CAT scans, PET scans, and genomic scans

Genetic Epidemiology

Volumn 15, Issue 1, 1998, Pages 1-18

  Rao, D C ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

False negatives; False positives; Genomic scan; Linkage; QTL

Indexed keywords

ACCURACY; ARTICLE; CLASSIFICATION; COMPUTER ASSISTED TOMOGRAPHY; COST; FEASIBILITY STUDY; GENETIC EPIDEMIOLOGY; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC SCREENING; GENOME; GENOTYPE; PHENOTYPE; POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE TRAIT; SAMPLE; SCINTISCANNING;

ALZHEIMER DISEASE; GENOME, HUMAN; HUMANS; LINKAGE (GENETICS); PREDICTIVE VALUE OF TESTS; QUANTITATIVE TRAIT, HERITABLE; RISK FACTORS; TOMOGRAPHY, EMISSION-COMPUTED; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0031907395     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2272(1998)15:1<1::AID-GEPI1>3.0.CO;2-B     Document Type: Article

References (35)

1. Breiman L, Friedman JH, Olshen RA and Stone CH (1984): "Classification and Regression Trees." Belmont, CA: Wadsworth International Group, Inc.
2. Carey G, and Williamson JA (1991): Linkage analysis of quantitative traits: Increased power by using selected samples. Am J Hum Genet 49:786-796.
3. Comuzzie AG, Hixson JE, Almasy L, Mitchell BD, Mahaney MC, Dyer TD, Stern MP, MacCluer JW, Blangero J (1997): A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nature Genet 15:273-276.
4. Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SCL, Jenkins SC, Palmer SM, Balfour KM, Rowe BR, Farrall M, Barnett AH, Bain SC, Todd JA (1994): A genomewide search for human type 1 diabetes susceptibility genes. Nature 371:130-136.
5. Eaves LJ (1994): Effect of genetic architecture on the power of human linkage studies to resolve the contribution of quantitative trait loci. Heredity 72:175-192.
6. Ebers GC, Kukay K, Bulman DE, Sadovnick AD, Rice G, Anderson C, Armstrong H, Cousin K, Bell RB, Hader W, Paty DW, Hashimoto S, Oger J, Duquette P, Warren S, Gray T, O'Connor P, Nath A, Auty A, Metz L, Francis G, Paulseth JE, Murray TJ, Pryse-Phillips W, Nelson R, Freedman M, Brunet D, Bouchard JP, Hinds D, Risch N (1996): A full genome search in multiple sclerosis. Nature Genet 13:472-476.
7. Elston RC (1992): Designs for the global search of the human genome by linkage analysis. In: Proceeding of the XVIth International Biometrie Conference, Hamilton, New Zealand, 39-51.
8. Elston RC, Guo X, Williams LV (1996): Two-stage global search designs for linkage analysis using pairs of affected relatives. Genet Epidemiol 13:535-558.
9. Feingold E, Brown PO, Siegmund D (1993): Gaussian-models for genetic linkage analysis using complete high-resolution maps of identity-by-descent. Am J Hum Genet 53:234-251.
10. Fulker DW, Cardon LR (1994): A sib-pair approach to interval mapping of quantitative traits. Am J Hum Genet 54:1092-1103.
11. Gschwend M, Levran O, Kruglyak L, Ranade K, Verlander PC, Shen S, Faurre S, Weissenbach J, Altay C, Lander ES, Auerbach AD, Botstein D (1996): A locus for fanconi anemia on 16q determined by homozygosity mapping. Am J Hum Genet 59:377-384.
12. Gu C, Rao DC (1998): A linkage strategy for detection of human QTLs: II. Optimization of study designs based on both extreme sibpairs and generalized relative risk ratios. Am J Hum Genet.
13. Gu C, Province M, Li Z, Rao DC (1996a): A meta-analysis methodology for combining non-parametric sibpair linkage results. Genet Epidemiol 13:302.
14. Gu C, Todorov AA, Rao DC (1996b): Combining extremely concordant sibpairs with extremely discordant sibpairs provides a cost effective way to linkage analysis of QTL. Genet Epidemiol 13:513-533.
