Eph receptor tyrosine kinases and their ligands in neural development

Current Opinion in Neurobiology

Volumn 6, Issue 1, 1996, Pages 127-133

  Friedman, Glenn C ^a   O'Leary, Dennis D M ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GLYCOSYLPHOSPHATIDYLINOSITOL; INSULIN RECEPTOR; NERVE GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; RECEPTOR;

CELL PROLIFERATION; CELL SURVIVAL; NERVE CELL DIFFERENTIATION; NERVE PROJECTION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; RETINA; REVIEW; RHOMBENCEPHALON;

EID: 0029943807     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(96)80018-3     Document Type: Note

References (72)

1. Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S: Oncogenes and signal transduction. Cell 1991, 64:281-302.
2. Schlessinger J, Ullrich A: Growth factor signaling by receptor tyrosine kinases. Neuron 1992, 9:383-391.
3. Van der Geer P, Hunter T, Lindberg RA: Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol 1994, 10:251-337.
4. Chao M: Neurotrophin receptors: a window into neuronal differentiation. Neuron 1992, 9:583-593.
5. Tuzi N, Gullick W: Eph, the largest known family of putative growth factor receptors. Br J Cancer 1994, 69:417-421.
6. Hirai H, Maru Y, Hagiwara K, Nishida J, Takaku F: A novel putative tyrosine kinase receptor encoded by the eph gene. Science 1987, 238:1717-1720.
7. Pandey A, Lindberg RA, Dixit VM: Receptor orphans find a family. Curr Biol 1995, 5:986-989.
8. Pasquale E: Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family. Cell Regul 1991, 2:523-534.
9. Pasquale E, Deerinck T, Singer S, Ellisman M: Cek5, a membrane receptor-type tyrosine kinase, is in neurons of the embryonic and postnatal avian brain. J Neurosci 1992, 12:3956-3967.
10. Pasquale E, Connor R, Rocholl D, Schnürch H, Risau W: Cek5, a tyrosine kinase of the Eph subclass, is activated during neural retina differentiation. Dev Biol 1994, 163:491-502.
11. Sajjadi F, Pasquale E: Five novel avian Eph-related tyrosine kinases are differentially expressed. Oncogene 1993, 8:1807-1813.
12. Siever D, Verderame M: Identification of a complete Cek7 receptor protein tyrosine kinase coding sequence and cDNAs of alternatively spliced transcripts. Gene 1994, 148:219-226.
13. Soans C, Holash J, Pasquale E: Characterization of the expression of the Cek8 receptor-type tyrosine kinase during development and in tumor cell lines. Oncogene 1994, 9:3353-3361.
14. Maisonpierre P, Barrezueta N, Yancopoulos G: Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression. Oncogene 1993, 8:3277-3288.
15. Taylor V, Miescher G, Pfarr S, Honegger P, Breitschopf H, Lassmann H, Steck A: Expression and developmental regulation of Ehk-1, a neuronal Elk-like receptor tyrosine kinase in brain. Neuroscience 1994, 63:163-178.
16. Lindberg R, Hunter T: cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol Cell Biol 1990, 10:6316-6324.
17. Ganju P, Shigemoto K, Brennan J, Entwistle A, Reith A: The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development. Oncogene 1994, 9:1613-1624.
18. Ruiz J, Robertson E: The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development. Mech Dev 1994, 46:87-100.
19. Mori T, Wanaka A, Taguchi A, Matsumoto K, Tohyama M: Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse. Mol Brain Res 1995, 29:325-335.
20. Ellis J, Liu Q, Breitman M, Jenkins N, Gilbert O, Copeland N, Tempest H, Warren S, Muir E, Schilling H et al.: Embryo brain kinase: a novel gene of the eph/elk receptor kinase family. Mech Dev 1995, 52:319-341.
21. Letwin K, Yee S-R Pawson T: Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using antiphosphotyrosine antibody. Oncogene 1988, 3:621-678.
22. Lhoták V, Greer P, Letwin K, Pawson T: Characterization of Elk, a brain-specific receptor tyrosine kinase. Mol Cell Biol 1991, 11:2496-2502.
23. Lai C, Lemke L: An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron 1991, 6:691-704.
