Acid sphingomyelinase-derived ceramide is not required for inflammatory cytokine signalling in murine macrophages

Cytokine

Volumn 10, Issue 9, 1998, Pages 654-661

  Manthey, Carl L ^a   Schuchman, Edward H ^b  

^a AMGEN INC   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Ceramide; Interleukin 1; Macrophages; Signalling; Sphingomyelinase; Tumour necrosis factor

Indexed keywords

CERAMIDE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROTEIN KINASE; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BONE MARROW; CONTROLLED STUDY; EARLY RESPONSE GENE; ENZYME INDUCTION; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALIA; MURINAE;

EID: 0032168147     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1998.0344     Document Type: Article

References (41)

1. + progenitors in human bone marrow. J Immunol 149:2681-2688.
2. 2. Riches DWH, Chan ED, Winston BW (1996) TNF-α-induced regulation and signalling in macrophages. Immunobiology 195:477-490.
3. 3. Ding, AJ, Nathan CF, Stuehr DJ (1988) Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J Immunol 141:2407-2412.
4. 4. Descoteaux A, Matlashewski G (1990) Regulation of tumor necrosis factor gene expression and protein synthesis in murine macrophages treated with recombinant tumor necrosis factor. J Immunol 145:846-853.
5. 5. Hori K, Milhich E, Ehrke MJ (1989) Role of tumor necrosis factor and interleukin 1 in gamma-interferon-promoted activation of mouse tumoricidal macrophages. Cancer Res 49:2606-2614.
6. 6. Strieter RM, Chensue SW, Basha MA, Standiford TJ, Lynch JP III, Baggiolini M, Kunkel SL (1990) Human alveolar macrophage gene expression of interleukin-8 by tumor necrosis factor-α, lipopolysaccharide, and interleukin-1β. Am J Respir Cell Mol Biol 2:321-326.
7. 7. Ghezzi P, Dinarello CA (1988) IL-1 induces IL-1: III. Specific inhibition of IL-1 production by IFN-γ. J Immunol 140:4238-4244.
8. 8. Wiegmann K, Schütze S, Machleidt T, Witte D, Krönke M (1994) Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell 78:1005-1015.
9. 9. Mathias S, Younes A, Kan C-C, Orlow I, Joseph C, Kolesnick RN (1993) Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1β. Science 259:519-522.
10. 10. Schutze S, Potthoff K, Machleidt T, Berkovic D, Wiegmann K, Krönke M (1992) TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell 71:1-20.
11. 11. Schütze S, Machleidt T, Krönke M (1994) The role of diacyglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction. J Leukocyte Biol 56:533-541.
12. 12. Adam-Klages S, Adam K, Wiegmann K, Struve S, Kolanus W, Schneider-Mergener J, Krönke M (1996) Fan, a novel WD-repeat protein couples the p55 TNFα-receptor to neutral sphingomyelinase. Cell 86:937-947.
13. 13. Machleidt T, Wiegmann K, Henkel T, Schutze S, Baeuerle P, Kronke M (1994) Sphingomyelinase activates proteolytic 1κB-α degradation in a cell-free system. J Biol Chem 269:13760-13765.
14. 14. Yang Z, Costanzo M, Golde DW, Kolesnick RN (1993) Tumor necrosis factor activation of the sphingomyelinase pathway signals nuclear factor KB translocation in intact HL-60 cells. J Biol Chem 268:20520-20523.
15. 15. Raines MA, Kolesnick RN, and Golde DW (1993) Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells. J Biol Chem 268:14572-14575.
16. 16. Moder V, Zimmerman GA, Prescott SM, McIntyre TM (1996) Endothelial cell inflammatory responses to tumor necrosis factor α: ceramide-dependent and independent mitogen-activated protein kinase cascades. J Biol Chem 271:13094-13102.
17. 17. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA, Brenner DA (1995) Ceramide activates the stress-activated protein kinases. J Biol Chem 270:22689-22692.
18. 18. Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, Haimovitz-Friedman A, Fuks Z, Kolesnick RN (1996) Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380:75-79.
19. 19. Bettaieb A, Record M, Come MG, Bras AC, Chap H, Leurent G (1996) Opposite effects of tumor necrosis factor alpha on the sphingomyelin-ceramide pathway in two myeloid leukemia cell lines: role of transverse sphingomyelin distribution in the plasma membrane. Blood 88:1465-1472.
