Ca2+-Dependent Mitogen-Activated Protein Kinase Activation in Spontaneously Hypertensive Rat Vascular Smooth Muscle Defines a Hypertensive Signal Transduction Phenotype

Circulation Research

Volumn 78, Issue 6, 1996, Pages 962-970

  Lucchesi, Pamela A ^a   Bell, Jeremy M ^a   Willis, Laura S ^b   Byron, Kenneth L ^a   Corson, Marshall A ^b   Berk, Bradford C ^b  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Hypertension; Kinase; Phosphatase; Signal transduction; Vascular smooth muscle

Indexed keywords

ANGIOTENSIN; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR BB;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CHELATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; HYPERTENSION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; SIGNAL TRANSDUCTION; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR SMOOTH MUSCLE;

ANGIOTENSIN II; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CELL CYCLE PROTEINS; CELLS, CULTURED; ENZYME ACTIVATION; HYPERTENSION; IMMEDIATE-EARLY PROTEINS; MUSCLE, SMOOTH, VASCULAR; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN KINASE C; PROTEIN-TYROSINE-PHOSPHATASE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SIGNAL TRANSDUCTION;

EID: 0029884826     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.78.6.962     Document Type: Article

References (52)

1. Dzau VJ, Jacob HJ, Lindpainter K, Ganten D, Lander ES. Genetic mapping in hypertension. J Vasc Surg. 1992;15:930.
2. Duff JL, Berk BC, Corson MA. Angiotensin II stimulates the pp44 and pp42 mitogen-activated protein kinases in cultured rat aortic smooth muscle cells. Biochem Biophys Res Commun. 1992;188: 257-264.
3. Duff JL, Monia BP, Berk BC. Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase (MKP-1) in vascular smooth muscle cells. J Biol Chem. 1995;270:7161-7166.
4. Zhang Y, Moreland S, Moreland RS. Regulation of vascular smooth muscle contraction: myosin light chain phosphorylation dependent and independent pathways. Can J Physiol Pharmacol. 1994;72:1386-1391.
5. Molloy CJ, Taylor DS, Weber H. Angiotensin II stimulation of rapid protein tyrosine phosphorylation and protein kinase C activation in rat aortic smooth muscle cells. J Biol Chem. 1993;268: 7338-7345.
6. Khalil RA, Menice CB, Wang C-LA, Morgan KG. Phosphotyrosine-dependent targeting of mitogen-activated protein kinase in differentiated contractile vascular cells. Circ Res. 1995;76:1101-1108.
7. Scott-Burden T, Resink TJ, Baur U, Burgin M, Buhler FR. Activation of S6 kinase in cultured vascular smooth muscle cells by submitogenic levels of thrombospondin. Biochem Biophys Res Commun. 1988;151:583-589.
8. Gille H, Kortenjann M, Thomae O, Moomaw C, Slaughter C, Cobb MH, Shaw PE. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. Embo J. 1995;14: 951-962.
9. Davis RG. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem. 1993;268:14553-14556.
10. Pages G, Lenormand P, L'Allemain G, Chambard JC, Meloche S, Pouysségur J. Mitogen-activated protein kinases p42MAPK and p44MAPK are required for fibroblast proliferation. Proc Natl Acad Sci USA. 1993;90:8319-8323.
11. + exchange. J Clin Invest. 1989;83:822-829.
12. Silver PJ, Lepore RE, Cumiskey WR, Kiefer D, Harris AL. Protein kinase C activity and reactivity to phorbol ester in vascular smooth muscle from spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). Biochem Biophys Res Commun. 1988;154:272-277.
13. Buchholz RA, Dundore RL, Cumiskey WR, Harris AL, Silver PJ. Protein kinase inhibitors and blood pressure control in spontaneously hypertensive rats. Hypertension. 1991;17:91-100.
14. Bruschi G, Bruschi ME, Capelli P, Regolisti G, Borghetti A. Increased sensitivity to protein kinase C activation in aortas of spontaneously hypertensive rats. J Hypertens. 1988;6:S248-S251.
15. Bendhack LM, Sharma RM, Bhalla RC. Altered signal transduction in vascular smooth muscle cells of spontaneously hypertensive rats. Hypertension. 1992;19(suppl II):II-142-II-148.
16. + antiporter activity and an altered skeletal muscle contractile response in the spontaneously hypertensive rat. J Hypertens. 1990;8:1027-1036.
17. 2+ modulation in genetic hypertension. Hypertension. 1989;14:145-151.
18. + exchange rate and more alkaline intracellular pH set-point in essential hypertension: effects of protein kinase modulation in platelets. J Hypertens. 1991;9: 1013-1019.
19. Rosskopf D, Fromter E, Siffert W. Hypertensive sodium-proton exchanger phenotype persists in immortalized lymphoblasts from essential hypertensive patients. J Clin Invest. 1993;92:2553-2559.
