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Volumn 55, Issue 10, 1996, Pages 1051-1059

Identification of phosphorylation sites in PHF-TAU from patients with Guam Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex

Author keywords

Alzheimer's disease; Guam ALS PDC; Neurofibrillary tangles; Tau

Indexed keywords

BRAIN PROTEIN; TAU PROTEIN;

EID: 0029823961     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199655100-00005     Document Type: Article
Times cited : (57)

References (48)
  • 1
    • 0026825109 scopus 로고
    • Amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam: Immunohistochemical studies
    • Hirano A. Amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam: Immunohistochemical studies. Keio J Med 1992;41:6-9
    • (1992) Keio J Med , vol.41 , pp. 6-9
    • Hirano, A.1
  • 2
    • 0003307596 scopus 로고
    • Neuropathological features of parkinsonism-dementia complex on Guam: Reappraisal and comparative study with Alzheimer's disease and Parkinson's disease
    • Hirano A, Llena J. Neuropathological features of parkinsonism-dementia complex on Guam: Reappraisal and comparative study with Alzheimer's disease and Parkinson's disease. Prog Neuropathol 1986;6:17-31
    • (1986) Prog Neuropathol , vol.6 , pp. 17-31
    • Hirano, A.1    Llena, J.2
  • 3
    • 0000035923 scopus 로고
    • Parkinsonism-dementia complex, an endemic disease on the island of Guam. II. Pathological features
    • Hirano A, Malamud N, Kurland LT. Parkinsonism-dementia complex, an endemic disease on the island of Guam. II. Pathological features. Brain 1961;84:662-79
    • (1961) Brain , vol.84 , pp. 662-679
    • Hirano, A.1    Malamud, N.2    Kurland, L.T.3
  • 4
    • 0028957084 scopus 로고
    • Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam: Immunochemical characterization of tau proteins
    • Buee-Scherrer V, Buee L, Hof PR, et al. Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam: Immunochemical characterization of tau proteins. Am J Pathol 1995;68:924-32
    • (1995) Am J Pathol , vol.68 , pp. 924-932
    • Buee-Scherrer, V.1    Buee, L.2    Hof, P.R.3
  • 6
    • 0027194825 scopus 로고
    • Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4-4.5 kD protein which is immunoreactive to anti-amyloid beta/A4 protein antibodies
    • Guiroy DC, Mellini M, Miyazaki M, et al. Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4-4.5 kD protein which is immunoreactive to anti-amyloid beta/A4 protein antibodies. Acta Neuropathol 1993;86:265-74
    • (1993) Acta Neuropathol , vol.86 , pp. 265-274
    • Guiroy, D.C.1    Mellini, M.2    Miyazaki, M.3
  • 7
    • 0028039176 scopus 로고
    • Amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam: Quantitative neuropathology, immunohistochemical analysis of neuronal vulnerability, and comparison with related neurodegenerative disorders
    • Hof PR, Nimchinsky EA, Buee-Scherrer V, et al. Amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam: Quantitative neuropathology, immunohistochemical analysis of neuronal vulnerability, and comparison with related neurodegenerative disorders. Acta Neuropathol 1994;88:397-404
    • (1994) Acta Neuropathol , vol.88 , pp. 397-404
    • Hof, P.R.1    Nimchinsky, E.A.2    Buee-Scherrer, V.3
  • 8
    • 0028284627 scopus 로고
    • Amyotrophic lateral sclerosis and parkinsonism-dementia complex from Guam: Differences in neurofibrillary tangle distribution and density in the hippocampal formation and neocortex
    • Hof PR, Perl D, Loerzel AJ, Steele JC, Morrison JH. Amyotrophic lateral sclerosis and parkinsonism-dementia complex from Guam: Differences in neurofibrillary tangle distribution and density in the hippocampal formation and neocortex. Brain Res 1994;650:107-16
