Neurodegeneration and aging: Role of the second genome

Journal of Neuroscience Research

Volumn 52, Issue 1, 1998, Pages 1-6

  Graeber, Manuel B ^a   Grasbon Frodl, Eva ^a,b   Eitzen, Ulrich V ^b   Kösel, Siegfried ^b  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Alzheimer's disease; Mitochondria; Neurodegenerative disorders; Parkinson's disease

Indexed keywords

MITOCHONDRIAL DNA;

AGING; ALZHEIMER DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE MUTATION; GENETIC PREDISPOSITION; LIFE EXPECTANCY; MITOCHONDRIAL RESPIRATION; NERVE CELL DEGENERATION; NEUROPATHOLOGY; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SHORT SURVEY;

AGED; AGING; ALZHEIMER DISEASE; DNA, MITOCHONDRIAL; HUMANS; MITOCHONDRIA; NERVE DEGENERATION; PARKINSON DISEASE;

EID: 0032053584     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19980401)52:1<1::AID-JNR1>3.0.CO;2-I     Document Type: Short Survey

References (69)

1. Anderson S, Bankier AT, Barrell BG, De Bruijn MHL, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJH, Staden R, Young IG (1981): Sequence and organization of the human mitochondrial genome. Nature 290:457-470.
2. Attardi G, Yoneda M, Chomyn A (1995): Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems. Biochim Biophys Acta 1271:241-248.
3. Bertoni-Freddari C, Fattoretti P, Casoli T, Spagna C, Meier-Ruge W, Ulrich J (1993): Morphological plasticity of synaptic mitochondria during aging. Brain Res 628:193-200.
4. Calleja M, Pena P, Ugalde C, Ferreiro C, Marco R, Garesse R (1993): Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced. J Biol Chem 268:18891-18897.
5. Chandrasekaran K, Giordano T, Brady DR, Stoll J, Martin LJ, Rapoport SI (1994): Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease. Mol Brain Res 24:336-340.
6. Chen JJ, Yu BP (1996): Detoxification of reactive aldehydes in mitochondria: effects of age and dietary restriction. Aging 8:334-340.
7. Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, Beal MF, Wallace DC (1992): Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nature 2:324-329.
8. Cortopassi G, Liu Y (1995): Genotypic selection of mitochondrial and oncogenic mutations in human tissue suggests mechanisms of age-related pathophysiology. Mutat Res 338:151-159.
9. Cortopassi G, Wang E (1995): Modelling the effects of age-related mtDNA mutation accumulation; complex I deficiency, superoxide and cell death. Biochim Biophys Acta 1271:171-176.
10. Craig EE, Hood DA (1997): Influence of aging on protein import into cardiac mitochondria. Am J Physiol 41:H2983-H2988.
11. Davis RE, Miller S, Herrnstadt C, Ghosh SS, Fahy E, Shinobu LA, Galasko D, Thal LJ, Beal MF, Howell N, Parker WD (1997): Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Proc Natl Acad Sci USA 94:4526-4531.
12. de Grey, AD (1997): A proposed refinement of the mitochondrial free radical theory of aging. Bioessays 19:161-166.
13. DiMauro S (1996): Mitochondrial encephalomyopathies: what next? J Inherit Metab Dis 19:489-503.
14. DiMauro S, Wallace DC (eds) (1993): "Mitochondrial DNA in Human Pathology." New York: Raven Press.
15. Egensperger R, Kösel S, Schnopp NM, Mehraein P, Graeber MB (1997): Association of the mitochondrial tRNA A4336G mutation with Alzheimer's and Parkinson's diseases. Neuropathol Appl Neurobiol 23:315-321.
16. Eimon PM, Chung SS, Lee CM, Weindruch R, Aiken JM (1996): Age-associated mitochondrial DNA deletions in mouse skeletal muscle: comparison of different regions of the mitochondrial genome. Dev Genet 18:107-113.
17. Fattoretti P, Bertoni-Freddari C, Caselli U, Paoloni R, Meier-Ruge W (1996): Morphologic changes in cerebellar mitochondria during aging. Anal Quant Cytol Histol 18:205-208.
18. Finkel E (1997): Piecing together the puzzle of ageing. Lancet 350:1150.
19. Furukawa Y, Shimadzu M, Rajput AH, Shimizu Y, Tagawa T, Mori H, Yokochi M, Narabayashi H, Hornykiewicz O, Mizuno Y, Kish SJ (1996): GTP-cyclohydrolase I gene mutations in hereditary progressive and dopa-responsive dystonia. Ann Neurol 39:609-617.
20. Gabbita SP, Butterfield DA, Hensley K, Shaw W, Carney JM (1997): Aging and caloric restriction affect mitochondrial respiration and lipid membrane status - an electron paramagnetic resonance investigation. Free Rad Biol Med 23:191-201.
