The Eph family receptors and ligands

Pharmacology and Therapeutics

Volumn 77, Issue 3, 1998, Pages 151-181

  Zhou, Renping ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Angiogenesis; Axonal guidance; Eph receptors; Ephrins; Topographic mapping

Indexed keywords

ERYTHROPOIETIN; PROTEIN TYROSINE KINASE; RECEPTOR;

EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIGAND BINDING; NEUROTROPISM; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INTERACTION; RECEPTOR BINDING; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; AXONS; GENE EXPRESSION REGULATION; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; NEOPLASMS; NEOVASCULARIZATION, PHYSIOLOGIC; NERVOUS SYSTEM; NEURAL PATHWAYS; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 0031919093     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(97)00112-5     Document Type: Review

References (181)

1. Andres A.-C., Reid H. H., Zurcher G., Blaschke R. L., Albrecht D., Ziemiecki A. Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis. Oncogene. 9:1994;1461-1467.
2. Bartley T., Hunt R. W., Welcher A. A., Boyle W. J., Parker V. P., Lindberg R. A., Lu H. S., Colombero A. M., Elliott R. L., Guthrie B. A., Holst P. L., Skrine J. D., Toso R. J., Zhang M., Fernandez E., Trail G., Varnum B., Yarden Y., Hunter T., Fox G. M. B61 is a ligand for the ECK receptor protein-tyrosine kinase. Nature. 368:1994;558-560.
3. Basu A., Raghunath M., Bishayee S., Das M. Inhibition of tyrosine kinase activity of the epidermal growth factor (EGF) receptor by a truncated receptor form that binds to EGF. role for interreceptor interaction in kinase regulation Mol. Cell. Biol. 9:1989;671-677.
4. Becker N., Seitanidou T., Murphy P., Mattei M. G., Topilko P., Nieto M. A., Wilkinson D. G., Charnay P., Gilardi-Hebenstreit P. Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech. Dev. 47:1994;3-17.
5. Becker N., Gilardi-Hebenstreit P., Seitanidou T., Wilkinson D., Charnay P. Characterisation of the Sek-1 receptor tyrosine kinase. FEBS Lett. 368:1995;353-357.
6. Beckmann M. P., Cerretti D. P., Baum P., Vanden Bos T., James L., Farrah T., Kozlosky C., Hollingsworth T., Shilling H., Maraskovsky E., Fletcher F. A., Lhotak V., Pawson T., Lyman S. D. Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors. EMBO J. 13:1994;3757-3762.
7. Bennett B. D., Wang Z., Kuang W. J., Wang A., Groopman J. E., Goeddel D. V., Scadden D. T. Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. J. Biol. Chem. 269:1994;14211-14218.
8. Bennett B. D., Zeigler F. C., Gu Q., Fendly B., Goddard A. D., Gillett N., Matthews W. Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk. Proc. Natl. Acad. Sci. USA. 92:1995;1866-1870.
9. Berclaz G., Andres A. C., Albrecht D., Dreher E., Ziemiecki A., Gusterson B. A., Crompton M. R. Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium. Biochem. Biophys. Res. Commun. 226:1996;869-875.
10. Bergemann A. D., Cheng H. J., Brambilla R., Klein R., Flanagan J. G. ELF-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites. Mol. Cell. Biol. 15:1995;4921-4929.
11. Bohme B., Holtrich U., Wolf G., Luzius H., Grzeschik K. H., Strebhardt K., Rubsamen-Waigmann H. PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2. Oncogene. 8:1993;2857-2862.
12. Bohme B., VandenBos T., Cerretti D. P., Park L. S., Holtrich U., Rubsamen-Waigmann H., Strebhardt K. Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity. J. Biol. Chem. 271:1996;24747-24752.
13. Bonhoeffer F., Huf J. Position-dependent properties of retinal axons and their growth cones. Nature. 315:1985;409-410.
14. Bouillet P., Oulad-Abdelghani M., Vicaire S., Garnier J.-M., Schuhbaur B., Dolle P., Chambon P. Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev. Biol. 170:1995;420-433.
15. Boxberg Y. V., Deiss S., Schwarz U. Guidance and topographic stabilization of nasal chick retinal axons on target-derived components in vitro. Neuron. 10:1993;345-357.
16. Boyd A. W., Ward L. D., Wicks I. P., Simpson R. J., Salvaris E., Wilks A., Welch K., Loudovaris M., Rockman S., Busmanis I. Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line. J. Biol. Chem. 267:1992;3262-3267.
17. Brambilla R., Klein R. Telling axons where to grow. a role for Eph receptor tyrosine kinases in guidance Mol. Cell. Neurosci. 6:1995;487-495.
