Distinct regulatory roles of lymphocyte costimulatory pathways on T helper type 2-mediated autoimmune disease

Journal of Experimental Medicine

Volumn 183, Issue 4, 1996, Pages 1473-1481

  Biancone, Luigi ^a   Andres, Giuseppe ^a   Ahn, Hannah ^a   Lim, Alice ^a   Dai, Charlotte ^a   Noelle, Randolph ^b   Hideo, Yagita ^c   De Martino, Cesare ^d   Stamenkovic, Ivan ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c JUNTENDO UNIVERSITY   (Japan)

^d SAN GALLICANO DERMATOLOGICAL INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; INTERLEUKIN 4;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CELL CONTACT; CONTROLLED STUDY; ETIOLOGY; HELPER CELL; IMMUNOPATHOGENESIS; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD2; ANTIGENS, CD40; AUTOIMMUNE DISEASES; BASE SEQUENCE; BLOOD VESSELS; CD40 LIGAND; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; IMMUNE COMPLEX DISEASES; MEMBRANE GLYCOPROTEINS; MERCURIC CHLORIDE; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; SIGNAL TRANSDUCTION; SKIN; SPLEEN; T-LYMPHOCYTE SUBSETS; TH2 CELLS;

EID: 0029963341     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.4.1473     Document Type: Article

References (28)

1. Kuchroo, V.K., M. Prabhu Das, J.A. Brown, A.M. Ranger, S.S. Zamvil, R.A. Sobel, H.L. Weiner, N. Nabavi, and L.H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell. 80:707-718.
2. Del Prete, G., E. Maggi, G. Pizzolo, and S. Romagnani. 1995. CD30, Th2 cytokines and HIV infection: a complex and fascinating link. Immunol. Today. 16:76-80
3. Durie, F.H., T.M. Foy, S.R. Masters, J.D. Laman, and R.J. Noelle. 1994. The role of CD40 in the regulation of humoral and cell-mediated immunity. Immunol. Today. 15:406-411.
4. Linsley, P.S., P.M. Wallace, J. Johnson, M.G. Gibson, J.L. Greene, J.A. Ledbetter, C. Singh, and M. A. Tepper. 1992. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science (Wash. DC). 257:792-795.
5. Linsley, P.S., W. Brady, L. Grosmaire, A. Aruffo, N.K. Damle, and J.A. Ledbetter. 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 173: 721-730.
6. De Boer, M , A. Kasran, J. Kwekkeboom, H. Walter, P. Vandenberghe, and J.L. Ceuppens. 1993. Ligation of B7 with CD28/CTLA-4 on T cells results in CD40 ligand expression, interleukin-4 secretion and efficient help for antibody production by B cells. Eur. J. Immunol. 23:3120-3125.
7. McArthur, J.G., and D.H. Raulet. 1993. CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4. J. Exp. Med. 178:1645-1653
8. Kato, K., M. Koyanagi, H. Okada, T. Takanashi, Y.W. Wong, A.F. Williams, K. Okumura, and H Yagita. 1992. CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation. J Exp. Med. 176:1241-1249.
9. Kanner, S.B., N.K. Damle, J. Blake, A. Aruffo, and J.A. Ledbetter. 1992. CD2/LFA-3 ligation induces phospholipase-C γ-1-tyrosine phosphorylation and regulates CD3 signaling. J. Immunol. 148:2023-2028.
10. Guckel, B., C. Berek, M. Lutz, P. Altevogt, V. Scirmacher. and B.A. Dyewski. 1991. Anti-CD2 antibodies induce T cell unresponsiveness in vivo. J. Exp. Med. 174:957-967.
11. Bromberg, J.S., K.D. Chavin, P. Altevogt, B.A. Kyewski, B. Guckel, A. Naji, and C.F. Barker. 1991 Anti-CD2 monoclonal antibodies alter cell-mediated immunity in vivo. Transplantation (Baltimore). 51:219-225.
12. Chavin, K.D., H.T. Lau, and J.S. Bromberg. 1992. Prolongation of allograft and xenograft survival in mice by anti-CD2 monoclonal antibodies. Transplantation (Baltimore). 54:286-291.
13. Qin, L., K.D. Chavin, J. Lin, H. Yagita, and J.S. Bromberg. 1994. Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival. J. Exp Med. 179:341-346.
14. Bigazzi, P.E. 1992. Lessons from animal models: the scope of mercury-induced autoimmunity. Clin Immunol. Immunopathol. 65:81-84.
15. Goldman, M., P. Druet, and E. Gleichmann. 1991. Th2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity. Immunol. Today. 12: 223-227.
16. Ochel, M., H.W. Vohr, C. Pfeiffer, and E. Gleichmann. 1991. IL-4 is required for the IgE and IgG1 increase and IgG1 autoantibody formation in mice treated with mercuric chloride. J. Immunol. 146:3006-3011.
17. Bogen, S.A., I. Fogelman, and A.K. Abbas. 1993. Analysis of IL-2, IL-4, and IFN-γ producing cells in situ during immune responses to protein antigens. J. Immunol. 150:4197-4205.
18. Noelle, R.J., M. Roy, D.M. Shepherd, I. Stamenkovic, J.A. Ledbetter, and A. Aruffo. 1992. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc. Natl. Acad. Sci. USA. 89: 6550-6554.
19. Yagita, H., T. Nakamura, and K. Karasuyama. 1989. Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells. Proc. Natl. Acad. Sci. USA. 86:645-649.
20. Nishikawa, K., Y.-J. Guo, M. Miyasaka, T. Tamatani, A.B. Collins, M.-S. Sy, R.T. McCluskey, and G. Andres. 1993. Antibodies to intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 prevent crescent formation in rat autoimmune glomerulonephritis. J. Exp Med. 177:667-677.
21. Biancone, L., G. Andres, H. Ahn, C. DeMartino, and I. Stamenkovic. 1995. Inhibition of the CD40-CD40 ligand pathway prevents murine membranous glomerulonephritis. Kidney Int. 48:458-468.
22. Ohara, J., and W.E. Paul. 1985. Production of a monoclonal antibody to and molecular characterization of B cell stimulatory factor 1. Nature (Lond.). 315:333-336.
23. Mosmann, T., J. Schumacher, D. Fiorentino, J. Leverah, K. Moore, and M. Bond. 1990. Isolation of monoclonal antibodies specific for IL-4, IL-5, 1L-6 and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay. J. Immunol. 145:2938-2942.
24. Ohno, H., T. Nakamura, H. Yagita, K. Okumura, M. Taniguchi, and T. Saito. 1991. Induction of negative signal through CD2 during antigen-specific T cell activation. J. Immunol. 147:2100-2106.
25. Chavin, K.D., L. Qin, R. Yon, J. Lin, H. Yagita, and J.S. Bromberg. 1994. Anti-CD2 mAbs suppress cytotoxic lymphocyte activity by the generation of the Th2 suppressor cells and receptor blockade. J. Immunol. 152:3729-3739.
26. Sayegh, M.H., E. Akalin, W.W. Hancock, M.E. Russell, C.B. Carpenter, P.S. Linsley, and L.A. Turka. 1995. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J. Exp. Med. 181:1869-1874.
27. Naora, H., J.G. Altin, and I.G. Young. 1994. TCR-dependent and -independent signaling mechanisms differentially regulate lymphokine gene expression in the murine T helper clone D10.G4.1. J. Immunol. 152:5691-5702.
28. Gollob, J.A., J. Li, E.L. Reinherz, and J. Ritz. 1995. CD2 regulates responsiveness of activated T cells to interleukin 12. J. Exp. Med. 182:721-731.