Oral administration of schistosome egg antigens and insulin B-chain generates and enhances Th2-type responses in NOD mice

Clinical Immunology and Immunopathology

Volumn 87, Issue 1, 1998, Pages 85-92

  Maron, Ruth ^a   Palanivel, Velupillai ^b   Weiner, Howard L ^a   Harn, Donald A ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Insulin B chain; Insulin dependent diabetes mellitus; Lacto n fucopentaose III; Oral feeding; Schistosome egg antigens; Th2 type responses

Indexed keywords

CD4 ANTIGEN; INSULIN; INTERLEUKIN 10; INTERLEUKIN 4; PARASITE ANTIGEN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOMODULATION; IMMUNOPATHOGENESIS; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; T LYMPHOCYTE ACTIVATION;

EID: 0031924980     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1997.4506     Document Type: Article

References (34)

1. Castano L., Eisenbarth G. S. Type-1 diabetes: A chronic autoimmune disease of human, mouse and rat. Ann. Immunol. 8:1990;647-679.
2. Bach J-F. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocrine Rev. 15:1994;516-542.
3. Leiter E. H., Serreze D. V., Prochaz K. A. M. The epidemiology of diabetes in NOD mice. Immunol. Today. 11:1990;147-149.
4. Shizuru A., Edwards-Taylor C., Banks B. A., Gregory A. K., Fathman C. G. Immunotherapy of the NOD mice: Treatment with an antibody to T-helper lymphocytes. Science. 240:1988;659-662.
5. Hayward, A. R. Shreiber, M. 1989, Neonatal injection of CD3 antibody into non obese diabetic mice reduces the incidence of insulitis and diabetes, J. Immunol. 143, 1555, 1559, 1989.
6. Bendelac A., Boitard C., Bedossa P., Bazin H., Bach J. F., Carnaud C. Adoptive T cell transfer of autoimmune non obese diabetic mouse diabetes does not require recruitment of host B-lymphocytes. J. Immunol. 141:1988;2625-2628.
7. +T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today. 16:1995;34-38.
8. Maron R., Blogg N. S., Polanski M., Hancock W. W., Weiner H. L. Oral tolerance to insulin and the insulin B-chain: Cell lines and cytokine patterns. Annals N.Y. Acad. Sci. 778:1996;346-357.
9. Bergerot I., Ploix C., Petersen J., Moulin V., Rask C., Fabien N., Lindblad M., Mayer A., Czerkinsky C., Holmgren J., Thivolet C. A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes. Proc. Natl. Acad. Sci. USA. 94:1997;4610-4615.
10. Daniel D., Wegman D. R. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B- (9-23). Proc. Natl. Acad. Sci. USA. 93:1996;956-960.
11. Hancock W. W., Polansky M., Zhang J., Blogg N., Weiner H. L. Suppression of insulitis in nonobese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-β, and prostaglandin-E. Am. J. Pathol. 147:1995;1193-1199.
12. Tian J., Atkinson M. A., C-Salzler M., Herschenfeld A., Forsthuber T., Lehmann P. V., Kaufmann D. L. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J. Exp. Med. 183:1996;1561-1567.
13. Day M. J., Tse A. G. D., Puklavec M., Simmonds S. J., Mason D. W. Targeting autoantigen to B cells prevents the induction of a cell-mediated autoimmune disease in rats. J. Exp. Med. 175:1992;655-659.
14. Saoudi A., Simmonds S., Huitinga I., Mason D. W. Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: Evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells. J. Exp. Med. 182:1995;335-344.
15. Pearce E. J., Caspar P., Grzych J-E., Lewis F. A., Sher A. Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasite helminth,Schistosoma mansoni. J. Exp. Med. 173:1991;159-166.
16. Grzych J-M., Pearce E. J., Cheever A., Caulada Z. A., Caspar P., Heiny S., Lewis F., Sher A. Egg deposition is the major stimulus for the production of Th2 cytokines in murine Schistosomiasis mansoni. J. Immunol. 146:1991;1322-1327.
17. Kullberg M. C., Pearce E. J., Heiny S. E., Sher A., Berzofsky J. A. Infection withSchistosoma mansonialters Th1/Th2 cytokine responses to a non-parasite antigen. J. Immunol. 148:1992;3264-3270.
18. +) outgrowth in murine schistosomiasis is genetically restricted and is largely due to activation by polylactosamine sugars. J. Immunol. 158:1997;338-344.
19. Velupillai P., Sypek J., Harn D. A. Interleukin-12 and -10 and gamma interferon regulate polyclonal and ligand-specific expansion of murine B-1 cells. Infect. Immun. 64:1996;4557-4560.
20. Yamashita T., Watanabe T., Saito T., Araki Y., Sendo F. Schistosoma japonicumsoluble egg antigens activate naive B cells to produce antibodies: Definition of parasite mechanisms of immune deviation. Immunology. 79:1993;189-195.
21. +T-cell subsets. Proc. Natl. Acad. Sci. USA. 9:1994;18-22.
22. Boros D. L., Warren K. S. Delayed hypersensitivity-type granuloma formation and dermal reaction induced and elicited by a soluble factor isolated fromSchsitosoma mansonieggs. J. Exp. Med. 132:1984;488-507.
23. Weiner H. L. Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol. Today. 18:1997;335-343.
24. Chen Y., Inobe J., Marks R., Gonnella P., Kuchroo V. K., Weiner H. L. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature. 376:1995;177-180.
25. Zheng X. X., Steel A. W., Hancock W. W., Stevens A. C., Nickerson P. W., Chaudhury P. R., Tian Y., Strom T. B. A noncytolitic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice. J. Immunol. 158:1997;4507-4512.
26. Floresvillanueva P. O., Chikunguwo S. M., Harris T. S., Stadecker M. J. Role of IL-10 on antigen-presenting cell function for schistosomal egg-specific monoclonal T helper cell responsesin vitroandin vivo. J. Immunol. 151:1993;3192-3198.
27. Kuchroo V. K., Das M. P., Brown J. A., Ranger A. M., Zanvill S. S., Sobol R. A., Weiner H. L., Nabavi N., Glimcher L. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 development pathways: Application to autoimmune disease therapy. Cell. 80:1995;707-712.
28. Wong S., Guerder S., Visintin I., Reich E. P., Swenson K. E., Flavell R. A., Janeway C. A. Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse. Diabetes. 44:1995;326-330.
29. Bicancone L., Andres G., DeMartino C., Stamenkovic I. Distinct regulatory roles of lymphocyte costimulatory pathways on T helper type 2-mediated autoimmune disease. J. Exp. Med. 183:1996;1473-1481.
30. T-Robinson A. W., Phillips R. S. B cells are required for the switch from Th1- to Th2-regulated immune responses toPlasmodium chabaudi chabaudiinfection. Infect. Immun. 62:1994;2490-2498.
31. Gajewski T. F., Pinnas M., Wong T., Fitch F. W. Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J. Immunol. 146:1991;1750-1758.
32. Levy-Holtzman R., Schechter I. Schistosome extracts with heat shock factor activity revealed by the gel shift assay. Parasitology. 108:1994;35-42.
33. Birk O. S., Elias D., Weiss A. S., Rosen A., van-der Zee R., Walker M. D., Cohen I. R. NOD mouse diabetes: the ubiquitous mouse hsp60 is a beta-cell target antigen of autoimmune T cells. J. Autoimmun. 9:1996;159-166.
34. +suppressor T cells in superantigen treated non-obese diabetic mice. J. Immunol. 151:1993;4362-4370.