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Volumn 184, Issue 4, 1998, Pages 348-350

Why is p53 protein stabilized in neoplasia? some answers but many more questions!

Author keywords

Imlm2; KET; P53; P73; Protein protein interaction; protein stability

Indexed keywords

MDM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN MDM2; PROTEIN P53; TUMOR PROTEIN;

EID: 0032038751     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199804)184:4<348::AID-PATH1227>3.0.CO;2-O     Document Type: Article
Times cited : (48)

References (35)
  • 1
    • 0026578054 scopus 로고
    • P53 in tumour pathology: Can ve trust immunohistochemistry?
    • Wynford-Thomas D. p53 in tumour pathology: can ve trust immunohistochemistry? J Pathai 1992; 166: 329-330.
    • (1992) J Pathai , vol.166 , pp. 329-330
    • Wynford-Thomas, D.1
  • 2
    • 0028299342 scopus 로고
    • P53 in tumour pathology: Can we trust immunohistochemistry?-revisited!
    • Hall PA, Lane DP. p53 in tumour pathology: can we trust immunohistochemistry?-revisited! J Palhol 1994; 172: 1 4.
    • (1994) J Palhol , vol.172 , pp. 14
    • Hall, P.A.1    Lane, D.P.2
  • 3
    • 0028363282 scopus 로고
    • The clinical utility of the immunocytochemical detection of p53 protein in cytological specimens
    • Dowcll SP, Derias N, Wilson POG. Lane DP, Hall PA. The clinical utility of the immunocytochemical detection of p53 protein in cytological specimens. Cancer Res 1994; 54: 2914-2918.
    • (1994) Cancer Res , vol.54 , pp. 2914-2918
    • Dowcll, S.P.1    Derias, N.2    Wilson, P.O.G.3    Lane, D.P.4    Hall, P.A.5
  • 4
    • 0027489384 scopus 로고
    • Clinical implications of the p53 tumor-suppressor gene
    • Harris CC, Hollstein M. Clinical implications of the p53 tumor-suppressor gene. A' Engl J Med 1993; 329: 1318 1327.
    • (1993) A' Engl J Med , vol.329 , pp. 13181327
    • Harris, C.C.1    Hollstein, M.2
  • 5
    • 0030460978 scopus 로고    scopus 로고
    • The p53 response to ionising radiation in adult and developing murine tissues
    • MacCallum DE. Hupp TR, Midgley CA, el al. The p53 response to ionising radiation in adult and developing murine tissues. Oncogene 1996; 13: 2575-2587.
    • (1996) Oncogene , vol.13 , pp. 2575-2587
    • MacCallum, D.E.1    Hupp, T.R.2    Midgley, C.A.3
  • 6
    • 0031940937 scopus 로고    scopus 로고
    • P53 expression above the basal cell layer in oral mucosa is an early event of malignant transformation and has predictive value for developing oral squamous cell carcinoma
    • Cruz IB, Snijders PJ, Meijer CJ, el al. p53 expression above the basal cell layer in oral mucosa is an early event of malignant transformation and has predictive value for developing oral squamous cell carcinoma. J Pathol 1998; 184..
    • (1998) J Pathol , pp. 184
    • Cruz, I.B.1    Snijders, P.J.2    Meijer, C.J.3
  • 7
    • 0030237476 scopus 로고    scopus 로고
    • P53: Integrating the complexity
    • Hall PA, Meek D, Lane DP. p53: integrating the complexity. J Patlml 1996: 180: 1 5.
    • (1996) J Patlml , vol.180 , pp. 15
    • Hall, P.A.1    Meek, D.2    Lane, D.P.3
  • 8
    • 0029972806 scopus 로고    scopus 로고
    • P53: Puzzle and paradigm
    • Ko LJ. Prives C. p53: puzzle and paradigm. Genes Der 1996; 10: 1054 1072.
    • (1996) Genes Der , vol.10 , pp. 10541072
    • Ko, L.J.1    Prives, C.2
  • 9
    • 0030941458 scopus 로고    scopus 로고
    • P53. the cellular gatekeeper for growth and division
    • Levine AJ. p53. the cellular gatekeeper for growth and division. Cell 1997: 88: 323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 10
    • 0029802591 scopus 로고    scopus 로고
    • P53 levels, functional domains and DNA damage determine the extent of the apoptotic response of tumo ir cells
    • Chen X, Ko LJ, Jayararman L, Prives C. p53 levels, functional domains and DNA damage determine the extent of the apoptotic response of tumo ir cells. Genes Dev 1996; 10: 2438-2451.
    • (1996) Genes Dev , vol.10 , pp. 2438-2451
    • Chen, X.1    Ko, L.J.2    Jayararman, L.3    Prives, C.4
  • 11
    • 0029814061 scopus 로고    scopus 로고
    • Anti-apoptotic activity of low levt Is of wild-type p53
