메뉴 건너뛰기




Volumn 29, Issue 4, 1998, Pages 524-532

The cellular immune responses induced in the follow-up of interferon-α treated patients with chronic hepatitis C may determine the therapy outcome

Author keywords

Chronic hepatitis C; HCV core and nonstructural antigens; HCV genotypes; Immunopathogenesis; Interferon ; T cells; Viral clearance; Viral load

Indexed keywords

ALPHA INTERFERON; HELICASE;

EID: 0032191747     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(98)80146-3     Document Type: Article
Times cited : (37)

References (38)
  • 1
    • 0025862146 scopus 로고
    • Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of disease
    • 1. Houghton M, Weiner A, Han J, Kuo G, Choo Q-L. Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of disease. Hepatology 1991; 14: 381-8.
    • (1991) Hepatology , vol.14 , pp. 381-388
    • Houghton, M.1    Weiner, A.2    Han, J.3    Kuo, G.4    Choo, Q.-L.5
  • 2
    • 0031030434 scopus 로고    scopus 로고
    • Influence of viral genotype and level of viremia on the severity of liver injury and the response to interferon therapy in Spanish patients with chronic C infection
    • 2. Fernandez I, Castellano G, Domingo MJ, Fuertes A, Colina F, Canga F, et al. Influence of viral genotype and level of viremia on the severity of liver injury and the response to interferon therapy in Spanish patients with chronic C infection. Scand J Gastroenterol 1997; 32: 70-6.
    • (1997) Scand J Gastroenterol , vol.32 , pp. 70-76
    • Fernandez, I.1    Castellano, G.2    Domingo, M.J.3    Fuertes, A.4    Colina, F.5    Canga, F.6
  • 3
    • 0031035147 scopus 로고    scopus 로고
    • HCV-RNA levels play an important role independently of genotype in predicting response to interferon therapy
    • 3. Picciotto A, Campo N, Brizzolara R, Sinelli N, Poggi G, Grasso S, et al. HCV-RNA levels play an important role independently of genotype in predicting response to interferon therapy. Eur J Gastroenterol Hepatol 1997; 9: 67-9.
    • (1997) Eur J Gastroenterol Hepatol , vol.9 , pp. 67-69
    • Picciotto, A.1    Campo, N.2    Brizzolara, R.3    Sinelli, N.4    Poggi, G.5    Grasso, S.6
  • 4
    • 0029778093 scopus 로고    scopus 로고
    • Circulating HCV-RNA, HCV genotype, and liver histology in asymptomatic individuals reactive for anti-hcv antibody and their follow-up study
    • 4. Okanoue T, Yasui K, Sakamoto S, Minami M, Nagao Y, Itoh Y, et al. Circulating HCV-RNA, HCV genotype, and liver histology in asymptomatic individuals reactive for anti-HCV antibody and their follow-up study. Liver 1996; 16: 241-7.
    • (1996) Liver , vol.16 , pp. 241-247
    • Okanoue, T.1    Yasui, K.2    Sakamoto, S.3    Minami, M.4    Nagao, Y.5    Itoh, Y.6
  • 5
    • 0028915929 scopus 로고
    • Hepatitis C virus (HCV) genotype, tissue HCV antigens, hepatocellular expression of HLA-A,B,C, and intercellular adhesion-1 molecules. Clues to pathogenesis of hepatocellular damage and response to interferon treatment in patients with chronic hepatitis C
    • 5. Ballardini G, Groff P, Pontisso P, Giostra F, Francesconi R, Lenzi M, et al. Hepatitis C virus (HCV) genotype, tissue HCV antigens, hepatocellular expression of HLA-A,B,C, and intercellular adhesion-1 molecules. Clues to pathogenesis of hepatocellular damage and response to interferon treatment in patients with chronic hepatitis C. J Clin Invest 1995; 95: 2067-75.
    • (1995) J Clin Invest , vol.95 , pp. 2067-2075
    • Ballardini, G.1    Groff, P.2    Pontisso, P.3    Giostra, F.4    Francesconi, R.5    Lenzi, M.6
  • 6
    • 0030741807 scopus 로고    scopus 로고
    • Naive and memory T cell infiltrates in chronic hepatitis C: Phenotypic changes with interferon treatment
    • 6. Imada K, Fukuda Y, Koyama Y, Nakano I, Yamada M, Katano Y, et al. Naive and memory T cell infiltrates in chronic hepatitis C: phenotypic changes with interferon treatment. Clin Exp Immunol 1997; 109: 59-66.