18. Brambilla R., Schnapp A., Casagranda F., Labrador J. P., Bergemann A. D., Flanagan J. G., Pasquale E. B., Klein R. Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases. EMBO J. 14:1995;3116-3126.
19. Brambilla B., Bruckner K., Orioli D., Bergemann A. D., Flanagen J. G., Klein R. Similarities and differences in the way transmembrane-type ligands interact with the Elk subclass of Eph receptors. Mol. Cell. Neurosci. 8:1996;199-209.
20. Bruckner K., Pasquale E. B., Klein R. Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science. 275:1997;1640-1643.
21. ras through the formation of a complex of receptors, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell. 73:1993;611-620.
22. Cance W. G., Craven R. J., Weiner T. M., Liu E. T. Novel protein kinases expressed in human breast cancer. Int. J. Cancer. 54:1993;571-577.
23. Carpenter M. K., Shilling H., VandenBos T., Beckmann M. P., Cerretti D. P., Kott J. N., Westrum L. E., Davison B. L., Fletcher F. A. Ligands for EPH-related tyrosine kinase receptors are developmentally regulated in the CNS. J. Neurosci. Res. 42:1995;199-206.
24. Cerretti D. P., Vanden Bos T., Nelson N., Kozlosky C. J., Reddy P., Maraskovsky E., Park L. S., Lyman S. D., Copeland N. G., Gilbert D. J., Jenkins N. A., Fletcher F. A. Isolation of LERK-5. a ligand of the eph-related receptor tyrosine kinases Mol. Immunol. 32:1995;1197-1205.
25. Chan J., Watt V. M. eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases. Oncogene. 6:1991;1057-1061.
26. Chen J., Nachabah A., Scherer C., Ganju P., Reith A., Bronson R., Ruley H. E. Germ-line inactivation of the murine Eck receptor tyrosine kinase by gene trap retroviral insertion. Oncogene. 12:1996;979-988.
27. Cheng H. J., Flanagan J. G. Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell. 79:1994;157-168.
28. Cheng H. J., Nakamoto M., Bergemann A. D., Flanagan J. G. Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map. Cell. 82:1995;371-381.
29. Ciossek T., Ullrich A. Identification of Elf-1 and B61 as high affinity ligands for the receptor tyrosine kinase MDK1. Oncogene. 14:1997;35-43.
30. Ciossek T., Lerch M. M., Ullrich A. Cloning, characterization, and differential expression of MDK2 and MDK5, two novel receptor tyrosine kinases of the eck/eph family. Oncogene. 11:1995;2085-9205. a.
31. Ciossek T., Millauer B., Ullrich A. Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system. Oncogene. 10:1995;97-108. b.
32. Colamarino S. A., Tessier-Lavigne M. The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell. 81:1995;621-629.
33. Connor R. J., Pasquale E. B. Genomic organization and alternatively processed forms of Cek5, a receptor protein-tyrosine kinase of the Eph subfamily. Oncogene. 11:1995;2429-2438.
34. Cross M., Dexter T. M. Growth factors in development, transformation, and tumorigenesis. Cell. 64:1991;271-280.
35. Daniel T. O., Stein E., Cerretti D. P., St. John P. L., Robert B., Abrahamson D. R. Elk and Lerk-2 in developing kidney and microvascular endothelial assembly. Kidney Int. 50(Suppl. 57):1996;S73-S81.
36. Davis S., Gale N. W., Aldrich T. H., Maisonpierre P. C., Lhotak V., Pawson T., Goldfarb M., Yancopoulos G. D. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science. 266:1994;816-819.
37. Donoghue M. J., Lewis R. M., Merlie J. P., Sanes J. R. The Eph kinase ligand AL-1 is expressed by rostral muscles and inhibits outgrowth from caudal neurons. Mol. Cell. Neurosci. 8:1996;185-198.
38. Drescher U., Kremoser C., Handwerker C., Loschinger J., Noda M., Bonhoeffer F. In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell. 82:1995;359-370.
39. Easty D. J., Guthrie B. A., Maung K., Farr C. J., Lindberg R. A., Toso R. J., Herlyn M., Bennett D. C. Protein B61 as a new growth factor. expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression Cancer Res. 55:1995;2528-2532.
40. Eide F. F., Vining E. R., Eide B. L., Zang K. L., Wang X. Y., Reichardt L. F. Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signalling. J. Neurosci. 16:1996;3123-3129.
41. Ellis C., Kasmi F., Ganju P., Walls E., Panayotou G., Reith A. D. A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn. Oncogene. 12:1996;1727-1736.
