A New 12-Kilodalton Dimer Associated with Pre-TCR Complex and Clonotype-Independent CD3 Complex on Immature Thymocytes

Journal of Immunology

Volumn 159, Issue 2, 1997, Pages 741-747

  Takase, Kan ^a,b   Wakizaka, Keisuke ^a   Von Boehmer, Harald ^d   Wada, Ikuo ^c   Moriya, Hideshige ^b   Saito, Takashi ^a  

^a CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c SAPPORO MEDICAL UNIVERSITY   (Japan)

^d INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL; ARTICLE; C57BL MOUSE; CAPPING PHENOMENON; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; DIMERIZATION; IMMUNOLOGY; METABOLISM; MOUSE; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD3; CELL DIFFERENTIATION; CELL LINE; DIMERIZATION; MICE; MICE, INBRED C57BL; RECEPTOR AGGREGATION; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0031570833     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Levelt, C. N., and K. Eichmann. 1995. Receptors and signals in early thymic selection. Immunity 3:667.
2. Groettrup, M., and H. von Boehmer. 1993. A role for a pre-T-cell receptor in T-cell development. Immunol. Today 14:610.
3. Uematsu, Y., S. Ryser, Z. Dembic, P. Borgulya, P. Krimpenfort, A. Berns, H. von Boehmer, and M. Steinmetz. 1988. In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes. Cell 52:214.
4. Hahu, S., M. Kimura, M. Katsuki, K. Hioki, and T. Nomuta. 1987. Correlation of T cell receptor gene rearrangements to T cell surface antigen expression and to serum immunoglobulin level in seid mice. Eur. J. Immunol. 17:1467.
5. Shores, E. W., S. O. Sharrow, I. Uppenkamp, and A. Singer. 1990 T cell receptor negative thymocytes from Seid mice can be induced to enter the CD4/CD8 differentiation pathway. Eur. J. Immunol. 20:69.
6. Mombaerts, P., J. Lacomini, R. S. Johnson, K. Herrup, S. Tonegawa, and V. E. Papaioannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68:869.
7. Shinkai, Y., G. Rathbun, K. P. Lam, E. M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, K. Young, A. M. Stall, and F. W. Alt. 1992. RAG2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68:855.
8. Mombaerts, P., A. R. Clarke, M. A. Rudnicki, J. Iacomini, S. Itohara, J. J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, M. L. Hooper, and S. Tonegawa. 1992. Mutations in T-cell antigen receptor genes a and β block thymocyte development at different stages. Nature 360:225.
9. von Boehmer, H. 1990. Developmental biology of T cells in T cell receptor transgenic mice. Annu. Rev. Immunol. 8:531.
10. Shinkai, Y., S. Kuyasu, K. Nakayama, K. M. Murphy, D. Y. Loh, E. L. Reinherz, and F. W. Alt. 1992. Restoration of T cell development in RAG2-deficient mice by functional TCR transgenes. Science 259:822.
11. Punt, J. A., R. T. Kubo, T. Saito, T. H. Finkel, S. Kathiresan, K. J. Blank, and Y. Hashimoto. 1991. Surface expression of a T cell receptor β (TCR-β) chain in the absence of TCR-α, -δ and -γ proteins. J. Exp. Med. 174:775.
12. Groettrup, M., A. Baron, G. Griffiths, R. Palacios, and H. von Boehmer. 1992. T cell receptor (TCR) β chain homodimers on the surface of immature but not mature α,γ,δ-chain-deficient T cell lines. EMBO J. 11:2735.
13. Groettrup, M., K. Ungewiss, O. Azogui, R. Palacios, M. J. Owen, A. C. Hayday, and H. von Boehmer. 1993. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kD glycoprotein. Cell 75:283.
14. Saint-Ruf, C., K. Ungewiss, M. Groettrup, L. Bruno, H. J. Fehling, and H. von Boehmer. 1994. Analysis and expression of a cloned pre-T cell receptor gene. Science 266:1208.
15. Fehling, H. J., A. Krotkova, C. Saint-Ruf, and H. von Boehmer. 1995. Crucial role of the pre-T-cell receptor a gene in development of αβ but not γδ T cells. Nature 375:795.
