LERK-7: A ligand of the eph-related kinases is developmentally regulated in the brain

Cytokine

Volumn 9, Issue 8, 1997, Pages 540-549

  Kozlosky, Carl J ^a   VandenBos, Tim ^a   Park, Linda ^a   Cerretti, Douglas Pat ^a   Carpenter, Melissa K ^a,b  

^a AMGEN INC   (United States)

^b CytoTherapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; COMPLEMENTARY DNA; PROTEIN TYROSINE KINASE;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DNA LIBRARY; DUODENUM CARCINOMA; FETUS; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HEART; HUMAN; HUMAN CELL; KIDNEY; LIGAND BINDING; LUNG; MEMBRANE BINDING; NONHUMAN; OVARY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN PHOSPHORYLATION; RAT; SPLEEN;

ANIMALIA; CERVUS ELAPHUS;

EID: 0031213678     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1997.0199     Document Type: Article

References (49)

1. 1. Cadena DL, Gill GN (1992) Receptor tyrosine kinases. FASEB J 6:2332-2337.
2. 2. Ullrich A, Schlessinger J (1990) Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212.
3. 3. Yarden Y, Ullrich A (1988) Growth factor receptor tyrosine kinases. Annu Rev Biochem 57:443-478.
4. 4. Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tam AW, Lee J, Yarden Y, Libermann TA, Schlessinger J, Seeburg PH (1984) Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 309:418-425.
5. 5. Yarden Y, Escobedo JA, Kuang WJ, Yang FT, Daniel TO, Tremble PM, Chen EY, Ando ME, Harkins RN, Francke U, Fried VA, Ullrich A, Williams LT (1986) Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature 323:226-232.
6. 6. Coussens L, Van Beveren C, Smith D, Chen E, Mitchell RL, Isacke CM, Verma IM, Ullrich A (1986) Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus. Nature 320:277-280.
7. 7. Williams DE, Lyman SD (1991) Characterization of the gene-product of the steel locus. Prog Growth Factor Res 3:235-242.
8. 8. Martin-Zanca D, Oskam R, Mitra G, Copeland T, Barbacid M (1989) Molecular and biochemical characterization of the human trk proto-oncogene. Mol Cell Biol 9:24-33.
9. 9. Barbacid M (1994) The Trk family of neurotrophin receptors. J Neurobiol 25:1386-1403.
10. 10. Lindsay RM, Wiegand SJ, Altar CA, Di Stefano PS (1994) Neurotrophic factors: from molecule to man. Trends Neurosci 17:182-190.
11. 11. Snider WD (1994) Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 77:627-638.
12. 12. van der Geer P, Hunter T, Lindberg RA (1994) Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol 10:251-337.
13. 13. Hirai H, Maru Y, Hagiwara K, Nishida J, Takaku F (1987) A novel putative tyrosine kinase receptor encoded by the eph gene. Science 238:1717-1720.
14. 14. Scales JB, Winning RS, Renaud CS, Shea LJ, Sargent TD (1995) Novel members of the eph receptor tyrosine kinase subfamily expressed during Xenopus development. Oncogene 11:1745-1752.
15. 15. Becker N, Seitanidou T, Murphy P, Mattei M-G, Topilko P, Nieto MA, Wilkinson DG, Charnay P, Gilardi-Hebenstreit P (1994) Several receptor tyrosine kinases genes of the Eph family are segmentally expressed in the developing hindbrain. Mech Dev 47:3-17.
16. 16. Henkemeyer M, Marengere LEM, McGlade J, Olivier JP, Conlon RA, Holmyard DP, Letwin K, Pawson T (1994) Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis. Oncogene 9:1001-1014.
17. 17. Tessier-Lavigne M (1995) Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps. Cell 82:345-348.
18. 18. Pandey A, Lindberg RA, Dixit VM (1995) Receptor orphans find a family. Current Biology 5:986-989.
19. 19. Hunt RW, Welcher AA, Boyle WJ, Parker VP, Lindberg RA, Lu HS, Colombero AM, Elliott RL, Guthrie BA, Holst PL, Skrine JD, Toso RJ, Zhang M, Fernandez E, Trail G, Varnum B, Yarden Y, Hunter T, Fox GM (1994) B61 is a ligand for the ECK receptor protein-tyrosine kinase. Nature 368:558-560.
20. 20. Beckmann MP, Cerretti DP, Baum P, Vanden Bos T, James L, Farrah T, Kozlosky C, Hollingsworth T, Shilling H, Maraskovsky E, Fletcher FA, Lhotak V, Pawson T, Lyman SD (1994) Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors. EMBO J 13:3757-3762.
21. 21. Davis S, Gale NW, Aldrich TH, Maisonpierre PC, Lhotak V, Pawson T, Goldfarb M, Yancopoulos GD (1994) Ligands for eph-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science 266:816-819.
22. 22. Kozlosky CJ, Maraskovsky E, McGrew JT, VandenBos T, Teepe M, Lyman SD, Srinivasan S, Fletcher FA, Gayle RB, Cerretti DP, Beckmann MP (1995) Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins. Oncogene 10:299-306.
23. 23. Shao H, Lou L, Pandey A, Verderame MF, Siever DA, Dixit VM (1995) cDNA cloning and characterization of a Cek7 receptor protein-tyrosine kinase ligand that is identical to the ligand (ELF-1) for the Mek-4 and Sek receptor protein-tyrosine kinases. J Biol Chem 270:3467-3470.
