Hydroxyurea accelerates the loss of epidermal growth factor receptor genes amplified as double-minute chromosomes in human glioblastoma multiforme

Neurosurgery

Volumn 39, Issue 5, 1996, Pages 976-983

  Canute, Gregory W ^a   Longo, Sharon L ^a   Longo, John A ^a   Winfield, Jeffrey A ^a   Nevaldine, Barbara H ^a   Hahn, Peter J ^a  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

Double minute chromosomes; Epidermal growth factor receptor; Gene amplification; Human glioblastoma multiforme; Hydroxyurea

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; HYDROXYUREA;

ARTICLE; ASTROCYTOSIS; CHROMOSOME ANALYSIS; GENE AMPLIFICATION; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROGNOSIS; PULSED FIELD GEL ELECTROPHORESIS; SOUTHERN BLOTTING; SURVIVAL RATE; TUMOR GROWTH;

AGED; ANIMALS; BLOTTING, SOUTHERN; CELL DIVISION; CELLS, CULTURED; CHROMOSOMES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS; EPIDERMAL GROWTH FACTOR; FEMALE; GENE AMPLIFICATION; GENES; GLIOBLASTOMA; HUMANS; HYDROXYUREA; MICE; MICE, INBRED BALB C; MIDDLE AGED;

EID: 0029802395     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006123-199611000-00019     Document Type: Article

References (42)