21. Graeber MB, Müller U (1998): Recent developments in the molecular genetics of mitochondrial disorders. J Neurol Sci (in press).
22. Graeber MB, Kupke KG, Müller U (1992): Delineation of the dystonia-parkinsonism syndrome locus in Xq 13. Proc Natl Acad Sci USA 89:8245-8248.
23. Hagen TM, Yowe DL, Bartholomew JC, Wehr CM, Do KL, Park JY, Ames BN (1997): Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc Natl Acad Sci USA 94:3064-3069.
24. Hayashi J, Ohta S, Kagawa Y, Kondo H, Kaneda H, Yonekawa H, Takai D, Miyabayashi S (1994): Nuclear but not mitochondrial genome involvement in human age-related mitochondrial dysfunction. Functional integrity of mitochondrial DNA from aged subjects. J Biol Chem 269:6878-6883.
25. Hill KA, Singh SM (1997): The evolution of species-type specificity in the global DNA sequence organization of mitochondrial genomes. Genome 40:342-356.
26. Hofmann S, Jaksch M, Bezold R, Mertens S, Aholt S, Paprotta A, Gerbitz KD (1997): Population genetics and disease susceptibility: characterization of central European haplogroups by mtDNA gene mutations, correlation with D loop variants and association with disease. Hum Mol Genet 6:1835-1846.
27. Holt IJ, Harding AE, Morgan-Hughes JA (1988): Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature 331:717-719.
28. Hutchin T, Cortopassi G (1995): A mitochondrial DNA clone is associated with increased risk for Alzheimer disease. Proc Natl Acad Sci USA 92:6892-6895.
29. Ikebe S, Tanaka M, Ozawa T (1995): Point mutations of mitochondrial genome in Parkinson's disease. Mol Brain Res 28:281-295.
30. Janetzky B, Hauck S, Youdim MBH, Riederer P, Jellinger K, Pantucek F, Zochling R, Boissl KW, Reichmann H (1994): Unaltered aconitase activity, but decreased complex I activity in Substantia nigra pars compacta of patients with Parkinson's disease. Neurosci Lett 169:126-128.
31. Jun AS, Brown MD, Wallace DC (1994): A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH dehydrogenase subunit 6 gene associated with maternally inherited Leber hereditary optic neuropathy and dystonia. Proc Natl Acad Sci USA 91:6206-6210.
32. Kalous M, Drahota Z (1996): The role of mitochondria in aging. Physiol Res 45:351-359.
33. Kapsa RM, Jean-Francois MJ, Lertrit P, Weng S, Siregar N, Ojaimi J, Donnan G, Masters C, Byrne E (1996): Mitochondrial DNA polymorphism in substantia nigra. J Neurol Sci 144:204-211.
34. Kösel S, Grasbon-Frodl EM, Mautsch U, Egensperger R, von Eitzen U, Frishman D, Hofmann S, Gerbitz KD, Mehraein P, Graeber MB (1997): Novel mutations of mitochondrial complex I in pathologically proven Parkinson disease. Neurogenet 1: (in press).
35. Kösel S, Grasbon-Frodl EM, Graeber MB (1998): A new approach to the genetic analysis of nervous system diseases: retrospective genotyping of archival brains. Prog Brain Res (in press).
36. Kowald A, Kirkwood TB (1993): Mitochondrial mutations, cellular instability and ageing: modelling the population dynamics of mitochondria. Mutat Res 295:93-103.
37. Langston JW, Ballard P, Tetrud JW, Irwin I (1983): Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219:979-980.
38. Linnane AW, Degli EM, Generowicz M, Luff AR, Nagley P (1995): The universality of bioenergetic disease and amelioration with redox therapy. Biochim Biophys Acta 1271:191-194.
39. Liu VW, Zhang C, Linnane AW, Nagley P (1997): Quantitative allele-specific PCR: demonstration of age-associated accumulation in human tissues of the A → G mutation at nucleotide 3243 in mitochondrial DNA. Hum Mutat 9:265-271.
40. Luft R (1994): The development of mitochondrial medicine. Proc Natl Acad Sci USA 91:8731-8738.
41. McNaught KS, Thull U, Carrupt PA, Altomare C, Cellamare S, Carotti A, Testa B, Jenner P, Marsden CD (1996): Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration. Biochem Pharmacol 51:1503-1511.
42. Mizuno Y, Ohta S, Tanaka M, Takamiya S, Suzuki K, Sato T, Oya H, Ozawa T, Kagawa Y (1989): Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease. Biochem Biophys Res Commun 163:1450-1455.
