772.
30. Tallarida R.J. Statistical analysis of drug combinations for synergism. Pain. 49:1992;93-97.
31. Tallarida, R.J., Murray, R.B., 1987. Manual of Pharmacologic Calculations with Computer Programs, 2nd ed. Springer, New York, NY, pp. 16-17.
32. Tallarida R.J., Porreca F., Cowan A. Statistical analysis of drug-drug and site-site interaction with isobologram. Life Sci. 45:1989;947-961.
33. Vercauteren M., Lauwers E., Meert T., De Hert S., Adriaensen H. Comparison of epidural sulfentanil plus clonidine with sufentanil alone for postoperative pain relief. Anesthesia. 45:1990;531-534.
34. Wheeler-Aceto H., Cowan A. Standarization of the rat paw formalin test for the evaluation of analgesics. Psychopharmacology. 104:1991;35-44.
35. Wheeler-Aceto H., Porreca F., Cowan A. The rat paw formalin test: Comparison of noxious agents. Pain. 40:1990;229-238.
36. Wilcox G.L., Carlsson K.H., Jochim A., Jurna I. Mutual potentiation of antinociceptive effects of morphine and clonidine on motor and sensory responses in rat spinal cord. Brain Res. 405:1987;84-93.
37. Yaksh T.L., Reddy S.V.R. Studies in primate on the analgesic effects associated with intrathecal actions of opiates, alpha-adrenergic agonists and baclofen. Anesthesiology. 54:1981;451-467.
38. Yamamoto T., Yaksh T.L. Comparison of the antinociceptive effects of pre- and posttreatment with intrathecal morphine and MK801, an NMDA antagonist on the formalin test in the rat. Anesthesiology. 77:1992;757-763.