    • (1997) Clin Exp Immunol , vol.109 , pp. 59-66
    • Imada, K.1    Fukuda, Y.2    Koyama, Y.3    Nakano, I.4    Yamada, M.5    Katano, Y.6
  • 7
    • 0027228023 scopus 로고
    • Changes in hepatitis C virus antigen in liver with antiviral therapy
    • 7. Di Bisceglie AM, Hoofnagle JH, Krawczynski K. Changes in hepatitis C virus antigen in liver with antiviral therapy. Gastroenterology 1993; 105: 858-62.
    • (1993) Gastroenterology , vol.105 , pp. 858-862
    • Di Bisceglie, A.M.1    Hoofnagle, J.H.2    Krawczynski, K.3
  • 8
    • 0028835980 scopus 로고
    • Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif
    • 8. Cerny A, McHutchison JG, Pasquinelli C, Brown ME, Brothers MA, Grabscheid B, et al. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif. J Clin Invest 1995; 95: 521-30.
    • (1995) J Clin Invest , vol.95 , pp. 521-530
    • Cerny, A.1    McHutchison, J.G.2    Pasquinelli, C.3    Brown, M.E.4    Brothers, M.A.5    Grabscheid, B.6
  • 9
    • 0029778817 scopus 로고    scopus 로고
    • Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection
    • 9. Rehermann B, Chang KM, McHutchison JG, Kokka R, Houghton M, Chisari FV. Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection. J Clin Invest 1996; 98: 1432-40.
    • (1996) J Clin Invest , vol.98 , pp. 1432-1440
    • Rehermann, B.1    Chang, K.M.2    McHutchison, J.G.3    Kokka, R.4    Houghton, M.5    Chisari, F.V.6
  • 10
    • 0027319205 scopus 로고
    • Compartmentalization of T lymphocytes to the site of disease: Intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C
    • 10. Minutello MA, Pileri P, Unutmaz D, Censini S, Kuo G, Houghton M, et al. Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C. J Exp Med 1993; 178: 17-25.
    • (1993) J Exp Med , vol.178 , pp. 17-25
    • Minutello, M.A.1    Pileri, P.2    Unutmaz, D.3    Censini, S.4    Kuo, G.5    Houghton, M.6
  • 12
    • 0027494373 scopus 로고
    • Peripheral-blood mononuclear cell responses to recombinant hepatitis C virus antigens in patients with chronic hepatitis C
    • 12. Schupper H, Hayashi P, Scheffel J, Aceituno S, Paglieroni T, Holland PV, et al. Peripheral-blood mononuclear cell responses to recombinant hepatitis C virus antigens in patients with chronic hepatitis C. Hepatology 1993; 18: 1055-60.
    • (1993) Hepatology , vol.18 , pp. 1055-1060
    • Schupper, H.1    Hayashi, P.2    Scheffel, J.3    Aceituno, S.4    Paglieroni, T.5    Holland, P.V.6
  • 13
    • 0029811057 scopus 로고    scopus 로고
    • T-and B-cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus-positive blood donors without viremia
    • 13. Lechmann M, Ihlenfeldt HG, Braunschweiger I, Giers G, Jung G, Matz B, et al. T-and B-cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus-positive blood donors without viremia. Hepatology 1996; 24: 790-5.
    • (1996) Hepatology , vol.24 , pp. 790-795
    • Lechmann, M.1    Ihlenfeldt, H.G.2    Braunschweiger, I.3    Giers, G.4    Jung, G.5    Matz, B.6
  • 14
    • 0029151623 scopus 로고
    • Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection
    • 14. Diepolder HM, Zachoval R, Hoffmann RM, Wierenga EA, Santantonio T, Jung MC, et al. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 1995; 346: 1006-7.
    • (1995) Lancet , vol.346 , pp. 1006-1007
    • Diepolder, H.M.1    Zachoval, R.2    Hoffmann, R.M.3    Wierenga, E.A.4    Santantonio, T.5    Jung, M.C.6
  • 16
    • 0027957464 scopus 로고
    • T-cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections
    • 16. Ferrari C, Valli A, Galati L, Penna A, Scaccaglia P, Giuberti T, et al. T-cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections. Hepatology 1994; 19: 286-95.
