-
1
-
-
0024514565
-
IL-1 induction-capacity of defined lipopolysaccharide partial structures
-
Loppnow H, Brade H, Dürrbaum I, Dinarello CA, Kusumoto S, Rietschel E Th, Flad H-D: IL-1 induction-capacity of defined lipopolysaccharide partial structures. J Immunol 1989, 142:3229-3238.
-
(1989)
J Immunol
, vol.142
, pp. 3229-3238
-
-
Loppnow, H.1
Brade, H.2
Dürrbaum, I.3
Dinarello, C.A.4
Kusumoto, S.5
Rietschel, E.Th.6
Flad, H.-D.7
-
2
-
-
0001045273
-
Structure-function relations of lipid A
-
Edited by Morrison DC, Ryan JL. Boca Raton: CRC Press, Inc
-
Takada H, Kotani S: Structure-function relations of lipid A. In Bacterial Endotoxic Lipopolysaccharides, vol. I. Molecular Biochemistry and Cellular Biology, Edited by Morrison DC, Ryan JL. Boca Raton: CRC Press, Inc; 1992:107-130.
-
(1992)
Bacterial Endotoxic Lipopolysaccharides, Vol. I. Molecular Biochemistry and Cellular Biology
, vol.1
, pp. 107-130
-
-
Takada, H.1
Kotani, S.2
-
3
-
-
0027446922
-
Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14
-
Pugin J, Schurer-Maly CC, Leturcq D, Moriarty A, Ulevitch RJ, Tobias PS: Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc Natl Acad Sci USA 1993, 90:2744-2748.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 2744-2748
-
-
Pugin, J.1
Schurer-Maly, C.C.2
Leturcq, D.3
Moriarty, A.4
Ulevitch, R.J.5
Tobias, P.S.6
-
4
-
-
0027982876
-
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
-
Springer TA: Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994, 76:301-314.
-
(1994)
Cell
, vol.76
, pp. 301-314
-
-
Springer, T.A.1
-
5
-
-
0023079312
-
Endotoxins and disease mechanisms
-
Morrison DC, Ryan JL: Endotoxins and disease mechanisms. Annu Rev Med 1987, 38:417-432.
-
(1987)
Annu Rev Med
, vol.38
, pp. 417-432
-
-
Morrison, D.C.1
Ryan, J.L.2
-
6
-
-
0026088437
-
Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes
-
Golenbock DT, Hampton RY, Qureshi N, Takayama K, Raetz CRH: Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes. J Biol Chem 1991, 266:19490-19498.
-
(1991)
J Biol Chem
, vol.266
, pp. 19490-19498
-
-
Golenbock, D.T.1
Hampton, R.Y.2
Qureshi, N.3
Takayama, K.4
Raetz, C.R.H.5
-
7
-
-
0027957516
-
The significance of the hydrophilic backbone and the hydrophobic fatty acid regions of lipid a for macrophage binding and cytokine induction
-
Kirikae T, Schade FU, Zähringer U, Kirikae F, Brade H, Kusumoto S, Kusama T, Rielschel E Th: The significance of the hydrophilic backbone and the hydrophobic fatty acid regions of lipid A for macrophage binding and cytokine induction. FEMS Immunol Med Microbiol 1994, 8:13-26.
-
(1994)
FEMS Immunol Med Microbiol
, vol.8
, pp. 13-26
-
-
Kirikae, T.1
Schade, F.U.2
Zähringer, U.3
Kirikae, F.4
Brade, H.5
Kusumoto, S.6
Kusama, T.7
Rielschel, E.Th.8
-
8
-
-
0023250759
-
Deacylated lipopolysaccharide inhibits neutrophil adherence to endothelium induced by lipopolysaccharide in vitro
-
Pohlman TH, Munford RS, Harlan JM: Deacylated lipopolysaccharide inhibits neutrophil adherence to endothelium induced by lipopolysaccharide in vitro. J Exp Med 1987, 165:1393-1402.
-
(1987)
J Exp Med
, vol.165
, pp. 1393-1402
-
-
Pohlman, T.H.1
Munford, R.S.2
Harlan, J.M.3
-
9
-
-
0028022163
-
Predominant role of the substituents on the hydroxyl groups of 3-hydroxy fatty acids of non-reducing glucosamine in lipid a for the endotoxic and antagonistic activity
-
Tanamoto K-I: Predominant role of the substituents on the hydroxyl groups of 3-hydroxy fatty acids of non-reducing glucosamine in lipid A for the endotoxic and antagonistic activity. FEBS Lett 1994, 351:325-329.
