Revisiting the Th1/Th2 paradigm

Scandinavian Journal of Immunology

Volumn 47, Issue 1, 1998, Pages 1-9

  Muraille, E ^a   Leo, O ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 10;

ANTIBODY PRODUCTION; ANTIGEN PRESENTATION; CELL POPULATION; CELL PROLIFERATION; DOWN REGULATION; EFFECTOR CELL; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE SUBPOPULATION;

EID: 0031963151     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-3083.1998-47-1.00383.x     Document Type: Review

References (94)

1. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996; 17138-46.
2. Reiner SL, Seder RA. T helper cell differentiation in immune response. Curr Opin Immunol 1995;7:360-6.
3. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996;383:787-93.
4. Mosmann TR, Cherwinski HM, Bond MW, Giedlin MA, Coofman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-57.
5. - T cells in non-MHC gene-controlled predisposition toward skewing into T helper type-2 immunity in BALB/ c mice. J Immunol 1997;158:5698-706.
6. Maruo S, Toyo-oka K, Oh-hora M et al. IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones. J Immunol 1996;156:1748-55.
7. Murphy EE, Terres G, Macatonia SE et al. B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation. J Exp Med 1994;180:223-31.
8. Kennedy MK, Picha KS, Shanebeck KD et al. Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0 clones. Eur J Immunol 1994;24:2271-8.
9. Lederer JA, Perez VL, DesRoches L et al. Cytokine transcriptional events during helper helper T cell subset differentiation. J Exp Med 1996;184:397-406.
10. Bucy RP, Panoskaltsis-Mortari A, Huang G-Q et al. Heterogeneity of single cell cytokine gene expression in clonal T cell populations. J Exp Med 1994;180:1251-62.
11. Manetti R, Gerosa F, Giudizi MG et al. Interleukin 12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J Exp Med 1994;179: 1273-1283.
12. + T cells. Eur J Immunol 1994;24:343-7.
13. Germann T, Guckes S, Bongartz M et al. Administration of IL-12 during ongoing immune responses fails to permanently suppress and can even enhance the synthesis of antigen-specific IgE. Int Immunol 1995;7:1649-57.
14. Jeannin P, Delneste Y, Life Y et al. Interleukin-12 increases interleukin-4 production by established human Th0 and Th2-like T cell clones. Eur J Immunol 1995;25:2247-52.
15. + T cells. J Immunol 1997;158:1085-94.
16. Bliss J, Van Cleave V, Murray K et al. IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response. J Immunol 1996;156:887-94.
17. Wang ZE, Zheng S, Corry DB et al. Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major. Proc Natl Acad Sci USA 1994;91:12932-6.
18. Szabo SJ, Dighe AS, Gubler U, Murphy KM. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med 1997;185:817-24.
19. Wynn TA, Jankovic D, Hieny S et al. IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ. J Immunol 1995;154:3999-4009.
20. Eng VM, Car BD, Schnyder B et al. The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon-γ in vivo. J Exp Med 1995;181:1893-8.
21. + T cells, interleukin 4 production is cytokine-autonomous whereas interferon γ production is cytokine-dependent. Proc Natl Acad Sci USA 1997;94:3189-94.
22. Drazen JM, Arm JP, Austen KF. Sorting out the cytokines of asthma. J Exp Med 1996;183:1-5.
23. Muller KM, Jaunin F, Masouyé I, Saurat JH, Hauser C. TH2 cells mediate IL-4-dependent local tissue inflammation. J Immunol 1993;150:5576-84.
24. Wynn TA, Cheever AW. Cytokine regulation of granuloma formation in shistosomiasis. Curr Opin Immunol 1995;7:505-11.
25. VanBuskirk AM, Wakely ME, Orosz CG. Transfusion of polarized TH2-like cell populations into SCID mouse cardiac allograft recipients results in acute allograft rejection. Transplantation 1996;62:229-38.
26. Buchanan KL, Murphy JW. Kinetics of cellular infiltration and cytokine production during the efferent phase of a delayed-type hypersensitivity reaction. Immunology 1997;90:189-97.
27. Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse helper T cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989;170:2081-95.
28. Moore KV, O'Garra A, de Waal Malefyt R, Vieira P, Mosmann TR. Interleukin-10. Annu Rev Immunol 1993;11:165-90.
29. Del Prete G, De Carli M, Almerigogna F et al. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J Immunol 1993;150:353-60.
30. Schandené L, Alonso-Vega C, Willems F et al. B7/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10. Immunology 1994;152:4368-74.
31. Warren HS, Kinnear BF, Phillips JH, Lanier LL. Production of IL-5 by human NK cells and regulation by IL-4, IL-10 and IL-12. Immunology 1995;1254:5144-52.
