Tubulin and FtsZ structures: Functional and therapeutic implications

BioEssays

Volumn 20, Issue 7, 1998, Pages 523-527

  Desai, Arshad ^a   Mitchison, Timothy J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CYTOSKELETON PROTEIN; FTSZ PROTEIN, BACTERIA; GUANOSINE TRIPHOSPHATE; PACLITAXEL; TUBULIN;

ARTICLE; BINDING SITE; CELL DIVISION; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DIMERIZATION; METABOLISM; PHYSIOLOGY; PROKARYOTIC CELL; PROTEIN CONFORMATION;

BACTERIAL PROTEINS; BINDING SITES; CELL DIVISION; CYTOSKELETAL PROTEINS; DIMERIZATION; GUANOSINE TRIPHOSPHATE; MODELS, MOLECULAR; PACLITAXEL; PROKARYOTIC CELLS; PROTEIN CONFORMATION; TUBULIN;

EID: 0032128172     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-1878(199807)20:7<523::AID-BIES1>3.0.CO;2-L     Document Type: Article

References (33)

1. Nogales E, Wolf SG, Downing KH (1998) Structure of the αß tubulin dimer by electron crystallography. Nature 391:199-203.
2. Löwe J, Amos LA (1998) Crystal structure of the bacterial cell-division protein FtsZ. Nature 391:203-206.
3. Larsson H, Wallin M, Edstrom A (1976) Induction of a sheet polymer of tubulin by Zn2+. Exp Cell Res 100:104-10.
4. Baker TS, Amos LA (1978) Structure of the tubulin dimer in zinc-induced sheets. J Mol Biol 123:89-106.
5. Amos LA, Baker TS (1979) The three-dimensional structure of tubulin protofilaments. Nature 279:607-612.
6. Nogales E, Wolf SG, Zhang SX, Downing KH (1995) Preservation of 2-D crystals of tubulin for electron crystallography. J Struct Biol 115:199-208.
7. Nogales E, Wolf SG, Downing KH (1997) Visualizing the secondary structure of tubulin: Three-dimensional map at 4 A. J Struct Biol 118:119-127.
8. Wolf SG, Nogales E, Kikkawa M, Gratzinger D, Hirokawa N, Downing KH (1996) Interpreting a medium-resolution model of tubulin: Comparison of zinc-sheet and microtubule structure. J Mol Biol 262:485-501.
9. Downing KH, Jontes J (1992) Projection map of tubulin in zinc-induced sheets at 4 A resolution. J Struct Biol 109:152-159.
10. Bramhill D (1997) Bacterial cell division. Annu Rev Cell Dev Biol 13:395-424.
11. Erickson HP (1995) FtsZ, a prokaryotic homolog of tubulin? Cell 80:367-370.
12. Erickson HP, Taylor DW, Taylor KA, Bramhill D (1996) Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers. Proc Natl Acad Sci USA 93:519-523.
13. Mukherjee A, Lutkenhaus J (1997) Dynamic assembly of FtsZ regulated by GTP hydrolysis. EMBO J 17:462-469.
14. Rossmann MG, Moras D, Olsen KW (1974) Chemical and biological evolution of nucleotide-binding protein. Nature 250:194-199.
15. Saraste M, Sibbald PR, Wittinghofer A (1990) The P-loop: A common motif in ATP- and GTP-binding proteins. Trends Biochem Sci 15:430-434.
16. Sosa H, Dias DP, Hoenger A, Whittaker M, Wilson-Kubalek E, Sablin E, Fletterick RJ, Vale RD, Milligan RA (1997) A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis. Cell 90:217-224.
17. Desai A, Mitchison TJ (1997) Microtubule polymerization dynamics. Annu Rev Cell Dev Biol 13:83-117.
18. Mitchison TJ (1993) Localization of an exchangeable GTP binding site at the plus end of microtubules. Science 261:1044-1047.
19. Melki R, Carlier MF, Pantaloni D, Timasheff SN (1989) Cold depolymerization of microtubules to double rings: Geometric stabilization of assemblies. Biochemistry 28:9143-9152.
20. Lu C, Erickson HP (1997) Straight and curved protofilaments of FtsZ, a bacterial cell division protein and tubulin homolog, related to GTP/GDP. Mol Biol Cell 8suppl:253a.
21. Cox MM (1994) Why does RecA protein hydrolyze ATP? Trends Biochem Sci 19:217-222.
22. Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT (1971) Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 93:2325-2327.
23. Horwitz SB (1994) Taxol (paclitaxel): Mechanisms of action. Ann Oncol 5 Suppl 6:S3-S6.
24. Felgner H, Frank R, Schliwa M (1996) Flexural rigidity of microtubules measured with the use of optical tweezers. J Cell Sci 109:509-516.
25. Venier P, Maggs AC, Carlier MF, Pantaloni D (1994) Analysis of microtubule rigidity using hydrodynamic flow and thermal fluctuations. J Biol Chem 269:13353-13360.
26. Long HJ (1994) Paclitaxel (Taxol): A novel anticancer chemotherapeutic drug. Mayo Clin Proc 69:341-345.
27. Casazza AM, Fairchild CR (1996) Paclitaxel (taxol): Mechanisms of Resistance. Cancer Treat Res 87:149-171.
28. Parekh H, Simpkins H (1997) The transport and binding of taxol. Gen Pharmacol 29:167-172
29. Giannakakou P, Sackett DL, Kang YK, Zhan Z, Buters JT, Fojo T, Poruchynsky MS (1997) Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization. J Biol Chem 272:17118-17125.
30. Nicolaou KC, Winssinger N, Pastor J, Ninkovic S, Sarabia F, He Y, Vourloumis D, Yang Z, Li T, Giannakakou P, Hamel E (1997) Synthesis of epothilones A and B in solid and solution phase. Nature 387: 268-272.
31. Kowalski RJ, Giannakakou P, Hamel E (1997) Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (taxol) J Biol Chem 272:2534-2541.
32. Lindel T, Jensen PR, Fenical W, Long BH, Casazza AM, Carboni J, Fairchild CR (1997) Eleutherobin, a new cytotoxin that mimics paclitaxel (taxol) by stabilizing microtubules. J Am Chem Soc 119:8744-8745.
33. Hung DT, Chen J, Schreiber SL (1996) (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chem Biol 3:287-293.