Evidence of stage-specific element for germ-line transcription of the TCR α gene located upstream of Jα49 locus

European Journal of Immunology

Volumn 28, Issue 4, 1998, Pages 1368-1378

  Hozumi, Katsuto ^a   Tanaka, Yasushi ^a   Sato, Takehito ^a   Wilson, Anne ^b   Habu, Sonoko ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Germ line transcription; Promoter; TCR gene

Indexed keywords

INTERLEUKIN 2 RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ARTICLE; FEMALE; GENE LOCUS; GENE REARRANGEMENT; GENETIC TRANSCRIPTION; HYBRIDOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; T LYMPHOCYTE RECEPTOR GENE; THYMOCYTE; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; GENE TRANSFER; GENETICS; IMMUNOLOGY; PROMOTER REGION; T LYMPHOCYTE;

ANIMALS; CELL DIFFERENTIATION; GENE REARRANGEMENT, T-LYMPHOCYTE; GENE TRANSFER TECHNIQUES; MICE; MICE, INBRED C57BL; PROMOTER REGIONS (GENETICS); RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC;

EID: 0031960066     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-4141(199804)28:04<1368::aid-immu1368>3.0.co;2-b     Document Type: Article

References (44)

1. Mombaerts, P., Clarke, A. R., Rudnicki, M. A., lacomini, J., Itohara, S., Lafaille, J. J., Wang, L., Ichikawa, Y., Jaenisch, R., Hooper, M. L. and Tonegawa, S., Mutations in T-cell antigen receptor genes a and β block thymocyte development at different stages. Nature 1992. 360: 225-231.
2. Mallick, C. A., Dudley, E. C., Viney, J. L., Owen, M. J. and Mayday, A. C., Rearrangement and diversity of T cell receptor β chain genes in thymocytes: a critical role for the β chain in development. Cell 1993. 73: 513-519.
3. Fehling, H. J. and von Boehmer, H., Early αβ T cell development in the thymus of normal and genetically altered mice. Curr. Opin. Immunol. 1997. 9: 263-275.
4. Shinkai, Y., Koyasu, S., Nakayama, K., Murphy, K., Loh, D. Y., Reinherz, E. L. and Alt, F. W., Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science 1993. 259: 822-825.
5. Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S. and Papaioannou, V. E., RAG-1-deficient mice have no mature B and T lymphocytes. Cell 1992. 68: 869-877.
6. Shinkai, Y., Rathbun, G., Lam, K., Oltz, E. M., Stewart, V., Mendelshon, M., Charron, J., Datta, M., Young, F., Stall, A. M. and Alt, F. W., RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 1992. 68: 855-867.
7. Yancopoulos, G. D., Blackwell, T. K., Suh, H., Hood, L. and Alt, F. W., Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell 1986. 44: 251-259.
8. Sleckman, B., Gorman, J. R. and Alt, F. W., Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements. Annu. Rev. Immunol. 1996. 14: 459-481.
9. Schatz, D. G., Oettinger, M. A. and Schlissel, M. S., V(D)J recombination: molecular biology and regulation. Annu. Rev. Immunol. 1992. 10: 359-383.
10. + thymocytes with CD3 expression: evidence of T cell commitment in the thymus. Int. Immunol. 1996. 8: 1473-1481.
11. Capone, M., Watrin, F., Fernex, C., Horvat, B., Krippl, B., Wu, L., Scollay, R. and Ferrier, P., TCRβ and TCRα gene enhancers confer tissue- and stage-specificity on V(D)J recombination events. EMBO J. 1993. 12: 4335-4346.
12. Lauzurica, P. and Krangel, M. S., Temporal and lineage-specific control of T cell receptor α/δ gene rearrangement by T cell receptor α and δ enhancers. J. Exp. Med. 1994. 179: 1913-1921.
13. H locus. EMBO J. 1993. 12: 4635-4645.
14. Serwe, M. and Sablitzky, F., V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J. 1993. 12: 2321-2327.
15. Bories J., Demengeot, J., Davidson, L. and Alt, F. W., Gene-targeted deletion and replacement mutations of the T-cell receptor β-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility. Proc. Natl. Acad. Sci. USA 1996. 93: 7871-7876.
16. Kottmann, A. H., Zevnik, B., Weite, M., Nielsen, P. J. and Köhler, G., A second promoter and enhancer element within the immunoglobulin heavy chain locus. Eur. J. Immunol. 1994. 24: 817-821.
17. Haars, R., Kronenberg, M., Gallatin, M., Weissman, I. L., Owen, F. L. and Hood, L., Rearrangement and expression of T cell antigen receptor and γ genes during thymic development. J. Exp. Med. 1986. 164: 1-24.
18. Petrie, H. T., Livak, F., Burtrum, D. and Mazel, S., T cell receptor gene recombination patterns and mechanism: cell death, rescue, and T cell production. J. Exp. Med. 1995. 182: 121-127.
19. Levelt, C. N., Wang, B., Ehrfeld, A., Terhorst, C. and Eichmann, K., Regulation of T cell receptor (TCR)-β locus allelic exclusion and initiation of TCR-α locus rearrangement in immature thymocytes by signaling through the CD3 complex. Eur. J. Immunol. 1995. 25: 1257-1261.
20. Leiden, J. M., Transcriptional regulation of T cell receptor gene. Annu. Rev. Immunol. 1993. 11: 539-570.
21. de Villartay, J., Hockett, R. D., Coran, D., Korsmeyer, S. J. and Cohen, D. I., Deletion of the human T-cell receptor δ-gene by a site-specific recombination. Nature 1988. 335: 170-174.
