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Volumn 151, Issue 1, 1997, Pages 69-80

Monoclonal antibodies to a 100-kd protein reveal abundant Aβ-negative plaques throughout gray matter of Alzheimer's disease brains

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY;

EID: 0030871478     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (32)

References (36)
  • 1
    • 0002941489 scopus 로고    scopus 로고
    • The neurofibrillary pathology of Alzheimer's disease
    • Edited by SB Prusiner, S DiMauro, RL Barchi. Boston, Butterworth Heineman Press
    • Goedert M, Trojanowski JQ, Lee VM-Y: The neurofibrillary pathology of Alzheimer's disease. The Molecular and Genetic Basis of Neurological Disease, ed. 2. Edited by SB Prusiner, S DiMauro, RL Barchi. Boston, Butterworth Heineman Press, 1997, pp 613-628
    • (1997) The Molecular and Genetic Basis of Neurological Disease, Ed. 2. , pp. 613-628
    • Goedert, M.1    Trojanowski, J.Q.2    Lee, V.M.-Y.3
  • 2
    • 0002275922 scopus 로고    scopus 로고
    • Implications of tau-rich neurofibrillary lesions for the pathobiology and diagnosis of Alzheimer's disease
    • Edited by S Appel. Mosby-Year Book, St. Louis
    • Trojanowski JQ, Clark CM, Schmidt ML, Aral H, Zhu C, Mawal-Dewan M, Lee VM-Y: Implications of tau-rich neurofibrillary lesions for the pathobiology and diagnosis of Alzheimer's disease. Current Neurology. Edited by S Appel. Mosby-Year Book, St. Louis, 1996, pp 93-113
    • (1996) Current Neurology , pp. 93-113
    • Trojanowski, J.Q.1    Clark, C.M.2    Schmidt, M.L.3    Aral, H.4    Zhu, C.5    Mawal-Dewan, M.6    Lee, V.M.-Y.7
  • 3
    • 0028170818 scopus 로고
    • Cell biology of the amyloid -protein precursor and the mechanism of Alzheimer's disease
    • Selkoe DJ: Cell biology of the amyloid -protein precursor and the mechanism of Alzheimer's disease. Annu Rev Cell Biol 1994, 10:373-403
    • (1994) Annu Rev Cell Biol , vol.10 , pp. 373-403
    • Selkoe, D.J.1
  • 5
    • 0029302244 scopus 로고
    • Apoptosis in the brain
    • Dickson DW: Apoptosis in the brain. Am J Pathol 1995, 146:1040-1044
    • (1995) Am J Pathol , vol.146 , pp. 1040-1044
    • Dickson, D.W.1
  • 6
    • 0029417023 scopus 로고    scopus 로고
    • Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
    • Busciglio J, Yankner BA: Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 1996, 378:776-779
    • (1996) Nature , vol.378 , pp. 776-779
    • Busciglio, J.1    Yankner, B.A.2
  • 7
    • 0029877684 scopus 로고    scopus 로고
    • Correlations between mental state and quantitative neuropathology in the Vienna longitudinal study on dementia
    • Bancher C, Jellinger K, Lassmann H, Fischer P, LebIhuber F: Correlations between mental state and quantitative neuropathology in the Vienna longitudinal study on dementia. Eur Arch Psychiatry Clih Neurosci 1996, 240:137-146
    • (1996) Eur Arch Psychiatry Clih Neurosci , vol.240 , pp. 137-146
    • Bancher, C.1    Jellinger, K.2    Lassmann, H.3    Fischer, P.4    Lebihuber, F.5
  • 9
    • 0029117593 scopus 로고
    • Sulfonated dyes attenuate the toxic effects of β-amyloid in a structure-specific fashion
    • Pollak SJ, Sadler IIJ, Hawtin SR, Tailor VJ, Shearman MS: Sulfonated dyes attenuate the toxic effects of β-amyloid in a structure-specific fashion. Neurosci Lett 1995, 197:211-214
    • (1995) Neurosci Lett , vol.197 , pp. 211-214
    • Pollak, S.J.1    Iij, S.2    Hawtin, S.R.3    Tailor, V.J.4    Shearman, M.S.5
  • 11
    • 33847478414 scopus 로고
    • Amyloid fibril toxicity and tau hyperphos-phorylation in Alzheimer's diseasecell culture and animal models
    • Yankner BA: Amyloid fibril toxicity and tau hyperphos-phorylation in Alzheimer's disease: cell culture and animal models. ISN Satellite Meeting 1995, pp 62-66
    • (1995) ISN Satellite Meeting , pp. 62-66
    • Yankner, B.A.1
  • 12
    • 0021867264 scopus 로고
    • The structure, biochemical properties and immunogenicity of neurofilament peripheral regions are determined by phosphorylation
    • Garden MJ, Schlaepfer WW, Lee VM-Y: The structure, biochemical properties and immunogenicity of neurofilament peripheral regions are determined by phosphorylation. J Biol Chem 1985, 260:9805-9817
    • (1985) J Biol Chem , vol.260 , pp. 9805-9817
    • Garden, M.J.1    Schlaepfer, W.W.2    Lee, V.M.-Y.3
  • 13
    • 0022512277 scopus 로고
    • Structural similarities and differences between neurofilament proteins from five different species as revealed by monoclonal antibodies
    • Lee VM-Y, Garden MJ, Schlaepfer WW: Structural similarities and differences between neurofilament proteins from five different species as revealed by monoclonal antibodies. J Neurosci 1986, 6:2179-2186
    • (1986) J Neurosci , vol.6 , pp. 2179-2186
    • Lee, V.M.-Y.1    Garden, M.J.2    Schlaepfer, W.W.3
  • 14
    • 0022642328 scopus 로고
    • Novel monoclonal antibodies provide evidence for the in situ existence of a non-phosphorylated form of the largest neurofilament subunit
    • Lee VM-Y, Garden MJ, Trojanowski JQ: Novel monoclonal antibodies provide evidence for the in situ existence of a non-phosphorylated form of the largest neurofilament subunit. J Neurosci 1986, 6:850-858
    • (1986) J Neurosci , vol.6 , pp. 850-858
    • Lee, V.M.-Y.1    Garden, M.J.2    Trojanowski, J.Q.3
  • 15
    • 0021330771 scopus 로고
    • Monoclonal antibodies to gel excised glial filament protein and their reactivity with other intermediate filaments
    • Lee VM-Y, Page CD, Wu H-L, Schlaepfer WW: Monoclonal antibodies to gel excised glial filament protein and their reactivity with other intermediate filaments. J Neurochem 1984, 42:25-32
    • (1984) J Neurochem , vol.42 , pp. 25-32
    • Lee, V.M.-Y.1    Page, C.D.2    Wu, H.-L.3    Schlaepfer, W.W.4
  • 16
    • 0027308924 scopus 로고
    • Abnormal tau phosphorylation at ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
    • Bramble GT, Goedert M, Jakes R, Merrick SE, Trojanowski JQ, Lee VM-Y: Abnormal tau phosphorylation at ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 1993, 10:1089-1099
    • (1993) Neuron , vol.10 , pp. 1089-1099
    • Bramble, G.T.1    Goedert, M.2    Jakes, R.3    Merrick, S.E.4    Trojanowski, J.Q.5    Lee, V.M.-Y.6
  • 17
    • 0027236786 scopus 로고
    • Alzheimer disease A68 proteins injected into rat brain induce codeposits of β-amyloid, ubiquitin and a1-antichymotrypsin
    • Shin R-W, Bramblett GT, Lee VM-Y, Trojanowski JQ: Alzheimer disease A68 proteins injected into rat brain induce codeposits of β-amyloid, ubiquitin and a1-antichymotrypsin. Proc Natl Acad Sci USA 1993, 90:68256828
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 68256828
    • Shin, R.-W.1    Bramblett, G.T.2    Lee, V.M.-Y.3    Trojanowski, J.Q.4
  • 18
    • 0026501888 scopus 로고
    • Hydrofluoric acid-treated TPHF proteins display the same biochemical properties as normal T
    • Greenberg SG, Davies P, Schein JD, Binder LI: Hydrofluoric acid-treated TPHF proteins display the same biochemical properties as normal T. J Biol Chem 1992, 267:564-569
