Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration

Biochemical Pharmacology

Volumn 51, Issue 11, 1996, Pages 1503-1511

  McNaught, Kevin St P ^a   Thull, Ulrike ^b   Carrupt, Pierre Alain ^b   Altomare, Cosimo ^c   Cellamare, Saverio ^c   Carotti, Angelo ^c   Testa, Bernard ^b   Jenner, Peter ^a   Marsden, C David ^d  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c UNIVERSITY OF BARI   (Italy)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

1,2,3,4 tetrahydroisoquinoline; 1 methyl 4 phenyl 1,2,3,6 tetrahydropyridine; 1 methyl 4 phenylpyridinium; 3 dimensional quantitative structure activity relationship; Comparative molecular field analysis; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ISOQUINOLINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; DOPAMINERGIC SYSTEM; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVITY; LIPOPHILICITY; MITOCHONDRIAL RESPIRATION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; ASCORBIC ACID; GLUTAMIC ACID; ISOQUINOLINES; MALATES; MALE; MITOCHONDRIA, LIVER; OXYGEN CONSUMPTION; RATS; RATS, WISTAR; ROTENONE; STRUCTURE-ACTIVITY RELATIONSHIP; SUCCINATES; TETRAMETHYLPHENYLENEDIAMINE;

EID: 0030070870     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00091-3     Document Type: Article

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