24. Chan J, Watt V: eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases. Oncogene 1991, 6:1057-1061.
25. Bennett B, Wang Z, Kuang W, Wang A, Groopman J, Goeddel D, Scadden D: Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. J Biol Chem 1994, 269:14211-14218.
26. Ciossek T, Millauer B, Ullrich A: Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system. Oncogene 1995, 9:97-108.
27. Xu Q, Holder N, Patient R, Wilson S: Spatially regulated expression of three receptor tyrosine kinase genes during gastrulation in the zebrafish. Development 1994, 120:287-299.
28. Fox G, Hoist P, Chute H, Lindberg R, Janssen A, Basu R, Welcher A: cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. Oncogene 1995, 10:897-905.
29. Gilardi-Hebenstreit P, Nieto M, Frain M, Mattei M-G, Chestier A, Wilkinson D, Charnay P: An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain. Oncogene 1992, 7:2499-2506.
30. Nieto MA, Gilardi-Hebenstreit P, Charnay P, Wilkinson DG: A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm. Development 1992, 116:1137-1150.
31. Becker N, Seitanidou T, Murphy P, Mattei M-G, Topilko P, Nieto MA, Wilkinson DG, Charnay P, Gilardi-Hebenstreit P: Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech Dev 1994, 47:3-17.
32. Henkemeyer M, Marengere L, McGlade J, Olivier J, Conlon R, Holmyard D, Letwin K, Pawson T: Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis. Oncogene 1994, 9:1001-1014.
33. Andres AC, Reid HH, Zurcher G, Blaschke RJ, Albrecht D, Ziemiecki A: Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis. Oncogene 1994, 9:1461-1467.
34. Cheng HJ, Nakamoto M, Bergemann AD, Flanagan JG: Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map. Cell 1995, 82:371-381.
35. Winslow JW, Moran P, Valverde J, Shih A, Yuan JQ, Wong SC, Tsai SP, Goddard A, Henzel WJ, Hefti F ef al.: Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation. Neuron 1995, 14:973-981.
36. Wicks IP, Wilkinson D, Salvaris E, Boyd AW: Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphold tumor cell lines. Proc Natl Acad Sci USA 1992, 89:1611-1615.
37. Bartley TD, Hunt RW, Welcher AA, Boyle WJ, Parker VP, Lindberg RA, Lu HS, Colombero AM, Elliott RL et al.: B61 is a ligand for the ECK receptor protein-tyrosine kinase. Nature 1994, 368:558-560.
38. Dixit VM, Green S, Sarma V, Holzman LB, Wolf FW, O'Rourke K, Ward PA, Prochownik EV, Marks RM: Tumor necrosis factor-α induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin. J Biol Chem 1990, 265:2973-2978.
39. Holzman LB, Marks RM, Dixit VM: A novel immediate-early response gene of endothellum is induced by cytokines and encodes a secreted protein. Mol Cell Biol 1990, 10:5830-5838.
40. Takahashi H, Ikeda T: Molecular cloning and expression of rat and mouse B61 gene: implications on organogenesis. Oncogene 1995, 11:879-883.
41. Beckmann MP, Cerretti DP, Baum P, VandenBos T, James L, Farrah T, Kozlosky C, Hollingsworth T, Shilling H, Maraskovsky E et al.: Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors. EMBO J 1994, 13:3757-3762.
42. Davis S, Gale N, Aldrich T, Maisonpierre P, Lhotak V, Pawson T, Goldfarb M, Yancopoulos G: Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science 1994, 266:816-819.
43. Shao H, Lou L, Pandey A, Pasquale E, Dixit V: cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase. J Biol Chem 1994, 269:26606-26609.
44. Brambilla R, Schnapp A, Casagranda F, Labrador J, Bergemann A, Flanagan J, Pasquale E, Klein R: Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases. EMBO J 1995, 14:3116-3126.
45. Koslzosky CJ, Maraskovsky E, McGrew JT, VandenBos T, Teepe M, Lyman SD, Srinivasan S, Fletcher FA, Gayle RB, Cerretti DP, Beckmann MP: Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins. Oncogene 1995, 10:299-306.
46. Cheng HJ, Flanagan JG: Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell 1994, 79:157-168.
