Developmental expression and distinctive tyrosine phosphorylation of the Eph-related receptor tyrosine kinase Cek9

Journal of Cell Biology

Volumn 135, Issue 3, 1996, Pages 781-795

  Soans, Chandrasen ^a   Holash, Jocelyn A ^a   Pavlova, Yelena ^a   Pasquale, Elena B ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE;

ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; CHICKEN; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; IN SITU HYBRIDIZATION; MOUSE; NERVE FIBER GROWTH; NONHUMAN; OPTIC TECTUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA GANGLION CELL; RETINOTECTAL PROJECTION; SIGNAL TRANSDUCTION; VISUAL SYSTEM;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY SPECIFICITY; BASE SEQUENCE; CHICK EMBRYO; CLONING, MOLECULAR; DNA, COMPLEMENTARY; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; ORGAN SPECIFICITY; PHOSPHORYLATION; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPHA4; RECEPTOR, EPHB2; RECEPTOR, EPHB5; RETINA; SEQUENCE ANALYSIS, DNA; TYROSINE;

ANIMALIA; GALLUS GALLUS;

EID: 0029844406     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.135.3.781     Document Type: Article

References (55)

1. Bartley T.D., R.W. Hunt, A.A. Welcher, W. Boyle, V.P. Parker, R.A. Lindberg, H.S. Lu, A.M. Colombero, R.L. Elliot, B.A. Guthrie, et al. 1994. Receptor affinity techniques: identification of a ligand for the ECK receptor protein-tyrosine kinase. Nature (Lond.). 368:558-560.
2. Becker, N., T. Seitanidou, P. Murphy, M.G. Mattei, P. Topilko, M.A. Nieto, D.G. Wilkinson, P. Charnay, and P. Gilardi-Hebenstreit. 1994. Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech. Dev. 47:3-17.
3. Beckmann, M.P., D.P. Ceretti, P. Baum, T.V. Bos, L. James, T. Farrah, C. Kozlosky, T. Hollingsworth, H. Shilling, E. Maraskovsky, F.A. Fletcher, V. Lhotak, T. Pawson, and S.D. Lyman. 1994. Molecular characterization of a family of ligands for Eph-related tyrosine kinase receptors. EMBO (Eur. Mol. Biol. Organ.) J. 13:3757-3762.
4. Bennett, B.D., F.C. Zeigler, Q. Gu, B. Fendly, A.D. Goddard, N. Gillett, and W. Matthews. 1995. Molecular cloning of a ligand for the EPH-relaled receptor protein-tyrosine kinase Htk. Proc. Natl. Acad. Sci. USA. 92:1866-1870.
5. Bergemann, A.D., H.-J. Cheng, R. Brambilla, R. Lein, J.G. Flanagan. 1995. ELF-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly formed somites. Mol. Cell Biol. 15:4921-4929.
6. Bishop, J.M. 1991. Molecular themes in oncogenesis. Cell. 64:234-248.
7. Blaikie, P., D. Immanuel, J. Wu, W. Li, V. Yajnik, and B. Margolis. 1994. A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. J. Biol. Chem. 269:32031-32034.
8. Brambilla, R., A. Schnapp, F. Casagranda, J.P. Labrador, A.D. Bergemann, J.G. Flanagan, E.B. Pasquale, and R. Klein. 1995. Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases. EMBO (Eur. Mol. Biol. Organ.) J. 14:3116-3126.
9. Cheng, H.-J., and J.G. Flanagan. 1994. Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell. 79:157-168.
10. Cheng, H.-J., M. Nakamoto, A.D. Bergemann, and J.G. Flanagan. 1995. Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map. Cell. 82:371-381.
11. Connor, R.J., and E.B. Pasquale. 1995. Genomic organization and alternatively processed forms of Cek5, a receptor protein-tyrosine kinase of the Eph subfamily. Oncogene. 11:2429-2438.
12. Davis, S., N.W. Gale, T.H. Aldrich, P.C. Maisonpierre, V. Lhotak, T. Pawson, M. Goldfarb, and G.D. Yancopoulos. 1994. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science (Wash. DC). 266:816-819.
13. Drescher, U., C. Kremoser, C. Handwerker, J. Löschinger, M. Noda, and F. Bonhoeffer. 1995. In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell. 82:359-370.