    • (1994) Hepatology , vol.19 , pp. 286-295
    • Ferrari, C.1    Valli, A.2    Galati, L.3    Penna, A.4    Scaccaglia, P.5    Giuberti, T.6
  • 17
    • 0030997098 scopus 로고    scopus 로고
    • Quantification and genotyping of serum HCV-RNA in patients with chronic hepatitis C undergoing interferon treatment
    • 17. Gerken G, Knolle P, Jakobs S, Meyer zum Büschenfelde K-H. Quantification and genotyping of serum HCV-RNA in patients with chronic hepatitis C undergoing interferon treatment. Arch Virol 1997; 142: 459-64.
    • (1997) Arch Virol , vol.142 , pp. 459-464
    • Gerken, G.1    Knolle, P.2    Jakobs, S.3    Meyer Zum Büschenfelde, K.-H.4
  • 18
    • 0027178527 scopus 로고
    • Typing of hepatitis C virus isolates and characterisation of new subtypes using a line probe assay
    • 18. Stuyver L, Rossau R, Wyseur A, Dzuhamel LM, Vanderborght B, van Heuverswyn H, et al. Typing of hepatitis C virus isolates and characterisation of new subtypes using a line probe assay. J Gen Virol 1993; 74: 1105-13.
    • (1993) J Gen Virol , vol.74 , pp. 1105-1113
    • Stuyver, L.1    Rossau, R.2    Wyseur, A.3    Dzuhamel, L.M.4    Vanderborght, B.5    Van Heuverswyn, H.6
  • 19
    • 0029739817 scopus 로고    scopus 로고
    • Liver-infiltrating and circulating CD4+ T cells in chronic hepatitis C: Immunodominant epitopes, HLA-restriction and functional significance
    • 19. Lörh HF, Schlaak JF, Kollmannsperger S, Dienes HP, Meyer zum Büschenfelde KH, Gerken G. Liver-infiltrating and circulating CD4+ T cells in chronic hepatitis C: immunodominant epitopes, HLA-restriction and functional significance. Liver 1996; 16: 174-82.
    • (1996) Liver , vol.16 , pp. 174-182
    • Lörh, H.F.1    Schlaak, J.F.2    Kollmannsperger, S.3    Dienes, H.P.4    Meyer Zum Büschenfelde, K.H.5    Gerken, G.6
  • 20
    • 0030790664 scopus 로고    scopus 로고
    • Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection
    • 20. Diepolder HM, Gerlach JT, Zachoval R, Hoffmann RM, Jung MC, Wierenga EA, et al. Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection. J Virol 1997; 71: 6011-9.
    • (1997) J Virol , vol.71 , pp. 6011-6019
    • Diepolder, H.M.1    Gerlach, J.T.2    Zachoval, R.3    Hoffmann, R.M.4    Jung, M.C.5    Wierenga, E.A.6
  • 21
    • 0029558878 scopus 로고
    • Infection of circulating and liver infiltrating T cells by hepatitis C virus of different subtypes
    • 21. Artini M, Nisini R, Missale G, Costanzo A, Accapezzato D, Balsano C, et al. Infection of circulating and liver infiltrating T cells by hepatitis C virus of different subtypes. Viral Immunol 1995; 8: 63-73.
    • (1995) Viral Immunol , vol.8 , pp. 63-73
    • Artini, M.1    Nisini, R.2    Missale, G.3    Costanzo, A.4    Accapezzato, D.5    Balsano, C.6
  • 22
    • 0029122171 scopus 로고
    • HCV replication in mononuclear cells stimulates anti-HCV-secreting B cells and reflects nonresponsiveness to interferon-alpha
    • 22. Löhr HF, Goergen B, Meyer zum Büschenfelde KH, Gerken G. HCV replication in mononuclear cells stimulates anti-HCV-secreting B cells and reflects nonresponsiveness to interferon-alpha. J Med Virol 1995; 46: 314-20.
    • (1995) J Med Virol , vol.46 , pp. 314-320
    • Löhr, H.F.1    Goergen, B.2    Meyer Zum Büschenfelde, K.H.3    Gerken, G.4
  • 23
    • 0028173126 scopus 로고
    • Effects of therapy with interferon-alpha on peripheral blood lymphocyte subsets and NK activity in patients with chronic hepatitis C
    • 23. Appasamy R, Bryant J, Hassanein T, Van Thiel DH, Whiteside TL. Effects of therapy with interferon-alpha on peripheral blood lymphocyte subsets and NK activity in patients with chronic hepatitis C. Clin Immunol Immunopathol 1994; 73: 350-7.