15. Hanis CL, Boerwinkle E, Chakraborty R, Ellsworth DL, Concannon P, Stirling B, Morrison VA, Wapelhorst B, Spielman RS, Gogolin-Ewens KJ, Shephard JM, Williams SR, Risch N, Hinds D, Iwasaki N, Ogata M, Omori Y, Petzold C, Rietzch H, Schöder HE, Schulze J, Cox NJ, Menzel S, Boriraj VV, Chen X, Lim LR, Lindner T, Mereu LE, Wang YQ, Xiang K, Yamagata K, Yang Y, Bell GI (1996): A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nature Genet 13:161-166.
16. Haseman JK and Elston RC (1972): The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2:3-19.
17. Holmans P (1993): Asymptotic properties of affected sibpair linkage analysis. American Journal of Hum Genet 52:362-374.
18. Lander ES, Kruglyak L (1995): Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nature Genet 11:241-247.
19. Lander ES, Schork NJ (1994): Genetic dissection of complex traits. Science 265:2037-2048.
20. Li Z, Rao DC (1996): Random effects model for meta-analysis of multiple quantitative sibpair linkage studies. Genet Epidemiol 13:377-383.
21. Mahtani MM, Widén E, Lento M, Thomas J, McCarthy M, Brayer J, Bryant B, Chan G, Daly M, Forblom C, Kanninen T, Kirby A, Kruglyak L, Munnelly K, Parkkonen M, Reeve-Daly MP, Weaver A, Brettin T, Duyk G, Lander ES, Groop LC (1996): Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nature Genet 14:90-94.
22. Multiple Sclerosis Genetics Group (1996): A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nature Genet 13:469-471.
23. Norman RA, Thompson DB, Foroud T, Garvey WT, Bennett PH, Bogardus C, Ravussin E, other members of the Pima Diabetes Gene Group (1997): Genomewide search for genes influencing percent body fat in Pima Indians: Suggestive Linkage at Chromosome 11q21-q22. Am J Hum Genet 60:166-173.
24. Olkin I (1992): Meta-analysis: Methods for combining independent studies. Stat Sci 7:277-318.
25. Posner MI, Raichle ME (1994): Images of mind. Scientific American Library.
26. Risen N, Zhang H (1995): Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 268:1584-1589.
27. Risen N, Zhang H (1996): Mapping quantitative trait loci with extreme discordant sib pairs: Sampling considerations. Am J Hum Genet 58:836-843.
28. Satsangi J, Parkes M, Louis E, Hashimoto L, Kato N, Welsh K, Terwilliger JD, Lathrop GM, Bell JI, Jewell DP (1996): Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nature Genet 14:199-202.
29. Sawcer S, Jones HB, Feakes R, Gray J, Smaldon N, Chataway J, Robertson N, Clayton D, Goodfellow PN, Compston A (1996): A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nature Genet 13:464-467.
30. Suarez BK, Hampe CL, Van Eerdewegh P (1994): Problems of replicating linkage claims in psychiatry. In ES Gershon, CR Cloninger (eds): "Genetic Approaches to Mental Disorders." Washington, DC: American Psychiatric Press, pp. 23-46.
31. Todorov AA, Rao DC (1997): Trade-off between false positives and false negatives in the linkage analysis of complex traits. Genet Epidemiol (in press).
32. Todorov AA, Borecki IB, Rao DC (1997a): Linkage analysis of complex traits using affected sibpairs: Effects of single-locus approximations on estimates of the required sample size. Genet Epidemiol (in press).
33. Todorov AA, Province MA, Borecki IB, Rao DC (1997b): Trade-off between sibship size and sampling scheme for detecting quantitative trait loci. Hum Hered (in press).
34. Wilson AF, Elston RC, Tran LD, Siervogel RM (1991): Use of the robust sib-pair method to screen for single-locus, multiple-locus, and pleiotropic effects. Application to traits related to hypertension. Am J Hum Genet 48:862-872.
35. Zhang H, Risen N (1996): Mapping quantitative-trait loci in humans by use of extreme concordant sib pairs: Selected sampling by parental phenotypes. Am J Hum Genet 59:951-957.