1. Ahn SY, Nevaldine B, Hahn PJ: Direct measurement by pulsedfield gel electrophoresis of induction and rejoining of x-ray-induced double-strand breaks in cultured mouse cells. Int J Radiat Biol 59:661-675, 1991.
2. Benner SE, Wahl GM, Von Hoff DD: Double-minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines. Anticancer Drugs 2:11-25, 1991.
3. Bigner SH, Vogelstein B: Cytogenetics and molecular genetics of malignant gliomas and medulloblastoma. Brain Pathol 1:12-18, 1990.
4. Bigner SH, Humphrey PA, Wong AJ, Vogelstein B, Mark J, Friedman HS, Bigner DD: Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts. Cancer Res 50:8017-8022, 1990.
5. Bigner SH, Mark J, Burger PC, Mahaley MS, Bullard DE, Muhlbaier LH, Bigner DD: Specific chromosomal abnormalities in malignant human gliomas. Cancer Res 48:405-411, 1988.
6. Borst PB, Van Der Bliek AM, Van Der Velde-Koerts T, Hes E: Structure of amplified DNA, analyzed by pulsed-field gradient gel electrophoresis. J Cell Biochem 34:247-258, 1987.
7. Chaffanet M, Chauvin C, Laine M, Berger F, Chedin M, Rost N, Nissou MF, Benabid AL: EGF receptor amplification and expression in human brain tumours. Eur J Cancer 28:11-17, 1992.
8. Christen RD, Shalinsky DR, Howell SB: Enhancement of the loss of multiple drug resistance by hydroxyurea. Semin Oncol 19:94-100, 1992.
9. Collins VP, James CD: Gene and chromosomal alterations associated with the development of human gliomas. FASEB J 7:926-930, 1993.
10. Coyle T, Levante S, Shetler M, Winfield J: In vitro and in vivo cytotoxicity of gossypol against central nervous system tumor cell lines. J Neuro-Oncol 19:25-35, 1994.
11. Di Fiore PP, Pierce JH, Fleming TP, Hazan R, Ullrich A, King CR, Schlessinger J, Aaronson SA: Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells. Cell 51:1063-1070, 1987.
12. Dolf G, Meyn RE, Curley D, Prather N, Story MD, Boman BM, Siciliano MJ, Hewitt RR: Extrachromasomal amplification of the epidermal growth factor receptor gene in human colon carcinoma cell line. Genes Chromosom Cancer 3:48-54, 1991.
13. Ekstrand AJ, James CD, Cavenee WK, Seliger B, Pettersson RF, Collins VP: Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res 51:2164-2172, 1991.
14. Engebraaten O, Bjerkvig R, Pedersen P-H, Laerum OD: Effects of EGF, bFGF, NGF and PDGF(bb) on cell proliferative, migratory and invasive capacities of human brain-tumor biopsies in vitro. Int J Cancer 53:209-214, 1993.
15. Fuller GN, Bigner SH: Amplified cellular oncogenes in neoplasms of the human central nervous system. Mutat Res 276:299-306, 1992.
16. Hahn PJ: Molecular biology of double-minute chromosomes. Bioessays 15:477-484, 1993.
17. Hahn PJ, Nevaldine B, Longo JA: Molecular structure and evolution of double-minute chromosomes in methotrexate-resistant cultured mouse cells. Mol Cell Biol 12:2911-2918, 1992.
18. Hurtt MR, Moossy J, Donovan-Peluso M, Locker J: Amplification of epidermal growth factor receptor gene in gliomas: Histopathology and prognosis. J Neuropathol Exp Neurol 51:84-90, 1992.
19. Leon SP, Zhu J, Black PMcL: Genetic aberrations in human brain rumors. Neurosurgery 34:708-722, 1994.
20. Levin VA: The place of hydroxyurea in the treatment of primary brain tumors. Semin Oncol 19:34-40, 1992.
21. Libermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield MD, Ullrich A, Schlessinger J: Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 313:144-147, 1985.
22. Lund-Johansen M, Bjerkvig R, Humphrey PA, Bigner SH, Bigner DD, Laerum O-D: Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro. Cancer Res 50:6039-6044, 1990.
23. Mahaley MS, Mettlin C, Natarajan N, Laws ER Jr, Peace BB: National survey of patterns of care for brain-tumor patients. J Neurosurg 71:826-836, 1989.
24. Muleris M, Almeida A, Dutrillaux AM, Pruchon E, Vega F, Delattre JY, Poisson M, Malfoy B, Dutrillaux B: Oncogene amplification in human gliomas: A molecular cytogenetic analysis. Oncogene 9:2717-2722, 1994.
25. Nevaldine B, Longo JA, King GA, Vilenchik M, Sagerman RH, Hahn PJ: Induction and repair of DNA double-strand breaks. Radiat Res 133:370-374, 1993.
26. Plucinski TM, Fager RS, Reddy GP: Allosteric interaction of components of the replitase complex is responsible for enzyme cross-inhibition. Mol Pharmacol 38:114-120, 1990.
27. Pollack IF, Randall MS, Kristofik MP, Kelly RH, Selker RG, Vertosick FT: Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium. J Neurosurg 73:106-112, 1990.
28. Pollack IF, Randall MS, Kristofik MP, Kelly RH, Selker RG, Vertosick FT: Response of low-passage human malignant gliomas in vitro to stimulation and selective inhibition of growth factor-mediated pathways. J Neurosurg 75:284-293, 1991.
29. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, Cold Spring Harbor Laboratory Press, 1989.
30. Santon JB, Cronin MT, MacLeod MT, Mendelsohn J, Masui H, Gill GN: Effects of epidermal growth factor receptor concentration on tumorigenicity of A431 cells in nude mice. Cancer Res 46:4701-4705, 1986.
31. Schoenlein PV, Shen DW, Barrett JT, Pastan I, Gottesman MM: Double-minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells. Mol Biol Cell 3:507-520, 1992.
32. Snapka RM, Varshavsky A: Loss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyurea. Proc Natl Acad Sci U S A 80:7533-7537, 1983.
33. Stark GR, Debatisse M, Giulotto E, Wahl GM: Recent progress in understanding mechanisms of mammalian DNA amplification. Cell 57:901-908, 1989.
34. VanDevanter DR, Piaskowski VD, Casper JT, Douglass EC, Von Hoff DD: Ability of circular extrachromosomal DNA molecules to carry amplified mycn proto-oncogenes in human neuroblastomas in vivo. J Natl Cancer Inst 82:1815-1821, 1990.
35. Velu TJ, Beguinot L, Vass WC, Willingham MC, Merlino GT, Pastan I, Lowy DR: Epidermal growth factor-dependent transformation by a human EGF receptor proto-oncogene. Science 238: 1408-1410, 1987.
36. Von Deimling A, Von Ammon K, Schoenfeld D, Wiestler OD, Seizinger BR, Louis DN: Subsets of glioblastoma multiforme defined by molecular genetic analysis. Brain Pathol 3:19-26, 1993.
37. Von Hoff DD, McGill JR, Forseth BJ, Davidson KK, Bradley TP, VanDevanter DR, Wahl GM: Elimination of extrachromosomally amplified myc genes from human tumor cells reduces their tumorigenicity. Proc Natl Acad Sci U S A 89:8165-8169, 1992.
38. Von Hoff DD, Waddelow T, Forseth B, Davidson K, Scott J, Wahl G: Hydroxyurea accelerates loss of extrachromosomally amplified genes from tumor cell. Cancer Res 51:6273-6279, 1991.
39. Whittle IR, Denholm SW, Gregor A: Management of patients aged over 60 years with supratentorial glioma: Lessons from an audit. Surg Neurol 36:106-111, 1991.
40. Winger MJ, Macdonald DR, Cairncross JG: Supratentorial anaplastic gliomas in adults: The prognostic importance of extent of resection and prior low-grade glioma. J Neurosurg 71:487-493, 1989.
41. Wong AJ, Bigner SH, Bigner DD, Kinzler KW, Hamilton SR, Vogelstein B: Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci U S A 84:6899-6903,1987.
42. Yarbro JW: Mechanism of action of hydroxyurea. Sem Oncol 19:1-10, 1992.