-
1
-
-
0030941458
-
p53, the cellular gatekeeper for growth and division
-
Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell, 88: 323-331, 1997.
-
(1997)
Cell
, vol.88
, pp. 323-331
-
-
Levine, A.J.1
-
2
-
-
0028231586
-
Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene
-
Fujiwara, T., Grimm, E. A., Mukhopadhyay, T., Zhang, W-W., Owen-Schaub, L. B., and Roth, J. A. Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res., 54: 2287-2291, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 2287-2291
-
-
Fujiwara, T.1
Grimm, E.A.2
Mukhopadhyay, T.3
Zhang, W.-W.4
Owen-Schaub, L.B.5
Roth, J.A.6
-
3
-
-
0029832231
-
In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug
-
Blagosklonny, M. V., and El-Deiry, W. S. In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug. Int. J. Cancer, 67: 386-392, 1996.
-
(1996)
Int. J. Cancer
, vol.67
, pp. 386-392
-
-
Blagosklonny, M.V.1
El-Deiry, W.S.2
-
4
-
-
9544244796
-
Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer
-
Roth, J. A., Nguyen, D., Lawrence, D. D., Kemp, B. L., Carrasco, C. H., Ferson, D. Z., Hong, W. K., Komaki, R., Lee, J. J., Nesbitt, J. C., Pisters, K. M. W., Putnam, J. B., Schea, R., Shin, D. M., Walsh, G. L., Dolormente, M. M., Han, C-I., Martin, F. D., Yen, N., Xu, K., Stephens, L. C., McDonnell, T. J., Mukhopadhyay, T., and Cai, D. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nat. Med., 2: 985-991, 1996.
-
(1996)
Nat. Med.
, vol.2
, pp. 985-991
-
-
Roth, J.A.1
Nguyen, D.2
Lawrence, D.D.3
Kemp, B.L.4
Carrasco, C.H.5
Ferson, D.Z.6
Hong, W.K.7
Komaki, R.8
Lee, J.J.9
Nesbitt, J.C.10
Pisters, K.M.W.11
Putnam, J.B.12
Schea, R.13
Shin, D.M.14
Walsh, G.L.15
Dolormente, M.M.16
Han, C.-I.17
Martin, F.D.18
Yen, N.19
Xu, K.20
Stephens, L.C.21
McDonnell, T.J.22
Mukhopadhyay, T.23
Cai, D.24
more..
-
5
-
-
0029889030
-
WAF1/CIP1 deficient in PCNA interaction
-
WAF1/CIP1 deficient in PCNA interaction. Clin. Cancer Res., 2: 1221-1229, 1996.
-
(1996)
Clin. Cancer Res.
, vol.2
, pp. 1221-1229
-
-
Prabhu, N.S.1
Blagosklonny, M.V.2
Zeng, Y.-X.3
Wu, G.S.4
Waldman, T.5
El-Deiry, W.S.6
-
6
-
-
0023339504
-
Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line
-
Cahilly-Snyder, L., Yang-Feng, T., Francke, U., and George, D. L. Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Somatic Cell Mol. Genet., 13: 235-244, 1987.
-
(1987)
Somatic Cell Mol. Genet.
, vol.13
, pp. 235-244
-
-
Cahilly-Snyder, L.1
Yang-Feng, T.2
Francke, U.3
George, D.L.4
-
7
-
-
0027325132
-
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
-
Oliner, J. D., Pietenpol, J. A., Thiagalingam, S., Gvuris, J., Kinzler, K. W., and Vogelstein, B. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature (Lond.), 362: 857-860, 1993.
-
(1993)
Nature (Lond.)
, vol.362
, pp. 857-860
-
-
Oliner, J.D.1
Pietenpol, J.A.2
Thiagalingam, S.3
Gvuris, J.4
Kinzler, K.W.5
Vogelstein, B.6
-
8
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
-
Momand, J., Zambetti, G. P., Olson, D. C., George, D., and Levine, A. J. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell, 69: 1237-1245, 1992.
