Analysis of glioma cell lines for amplification and overexpression of MDM2

Genes, Chromosomes and Cancer

Volumn 11, Issue 2, 1994, Pages 91-96

  He, Ju ^a   Reifenberger, Guide ^c   Liu, Lu ^c   Collins, V Peter ^b,c   James, C David ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; PROTEIN P53;

ARTICLE; AUTORADIOGRAPHY; CHROMOSOME 12Q; DNA SEQUENCE; GENE; GENE DOSAGE; GENE EXPRESSION; GLIOMA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; NORTHERN BLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING;

GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMAN; IMMUNOHISTOCHEMISTRY; PROTO-ONCOGENE PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0027969332     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.2870110205     Document Type: Article

References (24)

1. Amplification of the human putative oncogene INT1 in primary retinoblastoma tumors
2. Single‐step method of RNA isolation by acid guanidinium thiocyanate‐phenol‐chloroform extraction
3. TP53 gene mutations and 17p deletions in human astrocytomas
4. Genes for epidermal growth factor receptor, transforming growth factor‐alpha, and epidermal growth factor and their expression in human gliomas in vivo
5. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
6. Mapping of amplification units in the q13‐14 region of chromosome 12 in human sarcomas: Some amplica do not include MDM2.
7. p53 mutations in human malignant gliomas: Comparison of loss of heterozygosity with mutation frequency
8. p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression
9. Localization of chromosome 9p homozygous deletions in glioma cell lines with markers constituting a continuous linkage group
10. Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
11. Identification of an amplified, highly expressed gene in a human glioma
12. MDM2 gene amplification in metastatic osteosarcoma
13. p53 mutation and MDM2 amplification in human soft tissue sarcomas
14. Identification and cloning of a novel amplified DNA segment in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors
15. The mdm‐2 oncogene product forms a complex with the p53 protein and inhibits p53‐mediated transactivation
16. Amplification of a gene encoding a p53‐associated protein in human sarcomas
17. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
18. Identification and characterization of multiple mdm‐2 proteins and mdm‐2‐p53 protein complexes
19. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
20. SAS amplification in soft tissue sarcomas
21. Analysis of the p53 gene and its expression in human glioblastoma cells
22. Molecular cloning and chromosomal assignment of the human homolog of int‐1, a mouse gene implicated in mammary tumorigenesis
23. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification