The hydroxyurea-induced loss of double-minute chromosomes containing amplified epidermal growth factor receptor genes reduces the tumorigenicity and growth of human glioblastoma multiforme

Neurosurgery

Volumn 42, Issue 3, 1998, Pages 609-616

  Canute, Gregory W ^a,b   Longo, Sharon L ^a   Longo, John A ^b   Shetler, Michèle M ^a   Coyle, Thomas E ^a   Winfield, Jeffrey A ^a   Hahn, Peter J ^b  

^a Department of Neurosurgery ^*  (United States)

^b SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

Double minute chromosomes; Epidermal growth factor receptor; Human glioblastoma multiforme; Hydroxyurea; Tumorigenicity

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; HYDROXYUREA;

ANIMAL EXPERIMENT; ARTICLE; CANCER GROWTH; CARCINOGENICITY; CHROMOSOME LOSS; DOUBLE MINUTE CHROMOSOME; GLIOBLASTOMA; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CARCINOGENICITY TESTS; CELL CYCLE; CELL DIVISION; CHROMOSOMES; FEMALE; GENE AMPLIFICATION; GLIOBLASTOMA; HUMANS; HYDROXYUREA; MICE; MICE, NUDE; MIDDLE AGED; NUCLEIC ACID SYNTHESIS INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TUMOR CELLS, CULTURED;

EID: 0031931787     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006123-199803000-00031     Document Type: Article

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