Targeting cancer cell death with a bcl-x(S) adenovirus

Springer Seminars in Immunopathology

Volumn 19, Issue 3, 1998, Pages 279-288

  Han, Jeffrey S ^a   Núñez, Gabriel ^a   Wicha, Max S ^a   Clarke, Michael F ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; PROTEIN BCL 2;

ADENOVIRUS; APOPTOSIS; CANCER CELL; CELL DEATH; CELL SURVIVAL; GENE TARGETING; GENE TRANSFER; HUMAN; HYPERPLASIA; NEOPLASM; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE; VIRUS CELL TRANSFORMATION;

ADENOVIRIDAE; APOPTOSIS; BCL-X PROTEIN; CELL DEATH; GENES, TUMOR SUPPRESSOR; GENETIC VECTORS; HUMANS; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0031907215     PISSN: 03444325     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00787225     Document Type: Review

References (90)

1. Angel P, Karin M (1991) The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1072: 129
2. Armelin HA, Armelin MCS, Kelly K, Stewart T, Leder P, Cochran BH, Stiles CD (1984) Functional role for c-myc in mitogenic response to platelet-derived growth factor. Nature 310: 655
3. Baffy G, Miyashita T, Williamson JR, Reed JC (1993) Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production. J Biol Chem 268: 6511
4. Bissonnette RP, Echeverri F, Mahnoubi A, Green DR (1992) Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature 359: 552
5. Blackwell TK, Kretzner L, Blackwood EM, Eisenman RN, Weintraub H (1990) Sequence-specific DNA binding by the c-myc protein. Science 250: 1149
6. Blackwood EM, Eisenman RN (1991) Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251: 1211
7. Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G, Thompson CB (1993) bcl-x, a bcl-2 related gene that functions as a dominant regulator of apoptotic cell death. Cell 74: 597
8. Boyd JM, Gallo GJ, Elangovan B, Houghton AB, Malstrom S, Avery GJ, Ebb RG, Subramanian T, Chittenden T, Lutz RJ, Chinnadurai G (1995) Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family and interacts with viral and cellular survival-promoting proteins. Oncogene 11: 1921
9. Brenner MK, Rill DR, Moen RC, Krance RA, Mirro J, Anderson WF, Ihle JN (1993) Gene-marking to trace origin of relapse after autologous bone-marrow transplantation. Lancet 341: 85
10. Buttyan R, Zakeri Z, Lockshin R, Wolgemuth D (1988) Cascade induction of c-fos, c-myc, and heat shock 70 K transcripts during regression of the rat ventral prostate gland. Mol Endocrinol 2
11. Campos L, Rouault J-P, Sabido O, Oriol P, Roubi N, Vasselon C, Archimbaud E, Magaud J-P, Guyotat D (1993) High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy. Blood 81: 3091
12. Carson WE, Haldar S, Baiocchi RA, Croce CM, Caligiuri MA (1994) The c-kit ligand suppresses apoptosis of human natural killer cells through the upregulation of bcl-2. Proc Natl Acad Sci USA 91: 7553
13. Castle VP, Heidelberger KP, Bromberg J, Ou X, Dole M, Nunez G (1993) Expression of the apoptosis-suppressing protein Bcl-2 in neuroblastoma is associated with poor stage disease, unfavorable histology and N-myc amplification. Am J Pathol 143: 1543
14. Chinnaiyan AM, Orth K, O'Rourke K, Duan H, Poirier GG, Dixit VM (1996) Molecular ordering of the cell death pathway. J Biol Chem 271: 4573
15. Chinnaiyan AM, O'Rourke K, Lane BR, Dixit VM (1997) Interaction of CED-4 with CED-4 and CED-9: a molecular framework for cell death. Science 275: 1122
16. Chittenden T, Harrington EA, O'Connor R, Flemington C, Lutz RJ, Evan GI, Guild BC (1995) Induction of apoptosis by the Bcl-2 homologue Bak. Nature 374: 733
17. Chiu R, Boyle WJ, Meek W, Smeal T, Hunter T, Karin M (1988) The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 54: 541
18. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, Wyllie AH (1993) Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362: 849
19. S adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells. Proc Natl Acad Sci USA 92: 11024
20. Cleary ML, Smith SD, Sklar J (1986) Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47: 19
21. Collins MKL, Perkins GR, Rodriguez-Tarduchy G, Nieto MA, Lopez-Rivas A (1994) Growth factors as survival factors: regulation of apoptosis. Bioessays 16: 133
22. Colombel M, Symmans F, Gil S, O'Toole KM, Chopin D, Benson M, Olsson CA, Korsmeyer SJ, Buttyan R (1993) Detection of the apoptosis-suppressing protein bcl-2 in hormone-refractory human prostate cancers. Am J Pathol 143: 390
23. Colotta F, Polentarutti N, Sironi M, Mantovani A (1992) Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines. J Biol Chem 267: 18278
