PhoP-PhoQ activates transcription of pmrAB, encoding a two-component regulatory system involved in Salmonella typhimurium antimicrobial peptide resistance

Journal of Bacteriology

Volumn 178, Issue 23, 1996, Pages 6857-6864

  Gunn, John S ^a   Miller, Samuel I ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENETICS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROCESSING; REGULATORY MECHANISM; SALMONELLA TYPHIMURIUM; TRANSCRIPTION REGULATION;

AMPHIBIA; ANIMALIA; BACTERIA (MICROORGANISMS); HEXAPODA; MAMMALIA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0029809576     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.178.23.6857-6864.1996     Document Type: Article

References (46)

1. Alpuche-Aranda, C. M., J. A. Swanson, W. P. Loomis, and S. I. Miller, 1992. Salmonella typhimurium activates virulence gene transcription within acidilied macrophage phagosomes. Proc. Natl. Acad. Sci. USA 89:10079-10083.
2. Behlau. I., and S. I. Miller. 1993. A PhoP-repressed gene promotes Salmonella tphmurium invasion of epithelial cells. J. Bactcriol. 175:4475-4484.
3. Belden. W. J., and S. I. Miller. 1994. Further characterization of the PhoP regulon: identification of new PhoP-activated virulence loci. Infect. Immun. 62:5095-5101.
4. Buchmeier, N. A., and F. Heffron. 1989. Intracellular survival of wild-type Salmonella typhimurium and macrophage-sensitive mutants in diverse populations of macrophages. Infect. Immun. 57:1-7.
5. Chan, R. K., D. Botstein, T. Watanabe, and Y. Ogata. 1972. Specialized transduction of tetracycline resistance by pliage P22 in Salmonella typhimurium. II. Properties of a high-frequency-transducing lysate. Virology 50:883-898.
6. Conner, C. P., D. M. Heithoff, and M. J. Mahan. 1996. Salmonella genes that are induced in vivo encode several transport systems as well as tRNA modilication enzymes, abstr. B-111, p. 174. In Abstracts of the 96th General Meeting of the American Society for Microbiology 1996. American Society for Microbiology. Washington, D.C.
7. Davis, R. W., D. Botstein, and J. R. Roth. 1980. Advanced bacterial genetics: a manual for genetic engineering. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
8. Fields, P. I., E. A. Groisman, and F. Heffron. 1989. A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells. Science 243:1059-1062.
9. Fields, P. I., R. V. Swanson, C. G. Haidaris, and F. Heffron. 1986. Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent. Proc. Natl. Acad. Sci. USA 83:5189-5193.
10. Ganz, T., M. E. Selsted, D. Szklarek, S. L. Hartwig, K. Daher, D. F. Bainton, and R. I. Lehrer. 1985. Defensins: natural peptide antibiotics of human neutrophils, J. Clin. Invest. 76:1427-1435.
11. 2 + as an extracellular signal: environmental regulation of Salmonella virulence. Cell 84:165-174.
12. Gray, P. W., G. Flaggs, S. R. Leong, R. J. Gumina, J. Weiss, C. E. Ooi, and P. Elsbach. 1989. Cloning of a human neutrophil bactericidal protein. Structural and functional correlations. J. Biol. Chem. 264:9505-9509.
13. Groisman, E. A., E. Chiao, C. J. Lipps, and F. Heffron. 1989. Salmonella typhimurium phoP virulence gene is a transcriptional regulator. Proc. Natl. Acad. Sci. USA 86:7077-7081.
14. Groisman, E. A., C. Parra-Lopez, M. Salcedo, C. J. Lipps, and F. Heffron. 1992. Resistance to host antimicrobial peptides is necessary for Salmonella virulence. Proc. Natl. Acad. Sci. USA 89:11939-11943.
15. Gunn, J. S. Unpublished results.
16. Gunn, J. S., C. M. Alpuche-Aranda, W. P. Loomis. W. J. Beiden, and S. I. Miller. 1995. Characterization of the Salmonella typhimurium pagC/pagD chromosomal region. J. Bacteriol. 177:5040-5047.
17. Gunn, J. S., E. L. Hohmann, and S. I. Miller. 1996. Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP. J. Bacteriol. 178:6369-6373.
18. Guo, L., K. Lira, J. S. Gunn, B. Bainbridge, R. Darveau, M. Hackett, and S. I. Miller. Unpublished data.
19. 13P-NMR study. Mol. Microbiol. 11:481-487.
20. Hohmann, E. L., C. A. Oletta, K. P. Killeen, and S. I. Miller. 1996. phoP1 phoQ-deleted Salmonella typhi (TY800) is a safe and immunogenic single dose typhoid fever vaccine in volunteers. J. Infect. Dis. 173:1408-1414.
