New developments in hematopoietic stem cell expansion

Current Opinion in Hematology

Volumn 5, Issue 1, 1998, Pages 79-86

  Von Kalle, Christof ^a   Glimm, Hanno ^c   Schulz, Gregor ^b   Mertelsmann, Roland ^c   Henschler, Reinhard ^c  

^a TU BERGAKADEMIE FREIBERG   (Germany)

^b Cellgenix GmbH   (Germany)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALLOTRANSPLANTATION; AUTOTRANSPLANTATION; CELL CULTURE; GENE THERAPY; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; PRIORITY JOURNAL; REVIEW;

ANIMALS; ERYTHROPOIESIS; GENE THERAPY; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKOPOIESIS; MICE;

EID: 0031912788     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-199801000-00013     Document Type: Review

References (65)

1. Thomas ED, Storb R, Clift RA, Fefer M, Johnson FL, Neiman PF, Lerner KG, Glucksberg H, Buckner CD: Bone marrow transplantation. N Engl J Med 1975, 292:832-843.
2. Kessinger A, Armitage JO: The evolving role of autologous peripheral stem cell transplantation following high-dose therapy for malignancies. Blood 1991, 77:211-213.
3. To LB, Haylock DN, Simmons PJ, Juttner CA: The biology and clinical uses of Mood stem cells. Blood 1997, 89:2233-2258.
4. Dexter TM, Allen TD, LG Lajtha: Conditions controlling the proliferation of hematopoletic cells in vitro. J Cell Physical 1977, 91:335-344.
5. Gartner S, HS Kaplan: Long-term culture of human bone marrow cells. Proc Natl Acad Sci USA 1980, 77:4756-4759.
6. Spooncer E, Dexter TM: Transplantation of long-term cultured bone marrow cells. Transplantation 1983, 35:624-627.
7. Fraser CC, Szilvassy SJS, Eaves CJ, Humphries RK: Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive In vivo reconstituting ability. Proc Natl Acad Sci U S A 1992, 89:1968-1972.
8. Muench MO, Firpo MT, Moore MAS: Bone marrow transportation with interleukin-1 plus kit-ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution In mice without loss of stem cell lineage and proliferate potential. Blood 1993, 81:3463-3473.
9. Han M, Kobayashi M, Imamura M, Hashino S, Kobayashi H, Maeda S, Iwasaki H, Fujii Y, Musashi M, Sakurada K, et al.: In vitro expansion of murine hematopoietic progenitor cells In liquid cultures for bone marrow transplantation: effects of stem cell factor. Int J Hematol 1993, 57:113-120.
10. Brown RL, Sheng F, Dusing SK, Fischer R, Patchen M: Serum-free culture conditions for cells capable of producing long-term survival in Iethally irradiated mice. Stem Cells 1997, 15:237-245.
11. Rebel VI, Dragowska W, Eaves CJ, Humphries RK, Lansdorp PM: Amplification of Sca-1+ Lin-WGA+cells in serum-free cultures containing steel factor, Interleukin-6, and erythropoletin with maintenance of cells with long-term in vivo reconstituting potential. Blood 1994, 83:128-136.
12. Spangrude GJ, Brooks DM, Tumas DB: Long-term repopulation of Irradiated mice with limiting numbers of purified hematopoletic stem cells: in vivo expansion of stem cell phenotype out not function. Stood 1995, 85:1006-1016.
13. Knobel KM, McNally MA, Berson AE, Rood D, Chen K, Kilinki L, Tran K, Okarma TB, Lebkowski JS: Long-term reconstitution of mice after ex vivo expansion of bone marrow cells: differential activity of cultured bone marrow and enrciched stem cell populations. Exp Hematol 1994, 22:1227-1235.
14. Hotyoake TL, Freshney MG, McNair L, Parker AN, McKay PJ, Steward WP, Fitzsimons E, Graham GJ, Pragnell IB: Ex vivo expansion with stem cell factor and interleukin-11 augments both short-term recovery posttransplant and the ability to serially transplant marrow. Blood 1996, 87:4589-4595.