    • (1994) Brain Res , vol.650 , pp. 107-116
    • Hof, P.R.1    Perl, D.2    Loerzel, A.J.3    Steele, J.C.4    Morrison, J.H.5
  • 9
    • 0025737263 scopus 로고
    • Immunohistochemical study of the hippocampus in parkinsonism-dementia complex on Guam
    • Ito H, Goto S, Hirano H, Yen SH. Immunohistochemical study of the hippocampus in parkinsonism-dementia complex on Guam. J Geriat Psychiat Neurol 1991;4:134-42
    • (1991) J Geriat Psychiat Neurol , vol.4 , pp. 134-142
    • Ito, H.1    Goto, S.2    Hirano, H.3    Yen, S.H.4
  • 10
    • 0026077819 scopus 로고
    • Demonstration of beta-amyloid protein-containing neurofibrillary tangles in parkinsonism-dementia complex on Guam
    • Ito H, Hirano H, Yen S-H, Kato S. Demonstration of beta-amyloid protein-containing neurofibrillary tangles in parkinsonism-dementia complex on Guam. Neuropathol Appl Neurobiol 1991;17:365-73
    • (1991) Neuropathol Appl Neurobiol , vol.17 , pp. 365-373
    • Ito, H.1    Hirano, H.2    Yen, S.-H.3    Kato, S.4
  • 11
    • 0026567454 scopus 로고
    • Ultrastructural identification of neurofibrillary tangles in the spinal cords in Guamanian amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam
    • Kato S, Hirano A, Llena JF, Ito H, Yen SH. Ultrastructural identification of neurofibrillary tangles in the spinal cords in Guamanian amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam. Acta Neuropathol 1992;83:277-82
    • (1992) Acta Neuropathol , vol.83 , pp. 277-282
    • Kato, S.1    Hirano, A.2    Llena, J.F.3    Ito, H.4    Yen, S.H.5
  • 12
    • 0025331812 scopus 로고
    • Spinal cord neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis and parkinsonism-dementia complex: An immunohistochemical study
    • Matsumoto S, Hirano A, Goto S. Spinal cord neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis and parkinsonism-dementia complex: An immunohistochemical study. Neurology 1990;40:975-79
    • (1990) Neurology , vol.40 , pp. 975-979
    • Matsumoto, S.1    Hirano, A.2    Goto, S.3
  • 13
    • 0029164285 scopus 로고
    • Relationship of amyloid β/A4 protein to the neurofibrillary tangles in Guamanian parkinson-dementia
    • Schwab C, Steele JC, Akiyama H, McGeer EG, McGeer PL. Relationship of amyloid β/A4 protein to the neurofibrillary tangles in Guamanian parkinson-dementia. Acta Neuropathol 1995;90:287-98
    • (1995) Acta Neuropathol , vol.90 , pp. 287-298
    • Schwab, C.1    Steele, J.C.2    Akiyama, H.3    McGeer, E.G.4    McGeer, P.L.5
  • 14
    • 0027267251 scopus 로고
    • Rare neuropil threads in amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam and in the Ku peninsula of Japan
    • Wakayama I, Kihira T, Yoshida S, Garruto RM. Rare neuropil threads in amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam and in the Ku peninsula of Japan. Dementia 1993;4:75-80
    • (1993) Dementia , vol.4 , pp. 75-80
    • Wakayama, I.1    Kihira, T.2    Yoshida, S.3    Garruto, R.M.4
  • 15
    • 0002941489 scopus 로고    scopus 로고
    • The neurofibrillary pathology of Alzheimer's disease
    • Prusiner SB, Rosenberg RN, DiMauro S, Barchi RL, eds. Boston: Butterworth Heinemann, in press
    • Goedert M, Trojanowski JQ, Lee VM-Y. The neurofibrillary pathology of Alzheimer's disease. In: Prusiner SB, Rosenberg RN, DiMauro S, Barchi RL, eds. The molecular and genetic basis of neurological disease, 2nd ed. Boston: Butterworth Heinemann, 1996: (in press)
    • (1996) The Molecular and Genetic Basis of Neurological Disease, 2nd Ed.