-
(1994)
FEBS Lett
, vol.351
, pp. 325-329
-
-
Tanamoto, K.-I.1
-
10
-
-
0003341153
-
Bacterial lipopolysaccharides: A remarkable family of bioactive macroamphiphiles
-
edn 2. Edited by Neidhardt FCEA. Washington DC: American Society for Microbiology
-
Raetz CRH: Bacterial lipopolysaccharides: a remarkable family of bioactive macroamphiphiles. In Escherichia coli and Salmonella: Cellular and Molecular Biology, vol 1, edn 2. Edited by Neidhardt FCEA. Washington DC: American Society for Microbiology; 1996:1035-1063.
-
(1996)
In Escherichia Coli and Salmonella: Cellular and Molecular Biology
, vol.1
, pp. 1035-1063
-
-
Raetz, C.R.H.1
-
11
-
-
0022979638
-
Detoxification of bacterial lipopolysaccharides (endotoxins) by a human neutrophil enzyme
-
Munford RS, Hall CL: Detoxification of bacterial lipopolysaccharides (endotoxins) by a human neutrophil enzyme. Science 1986, 234:203-205.
-
(1986)
Science
, vol.234
, pp. 203-205
-
-
Munford, R.S.1
Hall, C.L.2
-
12
-
-
0026653049
-
Lipopolysaccharide antagonists
-
Lynn WA, Golenbock DT: Lipopolysaccharide antagonists. Immunol Today 1992, 13:271-276.
-
(1992)
Immunol Today
, vol.13
, pp. 271-276
-
-
Lynn, W.A.1
Golenbock, D.T.2
-
13
-
-
0027367583
-
Chemical structure of lipid a from Porphyromonas (Bacteroides) gingivalis lipopolysaccharide
-
Ogawa T: Chemical structure of lipid A from Porphyromonas (Bacteroides) gingivalis lipopolysaccharide. FEBS 1993, 332:197-201.
-
(1993)
FEBS
, vol.332
, pp. 197-201
-
-
Ogawa, T.1
-
14
-
-
0028907147
-
Structural study on the free lipid a isolated from lipopolysaccharide of Porphyromonas gingivalis
-
Kumada H, Haishima Y, Umemoto T, Tanamoto K-I: Structural study on the free lipid A isolated from lipopolysaccharide of Porphyromonas gingivalis. J Bacteriol 1995, 177:2098-2106.
-
(1995)
J Bacteriol
, vol.177
, pp. 2098-2106
-
-
Kumada, H.1
Haishima, Y.2
Umemoto, T.3
Tanamoto, K.-I.4
-
15
-
-
0030968308
-
Structure of the monophosphoryl lipid a moiety obtained from the lipopolysaccharide of Chlamydia trachomatis
-
Qureshi N, Kaltashov I, Walker K, Doroshenko V, Cotter RJ, Takayama K, Sievert TR, Rice PA, Lin J-S, Golenbock DT: Structure of the monophosphoryl lipid A moiety obtained from the lipopolysaccharide of Chlamydia trachomatis. J Biol Chem 1997, 272:10594-10600.
-
(1997)
J Biol Chem
, vol.272
, pp. 10594-10600
-
-
Qureshi, N.1
Kaltashov, I.2
Walker, K.3
Doroshenko, V.4
Cotter, R.J.5
Takayama, K.6
Sievert, T.R.7
Rice, P.A.8
Lin, J.-S.9
Golenbock, D.T.10
-
16
-
-
0026657821
-
Lipid a in Helicobacter pylori
-
Mattsby-Baltzer I, Mielniczuk Z, Larsson L, Lindgren K, Goodwin S: Lipid A in Helicobacter pylori. Infect Immun 1992, 60:4383-4387.
-
(1992)
Infect Immun
, vol.60
, pp. 4383-4387
-
-
Mattsby-Baltzer, I.1
Mielniczuk, Z.2
Larsson, L.3
Lindgren, K.4
Goodwin, S.5
-
17
-
-
0000062313
-
Composition and structure of lipopolysaccharides from Pseudomonas aeruginosa
-
Wilkinson SG: Composition and structure of lipopolysaccharides from Pseudomonas aeruginosa. Rev Infect Dis 1983, 5:S941-S949.
-
(1983)
Rev Infect Dis
, vol.5
-
-
Wilkinson, S.G.1
-
18
-
-
0025098547
-
Chemical, immunobiological and antigenic characterizations of lipopolysaccharides from Bacteroides gingivalis strains
-
Fujiwara T, Ogawa T, Sobue S, Hamada S: Chemical, immunobiological and antigenic characterizations of lipopolysaccharides from Bacteroides gingivalis strains. J Gen Microbiol 1990, 136:319-326.
