The influence of food on the absorption and metabolism of drugs: An update

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 21, Issue 3, 1996, Pages 201-211

  Williams, L ^a   Hill Jr , D P ^a   Davis, J A ^b   Lowenthal, D T ^b  

^a Bay Pines VA Medical Center   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE INTAKE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG METABOLISM; EATING; FAT INTAKE; FOOD DRUG INTERACTION; FOOD INTAKE; HUMAN; MALNUTRITION; MINERAL INTAKE; PROTEIN INTAKE; REVIEW; VITAMIN INTAKE;

EID: 0030464906     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03189714     Document Type: Review

References (82)

1. Welling P. (1985) : Nutrient effects on drug metabolism and action in the elderly. Drug Nutr. Interact., 4, 173-207.
2. Steinijans V., Hauschke D., Jonkman J H.G. (1992) : Controversies in bioequivalence studies. Clin. Pharmacokinet., 22, 247-253.
3. Toothaker R.D., Welling P.G. (1980) : The effect of food on drug unavailability. Annu. Rev. Pharmacol. Toxicol., 20, 173-199.
4. Sriwatanakul K., Weintraub M. (1983) : Understanding food-drug interactions. Comp. Ther., 9, 6-11.
5. Roberts J., Tumer N. (1988) : Age and diet effects on drug action. Pharmacol. Ther., 37' 111-149.
6. Abernethy D.R., Greenblatt D.J. (1986) : Drug disposition in obese humans: an update. Clin. Pharmacokinet., 11, 199-213.
7. Osis M. (1986) : Scheduling drug administration: drug and food interactions. Gerontion, 1, 810.
8. Roe D.A (1983) : Drugs and nutrition in the elderly. In: Roe D.A. (Ed.) Geriatric Nutrition. New Jersey, Prentice-Hall, pp. 155-173.
9. Roe D.A. (1985) : Therapeutic effects of drug-nutrient interactions in the elderly. J. Am. Diet. Assoc., 85, 174-181.
10. Welling P.G. (1977) : Influence of food and diet on gastrointestinal drug absorption: a review. J. Pharmacokinet. Biopharm., 5, 291-334.
11. Welling P.G. (1984) : Interactions affecting drug absorption. Clin. Pharmacokinet., 9, 404-434.
12. Lamy P.P. (1983) : Nutrition, drugs, and the elderly. Clin. Nutr., 2, 9-14.
13. Committee on Aging: Group for the advancement of psychiatry. (1994) : Impact of tacrine in the care of patients with Alzheimer's disease. Am. J. Geriatric. Psychiatry., 2, 285-289.
14. Welty D.F., Siedlik P.H., Posvar E.L. et al. (1994) : The temporal effect of food on tacrine bioavailability. J. Clin. Pharmacol., 34, 985-988.
15. Roe D.A. (1984) : Therapeutic significance of drug-nutrient interactions in the elderly. Pharmacol. Rev., 36, S109-S122.
16. McLean A.J., McNamara P.J., duSovich P. et al. (1978) : Food, splanchnic blood flow, and bioavailability of drugs subject to first-pass metabolism. Clin Pharmacol. Ther., 24, 5-10.
17. Randle N.W. (1987) : Food or nutrient effects on drug absorption: a review. Hosp. Pharm., 22, 694-718.
18. Jonkman J.H.G. (1989) : Food interactions with sustained release theophylline preparations: a review. Clin. Pharmacokinet., 16, 162-179.
19. Jacknowitz A. (1987) : Food and drug interactions. US Pharm., 12, 66-72.
20. Roe D.A. (1986) : Drug-food and drug-nutrient interactions. J. Environ. Pathol. Toxicol. Oncol , 5, 115-135.
21. Hathcock J.N (1985) : Metabolic mechanisms of drug-nutrient interactions. Fed. Proc., 44, 124-129.
22. Cook M.C., Taren D.L. (1990) : Nutritional implications of medication use and misuse in elderly. J. Fla. Med. Assoc., 77, 606-613.
23. Cutie A.J., Altman E., Lenkel L. (1983) : Compatibility of enteral products with commonly employed drug additives. J. Parenter. Enter. Nutr., 7, 186-191.
24. Roe D.A. (1986) : Drug-nutrient interactions in the elderly. Geriatrics, 41, 57-74.
25. Bauer L.A (1982) : Interference of oral phenytoin absorption by continuous nasogastric feedings. Neurology, 32, 570-572.
26. Kempster P.A., Wahlquist M.L. (1994) : Dietary factors in the management of Parkinson's disease. Nutr. Rev., 52, 51-58.
27. Growden J.H. (1994) : Metabolic determinants of fluctuations in levodopa response Drugs Nutr Neurol 3, .
28. Pincus J.H., Barry K M. (1987) . Plasma levels of amino acids correlate with motor fluctuations in Parkinsonism. Arch. Neurol., 44, 1006-1009.