    • Goedert, M.1    Trojanowski, J.Q.2    Lee, V.M.-Y.3
  • 16
    • 0029569152 scopus 로고
    • Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: Focusing on phosphatases
    • Trojanowski JQ, Lee VM-Y. Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: Focusing on phosphatases. FASEB J 1995;9:1570-76
    • (1995) FASEB J , vol.9 , pp. 1570-1576
    • Trojanowski, J.Q.1    Lee, V.M.-Y.2
  • 18
    • 0026578425 scopus 로고
    • Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent T and the accumulation of abnormal T-isoforms (A68 proteins)
    • Bramblett GT, Trojanowski JQ, Lee VM-Y. Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent T and the accumulation of abnormal T-isoforms (A68 proteins). Lab Invest 1992;66:212-22
    • (1992) Lab Invest , vol.66 , pp. 212-222
    • Bramblett, G.T.1    Trojanowski, J.Q.2    Lee, V.M.-Y.3
  • 19
    • 0025904444 scopus 로고
    • A68: A major subunit of paired helical filaments and derivatized forms of normal tau
    • Lee VM-Y, Balin BJ, Otvos L Jr, Trojanowski JQ. A68: A major subunit of paired helical filaments and derivatized forms of normal tau. Science 1991;251:675-78
    • (1991) Science , vol.251 , pp. 675-678
    • Lee, V.M.-Y.1    Balin, B.J.2    Otvos Jr., L.3    Trojanowski, J.Q.4
  • 20
    • 0027945346 scopus 로고
    • Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
    • Matsuo ES, Shin R-W, Billingsley ML, et al. Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron 1994;13: 989-1002
    • (1994) Neuron , vol.13 , pp. 989-1002
    • Matsuo, E.S.1    Shin, R.-W.2    Billingsley, M.L.3
  • 21
    • 0022365608 scopus 로고
    • The distribution of tau in the mammalian central nervous system
    • Binder LI, Frankfurter A, Rebhun LI. The distribution of tau in the mammalian central nervous system. J Cell Biol 1985;101:1371-78
    • (1985) J Cell Biol , vol.101 , pp. 1371-1378
    • Binder, L.I.1    Frankfurter, A.2    Rebhun, L.I.3
  • 22
    • 0026595846 scopus 로고
    • Tau proteins of Alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms
    • Goedert M, Spillantini MG, Cairns NJ, Crowther RA. Tau proteins of Alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms. Neuron 1992;8:159-68
    • (1992) Neuron , vol.8 , pp. 159-168
    • Goedert, M.1    Spillantini, M.G.2    Cairns, N.J.3    Crowther, R.A.4
  • 23
    • 0027984739 scopus 로고
    • Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: Identification of phosphorylation sites in tau
    • Goedert M, Jakes R, Crowther RA, Cohen P, Vanmechelen E, Vandermeeren M, Cras P. Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: Identification of phosphorylation sites in tau. Biochem J 1994;301:871-77
    • (1994) Biochem J , vol.301 , pp. 871-877
    • Goedert, M.1    Jakes, R.2    Crowther, R.A.3    Cohen, P.4    Vanmechelen, E.5    Vandermeeren, M.6    Cras, P.7
  • 24
    • 0027217679 scopus 로고
    • 202 in Alzheimer's disease recapitulates phosphorylation during development
    • 202 in Alzheimer's disease recapitulates phosphorylation during development. Proc Natl Acad Sci USA 1993;90:5066-70
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5066-5070
    • Goedert, M.1    Jakes, R.2    Crowther, R.A.3
  • 25
    • 0026501888 scopus 로고
    • Hydrofluoric acid-treated rPHF proteins display the same biochemical properties as normal tau
    • Greenberg SG, Davies P, Schein JD, Binder LI. Hydrofluoric acid-treated rPHF proteins display the same biochemical properties as normal tau. J Biol Chem 1992;267:564-69
    • (1992) J Biol Chem , vol.267 , pp. 564-569
    • Greenberg, S.G.1    Davies, P.2    Schein, J.D.3    Binder, L.I.4
  • 27
    • 0026611728 scopus 로고
    • Immunological and conformational characterization of a phosphorylated immunodominant epitope of the paired helical filaments found in Alzheimer's disease
    • Lang E, Szendrei GI, Lee VM-Y, Otvos L Jr. Immunological and conformational characterization of a phosphorylated immunodominant epitope of the paired helical filaments found in Alzheimer's disease. Biochem Biophys Res Commun 1992;187:783-90
