Transcription and demethylation of TCR β gene initiate prior to the gene rearrangement in c-kit+ thymocytes with CD3 expression: Evidence of T cell commitment in the thymus

International Immunology

Volumn 8, Issue 10, 1996, Pages 1473-1481

  Hozumi, Katsuto ^a   Kobori, Akiko ^a,b   Sato, Takehito ^a   Nishimura, Takashi ^a   Habu, Sonoko ^a  

^a TOKAI UNIVERSITY   (Japan)

^b KANAGAWA ACADEMY OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

c kit; Commitment; Pro T cells

Indexed keywords

CD3 ANTIGEN; STEM CELL FACTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ARTICLE; CYTOPLASM; DEMETHYLATION; FETUS LIVER; GENE REARRANGEMENT; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR GENE; THYMOCYTE;

ANIMALS; ANTIGENS, CD3; CELL DIFFERENTIATION; DNA METHYLATION; FEMALE; GENE REARRANGEMENT, T-LYMPHOCYTE; MICE; MICE, INBRED C57BL; PREGNANCY; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES; THYMUS GLAND; TRANSCRIPTION, GENETIC;

EID: 0029797879     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.10.1473     Document Type: Article

References (43)

1. Spangrude, G. J., Heimfeld, S. and Weissman, I. L. 1988. Purification and characterization of mouse hematopoietic stem cells. Science 241:58.
2. Okada, S., Nakauchi, H., Nagayoshi, K., Nishikawa, S., Nishikawa, S., Miura, Y. and Suda, T. 1991. Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule. Blood 78:1706.
3. de Vries, P., Brasel, K. A., McKenna, H. J., Williams, D. E. and Watson, J. D. 1992. Thymus reconstitution by c-kit-expressing hematopoietic stem cells purified from adult mouse bone marrow. J. Exp. Med. 176:1503.
4. Chervenak, R., Dempsey, D., Soloff, R., Wolcott, R. M. and Jennings, S. R. 1993 The expression of CD4 by T cell precursors resident in both the thymus and the bone marrow. J. Immunol. 151:4486.
5. Wu, L., Scollay, R., Egerton, M., Pearse, M., Spangrude, G. and Shortman, K. 1991. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature 349:71.
6. - murine thymocytes: in vivo developmental kinetics and T cell receptor β chain rearrangement status. J. Exp. Med. 177:1079.
7. - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 150:4244.
8. - thymocyte differentiation. J. Immunol. 152:4783.
9. Godfrey, D. I. and Zlotnik, A. 1993. Control points in early T-cell development. Immunol. Today 14:547.
10. Whitlock, C. A. and Witte, O. N. 1982. Long-term culture of B lymphocytes and their precursors from murine bone marrow. Proc. Natl Acad. Sci. USA 79:3608.
11. Era, T., Ogawa, M., Nishikawa, S., Okamoto, M., Honjo, T., Akagi, K., Miyazaki, J. and Yamamura, K. 1991 Differentiation of growth signal requirement of B lymphocyte precursor in directed by expression of immunoglobulin. EMBO J. 10:337.
12. Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D. and Hayakawa, K. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J Exp. Med. 173:1213.
13. Tsai, F., Keller, G., Kuo, F. C., Weiss, M., Chen, J., Rosenblatt, M., Alt, F. W. and Orkin, S. H. 1994. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371:221.
14. Georgopoulos, K., Bigby, M., Wang, J., Molnar, A., Wu, P., Winandy, S. and Sharpe, A. 1994. The Ikaros gene is required for the development of all lymphoid lineages. Cell 79:143.
15. Zhuang, Y., Soriano, P. and Weintraub, H. 1994. The helix-loop-helix gene E2A is required for B cell formation. Cell 79:875.
16. Bain, G., Robanus Maandag, E. C., Izon, D. J., Arnsen, D., Kruisbeek, A. M., Weintraub, B. C., Krop, I., Schlissel, M. S., Feeney, A. J., van Roon, M., van der Valk, M., te Riele, H. P. J., Berns, A. and Murre, C. 1994. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 79:885.
17. Lin, H. and Grosshedl, R. 1995. Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 376:263.
18. Urbánek, P., Wang, Z., Fetka, I., Wagner, E. F. and Busslinger, M. 1994. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax-5/BSAP. Cell 79:901.