-
(1992)
Cell
, vol.69
, pp. 1237-1245
-
-
Momand, J.1
Zambetti, G.P.2
Olson, D.C.3
George, D.4
Levine, A.J.5
-
9
-
-
0029913730
-
1 arrest and apoptosis functions of the p53 tumor suppressor protein
-
1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol. Cell. Biol., 16: 2445-2452, 1996.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 2445-2452
-
-
Chen, J.1
Wu, X.2
Lin, J.3
Levine, A.J.4
-
10
-
-
0029985647
-
Cell type-specific inhibition of p53-mediated apoptosis by mdm2
-
Haupt, Y., Barak, Y., and Oren, M. Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J., 15: 1596-1606, 1996.
-
(1996)
EMBO J.
, vol.15
, pp. 1596-1606
-
-
Haupt, Y.1
Barak, Y.2
Oren, M.3
-
11
-
-
0027244853
-
The p53-mdm-2 autoregulatory feedback loop
-
Wu, X., Bayle, J. H., Olson, D., and Levine, A. J. The p53-mdm-2 autoregulatory feedback loop. Genes Dev., 7: 1126-1132, 1993.
-
(1993)
Genes Dev.
, vol.7
, pp. 1126-1132
-
-
Wu, X.1
Bayle, J.H.2
Olson, D.3
Levine, A.J.4
-
12
-
-
0028834902
-
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
-
Jones, S. N., Roe, A. E., Donehower, L. A., and Bradley, A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature (Lond.), 378: 206-208, 1995.
-
(1995)
Nature (Lond.)
, vol.378
, pp. 206-208
-
-
Jones, S.N.1
Roe, A.E.2
Donehower, L.A.3
Bradley, A.4
-
13
-
-
0028823020
-
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
-
Montes de Oca Luna, R., Wagner, D. S., and Lozano, G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature (Lond.), 378: 203-206, 1995.
-
(1995)
Nature (Lond.)
, vol.378
, pp. 203-206
-
-
Montes De Oca Luna, R.1
Wagner, D.S.2
Lozano, G.3
-
14
-
-
0027956208
-
Enhanced translation: A novel mechanism of mdm2 oncogene overexpression identified in human tumor cells
-
Landers, J. E., Haines, D. S., Strauss, J. F., III, and George, D. L. Enhanced translation: a novel mechanism of mdm2 oncogene overexpression identified in human tumor cells. Oncogene, 9: 2745-2750, 1994.
-
(1994)
Oncogene
, vol.9
, pp. 2745-2750
-
-
Landers, J.E.1
Haines, D.S.2
Strauss III, J.F.3
George, D.L.4
-
15
-
-
0026740449
-
Amplification of a gene encoding a p53-associated protein in human sarcomas
-
Oliner, J. D., Kinzler, K. W., Meltzer, P. S., George, D. L., and Vogelstein, B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature (Lond.), 358: 80-83, 1992.
-
(1992)
Nature (Lond.)
, vol.358
, pp. 80-83
-
-
Oliner, J.D.1
Kinzler, K.W.2
Meltzer, P.S.3
George, D.L.4
Vogelstein, B.5
-
16
-
-
0027993963
-
MDM2 gene amplification in human breast cancer
-
Quesnel, B., Preudhomme, C., Fournier, J., Fenaux, P., and Peyrat, J. P. MDM2 gene amplification in human breast cancer. Eur. J. Cancer, 30A: 982-984, 1994.
-
(1994)
Eur. J. Cancer
, vol.30 A
, pp. 982-984
-
-
Quesnel, B.1
Preudhomme, C.2
Fournier, J.3
Fenaux, P.4
Peyrat, J.P.5
-
17
-
-
0027196974
-
Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
-
Reifenberger, G., Liu, L., Ichimura, K., Schmidt, E. E., and Collins, V. P. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res., 53: 2736-2739, 1993.