-
(1990)
J Gen Microbiol
, vol.136
, pp. 319-326
-
-
Fujiwara, T.1
Ogawa, T.2
Sobue, S.3
Hamada, S.4
-
19
-
-
0026506169
-
Low biological activity of Helicobacter pylori lipopolysaccharide
-
Muotiala A, Helander IM, Pyhala L, Kosunen TU, Moran AP: Low biological activity of Helicobacter pylori lipopolysaccharide. Infect Immun 1992, 60:1714-1716.
-
(1992)
Infect Immun
, vol.60
, pp. 1714-1716
-
-
Muotiala, A.1
Helander, I.M.2
Pyhala, L.3
Kosunen, T.U.4
Moran, A.P.5
-
20
-
-
0029154722
-
The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated
-
Ingalls RR, Rice PA, Qureshi N, Takayama K, Lin JS, Golenbock DT: The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated. Infect Immun 1995, 63:3125-3130.
-
(1995)
Infect Immun
, vol.63
, pp. 3125-3130
-
-
Ingalls, R.R.1
Rice, P.A.2
Qureshi, N.3
Takayama, K.4
Lin, J.S.5
Golenbock, D.T.6
-
21
-
-
0028902201
-
Ability of bacteria associated with chronic inflammatory disease to stimulate e-selectin expression and promote neutrophil adhesion
-
Darveau RP, Cunningham MD, Bailey T, Seachord C, Ratcliffe K, Bainbridge B, Dietsch M, Page RC, Aruffo A: Ability of bacteria associated with chronic inflammatory disease to stimulate e-selectin expression and promote neutrophil adhesion. Infect Immun 1995, 63:1311-1317.
-
(1995)
Infect Immun
, vol.63
, pp. 1311-1317
-
-
Darveau, R.P.1
Cunningham, M.D.2
Bailey, T.3
Seachord, C.4
Ratcliffe, K.5
Bainbridge, B.6
Dietsch, M.7
Page, R.C.8
Aruffo, A.9
-
22
-
-
0024515391
-
Diphosphoryl lipid a from Rhodopseudomonas sphaeroides ATCC 17023 blocks induction of cachectin in macrophages by lipopolysaccharide
-
Takayama K, Qureshi N, Beutler B, Kirkland TN: Diphosphoryl lipid A from Rhodopseudomonas sphaeroides ATCC 17023 blocks induction of cachectin in macrophages by lipopolysaccharide. Infect Immun 1989, 57:1336-1338.
-
(1989)
Infect Immun
, vol.57
, pp. 1336-1338
-
-
Takayama, K.1
Qureshi, N.2
Beutler, B.3
Kirkland, T.N.4
-
23
-
-
0024423590
-
Human endothelial cell adhesiveness for neutrophils, induced by Escherichia coli lipopolysaccharide in vitro, is inhibited by Bacteroides fragilis lipopolysaccharide
-
Magnuson DK, Weintraub A, Pohlman TH, Maier RV: Human endothelial cell adhesiveness for neutrophils, induced by Escherichia coli lipopolysaccharide in vitro, is inhibited by Bacteroides fragilis lipopolysaccharide. J Immunol 1989, 143:3025-3030.
-
(1989)
J Immunol
, vol.143
, pp. 3025-3030
-
-
Magnuson, D.K.1
Weintraub, A.2
Pohlman, T.H.3
Maier, R.V.4
-
24
-
-
0025166114
-
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
-
Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC: CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990, 249:1431-1433.
-
(1990)
Science
, vol.249
, pp. 1431-1433
-
-
Wright, S.D.1
Ramos, R.A.2
Tobias, P.S.3
Ulevitch, R.J.4
Mathison, J.C.5
-
25
-
-
0027446922
-
Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14
-
Pugin J, Schurer-Maly CC, Leturcq D, Moriarty A, Ulevitch RJ, Tobias PS: Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc Natl Acad Sci USA 1993, 90:2744-2748.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 2744-2748
-
-
Pugin, J.1
Schurer-Maly, C.C.2
Leturcq, D.3
Moriarty, A.4
Ulevitch, R.J.5
Tobias, P.S.6
-
26
-
-
0029758163
-
Helicobacter pylori and Porphyromonas gingivalis lipopolysaccharides are poorly transferred to recombinant soluble CD14
-
Cunningham MD, Seachord C, Ratcliffe K, Bainbridge B, Aruffo A, Darveau RP: Helicobacter pylori and Porphyromonas gingivalis lipopolysaccharides are poorly transferred to recombinant soluble CD14. Infect Immun 1996, 64:3601-3608.