15. Peters SO, Kittler ELW, Ramshaw HS, Quesenberry PJ: Ex vivo expansion of murine marrow cells with Interleukin-3 (IL-3), IL-6, IL-11, and stem cell factor leads to impaired engraftment in Irradiated hosts. Blood 1996, 87:30-37.
16. Eaves AC, Eaves CJ, Phillips GL, Bamett MJ: Culture purging in leukemia: past, present, and future. Leuk Lymphoma 1993, 11:259-263.
17. Gan OI, Murdoch B, Larochelle A, Dick JE: Differential maintenance of primltive human scid-repopulating cells, clonogenic progenitors, and long-term culture-initiating cells after incubation on human bone marrow stromal cells. Blood 1697, 90:641-650.
18. Koller MR, Manchel I, Palsson BO: Importance of parenchymal/stromal cell ratio for the ex vivo reconstitution of human hematopoiesis. Stem Cells 1997, 15:305-313.
19. Dexter TM, Simmons P, Pumell RA, Spooncer E, Schofield R: The regulation of hemopoletlc cell development by the stromal cell environment and diffusible regulatory molecules. Prog Clin Biol Res 1984, 148:13-33.
20. Verfaillie CM: Direct contact between human primitive hematopoletic progenitors and bone marrow stroma to not required for long-term in vitro hematopolesis. Blood 1992, 79:2821-2826.
21. Dao MA, Hannum CH, Kohn DB, Nolta JA: Flt3 ligand preserves the ability of human cd34(+) progenitors to sustain long-term hematopoiesis in immune-deficient mice after ex vivo retrovriral-medlated transduction. Blood 1997, 89:446-456. Evidence is given that FLT3 ligand, in conjunction with interleukin-3, interleukin-6, and stem cell factor, preserves the generative capacity of primitive human hematopoietic cells during in vitro transductions in suspension culture and might be able to replace the maintenance role provided by the stroma
22. Roecklein BA, Torokstorb B: Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus e6/e7 genes. Blood 1995, 85:997-1005.
23. Reems JA, Torok-Storb B: Cell cycle and functional differences between CD34+/CD38hi and CD34+/38lo human marrow cells after in vitro cytokine exposure. Blood 1995, 85:1480-1487.
24. Koller MR, Emerson SG, Palsson BO: Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures. Blood 1993, 82:378-384.
25. Bamett MJ, Eaves CJ, Phillips GL, Gascoyne RD, Hogge DE, Horsman DE, Humphries RK, Klingemann HG, Lansdorp PM, Nantel SH, et al.: Autograftlng with cultured marrow In chronic myeloid leukemia: results of a pilot study [see comments]. Blood 1994, 84:724-732.
26. Brugger W, Heimfeld S, Berenson RJ, Mertelsann R, Kanz L: Reconstitution of hematopoiesis after high-dose chemotherapy by autologous progenitor cells generated ex vivo. N Engl J Med 1995, 333:283-287.
27. Nolta JA, Dao MA, Wells S, Smogorzewska EM, Kohn DB: Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice. Proc Natl Acad Sci U S A 1996, 93:2414-2419.
28. Miller AD, Rosman GJ: Improved retroviral vectors for gene transfer and expression. Biotechniques 1989, 7:980-982.
29. Miller AD, Garcia JV, von Suhr N, Lynch CM, Wilson C, Eiden MV: Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus. J Virol 1991, 65:2220-2224.
30. Nienhuis AW: Gene transfer Into hematopoietic stem cells. Blood Cells 1994, 20:141-150.
31. Roe T, Reynolds T, Yu G, Brown P: Integration of murine leukemia virus DNA depends on mitosis. EMSO J 1993, 12:2099-2108.
