Mercuric chloride induces apoptosis in human T lymphocytes: Evidence of mitochondrial dysfunction

Toxicology and Applied Pharmacology

Volumn 153, Issue 2, 1998, Pages 250-257

  Guo, Tai Liang ^a   Miller, Mark A ^a   Shapiro, Irving M ^a   Shenker, Bruce J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C; DNA FRAGMENT; LIPOCORTIN 5; MERCURIC CHLORIDE;

APOPTOSIS; ARTICLE; BLOOD TOXICITY; CELL DEATH; CELL PH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ELECTRON TRANSPORT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MEMBRANE BINDING; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0032411886     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8549     Document Type: Article

References (38)

1. Castedo M., Macho A., Zamzami N., Hirsch T., Marchetti P., Uriel J., Kroemer G. Mitochondrial perturbations define lymphocytes undergoing apoptotic depletionin vivo. Eur. J. Immunol. 25:1995;3277-3284.
2. Chinnaiyan A. M., O'Rourke K., Lane B. R., Dixit V. M. Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death. Science. 275:1997;1122-1126.
3. Clarkson T. W. The toxicology of mercury. Crit. Rev. Clin. Lab. Sci. 34:1997;369-403.
4. Gold R., Schmied M., Giegerich G., Breitschopf H., Hartung H. P., Toyka K. V., Lassmann H. Differentiation between cellular apoptosis and necrosis by the combined use ofin situ. Lab. Invest. 71:1994;219-225.
5. Golstein P. Controlling cell death. Science. 275:1997;1081-1082.
6. Gorczyca W., Bigman K., Mittelman A., Ahmed T., Gong J., Melamed M. R., Darzynkiewicz Z. Induction of DNA strand breaks associated with apoptosis during treatment of leukemias. Leukemia. 7:1993;659-670.
7. Henkart P. A. ICE family proteases: Mediators of all apoptotic cell death? Immunity. 4:1996;195-201.
8. Hockenbery D. Defining apoptosis. Am. J. Pathol. 146:1995;16-19.
9. Kaufmann S. H., Desnoyers S., Ottaviano Y., Davidson N. E., Poirier G. G. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis. Cancer Res. 53:1993;3976-3985.
10. Kluck R. M., Bossy-Wetzel E., Green D. R., Newmeyer D. D. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science. 275:1997;1132-1136.
11. Korsmeyer S. J. Bcl-2: A repressor of lymphocyte death. Immunol. Today. 13:1992;285-288.
12. Kroemer G., Petit P., Zamzami N., Vayssiere J. L., Mignotte B. The biochemistry of programmed cell death. FASEB J. 9:1995;1277-1287.
13. Kroemer G., Zamzami N., Susin S. A. Mitochondrial control of apoptosis. Immunol. Today. 18:1997;44-51.
14. Li P., Nijhawan D., Budihardjo I., Srinivasula S. M., Ahmad M., Alnemri E. S., Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:1997;479-489.
15. Meisenholder G. W., Martin S. J., Green D. R., Nordberg J., Babior B. M., Gottlieb R. A. Events in apoptosis. Acidification is downstream of protease activation and BCL-2 protection. J. Biol. Chem. 271:1996;16260-16262.
16. Nath K. A., Croatt A. J., Likely S., Behrens T. W., Warden D. Renal oxidant injury and oxidant response induced by mercury. Kidney Int. 50:1996;1032-1043.
17. O I., Datar S., Koch C. J., Shapiro I. M., Shenker B. J. Mercuric compounds inhibit human monocyte function by inducing apoptosis: Evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve. Toxicology. 124:1997;211-224.
18. Pollard K. M., Hultman P. Effects of mercury on the immune system. Metal Ions Biol. Systems. 34:1997;421-440.
19. Reynolds J. E., Li J., Eastman A. Detection of apoptosis by flow cytometry of cells simultaneously stained for intracellular pH (carboxy SNARF-1) and membrane permeability (Hoechst 33342). Cytometry. 25:1996;349-357.
20. Schmid I., Uittenbogaart C. H., Giorgi J. V. Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry. Cytometry. 15:1994;12-20.
21. Seksek O., Henry-Toulme N., Sureau F., Bolard J. SNARF-1 as an intracellular pH indicator in laser microspectrofluorometry: A critical assessment. Analyt. Biochem. 193:1991;49-54.
22. Shah G. M., Kaufmann S. H., Poirier G. G. Detection of poly(ADP-ribose) polymerase and its apoptosis-specific fragment by a nonisotopic activity-western blot technique. Analyt. Biochem. 232:1995;251-254.
23. Shenker B. J., Rooney C., Vitale L., Shapiro I. M. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. I. Suppression of T-cell activation. Immunopharmacol. Immunotoxicol. 14:1992a;539-553.
24. Shenker B. J., Berthold P., Decker S., Mayro J., Rooney C., Vitale L., Shapiro I. M. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. II. Alterations in cell viability. Immunopharmacol. Immunotoxicol. 14:1992b;555-577.
25. Shenker B. J., Berthold P., Rooney C., Vitale L., DeBolt K., Shapiro I. M. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. III. Alterations in B-cell function and viability. Immunopharmacol. Immunotoxicol. 15:1993a;87-112.
26. Shenker B. J., Mayro J. S., Rooney C., Vitale L., Shapiro I. M. Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. IV. Alterations in cellular glutathione content. Immunopharmacol. Immunotoxicol. 15:1993b;273-290.
27. Shenker B. J., Datar S., Mansfield K., Shapiro I. M. Induction of apoptosis in human T-cells by organomercuric compounds: A flow cytometric analysis. Toxicol. Appl. Pharmacol. 143:1997;397-406.
28. Shenker B. J., Guo T. L., Shapiro I. M. Low level mercury exposure causes human T-cells to undergo apoptosis: Evidence of mitochondrial dysfunction. Environ. Res. 77:1998;149-159.
29. Stoian I., Oros A., Moldoveanu E. Apoptosis and free radicals. Biochem. Mol. Med. 59:1996;93-97.
30. Susin S. A., Zamzami N., Castedo M., Hirsch T., Marchetti P., Macho A., Daugas E., Geuskens M., Kroemer G. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J. Exp. Med. 184:1996;1331-1341.
31. Tewari M., Quan L. T., O'Rourke K., Desnoyers S., Zeng Z., Beidler D. R., Poirier G. G., Salvesen G. S., Dixit V. M. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 81:1995;801-809.
32. Wu D., Wallen H. D., Nunez G. Interaction and regulation of subcellular localization of CED-4 by CED-9. Science. 275:1997;1126-1129.
33. Vander Heiden M. G., Chandel N. S., Williamson E. K., Schumacker P. T., Thompson C. B. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell. 91:1997;627-637.
34. Veis D. J., Sorenson C. M., Shutter J. R., Korsmeyer S. J. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell. 75:1993;229-240.
35. Vermes I., Haanen C., Steffens-Nakken H., Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods. 184:1995;39-51.
36. Yang J., Liu X., Bhalla K., Kim C. N., Ibrado A. M., Cai J., Peng T. I., Jones D. P., Wang X. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science. 275:1997;1129-1132.
37. Zalups R. K., Lash L. H. Interactions between glutathione and mercury in the kidney, liver, and blood. Toxicology of Metal. 1996;CRC Press Inc. Boca Raton. p. 145-163.
38. Zamzami N., Hirsch T., Dallaporta B., Petit P. X., Kroemer G. Mitochondrial implication in accidental and programmed cell death: Apoptosis and necrosis. J. Bioeng. Biomembr. 29:1997;185-193.