Administration of an antibody to E-selectin in patients with septic shock

Critical Care Medicine

Volumn 24, Issue 2, 1996, Pages 229-233

  Friedman, Gilberto ^a   Jankowski, Stanislaw ^a   Shahla, Mohammad ^a   Goldman, Michel ^a   Rose, Richard M ^b   Kahn, Robert Jean ^a   Vincent, Jean Louis ^a  

^a ERASME HOSPITAL   (Belgium)

^b CYTEL CORPORATION   (United States)

Author keywords

adhesion molecules; critical illness; cytokines; endothelial cells; infection; monoclonal antibody; organ failure; sepsis; septic shock

Indexed keywords

CY 1787; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CRITICAL ILLNESS; DOSE RESPONSE; DRUG SAFETY; ENDOTHELIUM CELL; FEMALE; HUMAN; INFECTION; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE ACTIVATION; LEUKOCYTE ADHERENCE; MALE; MULTIPLE ORGAN FAILURE; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK; SURVIVAL RATE;

ADULT; AGED; ANTIBODIES, MONOCLONAL; BLOOD GAS ANALYSIS; E-SELECTIN; FEMALE; HEMODYNAMIC PROCESSES; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; PILOT PROJECTS; PROSPECTIVE STUDIES; SHOCK, SEPTIC; TIME FACTORS;

EID: 0030026098     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199602000-00008     Document Type: Article

References (28)

1. Bevilacqua MP, Pober JS, Wheeler ME, et al: Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines. J Clin Invest 1985; 76: 2003-2011
2. Doherty DE, Zagarella L, Henson PM, et al: Lipopolysaccharide stimulates monocyte adherence by effects on both the monocyte and the endothelial cell. J Immunol 1989; 143:3673-3679
3. Redl H, Dinges HP, Buurman WA, et al: Expression of endothelial leukocyte adhesion molecule-1 in septic but not traumatic/hypovolemic shock in the baboon. Am J Pathol 1991; 139:461-466
4. Albelda SM, Buck CA: Integrins and other cell adhesion molecules. FASEB J 1990; 4:2868-2880
5. Pilewski JM, Albelda SM: Adhesion molecules in the lung. Am Rev Respir Dis 1993; 148:531-537
6. Bevilacqua MP, Nelson RM: Selectins. J Clin Invest 1993; 91:379-387
7. Eichacker PQ, Farese A, Hoffman WD, et al: Leukocyte CD11b/18 antigen-directed monoclonal antibody improves early survival and decreases hypoxemia in dogs challenged with tumor necrosis factor. Am Rev Respir Dis 1992; 145: 1023-1029
8. Walsh CJ, Carey PD, Cook DJ, et al: Anti-CD18 antibody attenuates neutropenia and alveolar capillary-membrane injury during Gram-negative sepsis. Surgery 1991; 110:205-212
9. Eichacker PQ, Hoffman WD, Farese A, et al: Leukocyte CD18 monoclonal antibody worsens endotoxemia and cardiovascular injury in canines with septic shock. J Appl Physiol 1993; 745: 1885-1892
10. Todd RF, Freyer DR: The CD11/CD18 leukocyte glycoprotein deficiency. Hematol Oncol Clin North Am 1988; 2:13-31
11. Anderson DC, Schmalsteig FC, Arnaout MA: Abnormalities of polymorphonuclear leukocyte function associated with a heritable deficiency of high molecular weight surface glucoproteins (GP138): Common relationship to diminished cell adherence. J Clin Invest 1989; 74:536-551
12. Bevilacqua MP, Stengelin S, Gimbrone MAJ, et al: Endothelial leukocyte adhesion molecule 1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 1989; 243:1160-1165
13. Carlos T, Kovach N, Schwartz B, et al: Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: Endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1. Blood 1991; 77:2266-2271
14. Graber N, Gopal TV, Wilson D, et al: T cells bind to cytokine-activated endothelial cells via a novel, inducible sialoglycoprotein and endothelial leukocyte adhesion molecule-1. J Immunol 1990; 145:819-830
15. Leeuwenberg JFM, Jeuhomme TMAA, Buurman WA: Role of ELAM-1 in adhesion of monocytes to activated human endothelial cells. Scand J Immunol 1992; 35:335-341
16. Briscoe DM, Cotran RS, Pober JS: Effects of tumor necrosis factor, lipopolysaccharide, and IL-4 on the expression of vascular cell adhesion molecule-1 in vivo. J Immunol 1992; 149:2954-2960
17. Drake TA, Cheng J, Chang AL, et al: Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Escherichia coli sepsis. Am J Pathol 1993; 1428:1458-1470
18. Engelberts I, Van Hoof SCJ, Samyo SK, et al: Generalized inflammation during peritonitis evidenced by intracutaneous E-selectin expression. Clin Immunol Immunopath 1992; 65:330-334
19. Newman W, Beall LD, Carson CW, et al: Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock. J Immunol 1993; 150:644-654
20. Kuhns DB, Alyord G, Gallin JI: Increased circulating cytokines, cytokine antagonists, and E-selectin after intravenous administration of endotoxin in humans. J Infect Dis 1995; 171:145-152
21. Knaus WA, Draper EA, Wagner DP, et al: APACHE II: A severity of disease classification system. Crit Care Med 1985; 13:818-829
22. Vincent JL, Bakker J, Marécaux G, et al: Anti-TNF antibodies administration increases myocardial contractility in septic shock patients. Chest 1992; 101:810-815
23. Engelberts I, Samyo SK, Leeuwenberg JFM, et al: A role for ELAM-1 in the pathogenesis of MOF during septic shock. J Surg Res 1992; 53:136-144
24. Walsh CJ, Leeper-Woodford SK, Carey PD, et al: CD 18 adhesion receptors, tumor necrosis factor, and neutropenia during septic lung injury. J Surg Res 1991; 50:323-329
25. Debets JMH, Kampmeijer R, Van der Linden MP, et al: Plasma tumor necrosis factor and mortality in critically ill septic patients. Crit Care Med 1989; 17: 489-494
26. De Groote MA, Martin MA, Densen P, et al: Plasma tumor necrosis factor levels in patients with presumed sepsis. JAMA 1989; 262:249-251
27. Pinsky MR, Vincent JL, Deviere J, et al: Serum cytokine levels in human septic shock: Relation to multiple-systems organ failure and mortality. Chest 1993; 103:565-575
28. Bakker J, Vincent JL, Gris P, et al: Veno-arterial carbon dioxide gradient in human septic shock. Chest 1992; 101: 509-515