    • Lassus P. Ferlin M, Piette J, Hibner U. Anti-apoptotic activity of low levt Is of wild-type p53. EMBO J 1996; 15: 4566-573.
    • (1996) EMBO J , vol.15 , pp. 4566573
    • Lassus, P.1    Ferlin, M.2    Piette, J.3    Hibner, U.4
  • 12
    • 0028845158 scopus 로고
    • Small peptides activate the latent sequencespecific DNA binding function of p53
    • Hupp TR, Sparks A, Lane DP. Small peptides activate the latent sequencespecific DNA binding function of p53. Cell 1995: 83: 237-245.
    • (1995) Cell , vol.83 , pp. 237-245
    • Hupp, T.R.1    Sparks, A.2    Lane, D.P.3
  • 14
    • 0030983331 scopus 로고    scopus 로고
    • Participation of the human p53 3'UTR in translations! repression and activation following gamma-irradiation
    • Fu L, Benchimol S. Participation of the human p53 3'UTR in translations! repression and activation following gamma-irradiation. EMBO J 1997; 1 >: 4117-125.
    • (1997) EMBO J , vol.1 , pp. 4117-4125
    • Fu, L.1    Benchimol, S.2
  • 15
    • 0028455516 scopus 로고
    • Post-translational modification of p53
    • Meek DW. Post-translational modification of p53. Sentin Cancer Bioi 1994; 5: 203-210.
    • (1994) Sentin Cancer Bioi , vol.5 , pp. 203-210
    • Meek, D.W.1
  • 16
    • 0030448760 scopus 로고    scopus 로고
    • Cytoplasmical y sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptidc
    • Ostermeyer AG, Runko E, Winkfield B, Ahn B. Moll UM. Cytoplasmical y sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptidc. Proc Natl Acad Sei USA 1996; 93: 15 190-15 194.
    • (1996) Proc Natl Acad Sei USA , vol.93 , pp. 15190-15194
    • Ostermeyer, A.G.1    Runko, E.2    Winkfield, B.3    Ahn, B.4    Moll, U.M.5
  • 17
    • 0030048389 scopus 로고    scopus 로고
    • Zambe ti G. Cytoplasmic sequestration of wild-tvpe p53 protein impairs the Gl checkpoint after DNA damage
    • Moll UM. Ostermeyer AG, Haladay R. Winkfield B. Frazier M. Zambe ti G. Cytoplasmic sequestration of wild-tvpe p53 protein impairs the Gl checkpoint after DNA damage. Mol Ceil Biol 1996; 16: 1126-1137.
    • (1996) Mol Ceil Biol , vol.16 , pp. 1126-1137
    • Moll, U.M.1    Ostermeyer, A.G.2    Haladay, R.3    Winkfield, B.4    Frazier, M.5
  • 18
    • 0030942625 scopus 로고    scopus 로고
    • Regulation of DNA binding and transactivation of p53 in nuclear localisation and phosphoryUtion
    • Martinez JD. Craven MT. Joseloff E. Bowden GT. Regulation of DNA binding and transactivation of p53 in nuclear localisation and phosphoryUtion. Oncogene 1997; 14: 2511-2520.
    • (1997) Oncogene , vol.14 , pp. 2511-2520
    • Martinez, J.D.1    Craven, M.T.2    Joseloff, E.3    Bowden, G.T.4
  • 19
    • 0030800922 scopus 로고    scopus 로고
    • Maréchal V. mdm2: Keeping p53 under control
    • Piette J. Neel H, Maréchal V. mdm2: keeping p53 under control. Oncoge.ie 1997: 15: 1001-1010.
    • (1997) Oncoge.ie , vol.15 , pp. 1001-1010
    • Piette, J.1    Neel, H.2
  • 20
    • 0027222956 scopus 로고
    • Mapping of the p53 and mdm2 interactk n domains
    • Chen J. Maréchal V, Levine AJ. Mapping of the p53 and mdm2 interactk n domains. Mol Cell Biol 1993; 13: 4107-1114.
    • (1993) Mol Cell Biol , vol.13 , pp. 4107-1114
    • Chen, J.1    Maréchal, V.2    Levine, A.J.3
  • 21
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP. Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992; 69: 1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 22
    • 0027244853 scopus 로고
    • The p53-mdm-2 autoregulato-y feedback loop
    • Wu X, Bayle JH, Olson D, Levine AJ. The p53-mdm-2 autoregulato-y feedback loop. Genes Dev 1993: 7: 1126-1132.
    • (1993) Genes Dev , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 23
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by mdm2
    • Kubbutat MH. Jones SN, Vousden KH. Regulation of p53 stability by mdm2. Nature 1997; 387: 299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.1    Jones, S.N.2    Vousden, K.H.3
  • 24
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y, Maya R, Kazaz A, Oren M. mdm2 promotes the rapid degradation of p53. Mature 1997; 387: 296-299.
    • (1997) Mature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 25
    • 0030612360 scopus 로고    scopus 로고
