Mechanism of compound- and species-specific food effects of structurally related antiarrhythmic drugs, disopyramide and bidisomide

Pharmaceutical Research

Volumn 15, Issue 3, 1998, Pages 429-433

  Cook, Chyung S ^a   Zhang, Liming ^a   Osis, John ^a   Schoenhard, Grant L ^a   Karim, Aziz ^a  

^a PFIZER INC   (United States)

Author keywords

Bidisomide; Disopyramide; Dog; Food effect; Species difference

Indexed keywords

AMINO ACID MIXTURE; ANTIARRHYTHMIC AGENT; BIDISOMIDE; DISOPYRAMIDE; DISOPYRAMIDE PHOSPHATE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG METABOLISM; ENZYME MULTIPLIED IMMUNOASSAY TECHNIQUE; FEMALE; FOOD INTAKE; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; LIPID DIET; LIVER METABOLISM; MALE; NONHUMAN; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PORTAL VEIN; PRIORITY JOURNAL; SPECIES DIFFERENCE; STRAIN DIFFERENCE; TABLET;

ADULT; ANIMALS; ANTI-ARRHYTHMIA AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; DIETARY FATS; DISOPYRAMIDE; DOGS; FEMALE; FOOD-DRUG INTERACTIONS; HUMANS; INTESTINAL ABSORPTION; LIVER; MALE; PIPERIDINES; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031900289     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011976331738     Document Type: Article

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