-
(1996)
Infect Immun
, vol.64
, pp. 3601-3608
-
-
Cunningham, M.D.1
Seachord, C.2
Ratcliffe, K.3
Bainbridge, B.4
Aruffo, A.5
Darveau, R.P.6
-
27
-
-
0030760314
-
Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution
-
Beamer LJ, Carroll SF, Eisenberg D: Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution. Science 1997, 276:1861-1864. This article describes the structural characteristics of human bactericidal/permeability increasing protein (BPI) at a crystal structure resolution of 2.4A. BPI is closely related to lipopolysaccharide-binding protein (LBP) and alignment of the amino acid sequences shows that structurally important residues are conserved. BPI was shown to interact with the acyl chains of phosphatidylcholine and it was postulated that both BPI and LBP interact with the acyl chains of lipopolysaccharide. This provides the first evidence of those structural components of lipid A that are recognized by LBP.
-
(1997)
Science
, vol.276
, pp. 1861-1864
-
-
Beamer, L.J.1
Carroll, S.F.2
Eisenberg, D.3
-
28
-
-
0031025738
-
Identification of CD14 residues involved in specific lipopolysaccharide recognition
-
Shapiro RA, Cunningham MD, Ratcliffe K, Seachord C, Blake J, Bajorath J, Aruffo A, Darveau RP: Identification of CD14 residues involved in specific lipopolysaccharide recognition. Infect Immun 1997, 65:293-297. This article was the first to identify single point mutations in CD14 that have significant effects on its ability to bind to lipopolysaccharide (LPS). Specific charge reversal mutations had the greatest effect on LPS binding, pointing out the importance of charge in CD14 recognition of LPS. In addition, it was shown that CD14 can selectively recognize two different LPS species. Although this has therapeutic potential, additional data (RP Darveau, J Bajorath, C Seachord, MC Cunningham, unpublished data) suggest that CD14 presents a charged surface for LPS binding and the importance of specific charge interactions remains unknown.
-
(1997)
Infect Immun
, vol.65
, pp. 293-297
-
-
Shapiro, R.A.1
Cunningham, M.D.2
Ratcliffe, K.3
Seachord, C.4
Blake, J.5
Bajorath, J.6
Aruffo, A.7
Darveau, R.P.8
-
29
-
-
0028893488
-
A region of human CD14 required for lipopolysaccharide binding
-
Viriyakosol S, Kirkland TN: A region of human CD14 required for lipopolysaccharide binding. J Biol Chem 1995, 270:361-368.
-
(1995)
J Biol Chem
, vol.270
, pp. 361-368
-
-
Viriyakosol, S.1
Kirkland, T.N.2
-
30
-
-
0029053828
-
CD14 and innate recognition of bacteria
-
Wright SD: CD14 and innate recognition of bacteria. J Immunol 1995, 155:6-8.
-
(1995)
J Immunol
, vol.155
, pp. 6-8
-
-
Wright, S.D.1
-
31
-
-
0028941601
-
Enzymatically deacylated lipopolysaccharide (LPS) can antagonize LPS at multiple sites in the LPS recognition pathway
-
Kitchens RL, Munford RS: Enzymatically deacylated lipopolysaccharide (LPS) can antagonize LPS at multiple sites in the LPS recognition pathway. J Biol Chem 1995, 270:9904-9910.
-
(1995)
J Biol Chem
, vol.270
, pp. 9904-9910
-
-
Kitchens, R.L.1
Munford, R.S.2
-
32
-
-
0026721675
-
Lipopolysaccharide (LPS) partial structures inhibit responses to LPS in a human macrophage cell line without inhibiting LPS uptake by a CD14-mediated pathway
-
Kitchens RL, Ulevitch RJ, Munford RS: Lipopolysaccharide (LPS) partial structures inhibit responses to LPS in a human macrophage cell line without inhibiting LPS uptake by a CD14-mediated pathway. J Exp Med 1992, 176:485-494.
-
(1992)
J Exp Med
, vol.176
, pp. 485-494
-
-
Kitchens, R.L.1
Ulevitch, R.J.2
Munford, R.S.3
-
33
-
-
0028981285
-
CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition
-
Delude RL, Savedra R Jr, Zhao H, Thieringer R, Yamamoto S, Fenton MJ, Golenbock DT: CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition. Proc Natl Acad Sci USA 1995, 92:9288-9292.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9288-9292
-
-
Delude, R.L.1
Savedra R., Jr.2
Zhao, H.3
Thieringer, R.4
Yamamoto, S.5
Fenton, M.J.6
Golenbock, D.T.7
-
34
-
-
0028273393
-
Characterization of a Rickettsia rickettsii DNa fragment analogous to the fir A-ORF17-lpxa region of Escherichia coli
-
Shaw El, Wood DO: Characterization of a Rickettsia rickettsii DNA fragment analogous to the fir A-ORF17-lpxA region of Escherichia coli. Gene 1994, 14:109-113.
