Structure-activity relationships of alkyl- and alkoxy-substituted 1,4- dihydroquinoxaline-2,3-diones: Potent and systemically active antagonists for the glycine site of the NMDA receptor

Journal of Medicinal Chemistry

Volumn 40, Issue 5, 1997, Pages 730-738

  Cai, Sui Xiong ^a   Kher, Sunil M ^b   Zhou, Zhang Lin ^a   Ilyin, Victor ^a   Espitia, Stephen A ^a   Tran, Minhtam ^a   Hawkinson, Jon E ^a   Woodward, Richard M ^a   Weber, Eckard ^a   Keana, John F W ^b  

^a Department of Pharmacokinetics and Drug Metabolism   (United States)

^b UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDROQUINOXALINE 2,3 DIONE DERIVATIVE; 6,7 DICHLORO 5 NITRO 2,3 QUINOXALINEDIONE; 7 CHLORO 1,4 DIHYDRO 6 METHYL 5 NITROQUINOXALINE 2,3 DIONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; DRUG BIOAVAILABILITY; DRUG POTENCY; HALOGENATION; NERVE CELL NECROSIS; NEUROTOXICITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; ANTICONVULSANTS; BINDING SITES; BINDING, COMPETITIVE; CEREBRAL CORTEX; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; KYNURENIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR STRUCTURE; OOCYTES; QUINOXALINES; RATS; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 0001523208     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960654b     Document Type: Article

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