32. Miller DG, Adam MA, Miller AD: Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of Infection. Mol Cell Biol 1990, 10:4239-4242.
33. Dick JE, Magli MC, Huszar D, Phillips RA, Bernstein A: Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoletlc system of W/Wv mice. Cell 1985, 42:71-79.
34. Bodine DM, Karsson S, Papayannopoulou T, Nienhuis AW: Expression of human beta globin genes introduced into primitive murine hematopoietic progenitor cells by retrovirus mediated gene transfer. Prog Clin Biol Res 1989, 316:219-233.
35. Hollander GA, Luskey BD, Williams DA, Burakoff SJ: Functional expression of human CD8 in fully reconstituted mice after retroviral-medlated gene transfer of hemopoletic stem cells. J Immunol 1992, 149:438-444.
36. Lemischka IR, Raulet DH, Mulligan RC: Developmental potential and dynamic behavior of hematopoietic stem cells. Cell 1986, 45:917-927.
37. Stead RB, Kwok WW, Storb R, Miller AD: Canine model for gene therapy: inefficient gene expression In dogs reconstituted with autologous marrow infected with retroviral vectors. Blood 1988, 71:742-747.
38. Carter RF, Abrams OA, Dick JE, Kruth SA, Valli VE, Kamel RS, Dube ID: Autologous transplantation of canine long-term marrow culture cells genetically marked by retroviral vectors. Blood 1892, 79:356-364.
39. Lothrop CJ, al LZ, Niemeyer GP, Jones JB, Peterson MG, Smith JR, Baker HJ, Morgan RA, Eglitis MA, Anderson WF: Expression of a foreign gene in cats reconstituted with retroviral vector infected autologous bone marrow. Blood 1991, 78:237-245.
40. Kantoff PW, Flake AW, Eglitis MA, Scharf S, Bond S, Gilboa E, Erlich H, Harrison MR, Zanjani ED, Anderson WF: In utero gene transfer and expression: a sheep transplantation model. Blood 1989, 73:1066-1073.
41. van Beusechem VW, Kukler A, Heidt PJ, Valerio D: Long-term expression of human adenosine deaminase in rhesus monkeys transplanted with retrovirus-infected bone-marrow cells. Proc Natl Acad Sci U S A 1992, 89:7640-7644.
42. Bodine DM, Moritz T, Donahue RE, Luskey BD, Kessler SW, Martin DI, Orkin SH, Nienhuis AW, Williams DA: Long-term in vivo expression of a murin adenosine deaminase gene in rhesus monkey hematopoletic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells. Blood 1993, 82:1975-1980.
43. Kiem HP, Darovsky B, von KC, Goehle S, Stewart D, Graham T, Hackman R, Appelbaum FR, Deeg HJ, Miller AD, et al.: Retrovirus-mediated gene transduction into canine peripheral blood repopulatlng cells. Blood 1994, 83:1467-1473.
44. Kohn DB, Weinberg KI, Nolta JA, Heiss LN, Lenarsky C, Crooks GM, Hanley ME, Annett G, Brooks JS, Elkhoureiy A, et al.: Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency. Nat Med 1995, 1:1017-1023.
45. Brenner MK, Rill DR, Moen RC, Krance RA, Mirro JJ, Anderson WF, Ihle JN: Gene-marking to trace origin of relapse after autologous bonemarrow transplantation. Lancet 1993, 341:85-86.
46. Brenner MK, Rill DR, Holladay MS, Heslop HE, Moen RC, Buschle M, Krance RA, Santana VM, Anderson WF, Ihle JN: Gene marking to determine whether autologous marrow Infusion restores long-term haemopoiesis In cancer patients. Lancet 1993, 342:1134-1137.
47. Deisseroth AB, Zu Z, Claxton D, Hanania EG, Fu S, Ellerson D, Goldberg L, Thomas M, Janicek K, Anderson WF, et al.: Genetic marking shows that Ph+ cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML Blood 1994, 83:3068-3076.
48. Dunbar CE, Cottlerfox M, Oshaughnessy JA, Doren S, Carter C, Berenson R, Brown S, Moen RC, Greenblatt J, Stewart FM, et al.: Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation. Blood 1995, 85:3048-3057.