16. Wiest, D. L., K. P. Kearse, E. W. Shores, and A. Singer. 1994. Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes. J. Exp. Med. 180:1375.
17. Levelt, C. N., A. Ehrfeld, and K. Eichmann. 1993. Regulation of thymocyte development through CD3. I. Timepoint ligation of CD3∈ determines clonal deletion or induction of developmental program. J. Exp. Med. 177:707.
18. Levelt, C. N., P. Mombaerts, A. Iglesias, S. Tonegawa, and K. Eichmann. 1993. Restoration of early thymocyte differentiation in T-cell receptor β-chain deficient mutant mice by transmembrane signaling through CD3∈. Proc. Natl. Acad. Sci. USA 90:11401.
19. -/- mice in the absence of TCR β chain expression. Int. Immunol. 7:995.
20. Kuwabara, I., H. Ohno, J A. Punt, Y. Hashimoto, and T. Saito. 1994. Transition from TCR-β dimer to TCR-αβ-expressing cells by introduction of α-chain in an immature thymocyte cell line. J. Immunol. 152:2148.
21. Kubo, R., W. Born, J. W. Kappler, and M. Pigeon. 1989. Characterization of a monoclonal antibody which detects all murine α/β T cell receptors. J. Immunol. 142:2736.
22. Leo, O., M. Foo, D. H. Sachs, L. E. Samelson, and J. A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84:1374.
23. Ra, C., M. H. Jouvin, and J. P. Kinet. 1989. Complete structure of the mouse mast cell receptor for IgE (Fc∈RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells. J. Biol. Chem. 264:15323.
24. Ahluwalia, N., J. J. Bergeron, I. Wada, E. Degen, and D. B. Williams. 1996. The p88 molecular chaperone is identical to the endoplasmic reticulum membrane protein, calnexin. J. Biol. Chem. 270:10914.
25. Chirgwin, J. M., A. E. Przybyla, R. J. McDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J. Biochem. 18:5294.
26. Miyake, K., I. L. Weissman, J. S. Greenberger, and P. W. Kincade. 1991. Evidence for a role of the integrin VLA-4 in lymphohemopoiesis. J. Exp. Med. 173:599.
27. Wiest, D. L., W. H. Burgess, D. McKean, K. P. Kearse, and A. Singer. 1995. The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotypic-independent CD3 complexes. EMBO J. 14: 3425.
28. Orloff, D. G., C. Ra, S. J. Frank, R. D. Klausner, and J. P. Kinet. 1990. Family of disulfide-linked dimers containing the ζ and η chains of the T cell receptor and γ chain of Fc receptors. Nature 347:189.
29. Koyasu, S., L. D'Adamio, A. R. N. Arulanandam, S. Abraham, L. K. Clayton, and E. L. Reinherz. 1992. T cell receptor complexes containing FcRIγ homodimers in lieu of CD3ζ and CD3η components: a novel isoform expressed on large granular lymphocytes. J. Exp. Med. 175:203.
30. Park, S. Y., H. Arase, K. Wakizaka, N. Hirayama, S. Masaki, S. Sato, J. V. Ravetch, and T. Saito. 1995. Differential contribution of the FcRγ chain for the surface TCR expression among T cells localized in epithelia: analysis of FcRγ-deficient mice. Eur. J. Immunol. 25:2107.
31. Ohno, H., S. Ono, N. Hirayama, S. Shimada, and T. Saito. 1994. Preferential usage of the Fc receptor γ chain in the T cell antigen receptor complex by γ/δ T cells localized in epithelia. J. Exp. Med. 179:365.
32. Jacobs, H., D. Vandeputte, L. Tolkamp, E. de Vries, J. Borst, and A. Berns. 1994. CD3 components al the cell surface of pro-T cells can mediate pre-T cell development in vivo. Eur. J. Immunol. 24:934.
33. van Oers, N. S. C., H. von Boehmer, and A. Weiss. 1995. The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-ζ subunit. J. Exp. Med. 182: 1585.
34. + thymocytes in the absence of clonotypic T cell antigen receptor. Eur. J. Immunol. 26:1012.
35. 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes. EMBO J. 6:2267.