32. Taga K, Mostowski H, Tosato G. Human interleukin-10 can directly inhibit T-cell growth. Blood 1993;81:2964-71.
33. D'Andrea A, Aste-Amezaga M, Valiante NM. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993;178:1041-8.
34. Chensue SW, Ruth JH, Warmington K, Lincoln P, Kunkel SL. In vivo regulation of macrophage IL-12 production during type 1 and type 2 cytokine-mediated granuloma formation. J Immunol 1995;155:3546-51.
35. Hino A, Nariuchi H. Negative feedback mechanism suppress interleukin-12 production by antigen-presenting cells interacting with T helper 2 cells. Eur J Immunol 1996;26:623-8.
36. Koch F, Stanzl U, Jennewein P et al. High level IL-12 production by murine dendritic cells: up-regulation via MHC class II and CD40 molecules and down-regulation by IL-4 and IL-1. J Exp Med 1996;184:741-6.
37. Florkin S, Amraoui Z, Abramowicz D, Goldman M. Systemic release and protective role of IL-10 in staphylococcal enterotoxin B-induced shock in mice. J Immunol 1994;153:2618-23.
38. Gerard C, Bruyns C, Marchant A et al. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 1993;177:547-50.
39. + T lymphocyte and eosinophil infiltration into the mouse peritoneal cavity. J Immunol 1996;157:377-84.
40. Kühn R, Löhler J, Rennick D, Rajewski K, Müller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993;75:263-74.
41. Flores-Villanueva PO, Reiser H, Stadecker MJ. Regulation of T helper cell responses in experimental murine schistosomiasis by IL-10. Effect on expression of B7 and B7-2 costimulatory molecules by macrophages. J Immunol 1994;153:5190-9.
42. Kawamura T, Furue M. Comparative analysis of B7.1 and B7.2 expression in Langerhans cells: differential regulation by T helper type 1 and T helper type 2 cytokines. Eur J Immunol 1995;25:1913-17.
43. Freman GJ, Boussiotis VA, Anumanthan A et al. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially co-stimulates the initial production of IL-4. Immunity 1995;2:523-32.
44. Morton PA, Fu X, Stewart JA et al. Differential effects of CTLA-4 substitutions on the binding of human CD80 (B7-1) and CD86 (B7-2). J Immunol 1996;156:1047-54.
45. Ranger AM, Das MP, Kuchroo VK, Glimcher LH. B7-2 (CD86) is essential for the development of IL-4-producing cells. Int Immunol 1996;8:1549-60.
46. Punnonen J, de Waal Malefyt R, van Vlasselaer P, Gauchat JF, de Vries JE. IL-10 and viral IL-10 prevent IL-4-induced IgE synthesis by inhibiting the accessory cell function of monocytes. J Immunol 1993;151:1280-9.
47. + T lymphocyte migration. J Immunol 1993;151:4545-51.
48. Chen W-F, Zlotnik A. IL-10: a novel cytotoxic T cell differentiation factor. J Immunol 1991;147:528-34.
49. Schwarz MA, Hamilton LD, Tardelli L, Narula SK, Sullivan LM. Stimulation of cytotoxic activity by interleukin-10. J Immunother Emphasis Tumor Imm 1994;16:95-104.
50. Carson WE, Lindemann MJ, Baiocchi R et al. The functional characterization of interleukin-10 receptor expression on human natural killer cells. Blood 1995;12:3577-85.
51. Rousset F, Garcia E, Defrance T et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA 1992;89:1890-3.
52. Levy Y, Brouet J-C. Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the Bcl-2 protein. J Clin Invest 1994;93:424-8.
53. Giovarelli M, Musiani P, Modesti A et al. Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory. J Immunol 1995;155:3112-23.
54. Berman RM, Suzuki T, Tahara H et al. Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice. J Immunol 1996;157:231-8.
55. Lee MS, Mueller R, Wicker LS, Peterson LB, Sarvetnick N. IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity. J Exp Med 1996;183:2663-8.
56. Morris SC, Madden KB, Adamovicz JJ et al. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J Immunol 1994;152:1047-56.
57. Tripp CS, Wolf SF, Unanue ER. Interleukin 12 and tumor necrosis factor α are costimulalors of interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci USA 1993;90:3725-9.
58. + T cells. Int Immunol 1993;5:877-83.
59. Windhagen A, Anderson DE, Carrizosa A, Williams RE, Hafler DA. IL-12 induces human T cells secreting IL-10 with IFN-gamma. J Immunol 1996;157:1127-31.
60. Daftarian PM, Kumar A, Kryworuchko M, Diaz-Mitoma F. IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-alpha. J Immunol 1996;157:12-20.
61. Gerosa F, Paganin C, Peritt D et al. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10. J Exp Med 1996;183:2559-69.
62. Jeannin P, Delneste Y, Seveso M, Life P, Bonnefoy JY. IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells. J Immunol 1996;156:3159-65.