24. L is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis. Anticancer Res 55: 2576
25. Eilers M, Schirm S, Bishop JM (1991) The Myc protein activates transcription of the alpha-prothymosin gene. EMBO J 10: 133
26. El-Deirt WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817
27. Ellis H, Horvitz HR (1986) Genetic control of programmed cell death in the nematode C. elegans. Cell 44: 817
28. Ellis RE, Yuan J, Horvitz, HR (1991) Mechanisms and functions of cell death. Annu Rev Cell Biol 7: 663
29. Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell 69: 119
30. Fanidi A, Harrington EA, Evan GI (1992) Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature 359: 554
31. Farrow SN, White JHM, Martinou I, Raven T, Pun K, Grinham CJ, Martinou J, Brown R (1995) Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19 K. Nature 374: 731
32. Fisher DE (1994) Apoptosis in cancer therapy: crossing the threshold. Cell 78: 539
33. Fukunaga-Johnson N, Ryan JJ, Wicha M, Nunez G, Clarke MF (1995) Bcl-2 protects murine erythroleukemia cells from p53-dependent and -independent radiation-induced cell death. Carcinogenesis 16: 1761
34. Harrington EA, Bennett MR, Fanidi A, Evan GI (1994) c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J 13: 3286
35. Hartmann O, Benhamou E, Beaujean F, Kalifa C, Lejars O, Patte C, Behard C, Flamant F, Thyss A, Deville A, Vannier JP, Pautard-Muchemble B, Lemerle J (1987) Repeated high-dose chemotherapy followed by purged autologous bone marrow transplantation as consolidation therapy in metastatic neuroblastoma. J Clin Oncol 5: 1205
36. Haupt Y, Rowan S, Shaulian E, Vousden KH, Oren M (1995) Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev 9: 2170
37. Head DR, Kennedy PS, Goyette RE (1979) Metastatic neuroblastoma in bone marrow aspirate smears. Am J Clin Pathol 72: 1008
38. Hengartner M, Ellis R, Horvitz HR (1992) C. elegans gene ced-9 protects cells from programmed cell death. Nature 356: 494
39. Hengartner MO, Horvitz HR (1994) C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 76: 665
40. Hermeking H, Eick D (1994) Mediation of c-Myc-induced apoptosis by p53. Science 265: 2091
41. Hockenbery DM, Oltvai ZN, Yin X, Milliman CL, Korsmeyer SJ (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241
42. Irmler M, Hofmann K, Vaux D, Tschopp J (1997) Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4. FEBS Lett 406: 189
43. Kern SE, Kinzler KW, Bruskin A, Jarosz D, Friedman P, Prives C, Vogelstein B (1991) Identification of p53 as a sequence-specific DNA-binding protein. Science 252: 1708
44. Kerr JFR, Harmon B, Searle J (1974) An electron-microscope study of cell deletion in the anuran tadpole tail during spontaneous metamorphosis with special reference to apoptosis in striated muscle fibres. J Cell Sci 14:571
45. Kessinger A, Armitage JO (1991) The evolving role of autologous peripheral stem cell transplantation following high-dose therapy for malignancies. Blood 77: 211
46. Kiefer MC, Brauer MJ, Powers VC, Wu JJ, Umansky SR, Tomei LD, Barr PJ (1995) Modulation of apoptosis by the widely distributed Bcl-2 homlogue Bak. Nature 374: 736
47. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275: 1132
48. Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W, Reed JC (1993) Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res 53: 4701
49. Kuerbitz SJ, Plunkett BS, Walsh WV, Kastan MB (1992) Wild-type p53 is a cell cycle checkpoint determinant following radiation. Proc Natl Acad Sci USA 89: 7491
50. 2+ fluxes. Proc Natl Acad Sci USA 91: 6569
51. Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88: 323
52. Lowe S, Schmitt EM, Smith SW, Osborne BA, Jacks T (1993) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847
53. McDonnell TJ, Deane N, Platt FM, Nunez G, Jaeger U, McKearn JP, Korsmeyer SJ (1989) bcl-2 immunoglohulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 57: 79
54. Meikrantz W, Gisselbrecht S, Tam SW, Schlegel R (1994) Activation of cyclin A-dependent protein kinase during apoptosis. Proc Natl Acad Sci USA 91: 3754
55. Miyashita T, Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293
56. Naik P, Karrim J, Hanahan D (1996) The rise and fall of apoptosis during multistep tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors. Genes Dev 10: 2105
57. Nguyen M, Millar DG, Yong VW, Korsmeyer SJ, Shore GC (1993) Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence. J Biol Chem 268: 25265