    • MDM2: Arbiter of p53's destruction
    • Lane DP, Hall PA. MDM2: arbiter of p53's destruction. Trends Bim-htm Sei. 1997; 22: 372-374.
    • (1997) Trends Bim-htm Sei. , vol.22 , pp. 372-374
    • Lane, D.P.1    Hall, P.A.2
  • 26
    • 85034197879 scopus 로고    scopus 로고
    • P53 dependent stability in tumour cells is n M determined by mutation but is dependent on mdm2 binding
    • n press
    • Midgley CA, Lane DP. p53 dependent stability in tumour cells is n M determined by mutation but is dependent on mdm2 binding. Oncogene. ( n press).
    • Oncogene
    • Midgley, C.A.1    Lane, D.P.2
  • 27
    • 0030898754 scopus 로고    scopus 로고
    • Point mutations and nucleotic e insertions in thé mdm2 zinc finger structure of human tumours
    • Schlot! T. Reimer S. Jahns A, et al. Point mutations and nucleotic e insertions in thé mdm2 zinc finger structure of human tumours. J Patlvil 1997: 182: 54-61.
    • (1997) J Patlvil , vol.182 , pp. 54-61
    • Schlot, T.1    Reimer, S.2    Jahns, A.3
  • 28
    • 0031588025 scopus 로고    scopus 로고
    • Molecular characterization of the mdm2-p53 interaction
    • Bouger A. Bottger V, Garcia-Echeverria C. et al. Molecular characterization of the mdm2-p53 interaction. J Mol Biol 1997; 269: 744-756.
    • (1997) J Mol Biol , vol.269 , pp. 744-756
    • Bouger, A.1    Bottger, V.2    Garcia-Echeverria, C.3
  • 29
    • 0029760621 scopus 로고    scopus 로고
    • The MDV2 oncoprotein binds specifically to RNA through its ring finger domain
    • Elenbaas B, Dobbelstcin M, Roth J, Shenk T, Levine AJ. The MDV2 oncoprotein binds specifically to RNA through its ring finger domain. M'tl Meil 1996; 2: 439 451.
    • (1996) M'tl Meil , vol.2 , pp. 439451
    • Elenbaas, B.1    Dobbelstcin, M.2    Roth, J.3    Shenk, T.4    Levine, A.J.5
  • 30
    • 10144259344 scopus 로고    scopus 로고
    • MDMX: As novel p53-bindh g protein with some functional properties of MDM2
    • Shvarts A, Steegenga WT, Riteco N, et al. MDMX: as novel p53-bindh g protein with some functional properties of MDM2. EMBO J 1996; 15: 5349-5357.
    • (1996) EMBO J , vol.15 , pp. 5349-5357
    • Shvarts, A.1    Steegenga, W.T.2    Riteco, N.3
  • 31
    • 14444281159 scopus 로고    scopus 로고
    • Targetsd expression of MDM2 uncouples S phase from mitosis and inhibits manmary gland development independent of p53
    • Lundgren K. Montes de Oca Luna R. McNeill YB. et al. Targetsd expression of MDM2 uncouples S phase from mitosis and inhibits manmary gland development independent of p53. Genes Der 1997; 11: 714-725.
    • (1997) Genes Der , vol.11 , pp. 714-725
    • Lundgren, K.1    Montes De Oca Luna, R.2    McNeill, Y.B.3
  • 32
    • 0030892531 scopus 로고    scopus 로고
    • MDM-2 protein is expressed n different layers of normal human skin
    • Dazard J-E, Augias D, Neel H. et al MDM-2 protein is expressed n different layers of normal human skin. Oncogene 1997: 14: 1123-1128.
    • (1997) Oncogene , vol.14 , pp. 1123-1128
    • Dazard, J.-E.1    Augias, D.2    Neel, H.3
  • 33
    • 0030812331 scopus 로고    scopus 로고
    • Monoallelically expressed gene relattd to p53 at Ip36, a region frequently deleted in neuroblastoma and otli:r human cancers
    • Kaghad M. Bonnet H. Yang A, et al. Monoallelically expressed gene relattd to p53 at Ip36, a region frequently deleted in neuroblastoma and otli:r human cancers. Cell 1997; 90: 809-819.
    • (1997) Cell , vol.90 , pp. 809-819
    • Kaghad, M.1    Bonnet, H.2    Yang, A.3
  • 34
    • 0030884751 scopus 로고    scopus 로고
    • A novel protein with strong homology to tl e tumour suppressor p53
    • Schmale H, Bamburger C. A novel protein with strong homology to tl e tumour suppressor p53. Oncogene 1997; 15: 1363-1367.
    • (1997) Oncogene , vol.15 , pp. 1363-1367
    • Schmale, H.1    Bamburger, C.2
  • 35
    • 0031564954 scopus 로고    scopus 로고
    • P73 is a human p53 related protein th.it can induce apoptosis
    • Jost CA. Marin MC. Kaelin WG Jr. p73 is a human p53 related protein th.it can induce apoptosis. Nature 1997; 389: 191-194.
    • (1997) Nature , vol.389 , pp. 191-194
    • Jost, C.A.1    Marin, M.C.2    Kaelin Jr., W.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.