    • (1994) Clin Immunol Immunopathol , vol.73 , pp. 350-357
    • Appasamy, R.1    Bryant, J.2    Hassanein, T.3    Van Thiel, D.H.4    Whiteside, T.L.5
  • 24
    • 0028221369 scopus 로고
    • Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology
    • 24. Löhr HF, Schlaak JF, Gerken G, Fleischer B, Dienes HP, Meyer zum Büschenfelde KH. Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology. Liver 1994; 14: 161-6.
    • (1994) Liver , vol.14 , pp. 161-166
    • Löhr, H.F.1    Schlaak, J.F.2    Gerken, G.3    Fleischer, B.4    Dienes, H.P.5    Meyer Zum Büschenfelde, K.H.6
  • 25
    • 0029810790 scopus 로고    scopus 로고
    • Progressive liver injury in chronic hepatitis C virus infection correlates with increased intrahepatic expression of Th1-associated cytokines
    • 25. Napoli J, Bishop GA, McGuiness PH, Painter DM, McGaughan GW. Progressive liver injury in chronic hepatitis C virus infection correlates with increased intrahepatic expression of Th1-associated cytokines. Hepatology 1996; 24: 759-65.
    • (1996) Hepatology , vol.24 , pp. 759-765
    • Napoli, J.1    Bishop, G.A.2    McGuiness, P.H.3    Painter, D.M.4    McGaughan, G.W.5
  • 26
    • 0031026553 scopus 로고    scopus 로고
    • Detection of type 2-like T-helper cells in hepatitis C virus infection: Implications for hepatitis C virus chronicity
    • 26. Tsai SL, Liaw YF, Chen MH, Huang CY, Kuo GC. Detection of type 2-like T-helper cells in hepatitis C virus infection: implications for hepatitis C virus chronicity. Hepatology 1997; 25: 449-58.
    • (1997) Hepatology , vol.25 , pp. 449-458
    • Tsai, S.L.1    Liaw, Y.F.2    Chen, M.H.3    Huang, C.Y.4    Kuo, G.C.5
  • 27
    • 0029117193 scopus 로고
    • Interferon gamma production by peripheral blood lymphocytes to hepatitis C virus core protein in chronic hepatitis C infection
    • 27. Iwata K, Wakita T, Okumura A, Yoshioka K, Takayanagi M, Wands JR, et al. Interferon gamma production by peripheral blood lymphocytes to hepatitis C virus core protein in chronic hepatitis C infection. Hepatology 1995; 22: 1057-64.
    • (1995) Hepatology , vol.22 , pp. 1057-1064
    • Iwata, K.1    Wakita, T.2    Okumura, A.3    Yoshioka, K.4    Takayanagi, M.5    Wands, J.R.6
  • 28
    • 0031570824 scopus 로고    scopus 로고
    • CD30 induction and cytokine profiles in hepatitis C virus core-specific peripheral blood T lymphocytes
    • 28. Woitas RP, Lechmann M, Jung G, Kaiser R, Sauerbruch T, Spengler U. CD30 induction and cytokine profiles in hepatitis C virus core-specific peripheral blood T lymphocytes. J Immunol 1997; 159: 1012-8.
    • (1997) J Immunol , vol.159 , pp. 1012-1018
    • Woitas, R.P.1    Lechmann, M.2    Jung, G.3    Kaiser, R.4    Sauerbruch, T.5    Spengler, U.6
  • 29
    • 0031017478 scopus 로고    scopus 로고
    • Genetic analysis of the hepatitis C virus (HCV) genome from HCV-infected human T cells
    • 29. Sugiyama K, Kato N, Mizutani T, Ikeda M, Tanaka T, Shimotohno K. Genetic analysis of the hepatitis C virus (HCV) genome from HCV-infected human T cells. J Gen Virol 1997; 78: 329-36.
    • (1997) J Gen Virol , vol.78 , pp. 329-336
    • Sugiyama, K.1    Kato, N.2    Mizutani, T.3    Ikeda, M.4    Tanaka, T.5    Shimotohno, K.6
  • 30
    • 0027097077 scopus 로고
    • Replication of the hepatitis C virus in peripheral blood mononuclear cells
    • 30. Quian C, Camps J, Maluenda MD, Civeira MP, Prieto J. Replication of the hepatitis C virus in peripheral blood mononuclear cells. J Hepatol 1992; 16: 380-3.