-
(1994)
Gene
, vol.14
, pp. 109-113
-
-
Shaw, El.1
Wood, D.O.2
-
35
-
-
0028031940
-
The novel hexapeptide motif found in the acyltransferases Lpxa and LpxD of lipid a biosynthesis is conserved in various bacteria
-
Vuorio R, Härkönen T, Tolvanen M, Vaara M: The novel hexapeptide motif found in the acyltransferases LpxA and LpxD of lipid A biosynthesis is conserved in various bacteria. FEBS Letters 1994, 337:289-292.
-
(1994)
FEBS Letters
, vol.337
, pp. 289-292
-
-
Vuorio, R.1
Härkönen, T.2
Tolvanen, M.3
Vaara, M.4
-
36
-
-
0030579187
-
Cloning and expression of genes encoding lipid biosynthesis from Haemophilus influenzae type b
-
Servos S, Khan S, Maskell D: Cloning and expression of genes encoding lipid biosynthesis from Haemophilus influenzae type b. Gene 1996, 175:137-141.
-
(1996)
Gene
, vol.175
, pp. 137-141
-
-
Servos, S.1
Khan, S.2
Maskell, D.3
-
37
-
-
0030985685
-
Cloning, expression, and purification of UDP-3-O-Acyl-GlcNAc deacetylase from Pseudomonas aeruginosa: A metalloamidase of the lipid a biosynthesis pathway
-
Hyland SA, Eveland SS, Anderson MS: Cloning, expression, and purification of UDP-3-O-Acyl-GlcNAc deacetylase from Pseudomonas aeruginosa: a metalloamidase of the lipid A biosynthesis pathway. J Bacteriol 1997, 179:2029-2037.
-
(1997)
J Bacteriol
, vol.179
, pp. 2029-2037
-
-
Hyland, S.A.1
Eveland, S.S.2
Anderson, M.S.3
-
38
-
-
0030843585
-
Shortened hydroxyacyl chains on lipid a of Escherichia coli cells expressing a foreign UDP-N-acetylglucosamine O-acyltransferase
-
Odegaard TJ, Kaltashov IA, Cotter RJ, Steeghs L, van der Ley P, Khan S, Maskell DJ, Raetz CR: Shortened hydroxyacyl chains on lipid A of Escherichia coli cells expressing a foreign UDP-N-acetylglucosamine O-acyltransferase. J Biol Chem 1997, 272:19688-19696. These authors constructed the first genetically engineered strain with an altered lipid A fatty acid composition. The authors were able to complement an lpxA mutation in E. coli with the lpxA gene from Neisseria meningitidis. The resultant E. coli strain was viable yet the lipid A contained the shorter fatty acids characteristic of N. meningitidis. This approach to the study of lipid A function in bacteria will be invaluable in the study of lipid A function in host interactions.
-
(1997)
J Biol Chem
, vol.272
, pp. 19688-19696
-
-
Odegaard, T.J.1
Kaltashov, I.A.2
Cotter, R.J.3
Steeghs, L.4
Van Der Ley, P.5
Khan, S.6
Maskell, D.J.7
Raetz, C.R.8
-
39
-
-
0015463122
-
Isolation of a mutant of Salmonella typhimurium dependent on D-Arabinose-5-phosphate for growth and synthesis of 3-deoxy-D-mannoctulosonate (ketodeoxyoctonate)
-
Rick PD, Osborn MJ: Isolation of a mutant of Salmonella typhimurium dependent on D-Arabinose-5-phosphate for growth and synthesis of 3-deoxy-D-mannoctulosonate (ketodeoxyoctonate). Proc Nat Acad Sci USA 1972, 69:3756-3760.
-
(1972)
Proc Nat Acad Sci USA
, vol.69
, pp. 3756-3760
-
-
Rick, P.D.1
Osborn, M.J.2
-
40
-
-
0025220127
-
A mutant of Escherichia coli defective in the first step of endotoxin biosynthesis
-
Galloway SM, Raetz CRH: A mutant of Escherichia coli defective in the first step of endotoxin biosynthesis. J Biol Chem 1990, 169:6394-6402.