-
(1993)
Cancer Res.
, vol.53
, pp. 2736-2739
-
-
Reifenberger, G.1
Liu, L.2
Ichimura, K.3
Schmidt, E.E.4
Collins, V.P.5
-
18
-
-
0027368879
-
The human MDM-2 oncogene is overexpressed in leukemias
-
Bueso-Ramos, C. E., Yang, Y., de Leon, E., McCown, P., Stass, S. A., and Albitar, M. The human MDM-2 oncogene is overexpressed in leukemias. Blood, 82: 2617-2623, 1993.
-
(1993)
Blood
, vol.82
, pp. 2617-2623
-
-
Bueso-Ramos, C.E.1
Yang, Y.2
De Leon, E.3
McCown, P.4
Stass, S.A.5
Albitar, M.6
-
19
-
-
0028081261
-
The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin
-
Watanabe, T., Hotta, T., Ichikawa, A., Kinoshita, T., Nagai, H., Uchida, T., Murate, T., and Saito, H. The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin. Blood, 84: 3158-3165, 1994.
-
(1994)
Blood
, vol.84
, pp. 3158-3165
-
-
Watanabe, T.1
Hotta, T.2
Ichikawa, A.3
Kinoshita, T.4
Nagai, H.5
Uchida, T.6
Murate, T.7
Saito, H.8
-
20
-
-
0029033840
-
p53 mutation, murine double minute 2 amplification, and human papillomavirus infection are frequently involved but not associated with each other in esophageal squamous cell carcinoma
-
Shibagaki, I., Tanaka, H., Shimada, Y., Wagata, T., Ikenaga, M., Imamura, M., and Ishizaki, K. p53 mutation, murine double minute 2 amplification, and human papillomavirus infection are frequently involved but not associated with each other in esophageal squamous cell carcinoma. Clin. Cancer Res., 1: 769-773, 1995.
-
(1995)
Clin. Cancer Res.
, vol.1
, pp. 769-773
-
-
Shibagaki, I.1
Tanaka, H.2
Shimada, Y.3
Wagata, T.4
Ikenaga, M.5
Imamura, M.6
Ishizaki, K.7
-
21
-
-
0026669469
-
p53 function and dysfunction
-
Vogelstein, B., and Kinzler, K. W. p53 function and dysfunction. Cell, 70: 523-526, 1992.
-
(1992)
Cell
, vol.70
, pp. 523-526
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
22
-
-
0025853776
-
Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
-
Fakharzadeh, S. S., Trusko, S. P., and George, D. L. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J., 10: 1565-1569, 1991.
-
(1991)
EMBO J.
, vol.10
, pp. 1565-1569
-
-
Fakharzadeh, S.S.1
Trusko, S.P.2
George, D.L.3
-
23
-
-
0027498314
-
The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth
-
Finlay, C. A. The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth. Mol. Cell. Biol., 13: 301-306, 1993.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 301-306
-
-
Finlay, C.A.1
-
24
-
-
0029028353
-
Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
-
Martin, K., Trouche, D., Hagemeier, C., Sorensen, T. S., La Thangue, N. B., and Kouzarides, T. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature (Lond.), 375: 691-694, 1995.
-
(1995)
Nature (Lond.)
, vol.375
, pp. 691-694
-
-
Martin, K.1
Trouche, D.2
Hagemeier, C.3
Sorensen, T.S.4
La Thangue, N.B.5
Kouzarides, T.6
-
25
-
-
0029028354
-
Interaction between the retinoblastoma protein and the oncoprotein MDM2
-
Xiao, Z-X., Chen, J., Levine, A. J., Modjtahedl, N., Xing, J., Sellers, W. R., and Livingston, D. M. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature (Lond.), 375: 694-698, 1995.
-
(1995)
Nature (Lond.)