19. Hozumi, K., Kobori, A., Sato, T., Nozaki, H., Nishikawa, S., Nishimura, T. and Habu, S. 1994. Pro-T cells in fetal thymus express c-kit and RAG-2 but do not rearrange the gene encoding the T cell receptor β chain. Eur. J. Immunol. 24:1339.
20. Hozumi, K., Masuko, T., Nishimura, T., Habu, S. and Hashimoto, Y. 1993. Characterization of the T cells in aged rat bone marrow. Immunol. Lett. 36:137.
21. Takagaki, Y., Nakanishi, N., Ishida, I., Kanagawa, O. and Tonegawa, S. 1989. T cell receptor-γ and -δ genes preferentially utilized by adult thymocytes for the surface expression. J. Immunol. 142:2112.
22. Chun, J. J. M., Shatz, D. G., Oettinger, M. A., Jaenisch, R. and Baltimore, D. 1991. The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. Cell 64:189.
23. Pelkonen, J., Traunecker, A. and Karjalainen, K. 1987. A new mouse TCR Vg gene that shows remarkable evolutionary conservation. EMBO J. 6:1941.
24. Cedar, H. 1988. DNA methylation and gene activity. Cell 53:3.
25. Bird, A. 1992. The essentials of DNA methylation. Cell 70:5.
26. Anderson, P., Caligiuri, M., Ritz, J. and Schlossman, S. F. 1989. CDS-negative natural killer cells express ς TCR as part of a novel molecular complex. Nature 341:159.
27. Sakaguchi, N., Kashiwamura, S., Kimoto, M., Thalmann, P. and Melcher, F. 1988. B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties. EMBO J. 7:3457.
28. Schlissel, M., Corcoran, L. and Baltimore, D. 1991, Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription. J. Exp. Med. 173:711.
29. H gene segments. Cell 40:271.
30. Goodhardt, M., Cavelier, P., Doyen, N., Kallenbach, S., Babinet, C. and Rougeon, F. 1993. Methylation status of immunoglobulin κ gene segments correlates with their recombination potential. Eur. J. Immunol. 23:1789.
31. Perkonen, J., Tunnacliffe, A. and Paracious, R. 1988. Thymocyte clones from 14-day mouse embryos II. Transcription of T3γ gene may precede rearrangement of TCRδ and expression of T3δ, T3ε and T11 genes. Eur. J. Immunol. 18:1337.
32. Paracious, R. and Pelkonen, J. 1988. Prethymic and intrathymic mouse T-cell progenitors. Growth requirements and analysis of the expression of genes encoding TCR/T3 components and other T-cell-specific molecules. Immunol. Rev. 104:5.
33. Zúniga-Pflücker, J. C., Jiang, D. and Leonard, M. J. 1995. Requirement for TNF-α and IL-1α in fetal thymocyte commitment and differentiation. Science 268:1906.
34. Moore, T. A. and Zlotnik, A. 1995. T-cell lineage commitment and cytokine responses of thymic progenitors. Blood 86:1850.
35. Relink, A., Grawunder, U., Winkler, T. H., Karasuyama, H. and Melcher, F. 1994. IL-2 receptor a chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int. Immunol. 6:1257.
36. Chen, J., Ma, A., Young, F. and Alt, F. W. 1994. IL-2 receptor a chain expression during early B lymphocyte differentiation. Int. Immunol. 6:1265.
37. Ledbetter, J. A., Rouse, R. V., Micklem, S. H. and Herzenberg, L. A. 1980. T cell subsets defined by expression of Lyt-1, 2, 3 and Thy-1 antigens. J. Exp. Med. 152:280.
38. Fowlkes, B. J., Edison, L., Mathieson, B. J. and Chused, T. M. 1985. Early T lymphocytes. Differentiation in vivo of adult intrathymic precursor cells. J. Exp. Med. 162:802.
39. Wu, L., Antica, M., Johnson, G., Scollay, R. and Shortman, K. 1991. Developmental potential of the earliest precursor cells from the adult mouse thymus. J. Exp. Med. 174:1617.
40. Li, Y., Hayakawa, K. and Hardy, R. R. 1993. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178:951.
41. Melchers, F., Karasuyama, H., Haasner, D., Bauer, S., Kudo, A., Sakaguchi, N., Jameson, B. and Rolink, A. 1993. The surrogate light chain in B-cell development. Immunol. Today 14:60.
42. Matsuzaki, Y., Gyotoku, J., Ogawa, M., Nishikawa, S., Katsura, Y., Gachelin, G. and Nakauchi, H. 1993. Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation. J. Exp. Med. 178:1283.
43. Ardavin, C., Wu, L., Li, C. and Shortman, K. 1993. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature 362:761.