-
(1990)
J Biol Chem
, vol.169
, pp. 6394-6402
-
-
Galloway, S.M.1
Raetz, C.R.H.2
-
41
-
-
0023608175
-
Sequence analysis, transcriptional organization, and insertional mutagenesis of the envA gene of Escherichia coli
-
Beall B, Lutkenhaus J: Sequence analysis, transcriptional organization, and insertional mutagenesis of the envA gene of Escherichia coli. J Bacteriol 1987, 169:5408-5415.
-
(1987)
J Bacteriol
, vol.169
, pp. 5408-5415
-
-
Beall, B.1
Lutkenhaus, J.2
-
42
-
-
0017372730
-
The fira gene, a locus involved in the expression of rifampicin resistance in Escherichia coli
-
Lathe R, Lecocq J-P: The firA gene, a locus involved in the expression of rifampicin resistance in Escherichia coli. Mol Gen Genet 1977, 154:43-51.
-
(1977)
Mol Gen Genet
, vol.154
, pp. 43-51
-
-
Lathe, R.1
Lecocq, J.-P.2
-
43
-
-
0018717176
-
Membrane lipid biogenesis in Escherichia coli: Identification of genetic loci for phosphatidylglycerophosphate synthetase and construction of mutants lacking phosphatidylglycerol
-
Nishijima M, Raetz CRH: Membrane lipid biogenesis in Escherichia coli: identification of genetic loci for phosphatidylglycerophosphate synthetase and construction of mutants lacking phosphatidylglycerol. J Biol Chem 1979, 254:7837-7844.
-
(1979)
J Biol Chem
, vol.254
, pp. 7837-7844
-
-
Nishijima, M.1
Raetz, C.R.H.2
-
44
-
-
0025914432
-
A gene coding for 3-deoxy-D-manno-octulosonic-acid transferase in Escherichia coli
-
Clementz T, Raetz CRH: A gene coding for 3-deoxy-D-manno-octulosonic-acid transferase in Escherichia coli. J Biol Chem 1991, 266:9687-9696.
-
(1991)
J Biol Chem
, vol.266
, pp. 9687-9696
-
-
Clementz, T.1
Raetz, C.R.H.2
-
45
-
-
0025961808
-
Isolation and characterization of the Escherichia coli htrB gene, whose product is essential for bacterial viability above 33°C in rich media
-
Karow M, Fayet O, Cegielska A, Ziegelhoffer T, Georgopoulos C: Isolation and characterization of the Escherichia coli htrB gene, whose product is essential for bacterial viability above 33°C in rich media. J Bacteriol 1991, 173:741-750.
-
(1991)
J Bacteriol
, vol.173
, pp. 741-750
-
-
Karow, M.1
Fayet, O.2
Cegielska, A.3
Ziegelhoffer, T.4
Georgopoulos, C.5
-
46
-
-
0030868685
-
Identification of the gene encoding the Escherichia coli lipid a 4 kinase: Facile phosphorylation of endotoxin analogs with recombinant LpxK
-
Garrett TA, Kadrmas JL, Raetz CRH: Identification of the gene encoding the Escherichia coli lipid A 4 kinase: facile phosphorylation of endotoxin analogs with recombinant LpxK. J Biol Chem 1997, 272:21855-21864.
-
(1997)
J Biol Chem
, vol.272
, pp. 21855-21864
-
-
Garrett, T.A.1
Kadrmas, J.L.2
Raetz, C.R.H.3
-
47
-
-
0030888162
-
Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of lipid A
-
A. Identifying msbB as a gene encoding a structural, not a regulatory, protein for secondary fatty acid transfer to lipid A provided the definition needed to study this gene product in other systems.
-
(1997)
J Biol Chem
, vol.272
, pp. 10353-10360
-
-
Clementz, T.1
Zhou, Z.2
Raetz, C.R.H.3
-
48
-
-
0029974220
-
Function of the htrB high temperature requirement gene of Escherichia coli in the acylation of lipid A: HtrB catalyzed incorporation of laurate
-
Clementz T, Bednarski JJ, Raetz CRH: Function of the htrB high temperature requirement gene of Escherichia coli in the acylation of lipid A: HtrB catalyzed incorporation of laurate. J Biol Chem 1996, 271:12095-12102.
-
(1996)
J Biol Chem
, vol.271
, pp. 12095-12102
-
-
Clementz, T.1
Bednarski, J.J.2
Raetz, C.R.H.3
-
49
-
-
0030030428
-
A novel Escherichia coli lipid a mutant that produces an antiinflammatory lipopolysaccharide
-
Somerville JE Jr, Cassiano L, Bainbridge B, Cunningham MD, Darveau R: A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide. J Clin Invest 1996, 997:359-365. These authors employed a unique screen to identify mutations in Escherichia coli lipid A biosynthesis. Mutants with decreased ability to stimulate E-selectin expression from endothelial cells were identified. A mutation in the msbB gene resulted in the production of lipopolysaccharide that only lacked myristate, identifying the importance of this secondary fatty acid for host cell recognition. This was the first report of a lipid A mutation that was not conditionally lethal for growth and was used to confirm the significant role of lipid A when viable bacteria are presented to host defense cells.