42. Ellis J., Liu Q., Breitman M., Jenkins N. A., Gilbert D. J., Copeland N. G., Tempest H. V., Warren S., Muir E., Schilling H., Fletcher F. A., Ziegler S. F., Rogers J. H. Embryo brain kinase. a novel gene of the eph/elk receptor tyrosine kinase family Mech. Dev. 52:1995;319-341.
43. Eph Nomenclature Committee Unified nomenclature for Eph receptors and their ligands, the ephrins. Cell. 90:1997;403-404.
44. Flenniken A. M., Gale N. W., Yancopoulos G. D., Wilkinson D. G. Distinct and overlapping expression patterns of ligands Eph-related receptor tyrosine kinases during mouse embryogenesis. Dev. Biol. 179:1996;382-401.
45. Fletcher F. A., Renshaw B., Hollingsworth T., Baum P., Lyman S. D., Jenkins N. A., Gilbert D. J., Copeland N. G., Davison B. L. Genomic organization and chromosomal localization of mouse Eplg2, a gene encoding a binding protein for the receptor tyrosine kinase elk. Genomics. 24:1994;127-132.
46. Fox G. M., Holst P. L., Chute H. T., Lindberg R. A., Janssen A. M., Basu R., Welcher A. A. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. Oncogene. 10:1995;897-905.
47. Fraser S., Keynes R., Lumsden A. Segmentation in the chick embryo hindbrain is defined by cell lineage restriction. Nature. 344:1990;431-435.
48. Friedman G. C., O'Leary D. D. Eph receptor tyrosine kinases and their ligands in neural development. Curr. Opin. Neurobiol. 6:1996;127-133. a.
49. Friedman G. C., O'Leary D. D. M. Retroviral misexpression of engrailed genes in the chick optic tectum perturbs the topographic targeting of retinal axons. J. Neurosci. 16:1996;5498-5509. b.
50. Gale N. W., Flenniken A., Compton D. C., Jenkins N., Copeland N. G., Gilbert D. J., Davis S., Wilkinson D. G., Yancopoulos G. D. Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments. Oncogene. 13:1996;1343-1352. a.
51. Gale N. W., Holland S. J., Valenzuela D. M., Flenniken A., Pan L., Ryan T. E., Henkemeyer M., Strebhardt K., Hirai H., Wilkinson D. G., Pawson T., Davis S., Yancopoulos G. D. Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron. 17:1996;9-19. b.
52. Ganju P., Shigemoto K., Brennan J., Entwistle A., Reith A. D. The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development. Oncogene. 9:1994;1613-1624.
53. Gao P. P., Zhang J. H., Yokoyama M., Racey B., Dreyfus C. F., Black I. B., Zhou R. Regulation of topographic projection in the brain. Elf-1 in the hippocamposeptal system Proc. Natl. Acad. Sci. USA. 93:1996;11161-11166.
54. Gardner C. A., Darnell D. K., Poole S. J., Ordahl C. P., Barald K. F. Expression of an engrailed-like gene during development of the early embryonic chick nervous system. J. Neurosci. Res. 21:1988;426-437.
55. Gilardi-Hebenstreit P., Nieto M. A., Frain M., Mattei M. G., Chestier A., Wilkinson D. G., Charnay P. An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain. Oncogene. 7:1992;2499-2506.
56. Givol D., Yayon A. Complexity of FGF receptors. genetic basis for structural diversity and functional specificity FASEB J. 6:1992;3362-3369.
57. Goodman C. S., Shatz C. J. Developmental mechanisms that generate precise patterns of neuronal connectivity. Cell. 72/Neuron 10(Suppl.):1993;77-98.
58. Gurniak C. B., Berg L. J. A new member of the Eph family of receptors that lacks protein tyrosine kinase activity. Oncogene. 13:1996;777-786.
59. Guthrie S., Lumsden A. Formation and regeneration of rhombomere boundaries in the developing chick hindbrain. Development. 112:1991;221-229.
60. Hamill G. S., Jacobowitz D. M. A study of afferent projections to the rat interpeduncular nucleus. Brain Res. Bull. 13:1984;527-539.
61. Hanks S. K., Quinn A. M., Hunter T. The protein kinase family. conserved features and deduced phylogeny of the catalytic domains Science. 241:1988;42-52.
62. Henkemeyer M., Marengere L. E., McGlade J., Olivier J. P., Conlon R. A., Holmyard D. P., Letwin K., Pawson T. Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis. Oncogene. 9:1994;1001-1014.
63. Henkemeyer M., Orioli D., Henderson J. T., Saxton T. M., Roder J., Pawson T., Klein R. Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell. 86:1996;35-46.
64. Hirai H., Maru Y., Hagiwara K., Nishida J., Takaku F. A novel putative tyrosine kinase receptor encoded by the eph gene. Science. 238:1987;1717-1720.
65. Holash J. A., Pasquale E. B. Polarized expression of the receptor protein tyrosine kinase Cek5 in the developing avian visual system. Dev. Biol. 172:1995;683-693.
66. Holland S. J., Gale N. W., Mbamalu G., Yancopoulos G. D., Henkemeyer M., Pawson T. Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands. Nature. 383:1996;722-725.
67. Holzman L. B., Marks R. M., Dixit V. M. A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein. Mol. Cell. Biol. 10:1990;5830-5838.
68. Hunkapiller T., Hood L. Diversity of the immunoglobulin gene superfamily. Adv. Immunol. 44:1989;1-63.
69. Ikegaki N., Tang X. X., Liu X. G., Biegel J. A., Allen C., Yoshioka A., Sulman E. P., Brodeur G. M., Pleasure D. E. Molecular characterization and chromosomal localization of DRT (EPHT3). a developmentally regulated human protein-tyrosine kinase gene of the EPH family Hum. Mol. Genet. 4:1995;2033-2045.
70. Itasaki N., Nakamura H. Rostrocaudal polarity of the tectum in birds. correlation of en gradient and topographic order in retinotectal projection Neuron. 8:1992;787-798.
71. Itasaki N., Nakamura H. A role for gradient en expression in positional specification on the optic tectum. Neuron. 16:1996;55-62.
72. Itasaki N., Ichijo H., Hama C., Matsuno T., Nakamura H. Establishment of rostrocaudal polarity in the tectal primordium. engrailed and subsequent tecta polarity Development. 113:1991;1133-1144.
73. Iwase T., Tanaka M., Suzuki M., Naito Y., Sugimura H., Kino I. Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer. Biochem. Biophys. Res. Commun. 194:1993;698-705.
74. Jaye M., Schlessinger J., Dionne C. A. Fibroblast growth factor receptor tyrosine kinases - molecular analysis and signal transduction. Biochem. Biophys. Acta. 1135:1992;185-199.
75. Jones T. L., Chong L. D., Kim J., Xu R.-H., Kung H.-F., Daar I. O. Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand. Proc. Natl. Acad. Sci. USA. 95:1998;576-581.
76. Jones T. L., Karavanova I., Maeno M., Ong R. C., Kung H. F., Daar I. O. Expression of an amphibian homolog of the Eph family of receptor tyrosine kinases is developmentally regulated. Oncogene. 10:1995;1111-1117.
77. Jones T. L., Karavanova I., Chong L., Zhou R., Daar I. O. Identification of XLerk, an Eph family ligand regulated during mesoderm induction and neurogenesis in Xenopus laevis. Oncogene. 14:1997;2159-2166.
78. Kapeller R., Cantley L. Phosphatidylinositol 3-kinase. Bioessays. 16:1994;565-576.
79. Kennedy T. E., Seradini T., de la Torre J. R., Tessier-Lavigne M. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell. 78:1994;425-435.
80. Kenny D., Bronner-Fraser M., Marcelle C. The receptor tyrosine kinase QEK5 mRNA is expressed in a gradient within the neural retina and the tectum. Dev. Biol. 172:1995;708-716.
81. Kilpatrick T. J., Brown A., Lai C., Gassmann M., Goulding M., Lemke G. Expression of the Tyro4/Mek4/Cek4 gene specifically marks a subset of embryonic motor neurons and their muscle targets. Mol. Cell. Neurosci. 7:1996;62-74.
82. Kiyokawa E., Takai S., Tanaka M., Iwase T., Suzuki M., Xiang Y. Y., Naito Y., Yamada K., Sugimura H., Kino I. Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors. Cancer Res. 54:1994;3645-3650.
83. Kozlosky C. J., Maraskovsky E., McGrew J. T., VandenBos T., Teepe M., Lyman S. D., Srinivasan S., Fletcher F. A., Gayle R. B. 3rd, Cerretti D. P., Beckmann M. P. Ligands for the receptor tyrosine kinases hek and elk. isolation of cDNAs encoding a family of proteins Oncogene. 10:1995;299-306.
84. Kozlosky C. J., VandenBos T., Park L., Cerretti D. P., Carpenter M. K. LERK-7. a ligand of the Eph-related kinases is developmentally regulated in the brain Cytokine. 9:1997;540-549.
85. Krull C. E., Lansford R., Gale N. W., Collazo A., Marcelle C., Yancopoulos G. D., Fraser S. E., Bronner-Fraser M. Interaction of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration. Curr. Biol. 7:1997;571-580.
86. Lackmann M., Bucci T., Mann R. J., Kravets L. A., Viney E., Smith F., Moritz R. L., Carter W., Simpson R. J., Nicola N. A., Mackwell K., Nice E. C., Wilks A. F., Boyd A. W. Purification of a ligand for the EPH-like receptor HEK using a biosensor-based affinity detection approach. Proc. Natl. Acad. Sci. USA. 93:1996;2523-2527.
87. Lai C., Lemke G. An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron. 6:1991;691-704.
88. Laskowski M. B., Sanes J. R. Topographic mapping of motor pools onto skeletal muscles. J. Neurosci. 7:1987;252-260.
89. Lee A. M., Navaratnam D., Ichimiya S., Greene M. I., Davis J. G. Cloning of m-ehk2 from the murine inner ear, an eph family receptor tyrosine kinase expressed in the developing and adult cochlea. DNA Cell Biol. 15:1996;817-825.
90. Letwin K., Yee S. P., Pawson T. Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody. Oncogene. 3:1988;621-627.
91. Lhotak V., Pawson T. Biological and biochemical activities of a chimeric epidermal growth factor-Elk receptor tyrosine kinase. Mol. Cell. Biol. 13:1993;7071-7079.
92. Lhotak V., Greer P., Letwin K., Pawson T. Characterization of elk, a brain-specific receptor tyrosine. Mol. Cell. Biol. 11:1991;2496-2502.
93. Lickliter J. D., Smith F. M., Olsson J. E., Mackwell K. L., Boyd A. W. Embryonic stem cells express multiple Eph-subfamily receptor tyrosine kinases. Proc. Natl. Acad. Sci. USA. 93:1996;145-150.
94. Lindberg R. A., Hunter T. cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol. Cell. Biol. 10:1990;6316-6324.
95. Logan C., Wizenmann A., Drescher U., Monschau B., Bonhoeffer F., Lumsden A. Rostral optic tectum acquires caudal characteristics following ectopic engrailed expression. Curr. Biol. 6:1996;1006-1014.
96. Lopes da Silva F., Witter M. P., Boeijinga P. H., Lohman A. H. M. Anatomic organization and physiology of the limbic cortex. Physiol. Rev. 70:1990;453-511.
97. Lumsden A., Keynes R. Segmental patterns of neuronal development in the chick hindbrain. Nature. 337:1989;424-428.
98. Magal E., Holash J. A., Toso R. J., Chang D., Lindberg R. A., Pasquale E. B. B61, a ligand for the Eck receptor protein-tyrosine kinase, exhibits neurotrophic activity in cultures of rat spinal cord neurons. J. Neurosci. Res. 43:1996;735-744.
99. Maisonpierre P. C., Barrezueta N. X., Yancopoulos G. D. Ehk-1 and Ehk-2. two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression Oncogene. 8:1993;3277-3288.
100. Marcus R. C., Gale N. W., Morrison M. E., Mason C. A., Yancopoulos G. D. Eph family receptors and their ligands distribute in opposing gradients in the developing mouse retina. Dev. Biol. 180:1996;786-789.
101. Marshall C. J. Specificity of receptor tyrosine kinase signalling. transient versus sustained extracellular signal-regulated kinase activation Cell. 80:1995;179-185.
102. Maru Y., Hirai H., Yoshida M. C., Takaku F. Evolution, expression, and chromosomal location of a novel receptor tyrosine kinase gene, eph. Mol. Cell. Biol. 8:1988;3770-3776.
103. Maru Y., Hirai H., Takaku F. Overexpression confers an oncogenic potential upon the eph gene. Oncogene. 5:1990;445-447.
104. Meima L., Kljiavin I. J., Moran P., Shih A., Winslow J. W., Caras I. W. AL-1-induced growth cone collapse of rat cortical neurons is correlated with REK7 expression and rearrangement of the actin cytoskeletion. Eur. J. Neurosci. 9:1997;177-188.
105. Miescher G. C., Taylor V., Olivieri G., Mindermann T., Schrock E., Steck A. J. Extensive splice variation and localization of the Ehk-1 receptor tyrosine kinase in adult human brain and glial tumors. Mol. Brain Res. 46:1997;17-24.
106. Monschau B., Kremoser C., Ohta K., Tanaka H., Kaneko T., Yamada T., Handwerker C., Hornberger M. R., Loschinger J., Pasquale E. B., Siever D. A., Verderame M. F., Muller B. K., Bonhoeffer F., Drescher U. Shared and distinct functions of RAGS and Elf-1 in guiding retinal axons. EMBO J. 16:1997;1258-1267.
107. Mori T., Wanaka A., Taguchi A., Matsumoto K., Tohyama M. Localization of novel receptor tyrosine kinase genes of the eph family, MDK1 and its splicing variant, in the developing mouse nervous system. Mol. Brain Res. 34:1995;154-160. a.
108. Mori T., Wanaka A., Taguchi A., Matsumoto K., Tohyama M. Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse. Mol. Brain Res. 29:1995;325-335. b.
109. Muller B. K., Bonhoeffer F., Drescher U. Novel gene families involved in neural pathfinding. Curr. Opin. Genet. Dev. 6:1996;469-474.
110. Nakamoto M., Cheng H.-J., Friedman G. C., McLaughlin T., Hansen M. J., Yoon C. H., O'Leary D. D. M., Flanagan J. G. Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. Cell. 86:1996;755-766.
111. Nicola N. A., Viney E., Hilton D. J., Roberts B., Willson T. Molecular cloning of two novel transmembrane ligands for Eph-related kinases (LERKS) that are related to LERK-2. Growth Factors. 13:1996;141-149.
112. Nieto M. A., Gilardi-Hebenstreit P., Charnay P., Wilkinson D. A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm. Development. 116:1992;1137-1150.
113. Obermeir A., Bradshaw R. A., Seedorf K., Choides A., Schlessinger J., Ullrich A. Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLCγ EMBO J. 13:1994;1585-1590.
114. Ohta K., Nakamura M., Hirokawa K., Tanaka S., Iwama A., Suda T., Ando M., Tanaka H. The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development. Mech. Dev. 54:1996;59-69.
115. Ooi J., Yajnik V., Immanuel D., Gordon M., Moskow J. J., Buchberg A. M., Margolis B. The cloning of Grb10 reveals a new family of SH2 domain proteins. Oncogene. 10:1995;1621-1630.
116. Orike N., Pini A. Axon guidance. following the Eph plan Curr. Biol. 6:1996;108-110.
117. Orioli D., Klein R. The Eph receptor family - axonal guidance by contact repulsion. Trends Genet. 13:1997;354-359.
118. Orioli D., Henkemeyer M., Lemke G., Klein R., Pawson T. Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J. 15:1996;6035-6049.
119. Pandey A., Lazar D. F., Saltiel A. R., Dixit V. M. Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. J. Biol. Chem. 269:1994;30154-30157.
120. Pandey A., Duan H., Dixit V. M. Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase. J. Biol. Chem. 270:1995;19201-19204. a.
121. Pandey A., Lindberg R. A., Dixit V. M. Cell signalling. Receptor orphans find a family. Curr. Biol. 5:1995;986-989. b.
122. Pandey A., Shao H., Marks R. M., Polverini P. J., Dixit V. M. Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-α-induced angiogenesis. Science. 268:1995;567-569. c.
123. Park S., Sanchez M. P. The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. Oncogene. 14:1997;533-542.
124. Park S., Frisen J., Barbacid M. Abberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors. EMBO J. 16:1997;3106-3114.
125. Pasquale E. B. Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family. Cell Regul. 2:1991;523-534.
126. Pasquale E. B., Deerinck T. J., Singer S. J., Ellisman M. H. Cek5, a membrane receptor-type tyrosine kinase, is in neurons of the embryonic and postnatal avian brain. J. Neurosci. 12:1992;3956-3967.
127. Pasquale E. B., Connor R. J., Rocholl D., Schnurch H., Risau W. Cek5, a tyrosine kinase of the Eph subclass, is activated during neural retina differentiation. Dev. Biol. 163:1994;491-502.
128. Patel K., Nittenberg R., D'Souza D., Irving C., Burt D., Wilkinson D. G., Tickle C. Expression and regulation of Cek-8, a cell to cell signalling receptor in developing chick limb buds. Development. 122:1996;1147-1155.
129. Patel N. H., Martin-Blanco E., Coleman K. G., Poole S. J., Ellis M. C., Kornberg T. B., Goodman C. S. Expression of engrailed proteins in arthropods, annelids, and chordates. Cell. 58:1989;955-968.
130. Presente A., Sehgal A., Dudus L., Engelhardt J. F. Differentially regulated epithelial expression of an Eph family tyrosine kinase (fHek2) during tracheal surface airway and submucosal gland development. Am. J. Respir. Cell Mol. Biol. 16:1997;53-61.
131. Raper J. A., Grunewald E. B. Temporal retinal growth cones collapse on contact with nasal axons. Exp. Neurol. 109:1990;70-74.
132. Risold P. Y., Swanson L. W. Structural evidence for functional domains in the rat hippocampus. Science. 272:1996;1484-1486.
133. Robinson D., He F., Pretlow T., Kung H.-J. A tyrosine kinase profile of prostate carcinoma. Proc. Natl. Acad. Sci. USA. 93:1996;5958-5962.
134. Ruiz J. C., Robertson E. J. The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development. Mech. Dev. 46:1994;87-100.
135. Ruiz J. C., Conlon F. L., Robertson E. J. Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech. Dev. 48:1994;153-164.
136. Sajjadi F. G., Pasquale E. B. Five novel avian Eph-related tyrosine kinases are differentially expressed. Oncogene. 8:1993;1807-1813.
137. Sajjadi F. G., Pasquale E. B., Subramani S. Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor. New Biol. 3:1991;769-778.
138. Sakano S., Serizawa R., Inada T., Iwama A., Itoh A., Kato C., Shimizu Y., Shinkai F., Shimizu R., Kondo S., Ohno M., Suda T. Characterization of a ligand for receptor protein-tyrosine kinase HTK expressed in immature hematopoietic cells. Oncogene. 13:1996;813-822.
139. Scales J. B., Winning R. S., Renaud C. S., Shea L. J., Sargent T. D. Novel members of the eph receptor tyrosine kinase subfamily expressed during Xenopus development. Oncogene. 11:1995;1745-1752.
140. Schlessinger J. SH2/SH3 signalling proteins. Curr. Opin. Genet. Dev. 4:1996;25-30.
141. Serafini T., Kennedy T. E., Galko M. J., Mirzayan C., Jessell T. M., Tessier-Lavigne M. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-. 6. Cell 78:1994;409-424.
142. Shao H., Lou L., Pandey A., Pasquale E. B., Dixit V. M. cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase. J. Biol. Chem. 269:1994;26606-26609.
143. Shao H., Lou L., Pandey A., Verderame M. F., Siever D. A., Dixit V. M. cDNA cloning and characterization of a Cek7 receptor protein-tyrosine kinase ligand that is identical to the ligand (ELF-1) for the Mek-4 and Sek receptor protein-tyrosine kinases. J. Biol. Chem. 270:1995;3467-3470. a.
144. Shao H., Pandey A., O'Shea K. S., Seldin M., Dixit V. M. Characterization of B61, the ligand for the Eck receptor protein-tyrosine kinase. J. Biol. Chem. 270:1995;5636-5641. b.
145. Shigetani Y., Funahashi J., Nakamura H. EN-2 regulates the expression of the ligands for Eph type tyrosine kinase in chick embryonic tectum. Neurosci. Res. 27:1997;211-217.
146. Shirasaki R., Tamada A., Katsumata R., Murakami F. Guidance of cerebellofugal axons in the rat embryo. directed growth toward the floor plate and subsequent elongation along the longitudinal axis Neuron. 14:1995;961-972.
147. Siever D. A., Verderame M. F. Identification of a complete Cek7 receptor protein tyrosine kinase coding sequence and cDNAs of alternatively spliced transcripts. Gene. 148:1994;219-226.
148. Skorstengaard K., Jensen M. S., Sahl P., Petersen T. E., Magnusson S. Complete primary structure of bovine plasma fibronectin. Eur. J. Biochem. 161:1986;441-453.
149. Soans C., Holash J. A., Pasquale E. B. Characterization of the expression of the Cek8 receptor-type tyrosine kinase during development and in tumor cell lines. Oncogene. 9:1994;3353-3361.
150. Soans C., Holash J. A., Pavlova Y., Pasquale E. B. Developmental expression and distinctive tyrosine phosphorylation of the Eph-related receptor tyrosine kinase Cek9. J. Cell Biol. 135:1996;781-795.
151. Sperry R. W. Visuomotor coordination in the newt (Triturus viridescens) after regeneration of the optic nerve. J. Comp. Neurol. 79:1943;33-55.
152. Sperry R. W. Chemoaffinity in the orderly growth of nerve fiber patterns and connections. Proc. Natl. Acad. Sci. USA. 50:1963;703-710.
153. Stahl B., Muller B., von Boxberg Y., Cox E. C., Bonhoeffer F. Biochemical characterization of a putative axonal guidance molecule of the chick visual system. Neuron. 5:1990;733-743.
154. Stein E., Cerretti D. P., Daniel T. O. Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells. J. Biol. Chem. 271:1996;23588-23593.
155. Swanson L. W., Cowan W. M. An autoradiographic study of the organization of the efferent connections of the hippocampal formation in the rat. J. Comp. Neurol. 172:1977;49-84.
156. Swanson, L. W., Kohler, C. and Björklund, A. (1987) The limbic region I: the septohippocampal system. In: Handbook of Chemical Neuroanatomy, Vol. 5, Integrated Systems of the CNS, Part I, pp. 124-278, Björklund, A., Hökfelt, T. and Swanson, L. W. (eds.) Elsevier Science Publishers B.V., Amsterdam.
