Polyglutamine residues from Machado-Joseph disease gene enhance formation of aggregates of GST-polyglutamine fusion protein in E. coli

Journal of Microbiology and Biotechnology

Volumn 8, Issue 6, 1998, Pages 663-668

  Rhim, Hyangshuk ^b   Bok, Kyoung Sook ^a   Chang, Mi Jeong ^b   Kim, In Kyung ^b   Park, Sung Sup ^c   Kang, Seongman ^a  

^a Korea University   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Aggregates; GST fusion proteins; MJD gene; Polyglutamine

Indexed keywords

GLUTAMINE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DEATH; DENTATORUBROPALLIDOLUYSIAN ATROPHY; MACHADO JOSEPH DISEASE; NERVE DEGENERATION; NUCLEOTIDE SEQUENCE; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; TANDEM REPEAT;

EID: 0032413509     PISSN: 10177825     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 1989. In Current Protocols in Molecular Biology, Chap. 16, Wiley, NY, U.S.A.
2. Burke, J. R., J. J. Enghild, M. E. Martin, Y.-S. Jou, R. M. Myers, A. D. Roses, J. M. Vance, and W. J. Strittmatter. 1996. Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nature Med. 2: 347-350.
3. Colicelli, J. and H. Lehrach. 1997. HIP-1: A huntingtin interacting protein isolated by the yeast two-hybrid system. Hum. Mol. Genet. 6: 487-495.
4. Davies, S. W., M. Turmaine, B. A. Cozens, M. DiFiglia, A. H. Sharp, C. A. Ross, E. Scherzinger, E. E. Wanker, L. Mangiarini, and G. P. Bates. 1997. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90: 537-548.
5. Dupret, J. M., G. H. Goodfellow, S. A. Janezic, and D. M. Grant. 1994. Structure-function studies of human arylamine N-acetyltransferases NAT1 and NAT2: Functional analysis of recombinant NAT1/NAT2 chimeras expressed in E. coli. J. Biol. Chem. 269: 26830-26835.
6. Herrmann, C. H. and A. P. Rice. 1993. Specific interaction of the human immunodeficiency virus Tat proteins with a cellular protein kinase. Virology 197: 601-608.
7. Huntington's Disease Collaborative Research Group. 1993. A novel gene containing a trinucleotide repeat that is unstable on Huntington's disease chromosomes. Cell 72: 971-983.
8. Ikeda, H., M. Yamaguchi, S. Sugai, Y. Aze, S. Narumiya, and A. Kakizuka. 1996. Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo. Nature Genet. 13: 196-202.
9. Kahlem, P., C. Terre, H. Green, and P. Djian. 1996. Peptides containing glutamine repeats as substrates for transglutaminase-catalyzed cross-linking: Relevance to diseases of the nervous system. Proc. Natl. Acad. Sci. USA 93: 14580-14585.
10. Kalchman, M. A., H. B. Koide, K. McCutcheon, R. K. Graham, K. Nichol, K. Nishiyama, P. Kazemi-Esfariani, F. C. Lynn, C. Wellington, and M. Metzler. 1997. HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain. Nature Genet. 16: 44-53.
11. Martindale, D., A. Hackam, A. Wieczorek, L. Ellerby, C. Wellington, K. McCutcheon, R. Singaraja, P. Kazemi-Esfarjani, R. Devon, S. U. Kim, D. E. Bredson, F. Tufaro, and M. R. Hayden. 1998. Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates. Nature Genet. 18: 150-154.
12. Matilla, A., B. T. Koshy, C. J. Cummings, T. Isobe, H. T. Orr, and H. Y. Zoghbi. 1997. The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1. Nature 389: 974-978.
13. Ordway, J. M., S. Tallaksen-Greene, C.-A. Gutekunst, E. M. Bernstein, J. A. Cearley, H. W. Wiener, L. S. Dure, R. Lindsley, S. M. Hersch, R. S. Jope, R. L. Albin, and P. J. Detloff. 1997. Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse. Cell 91: 753-763.
14. Paulson, H. L., S. S. Das, P. B. Crino, M. K. Perez, S. C. Patel, D. Gotsdiner, K. H. Fischbeck, and R. N. Pittman. 1997. Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain. Ann. Neurol. 41: 453-462.
15. Reddy, P. S. and D. E. Housman. 1997. The complex pathology of trinucleotide repeats. Curr. Opin. Cell Biol. 9: 364-372.
16. Rhim, H., F. Chan, C. O. Echetebu, and A. P. Rice. 1993. Rapid purification of monomer HIV-2 Tat protein expressed in E. coli. Protein Expression Purif. 4: 24-31.
17. Rhim, H. and A. P. Rice. 1993. TAR RNA binding properties and relative transactivation activities of human immunodeficiency virus type 1 and 2 Tat proteins. J. Virol. 67: 1110-1121.
18. Ross, C. A. 1995. When more is less: Pathogenesis of glutamine repeat neurodegenerative diseases. Neuron 15: 493-496.
19. Scherzinger, E., R. Lurz, M. Turmaine, L. Mangiarini, B. Holenbach, R. Hasenbank, G. P. Bates, S. W. Davies, H. Lehrach, and E. E. Wanker. 1997. Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo. Cell 90: 549-558.
20. Smith, D. B. and K. S. Johnson 1988. Single-step purification of peptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67: 31-40.
21. Wanker, E. E., C. Rovira, E. Scherzinger, R. Hasenbank, S. Walter, D. Tait, and M. F. Perutz. 1996. Glutamine repeats and inherited neurodegenerative diseases: Molecular aspects. Curr. Opin. Struct. Biol. 6: 848-858.