Loss of heterozygosity at 5q21 in non-small cell lung cancer: A frequent event but without evidence of APC mutation

Journal of Pathology

Volumn 180, Issue 1, 1996, Pages 33-37

  Cooper, Cindy A ^a   Bubb, Vivien J ^a   Smithson, Nicola ^a   Carter, Robert L ^a   Gledhill, Sarah ^a   Lamb, David ^a   Wyllie, Andrew H ^a   Carey, Francis A ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Adenocarcinoma; APC; MCC; Non small cell lung cancer; Squamous carcinoma

Indexed keywords

ADENOCARCINOMA; ARTICLE; CHROMOSOME 5Q; GENETIC POLYMORPHISM; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; BASE SEQUENCE; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 5; GENES, APC; GENES, MCC; HUMANS; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL;

EID: 0029909652     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199609)180:1<33::AID-PATH642>3.0.CO;2-Y     Document Type: Article

References (35)

1. Dunnill MS, Gatter KC. Cellular heterogeneity in lung cancer. Histapathology 1986; 10: 461-475.
2. World Health Organisation. Histological Typing of Lung Tumours. 2nd edn. Geneva: WHO, 1981.
3. Wong AJ, Ruppert JM, Eggleton J, Hamilton SR, Baylin SB, Vogelstein B. Gene amplification of c-myc and n-myc in small cell carcinoma of the lung. Science 1986; 23: 461-464.
4. Tateishi M, Ishida T, Mitsudomi T, Kaneko S, Sugimachi K. Prognostic value of c-erbB-2 protein expression in human lung adenocarcinoma and squamous cell carcinoma. Eur J Cancer 1991; 27: 1372-1375.
5. Ashton-Rickardt PG, Wyllie AH, Bird CC, et al. MCC, a candidate familial polyposis gene in 5q21, shows frequent allele loss in colorectal and lung cancer. Oncogene 1991; 6: 1881-1886.
6. Miura I, Graziano SL, Cheng JQ, Doyle LA, Testa JR. Chromosome alterations in human small cell lung cancer: frequent involvement of 5q. Cancer Res 1991; 52: 1322-1328.
7. D'Amico D, Carbone DP, Johnson BE, Meltzer SJ, Minna JD. Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygozity in human small cell lung cancer. Cancer Res 1992; 52: 1996-1999.
8. Fong KM, Zimmerman PV, Smith PJ. Tumor progression and loss of heterozygosity at 5q and 18q in non-small cell lung cancer. Cancer Res 1995; 55: 220-223.
9. Bishop DT, Hall NR. The genetics of colorectal cancer. Eur J Cancer 1994; 30: 1946-1956.
10. Munemitsu S, Albert I, Souza B, Rubinfeld B, Polakis P. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci USA 1995; 92: 3046-3050.
11. Hinck L, Nelson W, Papkoff J. Wnt-1 modulates cell-cell adhesion in mammalian cells stabilising β-catenin binding to the cell adhesion protein cadherin. J Cell Biol 1994; 124: 729-741.
12. Funayama N, Fagotto F, McCrea P, Gumbiner B. Embryonic axis induction by the armidillo repeat domain of β-catenin: evidence for intracellular signalling. J Cell Biol 1995; 128: 959-968.
13. Munemitsu S, Souza B, Müller O, Albert I, Rubinfeld B, Polakis P. The APC gene product associates with microtubules in vivo and promotes their assembly in vitro. Cancer Res 1994; 54: 3676-3681.
14. Smith KJ, Levy DB, Maupin P, Pollard TD, Vogelstein B, Kinzler KW. Wild-type but not mutant APC associates with the microtubule cytoskeleton. Cancer Res 1994; 54: 3672-3675.
15. Midgley CA, White S, Howitt R, et al. APC expression in normal human tissues. (Submitted).
16. Tsuchiya E, Nakamura Y, Weng SY, et al. Allelotype of non-small lung carcinoma - comparison between loss of heterozygosity in squamous cell carcinoma and adenocarcinoma. Cancer Res 1992; 52: 2478-2481.
17. Gilliland FD, Samet JM, Lung cancer. In: Doll R, Fraumeni JF, Muir CF, eds. Trends in Cancer Incidence and Mortality. New York: Cold Spring Harbor Laboratory Press, 1994; 175-195.
18. Edwards CW. Pulmonary adenocarcinoma: a review of 106 cases and proposed new classification. J Clin Pathol 1987; 40: 125-135.
19. Horii A, Nakatsuru S, Miyoshi Y, et al. Frequent somatic mutations of the APC gene in human pancreatic cancer. Cancer Res 1992; 52: 6696-6698.
20. Nakatsuru S, Yanagisawa A, Ichii S, et al. Somatic mutations of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma. Hum Mol Genet 1992; 1: 559-563.
21. Miyoshi Y, Nagase H, Ando H, et al. Somatic mutations of the APC gene in colorectal tumours: mutation cluster region in the APC gene. Hum Mol Genet 1992; 4: 229-233.
22. Levi S, Urbono-Ispizua A, Gill R, et al. Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique. Cancer Res 1991; 51: 3497-3502.
23. Carey FA, Wallace WAH, Fergusson RJ, Kerr KM, Lamb D. Alveolar atypical hyperplasia in association with primary pulmonary adenocarcinoma: a clinico-pathological study of 10 cases. Thorax 1992; 47: 1041-1043.
24. Heighway J, Hoban PR, Wyllie AH. Ssp1 polymorphism in sequence encoding 3′ untranslated region of the APC gene. Nucleic Acids Res 1991; 19: 6966.
25. Groden J, Thilveris A, Samowitz W, et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 1991; 66: 589-600.
26. Heighway J, Hoban PR, Wyllie AH. Mae111 polymorphism in sequence encoding 3′ untranslated region of the MCC gene. Nucleic Acids Res 1992; 20: 1160.
27. Miyoshi Y, Nishisho I, Miki Y, et al. Insertion/deletion polymorphism and other restriction fragment length polymorphisms in the MCC gene. Jpn J Cancer Res 1992; 83: 10-14.
28. Curtis LJ, Bubb VJ, Gledhill S, Morris RG, Bird CC, Wyllie AH. Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer. Hum Mol Genet 1994; 3: 443-446.
29. Curtis L, Wyllie AH, Shaw J, et al. Evidence against involvement of APC mutations in papillary thyroid carcinoma. Eur J Cancer 1994; 7: 984-987.
30. Sano T, Tsujino T, Yoshida K, et al. Frequent loss of heterozygosity on chromosome 1q, 5q and 17p in human gastric carcinomas. Cancer Res 1991; 51: 2926-2931.
31. Boynton RF, Blount PL, Yin J, et al. Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers. Proc Natl Acad Sci USA 1992; 89: 3385-3388.
32. Morita R, Saito S, Ishikawa J, Ogawa O, Yoshida O, Yamakawa K. Common regions of deletion on chromosomes 5q, 6q and 10q in renal cell carcinoma. Cancer Res 1991; 51: 5817-5820.
33. Wieland I, Bohm M. Frequent allelic deletion at a novel locus on chromosome 5 in human lung cancer. Cancer Res 1994; 54: 1772-1774.
34. Auerbach O, Garfinkel L. The changing pattern of lung carcinoma. Cancer 1991; 68: 1973-1977.
35. Kerr KM, Carey FA, King G, Lamb D. Atypical alveolar hyperplasia: relationship with pulmonary adenocarcinoma, p53 and c-erbB-2 expression. J Pathol 1994; 174: 249-256.