ERK2 mediates oxytocin-stimulated PGE2 synthesis

American Journal of Physiology - Endocrinology and Metabolism

Volumn 274, Issue 4 37-4, 1998, Pages

  Strakova, Zuzana ^a   Copland, John A ^a   Lolait, Stephen J ^b   Soloff, Melvyn S ^a,c  

^a University of Texas Medical Branch School of Medicine   (United States)

^b BRISTOL ROYAL INFIRMARY   (United Kingdom)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

G proteins; Mitogen activated protein kinase; Oxytocin receptor; Prostaglandin E2; Protein kinase C

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 3,4,5 TRIMETHOXYBENZOIC ACID 8 (DIETHYLAMINO)OCTYL ESTER; CALCIMYCIN; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OXYTOCIN; OXYTOCIN RECEPTOR; PERTUSSIS TOXIN; PHOSPHOLIPASE C INHIBITOR; PROSTAGLANDIN E2; PROTEIN KINASE C INHIBITOR;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN PHOSPHORYLATION;

EID: 0031958585     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.274.4.e634     Document Type: Article

References (35)

1. ras-mitogen-activated protein kinase pathway by α2-adrenergic receptors expressed in fibroblasts. J. Biol. Chem. 268: 22235-22238, 1993.
2. Alessi, D. R. The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1β (Rsk-2) and p70 S6 kinase. FEBS Lett. 402: 121-123, 1997.
3. Alexandrova, M., and M. S. Soloff. Oxytocin receptors and parturition. I. Control of oxytocin receptor concentration in the rat myometrium at term. Endocrinology 106: 730-735, 1980.
4. 2α-induced abortion. Endocrinology 106: 739-743, 1980.
5. 2+ and phosphorylation. Biochem. J. 311: 189-195, 1995.
6. Anderson, N. G., J. L. Maller, N. K. Tonks, and T. W. Sturgill. Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase. Nature 343: 651-653, 1990.
7. Borsch-Haubold, A. G., R. M. Kramer, and S. P. Watson. Inhibition of mitogen-activated protein kinase kinase does not impair primary activation of human platelets. Biochem. J. 318: 207-212, 1996.
8. Chen, D. L., W. Y. Chan, and M. Manning. Agonist and antagonist specificities of decidual prostaglandin-releasing oxytocin receptors and myometrial uterotonic oxytocin receptors in pregnant rats. J. Reprod. Fertil. 102: 337-343, 1994.
9. Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
10. Cleveland, D. W., M. A. Lopata, R. J. MacDonald, N. J. Cowan, W. J. Rutter, and M. W. Kirschner. Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes. Cell 20: 95-105, 1980.
11. Cobb, M. H., and E. J. Goldsmith. How MAP kinases are regulated. J. Biol. Chem. 270: 14843-14846, 1995.
12. Cowley, S., H. Paterson, P. Kemp, and C. J. Marshall. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77: 841-852, 1994.
13. Crespo, P., N. Xu, W. F. Simonds, and J. S. Gutkind. Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits. Nature 369: 418-420, 1994.
14. Dikic, I., G. Tokiwa, S. Lev, S. A. Courtneidge, and J. Schlessinger. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383: 547-550, 1996.
15. 2+/calmodulin-sensitive tyrosine kinase. J. Biol. Chem. 271: 14169-14175, 1996.
16. Exton, J. H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu. Rev. Pharmacol. Toxicol. 36: 481-509, 1996.
17. Flint, A. P., W. M. Leat, E. L. Sheldrick, and H. J. Stewart. Stimulation of phosphoinositide hydrolysis by oxytocin and the mechanism by which oxytocin controls prostaglandin synthesis in the ovine endometrium. Biochem. J. 237: 797-805, 1986.
18. raf-1. J. Biol. Chem. 268: 20717-20720, 1993.