22. Shimizu, T., Takeshita, S., Muto, M., Kubo, E., Sado, T. and Yamagishi, H., Mouse germline transcript of TCR α joining region and temporal expression in ontogeny. Int. Immunol. 1993. 5: 155-160.
23. Levelt, C. N., Mombaerts, P., Iglesias, A., Tonegawa, S. and Eichmann, K., Restoration of early thymocyte differentiation in T-cell receptor β-chain-deficient mutant mice by transmembrane signaling through CD3ε. Proc. Natl. Acad. Sci. USA 1993. 90: 11401-11405.
24. -/- mice in the absence of TCR β chain expression. Int. Immunol. 1994. 6: 995-1001.
25. Letourneur, F. and Malissen, B., Derivation of a T cell hybridoma variant deprived of functional T cell receptor a and β chain transcripts reveals a nonfunctional α-mRNA of BW5147 origin. Eur. J. Immunol. 1989. 19: 2269-2274.
26. Sato, T., Sasahara, T., Nakamura, Y., Osaki, T., Hasegawa, T., Tadakuma, T., Arata, Y., Kumagai, Y., Katsuki, M. and Habu, S., Naive T cell can mediate delayed-type hypersensitivity response in T cell receptor transgenic mice. Eur. J. Immunol. 1994. 24: 1512-1516.
27. Wilson, A., de Villartay, J. and MacDonald, H. R., T cell receptor δ gene rearrangement and T early α (TEA) expression in immature aβ lineage thymocytes: implications for αβ/γδ lineage commitment. Immunity 1996. 4: 37-45.
28. Winoto, A. and Baltimore, D., αβ lineage-specific expression of the a T cell receptor gene by nearby silencers. Cell 1989. 59: 649-655.
29. Arden, B., Klotz, J. L., Siu, G. and Hood, L. E., Diversity and structure of genes of the a family of mouse T-cell antigen receptor. Nature 1985. 316: 783-787.
30. Villey, I., Caillol, D., Selz, F., Ferrier, P. and de Villartay, J., Defect in rearrangement of the most 5′ TCR-Jα following targeted deletion of T early α (TEA); implications for TCR a locus accessibility. Immunity 1996. 5: 331-342.
31. Villey, I., Quartier, P., Selz, F. and de Villartay, J., Germ-line transcription and methylation status of the TCR-Jα locus in its accessible configuration. Eur. J. Immunol. 1997. 27: 1619-1625.
32. Atchison, M. L. and Perry, R. P., The role of the (Greek small letter script kappa) enhancer and its binding factor NF-(Greek small letter script kappa)B in the developmental regulation of (Greek small letter script kappa) gene transcription. Cell 1987. 48: 121-128.
33. Hiramatsu, R., Akagi, K., Matsuoka, M., Sakumi, K., Nakamura, H., Kingsbury, L., David, C., Hardy, R. R., Yamamura, K. and Sakano, H., The 3′ enhancer region determines the B/T specificity and pro-B/pre-B specificity of immunoglobulin V(Greek small letter script kappa)-J (Greek small letter script kappa) joining. Cell 1995. 83: 1113-1123.
34. Gorman, J. R., van der Stoep, N., Monroe, R., Cogne, M., Davidson, L. and Alt, F. W., The Ig(Greek small letter script kappa)(Greek small letter script kappa) 3′ enhancer influences the ratio of Ig(Greek small letter script kappa) versus Igλ B lymphocytes. Immunity 1996. 5: 241-252.
35. Martin, D. J. and van Ness, B. G., Initiation and processing of two kappa immunoglobulin germ line transcripts in mouse B cells. Mol. Cell Biol. 1990. 10: 1950-1958.
36. Scherer, D. C., Brockman, J. A., Bendall, H. H., Zhang, G. M., Ballard, D. W. and Oltz, E. M., Corepression of RelA and c-Rel inhibits immunoglobulin (Greek small letter script kappa) gene transcription and rearrangement in precursor B lymphocytes. Immunity 1996. 5: 563-574.
37. Weaver, D. and Baltimore, D., B lymphocyte-specific protein binding near an immunoglobulin (Greek small letter script kappa)-chain gene J segment. Proc. Natl. Acad. Sci. USA 1987, 84: 1516-1520.
38. Ferradini, L., Gu, H., de Smet, A., Rajewsky, K., Reynaud, C. and Weil, J., Rearrangement-enhancing element upstream of the mouse immunoglobulin kappa chain J cluster. Science 1996. 271: 1416-1420.
39. Mombaerts, P., Anderson, S. J., Perlmutter, R. M., Mak, T. W. and Tonegawa, S., An activated lck transgene promotes thymocyte development in Rag-1 mutant mice. Immunity 1994. 1: 261-267.
40. Crompton, T., Gilmour, K. C. and Owen, M. J., The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte. Cell 1996. 86: 243-251.
41. Hozumi, K., Kobori, A., Sato, T., Nozaki, H., Nishikawa, S., Nishimura, T. and Habu, S., Pro-T cells in fetal murine thymus express c-kit and RAG-2 but do not rearrange the gene encoding the T cell receptor β chain. Eur. J. Immunol. 1994. 24: 1339-1344.
42. Winoto, A. and Baltimore, D., A novel inducible and T cell-specific enhancer located at the 3′ end of the T cell receptor a locus. EMBO J. 1989. 8: 729-733.
43. de Chasseval, R. and de Villartay, J., Functional characterization of the promoter for the human germ-line T cell receptor J α (TEA) transcript. Eur. J. Immunol. 1993. 23: 1294-1298.
44. Krimpenfort, P., de Jong, R., Uematsu, Y., Dembic, Z., Ryser, S., von Boehmer, H., Steinmetz, M. and Berns, A., Transcription of T cell receptor β-chain genes is controlled by a downstream regulatory element. EMBO J. 1988. 7: 745-750.