20. 20. Huwiler A, Brunner J, Hummel R, Vervoordeldonk M, Stabel S, van den Bosch H, Pfeilschifter J (1996) Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase. Proc Natl Acad Sci USA 93:6959-6963.
21. 21. Belka C, Wiegmann K, Adam D, Holland R, Neuloh M, Herrmann F, Krönke M, Brach MA (1995) Tumor necrosis factor (TNF)-α activates c-raf-1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase. EMBO J 14:1156-1165.
22. 22. Zhang YH, Yao B, Helikat S, Bayoumy S, Lin XH, Basu S, McGinley M, Chan-Hui PY, Lichenstein H, Kolesnick R (1997) Kinase suppressor of Ras is ceramide-activated protein kinase. Cell 89:63-72.
23. 23. Liu ZG, Hsu H, Goeddel DV, Karin M (1996) Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87:565-576.
24. 24. Schievella AR, Chen JH, Graham JR, Lin L-L (1997) MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase. J Biol Chem 272:12069-12075.
25. 25. Kolesnick RN (1987) 1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells. J Biol Chem 262:16759-16762.
26. 26. Kim M-Y, Lindardic C, Obeid L, Hannun Y (1991) Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-interferon: specific role in cell differentiation. J Biol Chem 266:484-489.
27. 27. Zumbansen M, Stoffel W (1997) Tumor necrosis factor α activates NF-κB in acid sphingomyelinase-deficient mouse embryonic fibroblasts. J Biol Chem 272:10904-10909.
28. 28. Kuno K, Sukegawa K, Ishikawa Y, Orii T, Matsushima K (1994) Acid sphingomyelinase is not essential for the IL-1 and tumor necrosis factor receptor signaling pathway leading to NFκB activation. Int Immunol 6:1269-1272.
29. 29. Higuchi M, Singh S, Jaffrezou JP, Aggarwal BB (1996) Acidic sphingomyelinase-generated ceramide is needed but not sufficient for TNFα-induced apoptosis and nuclear factor-kappa B activation. J Immunol 157:297-304.
30. 30. Welsh N (1996) Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F. J Biol Chem 271:8307-8312.
31. 31. Horinouchi K, Erlich S, Perl DP, Ferlinz K, Bisgaier CL, Sandhoff K, Desnick RJ, Stewart CL, Schuchman EH (1995) Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease. Nature Genet 10:288-293.
32. 32. Schnyder-Candrian S, Strieter RM, Kunkel SL, Walz A (1995) Interferon-alpha and interferon-gamma down-regulate the production of interleukin-8 and ENA-78 in human monocytes. J Leukocyte Biol. 57:929-935.
33. 33. Barber SA, Fultz MJ, Salkowski CA, Vogel SN. (1995) Differential expression of IRF-1, IEF-2, and ICSBP genes in LPS-responsive and LPS-hyporesponsive macrophages. Infect Immun 63:601-606.
34. 34. Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ, Davis RJ (1995) Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 270:7420-7426.
35. 35. Goldring CE, Reveneau S, Algarte M, Jeannin JF (1996) In vivo footprinting of the mouse inducible nitric oxide synthase gene: inducible protein occupation of numerous sites including Oct and NF-IL-6. Nucleic Acids Res 24:1682-1687.
36. 36. Tsukada J, Saito K, Waterman WR, Auron PE (1994) Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin-1 beta gene. Molecular and Cellular Biology 14:7285-7297.
37. 37. Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ (1997) Activation of the transcription factor MEF2C by the map kinase p38 in inflammation. Nature 386:296-299.
38. 38. Su B, Karin M (1996) Mitogen-activated protein kinase cascades and regulation of gene expression. Curr Opin Immunol 8:402-411.
39. 39. Santana P, Llanes L, Hernadez I, Gonzalez-Robayna I, Tabraue C, Gonzalez-Reyes J, Quintana J, Estevez F, Ruiz-de-Galarreta CM, Fanjul LF (1996) Interleukin-1 beta stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis. Endocrinology 137:2480-2489.
40. 40. Chen J, Nikolova-Karakashian M, Merril AH, Morgan ET (1995) Regulation of cytochrome P450 2C11 (CYP2C11) gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes. J Biol Chem 270:25233-25238.
41. 41. Santana P, Pena LA, Haimovitz-Friedman A, Martin S, Green D, McLoughlin M, Cordon-Cardo C, Shuchman EH, Fuks Z, Kolesnick R (1996) Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 86:189-199.