20. Hogue D, Michalak M, Fliegel L. The role of ion antiporters in the maintenance of intracellular pH in rat vascular smooth muscle cells. Mol Cell Biochem. 1991;102:125-137.
21. + exchange in segments of rat mesenteric artery. Am J Physiol. 1992;262:H1651-H1656.
22. Berk BC, Rao GN. Angiotensin II-induced vascular smooth muscle cell hypertrophy: PDGF A-chain mediates the increase in cell size. J Cell Physiol. 1993;154:368-380.
23. + exchange inhibitors decrease neointimal formation after rat carotid injury: effects on smooth muscle cell migration and proliferation. Circ Res. 1993;73: 269-275.
24. + antiport in essential hypertension. J Hypertens. 1990;8: 533-537.
25. + exchanger activity in normotensive and hypertensive subjects: effect of enalapril therapy upon antiport activity. J Hypertens. 1992;10:839-847.
26. Rosskopf D, Dusing R, Siffert W. Membrane sodium-proton exchange and primary hypertension. Hypertension. 1993;21:607-617.
27. + exchanger isoform expression in SHR and WKY rats: NHE-1 mRNA is not differentially regulated. Hypertension. 1994;24:734-738.
28. + antiporter protein in normotensive Wistar-Kyoto and spontaneously hypertensive rats. J Hypertens. 1994;12:775-781.
29. + antiporter phenotype, abundance, and phosphorylation of immortalized lymphoblasts from humans with hypertension. Hypertension. 1995;25:971-977.
30. + exchanger isoform 1 phosphorylation in normal Wistar-Kyoto and spontaneously hypertensive rats. Circ Res. 1995;76:825-831.
31. 2+ regulation-defective. J Biol Chem. 1994;269:13710-13715.
32. Chao TO, Byron KL, Lee K, Villereal M, Rosner MR. Activation of MAP kinases by calcium-dependent and calcium-independent pathways. J Biol Chem. 1992;267:19876-19883.
33. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 1979;18:5294-5299.
34. Lau LF, Nathans D. Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells. EMBO J. 1985; 4:3145-3151.
35. Fort P, Marty L, Piechachaezyk M, el-Sabrouty S, Dani C, Jeanteur PS, Blanchard JM. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res. 1985;13:1431-1442.
36. Duff JL, Marrero MB, Paxton WG, Charles CH, Lau LF, Bernstein KE, Berk BC. Angiotensin II induces 3CH134, a protein tyrosine phosphatase, in vascular smooth muscle cells. J Biol Chem. 1993; 268:26037-26040.
37. Okhuma S, Poole B. Fluorescence probe measurements of the intralysosomal pH in living cells and the perturbation of pH by various agents. Proc Natl Acad Sci USA. 1978;75:3327-3331.
38. Berk BC, Alexander RW, Brock TA, Gimbrone MA Jr, Webb RC. Vasoconstriction: a new activity for platelet-derived growth factor. Science. 1986;232:87-90.
39. 2+ mobilization and protein kinase C activation. J Biol Chem. 1989;264:526-530.
40. + exchange in cultured vascular smooth muscle cells: evidence for protein kinase C-dependent and -independent pathways. J Biol Chem. 1987;262: 5065-5072.
41. Charles CH, Sun H, Lau LF, Tonks NK. The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase. Proc Natl Acad Sci USA. 1993;90:5292-5296.
42. Chao TO, Foster DA, Rapp UR, Rosner MR. Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters and calcium. J Biol Chem. 1994;269: 7337-7341.
43. Huckle WR, Dy RC, Earp HS. Calcium-dependent increase in tyrosine kinase activity stimulated by angiotensin II. Proc Natl Acad Sci U S A. 1992;89:8837-8841.
44. 1 receptor is tyrosine and serine phosphorylated and can serve as a substrate for the src family of tyrosine kinases. Biochem Biophys Res Commun. 1994;200: 260-267.
45. Kai H, Griendling KK, Lassegue B, Ollerenshaw JD, Runge MS, Alexander RW. Agonist-induced phosphorylation of the vascular type 1 angiotensin receptor. Hypertension. 1994;24:523-527.
46. 2+-dependent signaling. Circ Res. 1995;76:1-15.
47. Tsuda T, Kawahara Y, Ishida Y, Koide M, Shii K, Yokoyama M. Angiotensin II stimulates two myelin basic protein/microtubule-associated protein 2 kinases in cultured vascular smooth muscle cells. Circ Res. 1992;71:620-630.
48. 2+-induced regulation of ion channel and MAP kinase function. Nature. 1995;376:737-745.
49. Clapham DE. Mutations in G protein-linked receptors: novel insights from disease. Cell. 1993;75:1237-1239.
50. + exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites. J Biol Chem. 1994;269:13703-13709.
51. + antiport activation in cultured rat aortic smooth muscle on calmodulin, calcium, and ATP: evidence for the involvement of calmodulin-dependent kinases. J Biol Chem. 1988;263: 16780-16786.
52. 2+/calmodulin-dependent protein kinase II. Biochem J. 1992;282:139-145.