-
(1996)
J Clin Invest
, vol.997
, pp. 359-365
-
-
Somerville J.E., Jr.1
Cassiano, L.2
Bainbridge, B.3
Cunningham, M.D.4
Darveau, R.5
-
50
-
-
0026541087
-
Isolation and characterization of the Escherichia coli msbB gene, a multicopy suppressor of null mutations in the high-temperature requirement gene htrB
-
Karow M, Georgopoulos C: Isolation and characterization of the Escherichia coli msbB gene, a multicopy suppressor of null mutations in the high-temperature requirement gene htrB. J Bacteriol 1992, 174:702-710.
-
(1992)
J Bacteriol
, vol.174
, pp. 702-710
-
-
Karow, M.1
Georgopoulos, C.2
-
51
-
-
0029908978
-
Regulation of UDP-3-O-[R-3-hydroxymyristoyl] -N-acetylglucosamir.e deacetylase in Escherichia coli: The second enzymatic step of lipid a biosynthesis
-
Sorensen PG, Lutkenhaus J, Young K, Eveland SS, Anderson MS, Raetz CRH: Regulation of UDP-3-O-[R-3-hydroxymyristoyl] -N-acetylglucosamir.e deacetylase in Escherichia coli: the second enzymatic step of lipid A biosynthesis. J Biol Chem 1996, 271:25898-25905. This article describes an increase in the specific activity of LpxC when the activity of LpxA is inhibited. An increase in the specific activity of LpxC, the first committed step in lipid A synthesis, indicates that E coli may be able to regulate the amount of lipid A synthesized in response to the lipid A content of its outer membrane. Several different innate host defense components act by disrupting the lipopolysaccharide barrier of the outer membrane and this article provides a means for testing the hypothesis that E. coli may respond to host attack by increasing lipid A synthesis.
-
(1996)
J Biol Chem
, vol.271
, pp. 25898-25905
-
-
Sorensen, P.G.1
Lutkenhaus, J.2
Young, K.3
Eveland, S.S.4
Anderson, M.S.5
Raetz, C.R.H.6
-
52
-
-
10544252685
-
Antibacterial agents that inhibit lipid A biosynthesis
-
Onishi HR, Pelak BA, Gerckens LS, Silver LL, Kahan FM, Chen M-H, Patchett AA, Galloway SM, Hyland SA, Anderson MS, Raetz CHR: Antibacterial agents that inhibit lipid A biosynthesis. Science 1996, 274:980-982.
-
(1996)
Science
, vol.274
, pp. 980-982
-
-
Onishi, H.R.1
Pelak, B.A.2
Gerckens, L.S.3
Silver, L.L.4
Kahan, F.M.5
Chen, M.-H.6
Patchett, A.A.7
Galloway, S.M.8
Hyland, S.A.9
Anderson, M.S.10
Raetz, C.R.H.11
-
53
-
-
0022447993
-
The interaction of Escherichia coli with normal human serum: The kinetics of serum-mediated lipopolysaccharide release and its dissociation from bacterial killing
-
Tesh VL, Duncan RL, Morrison DC: The interaction of Escherichia coli with normal human serum: the kinetics of serum-mediated lipopolysaccharide release and its dissociation from bacterial killing. J Immunol 1986, 137:1329-1335.
-
(1986)
J Immunol
, vol.137
, pp. 1329-1335
-
-
Tesh, V.L.1
Duncan, R.L.2
Morrison, D.C.3
-
54
-
-
0023815539
-
Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin
-
Ellison RT III, Giehl TJ, LaForce FM: Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin. Infect Immun 1988, 56:2774-2781.
-
(1988)
Infect Immun
, vol.56
, pp. 2774-2781
-
-
Ellison R.T. III1
Giehl, T.J.2
LaForce, F.M.3
-
55
-
-
0030739226
-
Mechanisms of action of bactericidal/permeability-increasing protein BPI on reconstituted outer membranes of gram-negative bacteria
-
Wiese A, Brandenburg K, Carroll SF, Rietschel ET, Seydel U: Mechanisms of action of bactericidal/permeability-increasing protein BPI on reconstituted outer membranes of gram-negative bacteria. Biochemistry 1997, 36:10311-10319.