, vol.375
, pp. 694-698
-
-
Xiao, Z.-X.1
Chen, J.2
Levine, A.J.3
Modjtahedl, N.4
Xing, J.5
Sellers, W.R.6
Livingston, D.M.7
-
26
-
-
0029824669
-
Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer
-
Sigalas, I., Calvert, A. H., Anderson, J. J., Neal, D. E., and Lunec, J. Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer. Nat. Med., 2: 912-917, 1996.
-
(1996)
Nat. Med.
, vol.2
, pp. 912-917
-
-
Sigalas, I.1
Calvert, A.H.2
Anderson, J.J.3
Neal, D.E.4
Lunec, J.5
-
27
-
-
14444281159
-
Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53
-
Lundgren, K., Montes de Oca Luna, R., McNeill, Y. B., Emerick, E. P., Spencer, B., Barfield, C. R., Lozano, G., Rosenberg, M. P., and Finlay, C. A. Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev., 11: 714-725, 1997.
-
(1997)
Genes Dev.
, vol.11
, pp. 714-725
-
-
Lundgren, K.1
Montes De Oca Luna, R.2
McNeill, Y.B.3
Emerick, E.P.4
Spencer, B.5
Barfield, C.R.6
Lozano, G.7
Rosenberg, M.P.8
Finlay, C.A.9
-
28
-
-
0029849620
-
Cancer cell cycles
-
Washington DC
-
Sherr, C. J. Cancer cell cycles. Science (Washington DC), 274: 1672-1677, 1996.
-
(1996)
Science
, vol.274
, pp. 1672-1677
-
-
Sherr, C.J.1
-
29
-
-
0028821895
-
Effects of a recombinant adenovirus expressing WAF1/CIP1 on cell growth, cell cycle, and apoptosis
-
Katayose, D., Wersto, R., Cowan, K. H., and Seth, P. Effects of a recombinant adenovirus expressing WAF1/CIP1 on cell growth, cell cycle, and apoptosis. Cell Growth Differ., 6: 1207-1212, 1995.
-
(1995)
Cell Growth Differ.
, vol.6
, pp. 1207-1212
-
-
Katayose, D.1
Wersto, R.2
Cowan, K.H.3
Seth, P.4
-
30
-
-
0028820762
-
The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo
-
Yang, Z-Y., Perkins, N. D., Ohno, T., Nabel, E. G., and Nabel, G. J. The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo. Nat. Med., 1: 1052-1056, 1995.
-
(1995)
Nat. Med.
, vol.1
, pp. 1052-1056
-
-
Yang, Z.-Y.1
Perkins, N.D.2
Ohno, T.3
Nabel, E.G.4
Nabel, G.J.5
-
31
-
-
0027359827
-
WAF1, a potential mediator of p53 tumor suppression
-
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., and Vogelstein, B. WAF1, a potential mediator of p53 tumor suppression. Cell, 75: 817-825, 1993.
