Reduced systemic availability of an antiarrhythmic drug, bidisomide, with meal co-administration: Relationship with region-dependent intestinal absorption

Pharmaceutical Research

Volumn 15, Issue 2, 1998, Pages 221-227

  Pao, Li Heng ^a,c   Zhou, Simon Yuji ^a   Cook, Chyung ^b   Kararli, Tugrul ^b   Kirchhoff, Carol ^b   Truelove, James ^b   Karim, Aziz ^b   Fleisher, David ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b PFIZER INC   (United States)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Bidisomide; Canine model; Disopyramide; Drug absorption; Food effects; Intestinal clearance; Regional dependent absorption; Site specific absorption; Viscosity

Indexed keywords

ANTIARRHYTHMIC AGENT; BIDISOMIDE; DISOPYRAMIDE; METHYLCELLULOSE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIALYSIS; DIET RESTRICTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; FOOD COMPOSITION; FOOD DRUG INTERACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; INTESTINE ABSORPTION; INTRADUODENAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIPID DIET; LOW FAT DIET; MALE; MEAL; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; DOGS; FEMALE; FOOD-DRUG INTERACTIONS; HUMANS; INFUSIONS, INTRAVENOUS; INTESTINAL ABSORPTION; MALE; PIPERIDINES; VISCOSITY;

EID: 0031915620     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011958400362     Document Type: Article

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