43. Moraes CT (1996): Mitochondrial disorders. Curr Opin Neurol 9:369-374.
44. Ozawa T (1997): Genetic and functional changes in mitochondria associated with aging. Physiol Rev 77:425-464.
45. Parker WD, Jr, Parks J, Filley CM, Kleinschmidt-DeMasters BK (1994): Electron transport chain defects in Alzheimer's disease brain. Neurology 44:1090-1096.
46. Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL (1997): Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047.
47. Poyton RO, McEwen JE (1996): Crosstalk between nuclear and mitochondrial genomes. Annu Rev Biochem 65:563-607.
48. Richter C (1995): Oxidative damage to mitochondrial DNA and its relationship to ageing. Int J Biochem Cell Biol 27:647-653.
49. Roses AD (1996): The Alzheimer diseases. Curr Opin Neurobiol 6:644-650.
50. Roses AD (1997): A model for susceptibility polymorphisms for complex diseases: apolipoprotein E and Alzheimer disease. Neurogenetics 1:3-11.
51. Sastre J, Pallardo FV, Pla R, Pellin A, Juan G, O'Connor JE, Estrela JM, Miquel J, Vina J (1996): Aging of the liver: age-associated mitochondrial damage in intact hepatocytes. Hepatology 24: 1199-1205.
52. Schapira AHV, Cooper JM, Dexter D, Jenner P, Clark JB, Marsden CD (1989): Mitochondrial complex I deficiency in Parkinson's disease. Lancet i:1269.
53. Schapira AHV, Mann VM, Cooper JM, Dexter D, Daniel SE, Jenner P, Clark JB, Marsden CD (1990): Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease. J Neurochem 55:2142-2145.
54. Schatz G (1994): Mitochondria - the next 100 years. KargerGazette 58:1-2.
55. Shoffner JM, Lott MT, Voljavec AS, Soueidan SA, Costigan DA, Wallace DC (1989): Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy. Proc Natl Acad Sci USA 86:7952-7956.
56. Shoffner JM, Brown MD, Torroni A, Lott MT, Cabell MF, Mirra SS, Beal MF, Yang CC, Gearing M, Salvo R, Watts RL, Juncos JL, Hansen LA, Crain BJ, Fayad M, Reckord CL, Wallace DC (1993): Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients. Genomics 17:171-184.
57. Sims NR (1996): Energy metabolism, oxidative stress and neuronal degeneration in Alzheimer's disease. Neurodegeneration 5:435-440.
58. Soong NW, Hinton DR, Cortopassi G, Arnheim N (1992): Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nature 2:318-323.
59. Swerdlow RH, Parks JK, Miller SW, Tuttle JB, Trimmer PA, Sheehan JP, Bennett JPJ, Davis RE, Parker WDJ (1996): Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol 40:663-671.
60. Takai D, Inoue K, Shisa H, Kagawa Y, Hayashi J (1995): Age-associated changes of mitochondrial translation and respiratory function in mouse brain. Biochem Biophys Res Commun 217:668-674.
61. Thart LM, Jansen JJ, Lemkes HHPJ, Deknijff P, Maassen JA (1996): Heteroplasmy levels of a mitochondrial gene mutation associated with diabetes mellitus decrease in leucocyte DNA upon aging. Hum Mutat 7:193-197.
62. Tysoe C, Robinson D, Brayne C, Dening T, Paykel ES, Huppert FA, Rubinsztein DC (1996): The tRNA(Gln) 4336 mitochondrial DNA variant is not a high penetrance mutation which predisposes to dementia before the age of 75 years. J Med Genet 33:1002-1006.
63. Wachsman JT (1996): The beneficial effects of dietary restriction: reduced oxidative damage and enhanced apoptosis. Mutat Res 350:25-34.
64. Wallace DC (1994): Mitochondrial DNA sequence variation in human evolution and disease. Proc Natl Acad Sci USA 91:8739-8746.
65. Wallace DC, Singh G, Lott MT, Hodge JA, Schurr TG, Lezza AMS, Elsas LJ, Nikoskelainen EK (1988): Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. Science 242:1427-1430.
66. Wei YH, Kao SH, Lee HC (1996a): Simultaneous increase of mitochondrial DNA deletions and lipid peroxidation in human aging. Ann NY Acad Sci 786:24-43.
67. Wei YH, Pang CY, You BJ, Lee HC (1996b): Tandem duplications and large-scale deletions of mitochondrial DNA are early molecular events of human aging process. Ann NY Acad Sci 786:82-101.
68. Wragg MA, Talbot CJ, Morris JC, Lendon CL, Goate AM (1995): No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant. Neurosci Lett 201:107-110.
69. Zhang C, Linnane AW, Nagley P (1993): Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans. Biochem Biophys Res Commun 195:1104-1110.