47. Shao H, Pandey A, O'Shea S, Seldin M, Dixit V: Characterization of B61, the ligand for the Eck receptor protein-tyrosine kinase. J Biol Chem 1995, 270:5636-5641.
48. Drescher U, Kremoser C, Handwerker C, Löschinger J, Noda M, Bonhoeffer F: In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell 1995, 82:359-370.
49. Bergemann AD, Cheng HJ, Brambilla R, Klein R, Flanagan JG: Elf-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites. Mol Cell Biol 1995, 15:4921-4929.
50. Brambilla R, Klein R: Telling axons where to grow: a role for Eph receptor tyrosine kinases in guidance. Mol Cell Neurosci 1996, 6:487-495.
51. Sperry RW: Chemoaffinity in the orderly growth of nerve fiber patterns and connections. Proc Natl Acad Sci USA 1963, 50:703-710.
52. Bonhoeffer F, Gierer A: How do retinal axons find their targets on the tectum? Trends Neurosci 1984, 7:378-381.
53. Gierer A: Directional cues for growing axons forming the retinotectal projection. Development 1987, 101:479-489.
54. Sanes JR: Topographic maps and molecular gradients. Curr Opin Neurobiol 1993, 3:67-74.
55. Kaprielian Z, Patterson P: The molecular basis of retinotectal topography. Bioessays 1994, 16:1-11.
56. Roskies A, Friedman GC, O'Leary DDM: Mechanisms and molecules controlling the development of retinal maps. Perspect Dev Neurobiol 1995, 3:63-75.
57. Tessier-Lavigne M: Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps. Cell 1995, 82:345-348.
58. Walter J, Kern-Veits B, Huf J, Stolze B, Bonhoeffer F: Recognition of position-specific properties of tectal cell membranes by retinal axons in vitro. Development 1987, 101:685-606.
59. Walter J, Henke-Fahle S, Bonhoeffer F: Avoidance of posterior tectal membranes by temporal retinal axons. Development 1987, 101:909-913.
60. Stahl B, Muller B, Von Boxberg Y, Cox E, Bonhoeffer F: Biochemical characterization of a putative axonal guidance molecule of the chick visual system. Neuron 1990, 5:735-743.
61. Cox EC, Müller B, Bonhoeffer F: Axonal guidance in the chick visual system: posterior tectal membranes induce collapse of growth cones from the temporal retina. Neuron 1990, 2:31-37.
62. Walter J, Muller B, Bonhoeffer F: Axonal guidance by an avoidance mechanism. J Physiol (Paris) 1990, 84:104-110.
63. Müller BK, Bonhoeffer F: A monoclonal antibody recognizing a putative guidance molecule reveals an anterior-posterior gradient in the embryonic tectum of chick and rat. Soc Neurosci Abstr 1994, 20:1086.
64. Müller BK, Jay DG, Bonhoeffer F: Chromophore-assisted laser inactivation of a repulsive guidance molecule. Soc Neurosci Abstr 1995, 21:292.
65. Nakumura H, O'Leary DDM: Inaccuracies in initial growth and arborization of chick retinotectal axons followed by course corrections and axon remodeling to develop topographic order. J Neurosci 1989, 9:3776-3795.
66. Holash JA, Pasquale EB: Polarized expression of the receptor protein tyrosine kinase Cek5 in the developing avian visual system. Dev Biol 1995, 172:683-693.
67. Lumsden A: The cellular basis of segmentation in the developing hindbrain. Trends Neurosci 1990, 13:329-335.
68. McGinnis W, Krumlauf R: Homeobox genes and axial patterning. Cell 1992, 68:283-302.
69. Schneider-Maunoury S, Topilko P, Seitanidou T, Levi G, Cohen-Tannoudji M, Pourin S, Babinet C, Charnay P: Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain. Cell 1993, 75:1199-1214.
70. Keynes R, Krumlauf R: Hox genes and regionalization of the nervous system. Annu Rev Neurosci 1994, 17:109-132.
71. Winning RS, Sargent TD: Pagliaccio, a member of the Eph family of receptor tyrosine kinase genes, has localized expression in a subset of neural crest and neural tissues in Xenopus laevis embryos. Mech Dev 1994, 46:219-229.
72. Xu Q, Alldus G, Holder N, Wilkinson DG: Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain. Development 1995, 121:4005-4016.