21. Kier, L. D., R. Weppelman. and B. N. Ames. 1977. Regulation of two phosphatases and a cyclic phosphodiesterase of Salmonella typhimurium. J. Bacteriol. 130:420-428.
22. Makela, P. H., M. Sarvas, S. Calcagno, and K. Lounatmaa. 1978. Isolation and characterization of polymyxin-resistant mutants of Salmonella. FEMS Microbiol. Lett. 3:323-326.
23. Mekalanos, J. J. 1983. Duplication and amplification of toxin genes in Vibrio cholerae. Cell 35:253-263.
24. Michaelis, S., H. Inuuye, D. Oliver, and J. Beckwith. 1983. Mutations that alter the signal sequence of alkaline phosphatase in Escherichia coli. J. Bacteriol. 154:366-374.
25. Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory. Cold Spring Hurbor, N.Y.
26. Miller, S. I., A. M. Kukral. and J. J. Mekalanos. 1989. A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence. Proc. Natl. Acad. Sci. USA 86:5054-5058.
27. Miller, S. I., and J. J. Mekalanos. 1990. Constitutive expression of the PhoP regulon attenuates Salmonella virulence and survival within macrophages. J. Bacteriol. 172:2485-2490.
28. Miller, S. I., W. S. Pulkkinen, M. E. Selsted, and J. J. Mekalanos. 1990. Characterization of detensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium. Infect. Immun. 58:3706-3710.
29. Miller, V. L., and J. J. Mekalanos. 1988. A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. J. Bacteriol. 170:2575-2583.
30. Nelson, D. L., and E. P. Kennedy. 1971. Magnesium transport in Eschirichia coli. J. Biol. Chem. 246:3042-3049.
31. Parra-Lopez, C., M. T. Baer, and E. A. Groisman. 1993. Molecular geneticanalysis of a locus required for resistance to antimicrobial peptides in Salmonella typhimurium. EMBO J. 12:4053-4062.
32. Parra-Lopez, C., R. Lin, A. Aspedon, and E. A. Groisman. 1994. A Salmonella protein that is required for resistance to antimicrobial peptides and transport of potassium. EMBO J. 13:3964-3972.
33. Pohl, J., H. A. Pereira, N. M. Martin, and J. K. Spitznagel. 1990. Amino acid sequence of CAP37, a human neutrophil granule-derived antibacterial and monocyte-specific chemotactic glycoprotein structurally similar to neutrophil elastase. FEBS Lett. 272:200-204.
34. Roland, K. L., L. E. Martin, C. R. Esther, and J. K. Spitznagel. 1993. Spontaneous pmrA mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence. J. Bacterial. 175:4154-4164.
35. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci USA 74:5463-5467.
36. Selsted, M. E., S. I. Miller, A. H. Menschen, and A. J. Ouellette. 1992. Enteric defensins: antibiotic peptide components of intestinal host defense. J. Cell Biol. 118:929-936.
37. Shafer. W. M., L. E. Martin, and J. K. Spitznagel. 1984. Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate. Infect. Immun. 45:29-35.
38. Soncini, F. C., E. Garcia Véscovi, and E. A. Groisman. 1995. Transcriptional autoregulation of the Salmonella typhimurium phoPQ operon. J. Bacteriol. 177:4364-4371.
39. Spitznagel, J. K. 1990. Antibiotic proteins of human neutrophils. J. Clin. Invest. 86:1381-1386.
40. Stinavage, P., L. E. Martin, and J. K. Spitznagel. 1989. O antigen and lipid A phosphoryl groups in resistance of Salmonella typhimurium LT-2 to nonoxidative killing in human polymorphonuclear neutrophils. Infect. Immun. 57:3894-3900.
41. Storm, D. R., K. S. Rasenthal, and P. E. Swanson. 1977. Polymyxin and related peptide antibiotics. Annu. Rev. Biochem. 46:723-763.
42. Vaara, M. 1981. Effect of ionic strength on polyrayxin resistance of pmrA mutants of Salmonella. FEMS Microbiol. Lett. 11:321-326.
43. Vaara, M. 1981. Increased outer membrane resistance to ethylcnediaminetetraacetate and cations in novel lipid A mutants. J. Bacteriol. 148:426-434.
44. Vaara, M. 1992. Agents that increase the permeability of the outer membrane. Microbiol. Rev. 56:395-411.
45. Vaara, M., T. Vaara, M. Jenson, I. Helander, M. Nurminen, E. T. Rietschel, and P. H. Makela. 1981. Characterization of the lipopolysacharride from the polymyxin-resistant pmrA mutants of Salmonella typhimurium. FEBS Lett. 129:145-149.
46. Vaara, M., T. Vaara, and M. Sarvas, 1979. Decreased binding of polymyxin by polymyxin-resistant mutants of Salmonella typhimurium. J. Bacteriol. 139:664-667.