    • (1992) Biochem Biophys Res Commun , vol.187 , pp. 783-790
    • Lang, E.1    Szendrei, G.I.2    Lee, V.M.-Y.3    Otvos Jr., L.4
  • 28
    • 0026758096 scopus 로고
    • Monoclonal antibodies with selective specificity for Alzheimer tau are directed against phosphatase-sensitive epitope
    • Mercken M, Vandermeeren M, Luebke U, et al. Monoclonal antibodies with selective specificity for Alzheimer tau are directed against phosphatase-sensitive epitope. Acta Neuropathol 1992;84: 265-72
    • (1992) Acta Neuropathol , vol.84 , pp. 265-272
    • Mercken, M.1    Vandermeeren, M.2    Luebke, U.3
  • 29
    • 0028593606 scopus 로고
    • Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404
    • Otvos L Jr, Feiner L, Lang E, Szendrei G, Goedert M, Lee VM-Y. Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404. J Neurosci Res 1994;39:669-73
    • (1994) J Neurosci Res , vol.39 , pp. 669-673
    • Otvos Jr., L.1    Feiner, L.2    Lang, E.3    Szendrei, G.4    Goedert, M.5    Lee, V.M.-Y.6
  • 30
    • 0028978701 scopus 로고
    • Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau
    • Seubert P, Mawal-Dewan M, Barbour R, et al. Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau. J Biol Chem 1995;270:18917-22
    • (1995) J Biol Chem , vol.270 , pp. 18917-18922
    • Seubert, P.1    Mawal-Dewan, M.2    Barbour, R.3
  • 31
    • 0029879046 scopus 로고    scopus 로고
    • Charaterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein
    • Hasegawa M, Jakes R, Crowther RA, Lee VM-Y, Ihara Y, Goedert M. Charaterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein. FEBS Let 1996;384:25-30
    • (1996) FEBS Let , vol.384 , pp. 25-30
    • Hasegawa, M.1    Jakes, R.2    Crowther, R.A.3    Lee, V.M.-Y.4    Ihara, Y.5    Goedert, M.6
  • 32
    • 0027388775 scopus 로고
    • Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location
    • Szendrei GI, Lee VM-Y, Otvos L Jr. Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location. J Neurosci Res 1993;34: 243-49
    • (1993) J Neurosci Res , vol.34 , pp. 243-249
    • Szendrei, G.I.1    Lee, V.M.-Y.2    Otvos Jr., L.3
  • 33
    • 0024529404 scopus 로고
    • Distribution of tau proteins in the normal human central and peripheral nervous system
    • Trojanowski JQ, Schuck T, Schmidt ML, Lee VM-Y. Distribution of tau proteins in the normal human central and peripheral nervous system. J Histochem Cytochem 1989;37:209-15
    • (1989) J Histochem Cytochem , vol.37 , pp. 209-215
    • Trojanowski, J.Q.1    Schuck, T.2    Schmidt, M.L.3    Lee, V.M.-Y.4
  • 34
    • 0027764272 scopus 로고
    • Analysis of paired helical filaments found in Alzheimer's disease using freeze drying rotary shadowing
    • Appelt DM Balin BJ. Analysis of paired helical filaments found in Alzheimer's disease using freeze drying rotary shadowing. J Structural Biol 1993;111:85-95
    • (1993) J Structural Biol , vol.111 , pp. 85-95
    • Appelt, D.M.1    Balin, B.J.2
  • 35
    • 0025238653 scopus 로고
    • Defined neurofilament, tau and beta-amyloid protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques
    • Arai H, Lee VM-Y, Otvos, L Jr, et al. Defined neurofilament, tau and beta-amyloid protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques. Proc Natl Acad Sci USA 1990;87:2249-53
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 2249-2253
    • Arai, H.1    Lee, V.M.-Y.2    Otvos Jr., L.3
  • 36
    • 0028630738 scopus 로고
    • Plaque-associated neuronal proteins: A recurrent motif in neuritic amyloid deposits throughout diverse cortical areas of the Alzheimer's disease brain
    • Schmidt ML, DiDario AG, Otvos L Jr, et al. Plaque-associated neuronal proteins: A recurrent motif in neuritic amyloid deposits throughout diverse cortical areas of the Alzheimer's disease brain. Exper Neurol 1994;130:311-22
    • (1994) Exper Neurol , vol.130 , pp. 311-322