58. Nunez G, London L, Hockenbery D, Alexander M, McKearn JP, Korsmeyer SJ (1990) Deregulated bcl-2 gene expression selectively prolongs survival of growth factor-deprived hematopoietic cell lines. J Immunol 144: 3602
59. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609
60. Parodi S, Mancuso T (1996) A general overview of the process of carcinogenesis. Tumori 82: 291
61. Pietilainen T, Lipponen P, Aaltomaa S, Eskelinen M, Kosma V, Syrjanen K (1995) Expression of c-myc proteins in breast cancer as related to established prognostic factors and survival. Anticancer Res 15: 959
62. Prendergast G, Ziff E (1991) Methylation-sensitive sequence-specific DNA binding by the c-myc basic region. Science 251: 186
63. Preston GA, Lyon TT, Yin Y, Lang JE, Solomon G, Annab L, Srimvasan DG, Alcorta DA, Barret JC (1996) Induction of apoptosis by c-Fos protein. Mol Cell Biol 16: 211
64. Raycroft L, Wu H, Lozano G (1990) Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science 249: 1049
65. Ross AA, Cooper BW, Lazarus HM, Mackay W, Moss TJ, Ciobanu N, Tallman MS, Kennedy MJ, Davidson NE, Sweet D, Winter C, Akard L, Jansen J. Copelan E, Meagher RC, Herzig RH, Klumpp TR, Kahn DG, Warner NE (1993) Detection and viability of tumor cells in peripheral blood stem cell collections from breast cancer patients using immunocytochemical and clonogenic assay techniques. Blood 82: 2605
66. Ryan JJ, Prochownik E, Gottlieb CA, Apel IJ, Merino R, Nunez G, Clarke MF (1994) c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle. Proc Natl Acad Sci USA 91: 5878
67. Sabbatini P, Lin J, Levine AJ, White E (1995) Essential role for p53-mediated transcription in E1A-induced apoptosis. Genes Dev 9: 2184
68. L protects cancer cells from p53-mediated apoptosis. Oncogene 11: 1389
69. Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ (1991) bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67: 879
70. Seto E, Usheva A, Zambetti GP, Momand J, Horikoshi N, Weinmann R, Levine AJ, Shenk T (1992) Wild-type p53 binds to the TATA-binding protein and represses transcription. Proc Natl Acad Sci USA 89: 12028
71. Sierra A, Lloveras B, Castellsague X, Moreno L, Garcia-Ramirez M, Fabra A (1995) Bcl-2 expression is associated with lymph node metastasis in human dutal breast carcinoma. Int J Cancer 60: 54
72. Smith CA, Williams GT, Kingston R, Jenkinson EJ, Owen JJT (1989) Antibodies to CD3/T-cell receptor complex induce cell death by apoptosis in immature T clls in thymic cultures. Nature 337: 181
73. Spector MS, Desnoyers S, Hoeppner DJ, Hengartner MO (1997) Interaction between the C. elegans cell-death regulators CED-9 and CED-4. Nature 385: 653
74. S sensitizes MCF-7 cells to chemotherapy induced apoptosis. Cancer Res 55: 2507
75. Tanaka S, Saito K, Reed JC (1993) Structure-function analysis of the Bcl-2 oncoprotein. J Biol Chem 268: 10920
76. Tsujimoto Y, Croce CM (1986) Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci USA 83: 5214
77. Vaux DL, Cory S, Adams JM (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335: 440
78. Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ (1993) Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75: 229
79. Vogelstein B (1990) A deadly inheritance. Nature 348: 681
80. Vogelstein B, Kinzler KW (1993) The multistep nature of cancer. Trends Genet 9: 138
81. Wagner AJ, Small MB, Hay N (1993) Myc-mediated apoptosis is blocked by ectopic expression of bcl-2. Mol Cell Biol 13: 2432
82. Wagner AJ, Kokontis JM, Hay N (1994) Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. Genes Dev 8: 2817
83. Weinberg RA (1991) Tumor suppressor genes. Science 254: 1138
84. Wu D, Wallen HD, Nunez G (1997) Interaction and regulation of subcellular localization of CED-4 by CED-9. Science 275: 1126
85. Wu D, Wallen HD, Inohara N, Nunez G (1997) Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9. J Biol Chem 272: 1
86. Wyllie AH, Kerr JF, Currie AR (1980) Cell death: the significance of apoptosis. Int Rev Cytol 68: 251
87. L and Bcl-2, displaces Bax and promotes cell death. Cell 80: 285
88. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng T, Jones DP, Wang X (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275: 1129
89. Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M (1991) Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352: 345
90. Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1B-converting enzyme. Cell 75: 641