Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis

New England Journal of Medicine

Volumn 332, Issue 17, 1995, Pages 1132-1137

  Cortelazzo, Sergio ^a   Finazzi, Guido ^a   Ruggeri, Marco ^a,b   Vestri, Oscar ^a   Galli, Monica ^a   Rodeghiero, Francesco ^b   Barbui, Tiziano ^a  

^a Ospedali Riuniti di Bergamo   (United States)

^b Department of Infectious Diseases   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; HYDROXYUREA; TICLOPIDINE;

ADULT; AGED; ARTICLE; BLOOD CLOTTING DISORDER; BONE MARROW SUPPRESSION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DISEASE ASSOCIATION; DISEASE CONTROL; FEMALE; FOLLOW UP; HEMOSTASIS; HIGH RISK POPULATION; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; STROKE; THROMBOCYTE COUNT; THROMBOCYTHEMIA; THROMBOSIS;

ADULT; AGED; AGED, 80 AND OVER; ASPIRIN; FEMALE; FOLLOW-UP STUDIES; HEMORRHAGE; HUMANS; HYDROXYUREA; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROSPECTIVE STUDIES; RISK; THROMBOCYTOSIS; THROMBOEMBOLISM; TICLOPIDINE;

EID: 0028913012     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199504273321704     Document Type: Article

References (19)

1. Schafer AI Essential thrombocythemia. Prog Hemost Thromb 1991; 10: 69-96
2. van Genderen PJJ, Michiels JJ Primary thrombocythemia: diagnosis, clinical manifestations and management. Ann Hematol 1993; 67: 57-62
3. Cortelazzo S, Viero P, Finazzi G, D'Emilio A, Rodeghiero F, Barbui T Incidence and risk factors for thrombotic complications in a historical cohort of 100 patients with essential thrombocythemia. J Clin Oncol 1990; 8: 556-562
4. Barbui T, Cortelazzo S, Viero P, Bassan R, Dini E, Semeraro N Thrombohaemorrhagic complications in 101 cases of myeloproliferative disorders: relationship to platelet number and function. Eur J Cancer Clin Oncol 1983; 19: 1593-1599
5. Lofvenberg E, Wahlin A Management of polycythaemia vera, essential thrombocythaemia and myelofibrosis with hydroxyurea. Eur J Haematol 1988; 41: 375-381
6. Lofvenberg E, Nordenson I, Wahlin A Cytogenetic abnormalities and leukemic transformation in hydroxyurea-treated patients with Philadelphia chromosome negative chronic myeloproliferative disease. Cancer Genet Cytogenet 1990; 49: 57-67
7. Murphy S, Iland H, Rosenthal D, Lazlo J Essential thrombocythemia: an interim report from the Polycythemia Vera Study Group. Semin Hematol 1986; 23: 177-182
8. Levine MN, Raskob G, Hirsh J Hemorrhagic complications of long-term anticoagulant therapy. Chest 1986; 89: 16S-25S
9. Miller AB, Hoogstraten B, Staquet M, Winkler A Reporting results of cancer treatment. Cancer 1981; 47: 207-214
10. Gardner MJ, Altman DG Confidence intervals rather than P values: estimation rather than hypothesis testing. BMJ 1986; 292: 746-750
11. Kaplan EL, Meier P Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 457-481
12. Mantel N, Haenszel W Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22: 719-748
13. Cox DR Regression models and life-tables. J R Stat Soc [B] 1972; 34: 187-220
14. Pearson TC, Messinezy M Polycythaemia and thrombocythaemia in the elderly. Baillieres Clin Haematol 1987; 1: 355-387
15. Turlure P, Le Prise PY, Letortorec S, Essential thrombocythemia (E.T.) clinical course and results of a multicenter prospective study. Blood 1993; 82: Suppl 1: 1979-1979 abstract.
16. Watson KV, Key N Vascular complications of essential thrombocythaemia: a link to cardiovascular risk factors. Br J Haematol 1993; 83: 198-203
17. Kaplan ME, Mack K, Goldberg JD, Donovan PB, Berk PD, Wasserman LR Long-term management of polycythemia vera with hydroxyurea: a progress report. Semin Hematol 1986; 23: 167-171
18. Murphy S, Peterson P, Iland HJ, Fruchtman S Hydroxyurea and other myelosuppressive agents in the treatment of essential thrombocythemia: analysis of leukemogenic potential. Thromb Haemost 1993; 69: 564-564 abstract.
19. Van de Pette JEW, Prochazka AV, Pearson TC, Singh AK, Dickson ER, Wetherley-Mein G Primary thrombocythaemia treated with busulphan. Br J Haematol 1986; 62: 229-237