63. Finke J, Ternes P, Lange W, Mertelsmann R, Dolken G. Expression of interleukin 10 in B lymphocytes of different origin. Leukemia 1993;7:1852-7.
64. Marietta EV, Chen Y, Weis JH. Modulation of expression of the antiinflammatory cytokines interleukin-13 and interleukin-10 by interleukin-3. Eur J Immunol 1996;26:49-56.
65. Nakajima H, Gleich GJ, Kita H. Constitutive production of IL-4 and IL-10 and stimulated production of IL-8 by normal peripheral blood eosinophils. J Immunol 1996;156:4859-66.
66. Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A. IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991;147:3815-22.
67. Ghanekar S, Zheng L, Logar A et al. Cytokine expression by human peripheral blood dendritic cells stimulated in vitro with HIV-1 and herpes simplex virus. J Immunol 1996;157:4028-36.
68. Enk AH, Katz SI. Identification and induction of keratinocyte-derived IL-10. Immunology 1992;149:92-5.
69. Roth I, Corry DB, Locksley RM et al. Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. J Exp Med 1996;184:539-48.
70. Platzer C, Meisel C, Vogt K, Platzer M, Volk HD. Up-regulation of monocytic IL-10 by tumor necrosis factor-α and cAMP elevating drugs. Int Immunol 1995;7:517-23.
71. Strassmann G, Patil-Koota V, Finkelman F, Fong M, Kambayashi T. Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E. J Exp Med 1994;180:2365-70.
72. Kalinski P, Hilkens CMU, Snijders A, Snijdewint FGM, Kapsenberg ML. IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturating human naive T helper cells. J Immunol 1997;159:28-35.
73. Suberville S, Bellocq A, Fouqueray B et al. Regulation of interleukin-10 production by β-adrenergic agonists. Eur J Immunol 1996;26:2601-5.
74. Haraguchi S, Good RA, Day NK. Immunosuppressive retroviral peptides: cAMP and cytokine patters. Immunol Today 1995;16:595-9.
75. Kambayashi T, Jacob CO, Zhou D et al. Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-alpha and IL-6 release by endotoxin-stimulated macrophages. J Immunol 1995;155:4909-16.
76. + subsets. J Immunol 1995;155:3322-8.
77. Ullrich SE. Mechanism involved in the systemic suppression of antigen-presenting cell function by UV irradiation. J Immunol 1994;152:3410-16.
78. van der Pouw-Kraan TC, Boeije LC, Smeenk RJ, Wijdenes J, Aarden LA. Prostaglandin E2 is a potent inhibitor of human interleukin 12 production. J Exp Med 1995;181:775-9.
79. Bordignon PP, Di Lucia P, Self C et al. β2-adrenoreceptor agonists specifically inhibit IL-12 production. Abstract presented at Second Symposium of Pathogenesis and Immunotherapy of Autoimmune Diseases. 1996. Milan, Italy.
80. + lymphocytes. J Immunol 1997;158:5589-95.
81. Moller DR, Wysocka M, Greenlee BM et al. Inhibition of human interleukin-12 production by pentoxyfilline. Immunology 1997;91:197-203.
82. + epidermal macrophage induction, and Langerhans cell depletion. Proc Natl Acad Sci USA 1992;89:8497-501.
83. Grabbe S, Steinbrink K, Steinert M, Luger TA, Schwartz T. Removal of the majority of epidermal Langerhans cells by topical or systemic steroid application enhances the effector phase of murine contact hypersensitivity. J Immunol 1995;155:4207-17.
84. Jung T, Schauer U, Rieger C. Interleukin-4 and interleukin-5 are rarely co-expressed by human T cells. Eur J Immunol 1995;25:2413-16.
85. Garlisi CG, Pennline KJ, Smith SR, Siegel MI, Umland SP. Cytokine gene expression in mice undergoing chronic graft-vs.-host disease. Mol Immunol 1993;30:669-77.
86. Miethke T, Wahl C, Heeg K et al. T cell-mediated lethal shock triggered in mice by the superantigen Staphylococcus aureus enterotoxin B: critical role of tumor necrosis factor. J Exp Med 1992;175:91-8.
87. de Kossodo S, Grau GE. Profiles of cytokine production in relation with susceptibility to cerebral malaria. J Immunol 1993;151:4811-20.
88. Ando K, Moriyama T, Guidotti LG et al. Mechanism of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis. J Exp Med 1993;178:1541-54.
89. Fleicher B, Fleicher S, Maier K et al. Clonal analysis of infiltrating T lymphocytes in liver tissue in viral hepatitis A. Immunology 1990;69:14-19.
90. Chaouat G, Assal-Meliani A, Martal J et al. IL-10 prevents naturally occurring fetal loss in the CBAxDBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau. J Immunol 1995;154:4261-8.
91. Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 1993;14:353-6.
92. + T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: implication for adoptive immunotherapy of virus carrier. Proc Natl Acad Sci USA 1997;94:6874-9.
93. Janeway CA. The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol Today 1992;13:11-15.
94. Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol 1994;12:991-1045.