Inhibition of the M(r) 70,000 S6 kinase pathway by rapamycin results in chromosome malsegregation in yeast and mammalian cells

Chromosoma

Volumn 107, Issue 6-7, 1998, Pages 498-506

  Bonatti, S ^a,b   Simili, M ^b   Galli, A ^b   Bagnato, P ^a   Pigullo, S ^a   Schiestl, R H ^c   Abbondandolo, A ^a,d  

^a UNIVERSITY OF GENOA   (Italy)

^b CNR   (Italy)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN; S6 KINASE; PROTEIN KINASE; RIBOSOMAL PROTEIN S6 KINASE KINASE; TUBULIN;

ANIMAL CELL; ANTIFUNGAL ACTIVITY; ATAXIA TELANGIECTASIA; CENTROSOME; CHROMOSOME SEGREGATION; CONFERENCE PAPER; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; INTERPHASE; LYMPHOBLAST; LYMPHOBLASTOID CELL LINE; LYMPHOCYTE; METAPHASE CHROMOSOME; MICRONUCLEUS; MITOSIS; NONHUMAN; YEAST; ANEUPLOIDY; ANIMAL; ARTICLE; BLOOD; DOSE RESPONSE; DRUG EFFECT; GENETICS; HAMSTER; METABOLISM; METAPHASE; PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; ULTRASTRUCTURE;

ANIMALIA; ATAXIA; ATAXIA TELANGIECTASIA; CRICETINAE; CRICETULUS GRISEUS; MAMMALIA;

ANEUPLOIDY; ANIMALS; ATAXIA TELANGIECTASIA; CHROMOSOME SEGREGATION; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HUMANS; LYMPHOCYTES; METAPHASE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; PHOSPHORYLATION; PROTEIN KINASES; SACCHAROMYCES CEREVISIAE; SIROLIMUS; TUBULIN;

EID: 0032217292     PISSN: 00095915     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004120050335     Document Type: Conference Paper

References (44)