19. Janknecht, R., W. H. Ernst, V. Pingoud, and A. Nordheim. Activation of ternary complex factor Elk-1 by MAP kinases. EMBO J. 12: 5097-5104, 1993.
20. Jeng, Y.-J., S. J. Lolait, Z. Strakova, C. Chen, J. A. Copland, D. Mellman, M. R. Hellmich, and M. S. Soloff. Molecular cloning and functional characterization of the oxytocin receptor from a rat pancreatic cell line (RINm5F). Neuropeptides 30: 557-565, 1996.
21. Lin, L. L., M. Wartmann, A. Y. Lin, J. L. Knopf, A. Seth, and R. J. Davis. cPLA2 is phosphorylated and activated by MAP kinase. Cell 72: 269-278, 1993.
22. Moore, J. J., G. R. Dubyak, R. M. Moore, and D. Vander Kooy. Oxytocin activates the inositol-phospholipid-protein kinase-C system and stimulates prostaglandin production in human amnion cells. Endocrinology 123: 1771-1777, 1988.
23. 2 by p42 microtubule-associated protein 2 kinase and protein kinase C. J. Biol. Chem. 268: 1960-1964, 1993.
24. Ohmichi, M., K. Koike, A. Nohara, Y. Kanda, Y. Sakamoto, Z. X. Zhang, K. Hirota, and A. Miyake. Oxytocin stimulates mitogen-activated protein kinase activity in cultured human puerperal uterine myometrial cells. Endocrinology 136: 2082-2087, 1995.
25. Pang, L., T. Sawada, S. J. Decker, and A. R. Saltiel. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J. Biol. Chem. 270: 13585-13588, 1995.
26. Sa, G., G. Murugesan, M. Jaye, Y. Ivashchenko, and P. L. Fox. Activation of cytosolic phospholipase A2 by basic fibroblast growth factor via a p42 mitogen-activated protein kinase-dependent phosphorylation pathway in endothelial cells. J. Biol. Chem. 270: 2360-2366, 1995.
27. Smith, R. J., L. M. Sam, J. M. Justen, G. L. Bundy, G. A. Bala, and J. E. Bleasdale. Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness. J. Pharmacol. Exp. Ther. 253: 688-697, 1990.
28. i-receptor interaction. Am. J. Physiol. 272 (Endocrinol. Metab. 35): E870-E876, 1997.
29. Sugimoto, Y., A. Yamasaki, E. Segi, K. Tsuboi, Y. Aze, T. Nishimura, H. Oida, N. Yoshida, T. Tanaka, M. Katsuyama, K.-Y. Hasumoto, T. Murata, M. Hirata, F. Ushikubi, M. Negishi, A. Ichikawa, and S. Narumiya. Failure of parturition in mice lacking the prostaglandin F receptor. Science 277: 681-683, 1997.
30. Toullec, D., P. Pianetti, H. Coste, P. Bellevergue, T. Grand-Perret, M. Ajakane, V. Baudet, P. Boissin, E. Boursier, F. Loriolle, L. Duhamel, D. Charon, and J. Kirilovsky. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266: 15771-15781, 1991.
31. Van Biesen, T., L. M. Luttrell, B. E. Hawes, and R. J. Lefkowitz. Mitogenic signaling via G protein-coupled receptors. Endocr. Rev. 17: 698-714, 1996.
32. ras by G protein-coupled receptor agonists in fibroblasts. Proc. Natl. Acad. Sci. USA 90: 1257-1261, 1993.
33. Van Straaten, F., R. Muller, T. Curran, C. Van Beveren, and I. M. Verma. Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein. Proc. Natl. Acad. Sci. USA 80: 3183-3187, 1983.
34. Xing, M., B. L. Firestein, G. H. Shen, and P. A. Insel. Dual role of protein kinase C in the regulation of cPLA2-mediated arachidonic acid release by P2U receptors in MDCK-D1 cells: involvement of MAP kinase-dependent and -independent pathways. J. Clin. Invest. 99: 805-814, 1997.
35. Zheng, L., W. Y. Paik, M. Cesnjaj, T. Balla, M. Tomic, K. J. Catt, and S. S. Stojilkovic. Effects of the phospholipase-C inhibitor, U-73122, on signaling and secretion in pituitary gonadotrophs. Endocrinology 136: 1079-1088, 1995.