-
(1997)
Biochemistry
, vol.36
, pp. 10311-10319
-
-
Wiese, A.1
Brandenburg, K.2
Carroll, S.F.3
Rietschel, E.T.4
Seydel, U.5
-
56
-
-
0030877188
-
Identification of novel chromosomal loci affecting Yersinia enterocolitica pathogenesis
-
Young GM, Miller VL: Identification of novel chromosomal loci affecting Yersinia enterocolitica pathogenesis. Mol Microbiol 1997, 25:319-328. This article identified Yersinia enterocolitica bacterial chromosomal genes that were preferentially expressed after intragastric ingestion in mice. One gene was found to encode a protein with homology to LpxA from Y. enterocolitica, yet was distinct from other characterized acyltransferases. These data remain speculative but suggest that Y. enterocolitica may contain an lpxA analogue which is activated in the in vivo environment and alters the lipid A fatty acid composition.
-
(1997)
Mol Microbiol
, vol.25
, pp. 319-328
-
-
Young, G.M.1
Miller, V.L.2
-
57
-
-
0003582512
-
A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence
-
Miller SI, Kukral AM, Mekalanos JJ: A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence. Proc Natl Acad Sci USA 1989, 86:5054-5058.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 5054-5058
-
-
Miller, S.I.1
Kukral, A.M.2
Mekalanos, J.J.3
-
58
-
-
0025318414
-
Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages
-
Miller SI, Mekalanos JJ: Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages. J Bacteriol 1990, 172:2485-2490.
-
(1990)
J Bacteriol
, vol.172
, pp. 2485-2490
-
-
Miller, S.I.1
Mekalanos, J.J.2
-
59
-
-
0030984298
-
Regulation of lipid a modifications by Salmonella typhimurium virulence genes phoP-phoQ
-
Guo L, Lim KB, Gunn JS, Bainbridge B, Darveau RP, Hackett M, Miller SI: Regulation of lipid A modifications by Salmonella typhimurium virulence genes phoP-phoQ. Science 1997, 276:250-253. This article examined the lipid A composition of Salmonella typhimurium strains with mutations in the virulence genes phoP-phoQ. It was found that mutations in the phoP-phoQ system, which regulates numerous genes in response to host microenvironments, induced structural modifications of lipid A. These modifications altered lipopolysaccharide-mediated expression of E-selectin by endothelial cells and tumor necrosis factor-α expression by adherent monocytes. These data provide the strongest evidence to date that lipid A may be altered in response to host microenvironments.
-
(1997)
Science
, vol.276
, pp. 250-253
-
-
Guo, L.1
Lim, K.B.2
Gunn, J.S.3
Bainbridge, B.4
Darveau, R.P.5
Hackett, M.6
Miller, S.I.7
-
60
-
-
0017842437
-
Isolation and characterization of polymyxin-resistant mutants of Salmonella
-
Makela PH, Msarvas M, Calcagno S, Lounatmaa K: Isolation and characterization of polymyxin-resistant mutants of Salmonella. FEMS Microbiol Lett 1978, 3:323-326.
-
(1978)
FEMS Microbiol Lett
, vol.3
, pp. 323-326
-
-
Makela, P.H.1
Msarvas, M.2
Calcagno, S.3
Lounatmaa, K.4
-
61
-
-
0027201144
-
Spontaneous pmra mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence
-
Roland KL, Martin LE, Esther CR, Spitznagel JK: Spontaneous pmrA mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence. J Bacteriol 1993, 175:4154-4164.
-
(1993)
J Bacteriol
, vol.175
, pp. 4154-4164
-
-
Roland, K.L.1
Martin, L.E.2
Esther, C.R.3
Spitznagel, J.K.4
-
62
-
-
0029809576
-
PhoP-PhoQ activates transcription of pmrAB, encoding a two-component regulatory system involved in Salmonella typhimurium antimicrobial peptide resistance
-
Gunn JS, Miller SI: PhoP-PhoQ activates transcription of pmrAB, encoding a two-component regulatory system involved in Salmonella typhimurium antimicrobial peptide resistance. J Bacteriol 1996, 178:6857-6864.
-
(1996)
J Bacteriol
, vol.178
, pp. 6857-6864
-
-
Gunn, J.S.1
Miller, S.I.2
-
63
-
-
0029671310
-
2+ as an extracellular signal: Environmental regulation of Salmonella virulence
-
2+ as an extracellular signal: environmental regulation of Salmonella virulence. Cell 1996, 84:165-174.
-
(1996)
Cell
, vol.84
, pp. 165-174
-
-
Garcia-Vescovi, E.1
Soncini, F.C.2
Groisman, E.A.3
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