1. Abbondandolo A, Bonatti S, Cercignani G, De Ferrari M, Ipata PL, Rocco M, Tozzi MG, Viaggi S (1989) The role of nucleotide pool alkylation in the induction of numerical chromosome aberrations. In: Resnick MA, Vig BK (eds) Mechanisms of chromosome distribution and aneuploidy. Alan R Liss, New York, pp 335-343
2. Abbondandolo A, Bonatti S, Pellerano P, Simili M (1993) Possible targets for the aneugenic activity of alkylating agents. In: Vig BK (ed) Chromosome segregation and aneuploidy. Springer, Berlin Heidelberg, pp 269-282
3. Aguilar MJ, Kamoshita S, Landing BH, Boder E, Sedgwick RP (1968) Pathological observations in ataxia-telangiectasia. A report on 5 cases. J Neuropathol Exp Neurol 27:659-676
4. Albers MW, Williams RT, Brown EJ, Tanaka A, Hall FL, Schreiber SL (1993) FKB-P-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line. J Biol Chem 268:22825-22829
5. Barbet NC, Schneider U, Helliwell SB, Stansfield I, Tuite MF, Hall MN (1996) TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell 7:25-42
6. Beamish H, Williams R, Chen P, Khanna KK, Hobson K, Watters D, Shiloh Y, Lavin M (1996) Rapamycin resistance in ataxiatelangiectasia. Oncogene 13:963-970
7. Beretta L, Gingras AC, Svitkin YV, Hall MN, Sonemberg N (1996) Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J 15:658-664
8. Bierer BE, Somers PK, Wandelss TJ, Burakoff SJ, Schreiber SL (1990) Probing immunosuppressant action with a nonnatural immunophilin ligand. Science 250:556-559
9. Bonatti S, Lohman PHM, Berends F (1983) Induction of micronuclei in Chinese hamster ovary cells treated with Pt co-ordination compounds. Mutat Res 116:149-154
10. Bonatti S, Simili M, Pellerano P, Tavosanis G, Abbondandolo A (1996) Cellular targets for the aneugenic action of alkylating agents. In: Abbondandolo A, Vig BK, Roi R (eds) Chromosome segregation and aneuploidy. IST, Genoa, pp 265-273
11. Brown EJ, Schreiber SL (1996) A signaling pathway to translational control. Cell 86:517-520
12. Calvo V, Crews CM, Vik TA, Bierer BE (1992) Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin. Proc Natl Acad Sci USA 89:7571-7575
13. Chan SMC, Botstein D (1993) Isolation and characterization of chromosome-gain and increase in ploidy mutants in yeast. Genetics 135:677-691
14. Cherrington PV, Pardee AB (1980) Synergic effects of epidermal growth factor and thrombine on the growth stimulation of diploid Chinese hamster fibroblasts. J Cell Physiol 105:25-32
15. Chou MM, Blenis J (1996) The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Racl. Cell 85:573-583
16. Chung J, Kuo CJ, Crabtree GR, Blenis J (1992) Rapamycin-FKBP specifically blocks growth-dependent activation of and signalling by the 70 kd S6 protein kinases. Cell 69:1227-1236
17. 389 are differentially regulated by rapamycin-insensitive kinase-kinases. Mol Cell Biol 16:6242-6251
18. Edelmann HML, Kuehne C, Petritsch C, Ballou LM (1996) Cell cycle regulation of p70 S6 kinase and p42/p44 mitogen-activated protein kinases in Swiss mouse 3T3 fibroblasts. J Biol Chem 271:963-971
19. Fukasawa K, Choi T, Kuriyama R, Rulong S, Vande Woude GF (1996) Abnormal centrosome amplification in the absence of p53. Science 271:1744-1747
20. Galli A, Schiestl RH (1995a) Salmonella test positive and negative carcinogens show different effects on intrachromosomal recombination in G2 cell cycle arrested yeast cells. Carcinogenesis 16:659-663
21. Galli A, Schiestl RH (1995b) On the mechanism of UV and γ-rays-induced intrachromosomal recombination in yeast cells synchronized in different stages of the cell cycle. Mol Gen Genet 248:301-310
22. Galli A, Schiestl RH (1998) Effect of DNA double and single strand breaks on intrachromosomal recombination events in cell cycle arrested yeast cells. Genetics 149:1235-1250
23. S6K by inducing dephosphorylation of the same subset of sites. J Biol Chem 270:21396-21403
24. Jefferies HB, Reinhard C, Kozma SC, Thomas G (1994) Rapamycin selectively represses translation of the 'polypyrimidine tract' mRNA family. Proc Natl Acad Sci USA 91:4441-4445
25. S6K. EMBO J 16:3693-3704
26. Knehr M, Poppe M, Schroeter D, Eickelbaum W, Finze E-M, Kiesewetter UL, Enulesci M, Arand M, Paweletz N (1996) Cellular expression of human centromere protein C demonstrates a cyclic behavior with highest in the Gl phase. Proc Natl Acad Sci USA 93:10234-10293
27. Kozma R, Thomas G (1994) p70S6K/p85S6K: mechanism of activation and role in mitogenesis. Cancer Biol 5:255-266
28. Kuo CJ, Chung J, Fiorentino DF, Flanagan WM, Blenis J, Crabtree GR (1992) Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 358:70-73
29. Lorenz MC, Heitman J (1995) TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. J Biol Chem 270:27351-27357
30. Miele M, Bonassi S, Bonatti S, Martini E, Miglio L, Ottaggio L, Queirolo P, Sertoli MR, Abbondandolo A (1998) Micronucleus analysis in peripheral blood lymphocytes from melanoma patients treated with dacarbazine. Anticancer Res 18:1967-1972
31. 1/S-phase growth arrest in T lymphocytes. J Biol Chem 268:3734-3738
32. Nuesse M, Viaggi S, Bonatti S (1989) Induction of kinetochore positive and negative micronuclei in V79 cells by alkylating agent diethylsulfate. Mutagenesis 4:174-178
33. Pearson RB, Dennis PB, Han J-W, Williamson NH, Kozma SC, Wettenhal REH, Thomas G (1995) The principal target of rapamycin-induced p70S6K inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO J 14:5279-5287
34. Pedersen S, Celis JE, Nielsen J, Christiansen J, Nielsen FC (1997) Distinct repression of translation by wortmannin and rapamycin. Eur J Biochem 247:449-456
35. Price DJ, Grove JR, Calvo V, Avruch J, Bierer BE (1992) Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science 257:973-977
36. Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G (1998) Phosphorylation and activation of p70S6K by PDK1. Science 279:707-710
37. Schiestl RH, Igarashi S, Hastings PJ (1988) Analysis of the mechanisms for reversion of a disrupted gene. Genetics 119:237-247
38. Schlegel R, Belinsky GS, Harris MO (1990) Premature mitosis induced in mammalian cells by the protein kinase inhibitors 2-aminopurine and 6-dimethylaminopurine. Cell Growth Differ 1:171-176
39. Simili M, Mazzetti P, Cini M, Franceschelli F, Bertacca A, Minks MA (1994) Contribution of known mitogenic signaling pathways to induction of DNA synthesis in quiescent Chinese hamster fibroblasts. Exp Cell Res 214:473-480
40. Simili M, Pellerano P, Tavosanis G, Bonatti S, Abbondandolo A (1995) The induction of aneuploidy by alkylated purines: effects on early and late cell cycle events. Mutagenesis 10: 105-111
41. Simili M, Pellerano P, Pigullo S, Tavosanis G, Ottaggio L, de Saint-Georges L, Bonatti S (1997) 6DMAP inhibition of early cell cycle events and induction of mitotic abnormalities. Mutagenesis 12:313-319
42. Terada N, Patel HR, Takase K, Kohno K, Nairn AC, Gelfand EW (1994) Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc Natl Acad Sci USA 91:11477-11481
43. Thomas G, Hall MN (1997) TOR signalling and control of cell growth. Curr Opin Cell Biol 9:782-787
44. Vesely J, Havlicek L, Stroud M, Blow JJ, Donella-Deanna A, Pinna L, Letham DS, Kato J, Detibaud L, Leclerc S, Meuer L (1994) Inhibition of cyclin-dependent kinases by purine analogues. Eur J Biochem 224:771-786