14. Ellis, L., E. Clauser, D.O. Morgan, M. Edery, R.A. Roth, and W.J. Rutter. 1986. Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose. Cell. 45:721-732.
15. Ellis, J., Q. Liu, M. Breitman, N.A. Jenkins, D.J. Gilbert, N.G. Copeland, H.V. Tempest, S. Warren, E. Muir, H. Schilling, F.A. Fletcher, S.F. Ziegler, and J.H. Rogers. 1995. Embryo brain kinase: a novel gene of the eph/elk receptor tyrosine kinase family. Mech. Dev. 52:319-341.
16. Ellis, C., F. Kasmi, P. Ganju, E. Walls, G. Panayotou, and A.D. Reith. 1996. A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn. Oncogene. 12:1727-1736.
17. Fox, G. M., P.L. Holst, H.T. Chute, R.L. Lindberg, A.M. Janssen, R. Basu, and A.A. Welcher. 1995. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. Oncogene. 10:897-905.
18. Ganju, P., K. Shigemoto, J. Brennan, A. Entwistle, and A.D. Reith. 1994. The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development. Oncogene. 9:1613-1624.
19. Garner, A.S., and T.H. Large. 1994. Isoforms of the avian TrkC receptor: a novel kinase insertion dissociates transformation and process outgrowth from survival. Neuron. 13:457-472.
20. Harlow, E., and D. Lane. 1988. Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. 726 pp.
21. Hauschka, S.D. 1994. The embryonic origin of muscle. In Myology. A.G. Engel and C. Franzini-Armstrong, editors. McGraw-Hill, Inc., New York. 3-73.
22. Hayman, M.J., and H. Beug. 1984. Identification of a form of the avian erythroblastosis virus erb-B gene product at the cell surface. Nature (Lond.). 309: 460-462.
23. Henkemeyer, M., L.E.M. Marengere, J. McGlade, L.P. Olivier, R.A. Conlon, D.P. Holmyard, K. Letwin, and T. Pawson. 1994. Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis. Oncogene. 9:1001-1014.
24. Henkemeyer, M., D. Orioli, J.T. Henderson, T.M. Saxton, J. Roder, T. Pawson, and R. Klein. 1996. Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell. 86:35-46.
25. Holash, J.A., and E.B. Pasquale. 1995. Polarized expression of the receptor protein tyrosine kinase Cek5 in the developing avian visual system. Dev. Biol. 172:683-693.
26. Hou, J., M. Kan, K. McKeehan, G. McBride, P. Adams, and W.L. McKeehan. 1991. Fibroblast growth factor receptors from liver vary in three structural domains. Science (Wash. DC). 251:665-668.
27. Irving, C., M.A. Nieto, R. DasGupta, P. Charnay, and D.G. Wilkinson. 1996. Progressive spatial restriction of Sek-1 and Krox-20 gene expression during hindbrain segmentation. Dev. Biol. 173:26-38.
28. Kavanaugh, W.M., and L.T. Williams. 1994. An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. Science (Wash. DC). 266:1862-1865.
29. Kazlauskas, A., D.L. Durden, and J.A. Cooper. 1991. Functions of the major tyrosine phosphorylation site of the PDGF receptor β-subunit. Cell Regul. 2: 413-425.
30. Kenny, D., M. Bronner-Fraser, and C. Marcelle. 1995. The receptor tyrosine kinase QEK5 mRNA is expressed in a gradient within the neural retina and the tectum. Dev. Biol. 172:708-716.
31. Kozak, M. 1992. The scanning model for translation: an update. J. Cell Biol. 108:229-241.
32. Lhoták, V., P. Greer, K. Letwin, and T. Pawson. 1991. Characterization of Elk, a brain-specific receptor tyrosine kinase. Mol. Cell. Biol. 11:2496-2502.
33. Lindberg, R.A., and T. Hunter. 1990. cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol. Cell Biol. 10:6316-6324.
34. Longati, P., A. Bardelli, C. Ponzetto, L. Naldini, and P.M. Comoglio. 1993. Tyrosines 1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor). Oncogene. 9:49-57.