29. Montamat S , Cusack B., Vestal R.E. (1989) : Management of drug therapy in the elderly. N. Engl. J. Med., 321, 303-309.
30. Melander A., Danielson K., Hanson A. et al. (1977) : Enhancement of hydralazine bioavailability by food. Clin. Pharmacol. Ther., 22, 104-107.
31. Melander A., Danielson K., Schersten B. et al. (1977) : Enhancement of the bioavailability of propanolol and metroprolol by food. Clin. Pharmacol. Ther., 30, 108-112.
32. Coon M.J. (1978) : Oxygen activation in the metabolism of lipids, drugs, and carcinogens. Nutr. Rev., 36, 319-328.
33. Liedholm H., Melander A. (1986) : Concomitant food intake can increase the bioavailability of propranolol by transient inhibition of its presystemic primary conjugation. Clin. Pharmacol. Ther., 40, 29-36.
34. Daneshmend T.K., Roberts C.J. (1982) : The influence of food on the oral and intravenous pharmacokinetics of a high clearance drug: a study with Labetalol. Br. J. Clin. Pharmacol., 14, 73-78.
35. Hathcock J.N. (1985) : Nutrient and non-nutrient effects of drug metabolism. Drug Nutr. Interact., 4, 217-234.
36. Watkins P.B., Wrighton S.A., Schuetz E.G., Molowa D.T., Guzelian P.S. (1987) : Identification of glucocorticoid-inducible cytochrome P-450 in the intestinal mucosa of rats and man. J. Clin. Invest., 80, 1029-1036.
37. Kaminsky L.S., Fasco M.J. (1992) : Small intestinal cytochrome P450. Crit. Rev. Toxicol., 21, 407-422.
38. Gonzalez F. (1992) : Human cytochromes P450: problems and prospects. Trends Pharm. Sci., 13, 346-352.
39. Krishna D.R., Klotz U. (1994) : Extrahepatic metabolism of drugs in humans. Clin. Pharmacokinet., 26, 144-160.
40. Ducharme M.P., Provenzano R., Dehoorne-Smith M., Edwards D.J. (1993) : Trough concentrations of cyclosporine in blood following administration with grapefruit juice. Br. J. Clin. Pharmacol., 36, 457-459.
41. Benton R., Honig P., Zamani K. et al. (1994) : Grapefruit juice alters terfenadine pharmacokinetics resulting in prolongation of QTc. Clin. Pharmacol. Ther., 55, 146.
42. Kivisto K.T., Neuvonen P.J., Klotz U. (1994) : Inhibition of terfenadine metabolism: pharmacokinetic and pharmacodynamic consequences. Clin. Pharmacokinet., 27, 1-5.
43. Bailey D.G., Arnold J.M., Spence J.D. (1994) : Grapefruit juice and drugs: how significant is the interaction? Clin. Pharmacokinet., 26, 91-98.
44. Anderson K.E. (1988) : Influences of diet and nutrition on clinical pharmacokinetics. Clin. Pharmacokinet., 14, 325-346.
45. Pantuck E.J., Pantuck E.B., Kappas A. et al. (1991) : Effects of protein and carbohydrate content of diet on drug conjugation. Clin. Pharmacol. Ther., 50, 254-258.
46. Anderson K.E., Conney A.H., Kappas A. (1979) : Nutrition and oxidative drug metabolism in man: relative influence of dietary lipids, carbohydrates, and protein. Clin. Pharmacol. Ther., 26, 493-501.
47. Kappas A., Anderson K.E., Conney A.H. et al. (1976) : Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man. Clin. Pharmacol. Ther., 20, 643-653
48. Anderson K.E., Conney A.M., Kappas A. (1982) : Nutritional influences on chemical biotransformation in humans. Nutr. Rev., 40, 161-171.
49. Anderson K.E., Pantuck E.J., Conney A.H. et al. (1985) : Nutrient regulation of chemical metabolism in humans. Fed. Proc., 44, 130-133.
50. Fagan T.C., Walle T., Oexmann M.J. et al. (1987) : Increased clearance of propranolol and theophylline by high-protein compared with high-carbohydrate diet. Clin. Pharmacol. Ther., 41, 402-406.
51. Berlinger W.G., Park G.D., Spector R (1985) : The effect of dietary protein on the clearance of allopurinol and oxypurinol. N. Engl. J. Med., 313, 771-776.
52. Herman R.J., Chaudhary A., Szakacs C. (1994) : Disposition of lorazepam in Gilbert's syndrome: effects of fasting, feeding, and enterohepatic circulation. J. Clin. Pharmacol., 34, 978-984.
53. Guengerich F.P. (1984) : Effects of nutritive factors on metabolic processes involving bioactivation and detoxification of chemicals. Annu. Rev. Nutr., 4, 207-231.
54. Thurman R.G., Kauffman R.C. (1980) : Factors regulating drug metabolism in intact hepatocytes. Pharmacol. Rev., 31, 229-251.
