Use of combinatorial library screening to identify inhibitors of a bacterial two-component signal transduction kinase

Molecular Diversity

Volumn 4, Issue 3, 1998, Pages 173-182

  Roychoudhury, Siddhartha ^a   Blondelle, Sylvie E ^b   Collins, Susan M ^a,c   Davis, Michael C ^a   McKeever, Helana D ^a   Houghten, Richard A ^b   Parker, Christian N ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^b TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^c NORTHWESTERN MEMORIAL HOSPITAL   (United States)

Author keywords

Antibacterial compounds; Bacterial signal transduction; CheA; Combinatorial chemistry; Deconvolution; Enzyme inhibition; Histidine protein kinase; Synthetic peptides

Indexed keywords

AMINO ACID; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; MEMBRANE PROTEIN; METHYL ACCEPTING CHEMOTAXIS PROTEINS; METHYL-ACCEPTING CHEMOTAXIS PROTEINS; PEPTIDE LIBRARY;

ARTICLE; CHEMISTRY; COMBINATORIAL CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG DESIGN; IC 50;

AMINO ACIDS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; COMBINATORIAL CHEMISTRY TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; INHIBITORY CONCENTRATION 50; MEMBRANE PROTEINS; PEPTIDE LIBRARY;

EID: 0032227710     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009695718427     Document Type: Article

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