35. Maisonpierre, P.C., N.X. Barrezueta, and G.D. Yancopoulos. 1993. Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression. Oncogene. 8:3277-3776.
36. Nieto, M.A., P. Gilardi-Hebenstreit, P. Charnay, and D.G. Wilkinson. 1992. A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm. Development. 116:1137-1150.
37. Ohta, K., M. Nakamura, K. Hirokawa, S. Tanaka, A. Iwama, T. Suda, M. Ando, and H. Tanaka. 1996. The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development. Mech. Dev. 54:59-69.
38. Pandey, A., D.F. Lazar, A.R. Saltiel, and V.M. Dixit. 1994. Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. J. Biol. Chem. 269:30154-30157.
39. Pandey, A., H. Shao, R.M. Marks, P.J. Polverini, and V.M. Dixit. 1995. Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-α-induced angiogenesis. Science (Wash. DC). 268:567-569.
40. Pasquale, E.B. 1991. Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family. Cell Regul. 2: 523-534.
41. Pasquale, E.B., R.J. Connor, D. Rocholl, H. Schnürch, and W. Risau. 1994. Cek5, a tyrosine kinase of the Eph subclass, is activated during neural retina differentiation. Dev. Biol. 163:491-502.
42. Patel, K., R. Nittenberg, D. D'Souza, C. Irving, D. Burt, D.G. Wilkinson, and C. Tickle. 1996. Expression and regulation of Cek8, a cell to cell signalling receptor in developing chick limb buds. Development. 122:1147-1155.
43. Privalsky, M.L., and J.M. Bishop. 1984. Subcellular localization of the v-erb-B protein, the product of a transforming gene of avian erythroblastosis virus. Virology. 135:356-368.
44. Ruiz, J.C., and E.J. Robertson. 1994. The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development. Mech. Dev. 46:87-100.
45. Sajjadi F.G., and E.B. Pasquale. 1993. Five novel avian Eph-related tyrosine kinases are differentially expressed. Oncogene. 8:1807-1813.
46. Schlessinger, J., and A. Ullrich. 1992. Growth factor signaling by receptor tyrosine kinases. Neuron. 9:383-391.
47. Shao, H., L. Lou, A. Pandey, E.B. Pasquale, and V.M. Dixit. 1994. cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase. J. Biol. Chem. 269:26606-26609.
48. Siever, D.A., and M.F. Verderame. 1994. Identification and complete Cek7 receptor protein tyrosine kinase coding sequence and cDNAs of alternatively spliced transcripts. Gene. 148:219-226.
49. Simmons, D.M., J.L. Arriza, and L.W. Swanson. 1989. A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radiolabeled single-stranded RNA probes. J. Histotechnol. 12:169-181.
50. Soans, C., J.A. Holash, and E.B. Pasquale. 1994. Characterization of the expression of the Cek8 receptor-type tyrosine kinase during development and in tumor cell lines. Oncogene. 9:3353-3361.
51. van der Geer, P., and T. Hunter. 1991. Tyrosine 706 and 807 phosphorylation site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate phosphalidylinositol-3 kinase but show differential defects in their ability to induce early response gene transcription. Mol. Cell. Biol. 11:4698-4709.
52. van der Geer, P., T. Hunter, and R.A. Lindberg. 1994. Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol. 10:251-337.
53. Xu, Q., N. Holder, R. Patient, and S.W. Wilson. 1994. Spatially regulated expression of three receptor tyrosine kinase genes during gastrulation in the zebrafish. Development. 120:287-299.
54. Xu, Q., G. Alldus, N. Holder, and D.G. Wilkinson. 1995. Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain. Development. 121: 4005-4016.
55. Zhou, R., T.D. Copeland, L.F. Kromer, and N.T. Schulz. 1994. Isolation and characterization of Bsk, a growth factor receptor-like tyrosine kinase associated with the limbic system. J. Neurosci. Res. 37:129-143.