157. Takahashi H., Ikeda T. Molecular cloning and expression of rat and mouse B61 gene. implications on organogenesis Oncogene. 11:1995;879-883.
158. Taneja R., Thisse B., Rijli F. M., Thisse C., Bouillet P., Dolle P., Chambon P. The expression pattern of the mouse receptor kinase gene MDK1 is conserved through evolution and requires Hoxa-2 for rhombomere-specific expression in mouse embryos. Dev. Biol. 177:1996;397-412.
159. Tang X. X., Biegel J. A., Nycum L. M., Yoshioka A., Brodeur G. M., Pleasure D. E., Ikegaki N. cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain. Genomics. 29:1995;426-437.
160. Tang X. X., Pleasure D. E., Ikegaki N. cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors. Genomics. 41:1997;17-24.
161. Taylor V., Miescher G. C., Pfarr S., Honegger P., Breitschopf H., Lassmann H., Steck A. J. Expression and developmental regulation of Ehk-1, a neuronal Elk-like receptor tyrosine kinase in brain. Neuroscience. 63:1994;163-178.
162. Tessier-Lavigne M. Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps. Cell. 82:1995;345-348.
163. Tuzi N. L., Gullick W. J. eph, the largest known family of putative growth factor receptors. Br. J. Cancer. 69:1994;417-421.
164. Udin S. B., Fawcett J. W. Formation of topographic maps. Annu. Rev. Neurosci. 11:1988;289-327.
165. Valenzuela D. M., Rojas E., Griffiths J. A., Compton D. L., Gisser M., Ip N. Y., Goldfarb M., Yancopoulos G. D. Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family. Oncogene. 10:1995;1573-1580.
166. van der Geer P., Hunter T., Lindberg R. A. Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol. 10:1994;251-337.
167. Wang H. U., Anderson D. J. Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. Neuron. 18:1997;383-396.
168. Wicks I. P., Wilkinson D., Salvaris E., Boyd A. W. Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines. Proc. Natl. Acad. Sci. USA. 89:1992;1611-1615.
169. Wigston D. J., Sanes J. R. Selective reinnervation of adult mammalian muscle by axons form different segmental levels. Nature. 299:1982;464-467.
170. Williams A. F., Barclay A. N. The immunoglobulin superfamily - domains for cell surface recognition. Annu. Rev. Immunol. 6:1988;381-405.
171. Winning R. S., Sargent T. D. Pagliaccio, a member of the Eph family of receptor tyrosine kinase genes, has localized expression in a subset of neural crest and neural tissues in Xenopus laevis embryos. Mech. Dev. 46:1994;219-229.
172. Winning R. S., Scales J. B., Sargent T. D. Disruption of cell adhesion in Xenopus embryos by Pagliaccio, an Eph-class receptor tyrosine kinase. Dev. Biol. 179:1996;309-319.
173. Winslow J. W., Moran P., Valverde J., Shih A., Yuan J. Q., Wong S. C., Tsai S. P., Goddard A., Henzel W. J., Hefti F., Beck K. D., Caras I. W. Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation. Neuron. 14:1995;973-981.
174. Xu Q. L., Wilkinson D. G. Eph-related receptors and their ligands - mediators of contact dependent cell interactions. J. Mol. Med. 75:1997;576-586.
175. Xu Q., Alldus G., Holder N., Wilkinson D. G. Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain. Development. 121:1995;4005-4016.
176. Xu Q., Alldus G., Macdonald R., Wilkinson D. G., Holder N. Function of the Eph-related kinase rtk1 in patterning of the zebrafish forebrain. Nature. 381:1996;319-322.
177. Yarden Y., Ullrich A. Growth factor receptor tyrosine kinases. Annu. Rev. Biochem. 57:1988;443-487.
178. Zhang J.-H., Cerretti D. P., Yu T., Flanagan J. G., Zhou R. Detection of ligands in regions anatomically connected to neurons expressing the Eph receptor Bsk. potential roles in neuron-target interaction J. Neurosci. 16:1996;7182-7192.
179. Zhang J.-H., Pimenta A. F., Levitt P., Zhou R. Dynamic expression suggests multiple roles of the Eph family receptor brain-specific kinase (Bsk) during mouse neurogenesis. Mol. Brain Res. 47:1997;202-214.
180. Zhou R., Copeland T. D., Kromer L. F., Schulz N. T. Isolation and characterization of Bsk, a growth factor receptor-like tyrosine kinase associated with the limbic system. J. Neurosci. Res. 37:1994;129-143.
181. Zola-Morgan S., Squire L. R. Neuroanatomy of memory. Annu. Rev. Neurosci. 16:1993;547-563.