55. Ginter E., Vejmolova J. (1981) : Vitamin C-status and pharmacokinetic profile of antipyrine in man. Br. J. Clin. Pharmacol., 12, 256-258.
56. Smithard D.J., Langman M.J.S. (1978) : The effect of vitamin supplementation upon antipyrine metabolism in the elderly. Br. J. Clin. Pharmacol., 5, 181-185.
57. Holloway D.E., Hutton S.W., Peterson F.J. et al. (1982) : Lack of effect of subclinical ascorbic acid deficiency upon antipyrine metabolism in man. Am. J. Clin. Nutr., 35, 917-924.
58. Trang J.M., Blanchard J., Conrad K.A. et al. 91982) : The effect of vitamin C on the pharmacokinetics of caffeine in elderly men. Am. J. Clin. Nutr., 35, 487-494.
59. Houston J.B. (1977) : Effect of vitamin C supplementation on antipyrine disposition in man. Br. J. Clin. Pharmacol., 4, 236-239.
60. Wilson J.T., Van Boxtel C.J., Alvan G. et al. (1976) : Failure of vitamin C to affect the pharmacokinetic profile of antipyrine in man. J. Clin. Pharmacol., 16, 265-270.
61. Houston J.B., Levy G. (1976) : Drug biotransformation interactions in man. VI: Acetaminophen and ascorbic acid. J. Pharm Sci., 65, 1218-1221.
62. Cotzias G.C. (1969) : Metabolic modification of some neurologic disorders. JAMA, 210, 1255-1262.
63. Hathcock J.N. (1987) : Nutrient-drug interactions. Clin. Geriatr. Med., 3, 297-307.
64. Pantuck E.J., Pantuck C.B., Garland W.A. et al. (1979) : Stimulatory effect of Brussels sprouts and cabbage on human drug metabolism. Clin Pharmacol. Ther., 25, 88-95.
65. Pantuck E.J., Pantuck C.B., Anderson K.E. et al. (1984) : Effects of Brussels sprouts and cabbage on drug conjugations in humans. Clin. Pharmacol. Ther., 35, 161-169.
66. Kappas A., Alvares A.P , Anderson K.E. et al. (1978) : Effect of charcoal-broiled beef on antipyrine and theophylline metabolism. Clin. Pharmacol. Ther., 23, 445-450.
67. Conney A.H., Pantuck E.J., Hsiao K-C. et al. (1976) : Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef. Clin. Pharmacol. Ther., 20, 633-642.
68. Anderson K.E., Schneider J , Pantuck E.J. (1983) : Acetaminophen metabolism in subjects fed charcoal-broiled beef Clin. Pharmacol. Ther , 34, 369-374.
69. Monks T.J., Caldwell J., Smith R.L. (1979) : Influence of methylxanthine-containing foods on the theophylline metabolism and kinetics. Clin Pharmacol. Ther., 26, 513-524.
70. Drouillard D.D., Vestal E.S., Dvorchik B.H. (1978) : Studies on theobromine disposition in normal subjects. Clin. Pharmacol. Ther., 23, 296-302.
71. Brodie M.J., Boobis A.R., Toverud E-L. et al. (1980) : Drug metabolism in white vegetarians. Br. J. Clin. Pharmacol., 9, 523-525.
72. Reidenberg M.M., Kostenbauder H., Adams W.P. (1969) : Rate of metabolism in obese volunteers before and during starvation and in azotemic patients. Metabolism, 18, 209-213.
73. Reidenberg M M. (1976) : Obesity and fasting: effects on drug metabolism and drug action in man. Clin. Pharmacol. Ther., 22, 729-734.
74. Roe D.A. (1984) : Nutrient and drug interactions. Nutr. Rev., 42, 141-154.
75. Buchanan N., Robinson R., Koornhof H.J. et al. (1979) : Penicillin pharmacokinetics in kwashiorkor. Am. J. Clin. Nutr., 32, 2233-2236.
76. Lewis G.P., Jusko W.J., Burke C.W. et al. (1971) : Prednisone side effects and serum-protein levels. Lancet, 2, 778-781.
77. Fleming C.R., Higgins J.A. (1977) : Alcohol: nutrient and poison (editorial). Ann. Intern. Med., 87, 492-493.
78. Rall T.W. 91990) : Hypnotics and sedatives; ethanol. In: Gilman A.C., Rall T.W., Nigs A.S. et al (Eds): Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th edn. New York, Pergamon Press, pp. 345-382.
79. Humphrey M.J., Smith D.A. (1992) : Role of metabolism and pharmacokinetic studies in the discovery of new drugs - present and future perspectives. Xenobiotica, 22, 743-755.
80. Gumbleton M., Sneader W. (1994) : Pharmacokinetic considerations in rational drug design. Clin. Pharmacokinet., 26, 161-168.
81. Krstenansky P.M., Cluxton Jr R. (1987) : Astemizole: a long-acting, nonsedating antihistamine Drug Intell. Clin. Pharm., 21, 947-953.
82. Weintraub M., Evans P. (1987) : Astemizole: a long-acting and less sedating HI-blocking antihistamine. Hosp. Formulary, 22, 918-927.