Amyloid plaques in Guam amyotrophic lateral sclerosis/ parkinsonism-dementia complex contain species of Aβ similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging

Acta Neuropathologica

Volumn 95, Issue 2, 1998, Pages 117-122

  Schmidt, M L ^a   Lee, V M Y ^a   Saido, T ^b   Perl, D ^c   Schlick, T ^a   Iwatsubo, T ^d   Trojanowski, J Q ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Tokyo Metropolitan Institute of Gerontology   (Japan)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Amyloid plaques; Amyotrophic lateral sclerosis parkinsonism dementia complex; End terminus specific anti amyloid protein antibodies; Guam; N terminal modification of amyloid protein

Indexed keywords

AMYLOID;

ADULT; AGED; AGING; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CLINICAL ARTICLE; DEMENTIA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PARKINSONISM; PRIORITY JOURNAL; SENILE PLAQUE;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYOTROPHIC LATERAL SCLEROSIS; BRAIN; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; ORGAN SPECIFICITY; PARKINSON DISEASE; SENILE PLAQUES; SYNDROME;

EID: 0031907909     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050774     Document Type: Article

References (35)

1. Arai H, Lee VM-Y, Otvos L Jr, Greenberg BD, Lowery DE, Sharma SK, Schmidt ML, Trojanowski JQ (1990) Defined neurofilament, tau and beta-amyloid protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques. Proc Natl Acad Sci USA 87: 2249-2253
2. Braak H, Braak E (1995) Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 16: 271-284
3. Buée-Scherrer V, Buée L, Hof PR, Leveugle B, Gilles C, Loerzel AJ, Perl DP, Delacourte A (1995) Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. Am J Pathol 68: 924-932
4. Dickson DW, Crystal HA, Mattiace LA, Masur DM, Blau A, Davies P, Yen S-H, Aronson MK (1991) Identification of normal and pathologic aging in prospectively studied nondemented elderly humans. Neurobiol Aging 13: 179-189
5. Fukumoto H, Asami-Odaka A, Suzuki N, Shimada H, Ihara Y, Iwatsubo T (1996) Amyloid β protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of Aβ42(43) and association of Aβ40 with cored plaques. Am J Pathol 148: 259-265
6. Gentleman SM, Perl DP, Allsop D, Clinton J, Royston MC, Roberts GW (1991) Beta (A4)-amyloid protein and parkinsonian-dementia complex in Guam. Lancet 337: 55-56
7. Glenner GG, Wong CW (1984) Alzheimer's disease. Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120: 885-890
8. Goedert M, Trojanowski JQ, Lee VM-Y (1997) The neurofibrillary pathology of Alzheimer's disease. In: Prusiner SB, DiMauro S, Barchi RL (eds) The molecular and genetic basis of neurological disease, 2nd edn. Butterworth-Heineman, Boston, pp 613-628
9. PHF proteins display the same biochemical properties as normal τ. J Biol Chem 267: 564-569
10. Guiroy DC, Mellini M, Miyazaki M, Hilbich C, Safar J, Garruto RM, Yanagihara R, Beyreuther K, Gajdusek DC (1993) Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4- to 4.5-kilodalton protein which is immunoreactive to anti-amyloid β/A4-protein antibodies. Acta Neuropathol 86: 265-274
11. Hirano A, Malamud N, Kurland LT (1961) Parkinsonism-dementia complex, an endemic disease on the Island of Guam. II. Pathological features. Brain 84: 662-679
12. Hirano A, Malamud N, Elizan TS, Kurland LT (1966) Amyotrophic lateral sclerosis and Parkinson-dementia complex on Guam. Arch Neurol 15: 35-51
13. Hof PR, Nimchinsky EA, Buée-Scherrer V, Buée L, Nasrallah J, Hottinger AF, Purohit DP, Loerzel AJ, Steele JC, Delacourte A, Bouras C, Morrison JH, Perl DP (1994) Amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam: quantitative neuropathology, immunohistochemical analysis of neuronal vulnerability, and comparison with related neurodegenerative disorders, Acta Neuropathol 88: 397-404
14. Hot PR, Perl DP, Loerzel AJ, Steele JC, Morrison JH (1994) Amyotrophic lateral sclerosis and parkinsonism-dementia complex from Guam: differences in neurofibrillary tangle distribution and density in the hippocampal formation and neocortex. Brain Res 650: 107-116
15. Ito H, Hirano A, Yen S-H, Kato S (1991) Demonstration of β amyloid protein-containing neurofibrillary tangles in parkinsonism-dementia complex on Guam. Neuropathol Appl Neurobiol 17: 365-373
16. Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y (1994) Visualization of Aβ42(43)-positive and Aβ40-positive senile plaques with end-specific Aβ-monoclonal antibodies: evidence that an initially deposited Aβ species is Ab1- 42(43). Neuron 13: 45-53
17. Iwatsubo T, Mann DMA, Odaka A, Suzuki N, Ihara Y (1995) Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in Down syndrome. Ann Neurol 37: 294-299
18. Iwatsubo T, Saido TC, Mann DMA, Lee VM-Y, Trojanowski JQ (1996) Full-length Aβ(1-42(43)) as well as amino-terminally modified and truncated Aβ42(43) deposit in diffuse plaques. Am J Pathol 49: 1823-1830
19. Kato S, Hirano A, Llena JF, Ito H, Yen SH (1992) Ultrastructural identification of neurofibrillary tangles in the spinal cords in Guamanian amyotrophic lateral sclerosis and parkinsonism- dementia complex on Guam. Acta Neuropathol 83: 277-282
20. Kim KS, Miller DL, Sapienza VJ, Chen J, Bai C, Grundke- Iqbal I, Currie JR, Wisniewski HM (1988) Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci Res Commun 2: 121- 130
21. Kurland LT (1988) Amyotrophic lateral sclerosis and Parkinson's disease complex on Guam linked to an environmental neurotoxin. Trends Neurosci 11: 51-53
22. Lang E, Szendrei GI, Lee VM-Y, Otvos L Jr (1992) Immunological and conformational characterization of a phosphorylated immunodominant epitope on the paired helical filaments found in Alzheimer's disease. Biochem Biophys Res Commun 187: 783-790
23. Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ (1996) Sequence of deposition of heterogeneous amyloid Aβ peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol Dis 3: 16-32
24. Masters CL, Simms G, Weiman NA, Multhaup G, McDonald BL, Beyreuther K (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 82: 4245-4249
25. Mawal-Dewan M, Schmidt ML, Balin B, Perl DP, Lee VM-Y, Trojanowski JQ (1996) Identification of phosphorylation sites in PHF-TAU from patients with Guam amyotrophic lateral sclerosis/Parkinsonism-dementia complex. J Neuropathol Exp Neurol 55: 1051-1059
26. Oyanagi K, Makifuchi T, Ohtoh T, Chen K-M, Gajdusek DC, Chase TN (1997) Distinct pathological features of the Gallyas-and tau-positive glia in the parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam. J Neuropathol Exp Neurol 56: 308-316
27. Saido TC, Iwatsubo T, Mann DMA, Shimada H, Ihara Y, Kawashima S (1995) Dominant and differential deposition of distinct β-amyloid peptide species, Aβn3(pE), in senile plaques. Neuron 14: 1-20
28. Saido TC, Yamao-Harigaya W, Iwatsubo T, Kawashima S (1996) Amino- and carboxyl-terminal heterogeneity of β-amyloid peptides deposited in human brain. Neurosci Lett 215: 173- 176
29. Saido TC, Yokota M, Tani E, Kawashima S (1997) Post-secretory catabolism of β-amyloid in brain. In: Alzheimer's disease: biology, diagnosis and therapeutics. Wiley, New York, pp 337- 346
30. Schmidt ML, DiDario AG, Otvos L Jr, Hoshi N, Kant A, Lee VM-Y, Trojanowski JQ (1994) Plaque-associated neuronal proteins: a recurrent motif in neuritic amyloid deposits throughout diverse cortical areas of the Alzheimer's disease brain. Exp Neurol 130: 311-322
31. Schmidt ML, Lee VM-Y, Forman M, Chiu T-S, Trojanowski JQ (1997) Monoclonal antibodies to a novel 100 kD protein reveal abundant Aβ-negative plaques throughout grey matter of Alzheimer's disease brain. Am J Pathol 151: 69-80
32. Schwab C, Steele JC, Akiyama H, McGeer EG, McGeer PL (1995) Relationship of amyloid β/A4 protein to the neurofibrillary tangles in Guamanian Parkinson-dementia. Acta Neuropathol 90: 287-298
33. Shankar SK, Yanagihara R, Garruto RM, Grundke-Iqbal I, Kosik KS, Gajdusek DC (1989) Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Ann Neurol 25: 146-151
34. Stern RA, Otvos L Jr, Trojanowski JQ, Lee VM-Y (1989) Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer's disease beta-protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system. Am J Pathol 134: 973-978
35. Yamaguchi H, Sugihara S, Ishiguro K, Takashima A, Hirai S (1995) Immunohistochemical analysis of COOH termini of amyloid beta protein (Aβ) using end-specific antisera for Aβ40 and Aβ42 in Alzheimer's disease and normal aging. Int J Exp Clin Invest 2: 7-16