    • (1992) J Biol Chem , vol.267 , pp. 564-569
    • Greenberg, S.G.1    Davies, P.2    Schein, J.D.3    Binder, L.I.4
  • 19
    • 0026611728 scopus 로고
    • Immunological and conformational characterization of a phosphorylated immunodominant epitope on the paired helical filaments found in Alzheimer's disease
    • Lang E, Szendrei Gl, Lee VM-Y, Otvos L Jr: Immunological and conformational characterization of a phosphorylated immunodominant epitope on the paired helical filaments found in Alzheimer's disease. Biochem Biophys Res Commun 1992, 187:783-790
    • (1992) Biochem Biophys Res Commun , vol.187 , pp. 783-790
    • Lang, E.1    Szendrei, G.2    Lee, V.M.-Y.3    Otvos Jr., L.4
  • 20
    • 0025904444 scopus 로고
    • A68: A major subunit of paired helical filaments and derivatized forms of normal tau
    • Lee VM-Y. Balin BJ, Otvos L Jr, Trojanowski JQ: A68: a major subunit of paired helical filaments and derivatized forms of normal tau. Science 1991, 251:675-678
    • (1991) Science , vol.251 , pp. 675-678
    • Lee, V.M.-Y.1    Balin, B.J.2    Otvos Jr., L.3    Trojanowski, J.Q.4
  • 21
    • 0029664624 scopus 로고    scopus 로고
    • Amyloids β40 and 042 are generated intracellularly in cultured human neurons, and their secretion increases with maturation
    • Turner RS, Suzuki N, Chyung AS, Younkin SG, Lee VM-Y: Amyloids β40 and 042 are generated intracellularly in cultured human neurons, and their secretion increases with maturation. J Biol Chem 1996, 271: 8966-8970
    • (1996) J Biol Chem , vol.271 , pp. 8966-8970
    • Turner, R.S.1    Suzuki, N.2    Chyung, A.S.3    Younkin, S.G.4    Lee, V.M.-Y.5
  • 22
    • 0028630738 scopus 로고
    • Plaque-associated neuronal proteinsa recurrent motif in neuritic amyloid deposits throughout diverse cortical areas of the Alzheimer's disease brain
    • Schmidt ML, DiDario AG, Otvos L Jr, Hoshi N, Kant A, Lee VM-Y, Trojanowski JQ: Plaque-associated neuronal proteins: a recurrent motif in neuritic amyloid deposits throughout diverse cortical areas of the Alzheimer's disease brain. Exp Neurol 1994, 130:311-322
    • (1994) Exp Neurol , vol.130 , pp. 311-322
    • Schmidt, M.L.1    Didario, A.G.2    Otvos Jr., L.3    Hoshi, N.4    Kant, A.5    Lee, V.M.-Y.6    Trojanowski, J.Q.7
  • 23
    • 0023916455 scopus 로고
    • Bai C, Grundke-lqbal I, Currie JR, Wisniewski HMProduction and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide
    • Kirn KS, Miller DL, Sapienza VJ, Chen CJ. Bai C, Grundke-lqbal I, Currie JR, Wisniewski HM: Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci Res Commun 1988, 2:121-130
    • (1988) Neurosci Res Commun , vol.2 , pp. 121-130
    • Kirn, K.S.1    Miller, D.L.2    Sapienza, V.J.3    Chen, C.J.4
  • 25
    • 0025289562 scopus 로고
    • Large amounts of neocortical β/A4 deposits without neuritic plaques nor tangles in a psy-. chometrically assessed, nondemented person
    • Delaere P, Duyckaerts C, Masters CL, Beyreuther K, Piette F, Hauw JJ: Large amounts of neocortical β/A4 deposits without neuritic plaques nor tangles in a psy-. chometrically assessed, nondemented person. NeurosciLett 1990, 116:87-93
    • (1990) NeurosciLett , vol.116 , pp. 87-93
    • Delaere, P.1    Duyckaerts, C.2    Masters, C.L.3    Beyreuther, K.4    Piette, F.5    Hauw, J.J.6
  • 27
    • 0030004466 scopus 로고    scopus 로고
    • Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders
    • Schmidt ML, Martin JA, Lee VM-Y, Trojanowski JQ: Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders. Acta Neuropathol 1996, 91:475-481