24. 24. Cheng H-J, Flanagan JG (1994) Identification and cloning of ELF-1, a developmentally expressed ligand for the mek4 and sek receptor tyrosine kinases. Cell 79:157-168.
25. 25. Shao H, Lou L, Pandey A, Pasquale EB, Dixit VM (1994) cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase. J Biol Chem 269:26606-26609.
26. 26. Bennett BD, Zeigler FC, Gu Q, Fendly B, Goddard AD, Gillett N, Matthews W (1995) Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk. Proc Natl Acad Sci USA 92:1866-1870.
27. 27. Cerretti DP, VandenBos T, Nelson N, Kozlosky CJ, Reddy P, Maraskovsky E, Park LS, Lyman SD, Copeland NG, Gilbert DJ, Jenkins NA, Fletcher RA (1995) Isolation of LERK-5: a ligand of the eph-related kinases. Molec Immun 32:1197-1205.
28. 28. Bergemann AD, Cheng H-J, Brambilla R, Klein R, Flanagan JG (1995) ELF-2, a new member of the eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites. Mol Cell Biol 15:4921-4929.
29. 29. Gale NW, Flenniken A, Compton DC, Jenkins N, Copeland NG, Gilbert DJ, Davis S, Wilkinson DG, Yancopoulos GD (1996) Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments. Oncogene 13:1343-1352.
30. 30. Carpenter MK, Shilling H, VandenBos T, Beckmann MP, Cerretti DP, Kott JN, Westrum LE, Davison BL, Fletcher FA (1995) Ligands for the EPH-related kinase receptors are developmentally regulated in the CNS. J Neurosci Res 42:199-206.
31. 31. Fletcher FA, Carpenter MK, Shilling H, Baum P, Ziegler SF, Gimpel S, Hollingsworth T, Vanden Bos T, James L, Hjerrild K, Davison BL, Lyman SD, Beckmann MP (1994) LERK-2, a binding protein for the receptor-tyrosine kinase ELK, is evolutionarily conserved and expressed in a developmentally regulated pattern. Oncogene 9:3241-3247.
32. 32. Drescher U, Kremoser C, Handwerker C, Loschinger J, Noda M, Bonhoeffer F (1995) In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell 82:359-370.
33. 33. Winslow JW, Moran P, Valverde J, Shih A, Yuan JQ, Wong SC, Tsai SP, Goddard A, Henzel WJ, Hefti F, Beck KD, Caras IW (1995) Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation. Neuron 14:973-981.
34. 34. Zhang J-H, Cerretti DP, Flanagan JG, Zhou R (1996) Detection of Ligands in Regions Anatomically Connected to Neurons Expressing the Eph Receptor Bsk: Potential Roles in Neuron-Target Interaction. J Neurosci 16:7182-7192.
35. 35. Daniel TO, Stein E, Cerretti DP, St. John PL, Robert B, Abrahamson DR (1996) ELK and LERK-2 in developing kidney and microvascular endothelial assembly. Kidney Int (Suppl.) 57:S73-S81.
36. 36. Pandey A, Shao H, Marks RM, Polverini PJ, Dixit VM (1995) Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis. Science 268:567-569.
37. 37. von Heijne G (1986) A new method for predicting signal sequence cleavage sites. Nucleic Acids Res 14:4683-4690.
38. 38. Cross GAM (1990) Glycolipid anchoring of plasma membrane proteins. Annu Rev Cell Biol 6:1-39.
39. 39. Ferguson MA, Williams AF (1988) Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures. Annu Rev Biochem 57:285-320.
40. 40. Brambilla R, Schnapp A, Casagranda F, Labrador JP, Bergemann AD, Flanagan JG, Pasquale EB, Klein R (1995) Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases. Embo J 14:3116-3126.
41. 41. Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DG, Pawson T, Davis S, Yancopoulos GD (1996) Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenssis. Neuron 17: 9-19.
42. 42. Cheng HJ, Nakamoto M, Bergemann AD, Flanagan JG (1995) Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map. Cell 82:371-381.
43. 43. Devereux J, Haeberli P, Smithies O (1984) A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res 12:387-395.
44. 44. McMahan CJ, Slack JL, Mosley B, Cosman D, Lupton SD, Brunton LL, Grubin CE, Wignall JM, Jenkins NA, Brannan CI, Copeland NG, Huebner K, Croce CM, Cannizzarro LA, Benjamin D, Dower SK, Spriggs MK, Sims JE (1991) A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J 10:2821-2832.
45. 45. Hunter WM, Greenwood FC (1962) Preparation of iodine-131 labeled human growth hormone of high specific activity. Nature 194:495-496.
46. 46. Park LS, Friend D, Gillis S, Urdal DL (1986) Characterization of the cell surface receptor for human granulocyte/macrophage colony-stimulating factor. J Exp Med 164:251-262.
47. 47. Lindberg RA, Hunter T (1990) cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol Cell Biol 10:6316-6324.
48. 48. Cerretti DP, Wignall J, Anderson D, Tushinski RJ, Gallis BM, Stya M, Gillis S, Urdal DL, Cosman D (1988) Human macrophage-colony stimulating factor: alternative RNA and protein processing from a single gene. Mol Immunol 25:761-770.
49. 49. Sambrook J, Fritsch E, Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Press, Cold Spring Harbor.