    • (1992) J Hepatol , vol.16 , pp. 380-383
    • Quian, C.1    Camps, J.2    Maluenda, M.D.3    Civeira, M.P.4    Prieto, J.5
  • 31
    • 0030249520 scopus 로고    scopus 로고
    • The quantitative humoral immune response to the hepatitis C virus is correlated with disease activity and response to interferon-alpha
    • 31. Löhr HF, Elste C, Dienes HP, Michel G, Braun HB, Meyer zum Büschenfelde KH, et al. The quantitative humoral immune response to the hepatitis C virus is correlated with disease activity and response to interferon-alpha. J Hepatol 1996; 25: 292-300.
    • (1996) J Hepatol , vol.25 , pp. 292-300
    • Löhr, H.F.1    Elste, C.2    Dienes, H.P.3    Michel, G.4    Braun, H.B.5    Meyer Zum Büschenfelde, K.H.6
  • 32
    • 0028081347 scopus 로고
    • Significance of IgG and IgM HCV antibody secretion in vitro in patients with chronic hepatitis C: Correlation with disease activity and response to interferon-alpha
    • 32. Löhr H, Nagel C, Dienes HP, Simpson B, Michel G, Goergen B, et al. Significance of IgG and IgM HCV antibody secretion in vitro in patients with chronic hepatitis C: correlation with disease activity and response to interferon-alpha. Hepatology 1994; 20: 1383-9.
    • (1994) Hepatology , vol.20 , pp. 1383-1389
    • Löhr, H.1    Nagel, C.2    Dienes, H.P.3    Simpson, B.4    Michel, G.5    Goergen, B.6
  • 33
    • 0028863107 scopus 로고
    • Significance of anti-hepatitis C virus core IgM antibodies in patients with chronic hepatitis C
    • 33. Pawlotsky JM, Darthuy F, Remire J, Pellet C, Udin L, Stuyver L, et al. Significance of anti-hepatitis C virus core IgM antibodies in patients with chronic hepatitis C. J Med Virol 1995; 47: 285-91.
    • (1995) J Med Virol , vol.47 , pp. 285-291
    • Pawlotsky, J.M.1    Darthuy, F.2    Remire, J.3    Pellet, C.4    Udin, L.5    Stuyver, L.6
  • 34
    • 0031041092 scopus 로고    scopus 로고
    • Antibody production against hepatitis C virus core and nonstructural 3 proteins is highly sensitive to deficits in T-cell function
    • 34. Ando Y, Sonnerborg A, Barkholt L, Birkett A, Ericzon BG, Sallberg M. Antibody production against hepatitis C virus core and nonstructural 3 proteins is highly sensitive to deficits in T-cell function. Clin Diagn Lab Immunol 1997; 4: 104-6.
    • (1997) Clin Diagn Lab Immunol , vol.4 , pp. 104-106
    • Ando, Y.1    Sonnerborg, A.2    Barkholt, L.3    Birkett, A.4    Ericzon, B.G.5    Sallberg, M.6
  • 35
    • 0031024880 scopus 로고    scopus 로고
    • Humoral immune response to the hyper-variable region of hepatitis C virus differs between genotypes 1b and 2a
    • 35. Yoshioka K, Aiyama T, Okumura A, Takayanagi M, Iwata K, Ishikawa T, et al. Humoral immune response to the hyper-variable region of hepatitis C virus differs between genotypes 1b and 2a. J Infect Dis 1997; 175: 505-10.
    • (1997) J Infect Dis , vol.175 , pp. 505-510
    • Yoshioka, K.1    Aiyama, T.2    Okumura, A.3    Takayanagi, M.4    Iwata, K.5    Ishikawa, T.6
  • 36
    • 0031043398 scopus 로고    scopus 로고
    • Hepatitis C viral quasispecies and liver damage in patients with chronic hepatitis C virus infection
    • 36. Hayashi J, Kishihara Y, Yamaji K, Furusyo N, Yamamoto T, Pae Y, et al. Hepatitis C viral quasispecies and liver damage in patients with chronic hepatitis C virus infection. Hepatology 1997; 25: 697-701.
    • (1997) Hepatology , vol.25 , pp. 697-701
    • Hayashi, J.1    Kishihara, Y.2    Yamaji, K.3    Furusyo, N.4    Yamamoto, T.5    Pae, Y.6
  • 38
    • 0030848161 scopus 로고    scopus 로고
    • Induction of a CD8+cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help
    • 38. Bennett SR, Carbone FR, Karamalis F, Miller JF, Heath WR. Induction of a CD8+cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help. J Exp Med 1997; 186: 65-70.
    • (1997) J Exp Med , vol.186 , pp. 65-70
    • Bennett, S.R.1    Carbone, F.R.2    Karamalis, F.3    Miller, J.F.4    Heath, W.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.