    • (1996) Acta Neuropathol , vol.91 , pp. 475-481
    • Schmidt, M.L.1    Martin, J.A.2    Lee, V.M.-Y.3    Trojanowski, J.Q.4
  • 30
    • 0028853478 scopus 로고
    • DiFiglia M, McKee AC, MacDonald M, Gusella JF, Landwhermeyer GB, Bird ED, Richardson EP Jr, Hedley-Whyte ETAn improved approach to prepare human brain for research
    • Vonsattel JP, Aizawa H, Ge P. DiFiglia M, McKee AC, MacDonald M, Gusella JF, Landwhermeyer GB, Bird ED, Richardson EP Jr, Hedley-Whyte ET: An improved approach to prepare human brain for research. J Neuropathol Exp Neurol 1995, 54:42-56
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 42-56
    • Vonsattel, J.P.1    Aizawa, H.2    Ge, P.3
  • 31
    • 0025345913 scopus 로고
    • Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles
    • Schmidt ML, Lee VM-Y, Trojanowski JQ: Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles. Am J Pathol 1990, 136: 1069-1075
    • (1990) Am J Pathol , vol.136 , pp. 1069-1075
    • Schmidt, M.L.1    Lee, V.M.-Y.2    Trojanowski, J.Q.3
  • 32
    • 0025905505 scopus 로고
    • Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads
    • Schmidt ML, Lee VM-Y, Trojanowski JQ: Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads. Lab Invest 1991, 64:352-357
    • (1991) Lab Invest , vol.64 , pp. 352-357
    • Schmidt, M.L.1    Lee, V.M.-Y.2    Trojanowski, J.Q.3
  • 33
    • 0029087813 scopus 로고
    • Chemical and immunological heterogeneity of fibrillar amyloid in plaques of Alzheimer's disease and Down's syndrome brains revealed by confocal microscopy
    • Schmidt ML, Robinson KA, Lee VM-Y, Trojanowski JQ: Chemical and immunological heterogeneity of fibrillar amyloid in plaques of Alzheimer's disease and Down's syndrome brains revealed by confocal microscopy. Am J Pathol 1995, 147:503-515
    • (1995) Am J Pathol , vol.147 , pp. 503-515
    • Schmidt, M.L.1    Robinson, K.A.2    Lee, V.M.-Y.3    Trojanowski, J.Q.4
  • 34
    • 0027945346 scopus 로고
    • Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
    • Matsuo ES, Shin R-W, Billingsley ML, Van de Voorde A, O'Connor M, Trojanowski JQ, Lee VM-Y: Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron 1994, 13:989-1002
    • (1994) Neuron , vol.13 , pp. 989-1002
    • Matsuo, E.S.1    Shin, R.-W.2    Billingsley, M.L.3    Van De Voorde, A.4    O'Connor, M.5    Trojanowski, J.Q.6    Lee, V.M.-Y.7
  • 35
    • 0029823961 scopus 로고    scopus 로고
    • Identification of phosphorylation sites in PHF-TAU from patients with Guam amyotrophic lateral sclerosis/Parkinsonism-dementia complex
    • Mawal-Dewan M, Schmidt ML, Baiin B, Perl DP, Lee VM-Y, Trojanowski JQ: Identification of phosphorylation sites in PHF-TAU from patients with Guam amyotrophic lateral sclerosis/Parkinsonism-dementia complex. J Neuropathol Exp Neurol 1996, 55:10511059
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 10511059
    • Mawal-Dewan, M.1    Schmidt, M.L.2    Baiin, B.3    Perl, D.P.4    Lee, V.M.-Y.5    Trojanowski, J.Q.6
  • 36
    • 0026578425 scopus 로고
    • Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent T and accumulations of abnormal r-isoforms (A68 proteins)
    • Bramblett GT, Trojanowski JQ, Lee VM-Y: Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent T and accumulations of abnormal r-isoforms (A68 proteins). Lab Invest 1992, 66:212-222
    • (1992) Lab Invest , vol.66 , pp. 212-222
    • Bramblett, G.T.1    Trojanowski, J.Q.2    Lee, V.M.-Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.