    • Schmidt, M.L.1    DiDario, A.G.2    Otvos Jr., L.3
  • 37
    • 0029087813 scopus 로고
    • Chemical and immunological heterogeneity of fibrillar amyloid in plaques of Alzheimer's disease and Down's syndrome brains revealed by confocal microscopy
    • Schmidt ML, Robinson KA, Lee VM-Y, Trojanowski J.Q. Chemical and immunological heterogeneity of fibrillar amyloid in plaques of Alzheimer's disease and Down's syndrome brains revealed by confocal microscopy. Am J Pathol 1995;147:503-15
    • (1995) Am J Pathol , vol.147 , pp. 503-515
    • Schmidt, M.L.1    Robinson, K.A.2    Lee, V.M.-Y.3    Trojanowski, J.Q.4
  • 38
    • 0030004466 scopus 로고    scopus 로고
    • Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders
    • Schmidt ML, Martin JA, Lee VM-Y, Trojanowski JQ. Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders. Acta Neuropathol 1996;91:475-81
    • (1996) Acta Neuropathol , vol.91 , pp. 475-481
    • Schmidt, M.L.1    Martin, J.A.2    Lee, V.M.-Y.3    Trojanowski, J.Q.4
  • 39
    • 0028607409 scopus 로고
    • Studies of childhood brain tumors using immunohistochemistry and microwave technology: Methodological considerations
    • Yachnis AT, Trojanowski JQ. Studies of childhood brain tumors using immunohistochemistry and microwave technology: Methodological considerations. J Neurosci Meth 1994;55:191-200
    • (1994) J Neurosci Meth , vol.55 , pp. 191-200
    • Yachnis, A.T.1    Trojanowski, J.Q.2
  • 40
    • 0029919164 scopus 로고    scopus 로고
    • Human fetal hippocampal development: II. The neuronal cytoskeleton
    • Arnold SE, Trojanowski JQ. Human fetal hippocampal development: II. The neuronal cytoskeleton. J Comp Neurol 1996;367:293-307
    • (1996) J Comp Neurol , vol.367 , pp. 293-307
    • Arnold, S.E.1    Trojanowski, J.Q.2
  • 41
    • 0024745894 scopus 로고
    • Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
    • Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA. Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 1989;3:519-26
    • (1989) Neuron , vol.3 , pp. 519-526
    • Goedert, M.1    Spillantini, M.G.2    Jakes, R.3    Rutherford, D.4    Crowther, R.A.5
  • 42
    • 0028840239 scopus 로고
    • Paired helical filament tau (PHFtau) in Niemann-Pick Type C disease is similar to PHFtau in Alzheimer's disease
    • Auer IA, Schmidt ML, Lee VM-Y, et al. Paired helical filament tau (PHFtau) in Niemann-Pick Type C disease is similar to PHFtau in Alzheimer's disease. Acta Neuropath 1995;90:547-51
    • (1995) Acta Neuropath , vol.90 , pp. 547-551
    • Auer, I.A.1    Schmidt, M.L.2    Lee, V.M.-Y.3
  • 44
    • 0027327267 scopus 로고
    • Association of apolipoprotein E allele ∈4 with late-onset familial and sporadic Alzheimer's disease
    • Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele ∈4 with late-onset familial and sporadic Alzheimer's disease. Neurol 1994;43:1467-72
    • (1994) Neurol , vol.43 , pp. 1467-1472
    • Saunders, A.M.1    Strittmatter, W.J.2    Schmechel, D.3
  • 45
    • 0029087026 scopus 로고
    • Candidate gene for the chromosome 1 familial Alzheimer's disease locus
    • Levy-Lahad E, Wasco W, Poorkaj P, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995;269:973-77
    • (1995) Science , vol.269 , pp. 973-977
    • Levy-Lahad, E.1    Wasco, W.2    Poorkaj, P.3
  • 46
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington R, Rogaev EI, Liang Y, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995;375:754-60
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3
  • 48
    • 0029003629 scopus 로고
    • The frequency and associated risk factors for dementia in patients with Parkinson's disease
    • Marder K, Tang M-X, Cote L, Stern Y, Mayeux R. The frequency and associated risk factors for dementia in patients with Parkinson's disease. Arch Neurol 1995;52:695-701
    • (1995) Arch Neurol , vol.52 , pp. 695-701
    • Marder, K.1    Tang, M.-X.2    Cote, L.3    Stern, Y.4    Mayeux, R.5


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