-
(1993)
Cell
, vol.75
, pp. 817-825
-
-
El-Deiry, W.S.1
Tokino, T.2
Velculescu, V.E.3
Levy, D.B.4
Parsons, R.5
Trent, J.M.6
Lin, D.7
Mercer, W.E.8
Kinzler, K.W.9
Vogelstein, B.10
-
32
-
-
0030614514
-
WAF1/CIP1, Rb, and c-myc signaling in phorbol ester-resistant cancer cells
-
WAF1/CIP1, Rb, and c-myc signaling in phorbol ester-resistant cancer cells. Cancer Res., 57: 320-325, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 320-325
-
-
Blagosklonny, M.V.1
Prabhu, N.S.2
El-Deiry, W.S.3
-
33
-
-
0028294605
-
1 arrest and apoptosis
-
1 arrest and apoptosis. Cancer Res., 54: 1169-1174, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 1169-1174
-
-
El-Deiry, W.S.1
Harper, J.W.2
O'Connor, P.M.3
Velculescu, V.E.4
Canman, C.E.5
Jackman, J.6
Pietenpol, J.A.7
Burrell, M.8
Hill, D.E.9
Wang, Y.10
Wiman, K.G.11
Mercer, W.E.12
Kastan, M.B.13
Kohn, K.W.14
Elledge, S.J.15
Kinzler, K.W.16
Vogelstein, B.17
-
34
-
-
0028147405
-
Physical and functional interaction between wild-type p53 and mdm2 proteins
-
Haines, D. S., Landers, J. E., Engle, L. J., and George, D. L. Physical and functional interaction between wild-type p53 and mdm2 proteins. Mol. Cell. Biol., 14: 1171-1178, 1994.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 1171-1178
-
-
Haines, D.S.1
Landers, J.E.2
Engle, L.J.3
George, D.L.4
-
35
-
-
0030795068
-
Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein
-
Landers, J. E., Cassel, S. L., and George, D. L. Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein. Cancer Res., 57: 3562-3568, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 3562-3568
-
-
Landers, J.E.1
Cassel, S.L.2
George, D.L.3
-
36
-
-
0029033861
-
The retinoblastoma protein and cell cycle control
-
Weinberg, RA. The retinoblastoma protein and cell cycle control. Cell, 81: 323-330, 1995.
-
(1995)
Cell
, vol.81
, pp. 323-330
-
-
Weinberg, R.A.1
-
37
-
-
0028177401
-
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein
-
Slebos, R. J., Lee, M. H., Plunkett, B. S., Kessis, T. D., Williams, B. O., Jacks, T., Hedrick, L., Kastan, M. B., and Cho, K. R. p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc. Natl. Acad. Sci. USA, 91: 5320-5324, 1994.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 5320-5324
-
-
Slebos, R.J.1
Lee, M.H.2
Plunkett, B.S.3
Kessis, T.D.4
Williams, B.O.5
Jacks, T.6
Hedrick, L.7
Kastan, M.B.8
Cho, K.R.9
-
38
-
-
0029863840
-
Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts
-
Herrera, R. E., Sah, V. P., Williams, B. O., Makela, T. P., Weinberg, R. A., and Jacks, T. Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol. Cell. Biol., 16: 2402-2407, 1996.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 2402-2407
-
-
Herrera, R.E.1
Sah, V.P.2
Williams, B.O.3
Makela, T.P.4
Weinberg, R.A.5
Jacks, T.6
-
39
-
-
0028973212
-
WAF1/CIP1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines
-
WAF1/CIP1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines. Oncogene, 11: 1899-1905, 1995.
-
(1995)
Oncogene
, vol.11
, pp. 1899-1905
-
-
Sheikh, M.S.1
Rochefort, H.2
Garcia, M.3
-
41
-
-
0030575937
-
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
-
Washington DC
-
Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., and Pavletich, N. P. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science (Washington DC), 274: 948-953, 1996.
-
(1996)
Science
, vol.274
, pp. 948-953
-
-
Kussie, P.H.1
Gorina, S.2
Marechal, V.3
Elenbaas, B.4
Moreau, J.5
Levine, A.J.6
Pavletich, N.P.7
-
42
-
-
0344188096
-
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
-
Washington DC
-
Bischoff, J. R., Kirn, D. H., Williams, A., Heise, C., Horn, S., Muna, M., Ng, L., Nye, J. A., Sampson-Johannes, A., Fattaey, A., and McCormick, F. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science (Washington DC), 274: 373-376, 1996.
-
(1996)
Science
, vol.274
, pp. 373-376
-
-
Bischoff, J.R.1
Kirn, D.H.2
Williams, A.3
Heise, C.4
Horn, S.5
Muna, M.6
Ng, L.7
Nye, J.A.8
Sampson-Johannes, A.9
Fattaey, A.10
McCormick, F.11
|