49. Bordignon C, Notarangelo LD, Nobili N, Ferrari G, Casorati G, Panina P, Mazzolari E, Maggioni D, Rossi C, Servida P, Ugazio AG, Mavilio F: Gene therapy in peripheral blood lymphocytes and bone marrow for ADA(-) Immunodeficlent patients. Science 1995, 270:470-475.
50. von Kalle C, Kiem HP, Goehle S, Darovsky B, Heimfeld S, Torok SB, Storb R, Schuening FG: Increased gene transfer into human hematopoletic progenitor cells by extended in vitro exposure to a pseudotyped retroviral vector. Blood 1994, 84:2890-2897.
51. Petzer AL, Zandstra PW, Piret JM, Eaves CJ: Differential cytokine effects on primitive (cd34+cd38(-)) human hematopoletic cells: novel responses to flt3-ligand and thrombopoietin. J Exp Mad 1996, 183:2551-2558. Systematic analysis of the condition required for the expansion of long term culture-initiating cells in suspension culture.
52. Zandstra PW, Conneally E, Petzer AL, Piret JM, Eaves CJ: Cytokine manipulation of primitive human hematopoletic call self-renewal. Proc Natl Acad Sci U S A 1997, 94:4698-4703.
53. Podsakoff G, Wong KJ, Chatterjee S: Efficient gene transfer into nondividing cells by adeno-associated virus-based vectors. J Virol 1994, 68:5656-5666.
54. Halbert CL, Alexander IE, Wolgamot GM, Miller AD: Adeno-associated virus vectors transduce primary cells much less efficiently than immortalized cells. J Virol 1995, 69:1473-1479.
55. Fisheradams G, Wong KK, Podsakoff G, Forman SJ, Chatterjee S: Integration of adeno-associated virus vectors In cd34(+) human hematopoletic progenitor cells after transduction. Blood 1996, 88:492-504.
56. Bieniasz PD, Weiss RA, Mcclure MO: Cell cycle dependence of foamy retrovirus Infection. J Virol 1995, 89:7295-7299.
57. Russell DW, Miller AD: Foamy virus vectors. J Virol 1996, 70:217-222.
58. Hirata RK, Miller AD, Andrews RG, Russell DW: Transduction of hematopoletic cells by foamy virus vectors. Blood 1996, 88:3654-3661.
59. Naldini L, Blomer U, Gallay P, Dry D, Mulligan R, Gage FH, Verma IM, Trono D: In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996, 272:263-267.
60. Petzer AL, Hogge DE, Lansdorp PM, Reid DS, Eaves CJ: Self-renewal of primitive human hematopoletic cells (long-term-curture-initiating cells) In vitro and their expansion In defined medium. Proc Natl Acad Sci U S A 1996, 93:1470-1474.
61. Bhatia R, Mcglave PB, Miller JS, Wissink S, Un WN, Verfaillie CM: A clinically suitable ex vivo expansion culture system for ltc-ic and cfc using stroma-conditloned medium. Exp Hematol 1997, 25:980-991.
62. Henschler R, Brugger W, Luft T, Frey T, Mertelsmann R, Kanz L: Maintenance of transplantation potential in ex vivo expanded CD34(+)-selected human peripheral blood progenitor cells. Blood 1994, 84:2898-2903.
63. Petzer AL, Eaves CJ, Bamett MJ, Eaves AC: Selective expansion of primitive normal hematopoietic cells in cytokine-supplemented cultures of purified cells from patients with chronic myelold leukemia. Blood 1997, 90:64-69.
64. Conneally E, Cashman J, Petzer AL, Eaves CJ: In vitro expansion of human lympho-myelold stem cells from cord blood demonstrated using a quantitative in vivo repopulating assay. Blood 1996.
65. Piacibello W, Sanavio F, Garetto L, Severino A, Bergandi D, Ferrario J, Fagioli F, Berger M, Ag lietta M: Extensive amplification and selfrenewal of human primitive hematopoletic stem cells from cord blood. Blood 1997, 89:2644-2653.