Antibody production against hepatitis C virus core and nonstructural 3 proteins is highly sensitive to deficits in T-cell function

Clinical and Diagnostic Laboratory Immunology

Volumn 4, Issue 1, 1997, Pages 104-106

  Ando, Yoko ^a   Sönnerborg, Anders ^a   Barkholt, Lisbeth ^a   Birkett, Ashley ^b   Ericzon, Bo Göran ^a   Sällberg, Matti ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Immune Complex Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; SYNTHETIC PEPTIDE; VIRUS ANTIBODY; VIRUS PROTEIN;

ANTIBODY PRODUCTION; ARTICLE; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME IMMUNOASSAY; HEPATITIS C; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0031041092     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/cdli.4.1.104-106.1997     Document Type: Article

References (16)

1. Chazouilleres, O., M. Kim, C. Combs, L. Ferrell, P. Bacchetti, J. Roberts, N. L. Ascher, P. Neuwald, J. Wilber, M. Urdea, S. Quan, R. Sanchez-Pescador, and T. L. Wright. 1994. Quantitation of hepatitis C virus RNA in liver transplant recipients. Gastroenterology 106:994-999.
2. Chen, M., A. Sönnerborg, and M. Sällberg. 1995. Levels of hepatitis C virus (HCV) RNA in serum and their relationship to levels of immunoglobulin M and G antibodies against HCV core protein. J. Clin. Microbiol. 33:778-780.
3. Chiba, J., H. Ohba, Y. Matsuura, Y. Watanabe, T. Katayama, S. Kikuchi, I. Saito, and T. Miyamura. 1991. Serodiagnosis of hepatitis C virus (HCV) infection with an HCV core protein molecularly expressed by a recombinant baculovirus. Proc. Natl. Acad. Sci. USA 88:4641-4645.
4. Cribier, B., D. Rey, C. Schmitt, J. M. Lang, A. Kirn, and F. Stoll-Keller. 1995. High hepatitis C viraemia and impaired antibody response in patients coinfected with HIV. AIDS 9:1131-1136.
5. Diepolder, H. M., R. Zachoval, R. M. Hoffmann, E. A. Wierenga, T. Santantonio, M. C. Jung, D. Eichenlaub, and G. R. Pape. 1995. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 346:1005-1007.
6. Hagiwara, H., N. Hayashi, E. Mita, T. Takehara, A. Kasahara, H. Fusamoto, and T. Kamada. 1993. Quantitative analysis of hepatitis C virus RNA in serum during interferon alpha therapy. Gastroenterology 104:877-883.
7. Jin, L., and D. Peterson. 1995. Expression, isolation, and characterization of the hepatitis C virus ATPase/RNA helicase. Arch. Biol. Chem. 323:47-53.
8. Nasoff, M. S., S. L, Zebedee, G. Inchauspe, and A. M. Prince. 1991. Identification of an immunodominant epitope within the capsid protein of hepatitis C virus. Proc. Natl. Acad. Sci. USA 88:5462-5466.
9. Okamoto, H., F. Tsuda, A. Machida, E. Munekata, Y. Akahane, Y. Sugai, K. Mashiko, T. Mitsui, T. Tanaka, Y. Miyakawa, and M. Mayumi. 1992. Antibodies against synthetic oligopeptides deduced from the putative core gene for the diagnosis of hepatitis C virus infection. Hepatology 15:180-186.
10. Sällberg, M, U. Ruden, B. Wahren, and L. O. Magnius. 1992. Immune response to a single peptide containing an immunodominant region of hepatitis C virus core protein: the isotypcs and the recognition site. Immunol. Lett. 33:27-34.
11. Sällberg, M, U. Ruden, B. Wahren, and L. O. Magnius. 1993. Antigenic regions within the hepatitis C virus envelope 1 and non-structural proteins: identification of an IgG3 restricted recognition site within the envelope 1 protein. Clin. Exp. Immunol. 91:489-494.
12. Shindo, M., A. M. Di Bisceglie, L. Cheung, J. W.-K. Shih, K. Cristiano, S. M. Feinstone, and J. H. Hoofnagle. 1991. Decrease in serum hepatitis C viral RNA during alpha-interferon therapy for chronic hepatitis C. Ann. Intern. Med. 115:700-704.
13. Urushihara, A., T. Sodeyama, A. Matsumoto, and E. Tanaka. 1994. Changes in antibody liters to hepatitis C virus following interferon therapy for chronic infection. J. Med. Virol. 42:348-356.
14. Yun, Z. B., G. Lindh, O. Weiland, B. Johansson, and A. Sönnerborg. 1993. Detection of hepatitis C virus RNA by PCR related to HCV antibodies in serum and liver hostology in Swedish blood donors. J. Med. Virol. 39:57-61.
15. Zhang, Z. X., M. Chen, K. Wallhagen, J. Trojnar, L. O. Magnius, B. Wahren, and M. Sällberg. 1994. Molecular basis for antibody cross-reactivity between the hepatitis C virus core protein and the host-derived GOR protein. Clin. Exp. Immunol. 96:403-409.
16. Zhang, Z. X., M. Chen, A. Sönnerborg, O. Weiland, and M. Sällberg. 1995. Distinguishing acute from symptomatic chronic hepatitis C virus (HCV) infection by site-directed serology of the HCV structural proteins. J. Infect. Dis. 171:1356-1359.