The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27

Genome Research

Volumn 6, Issue 3, 1996, Pages 226-233

  Edwards, Y H ^a   Putt, W ^a   Lekoape, K M ^b   Stott, D ^b   Fox, M ^a   Hopkinson, D A ^a   Sowden, J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DNA BINDING PROTEIN; GLYCINE CLEAVAGE SYSTEM; TRANSCRIPTION FACTOR;

ARTICLE; CHROMOSOME 6Q; EMBRYO DEVELOPMENT; FETUS; FETUS DEATH; FETUS MEMBRANE; GENE STRUCTURE; HUMAN; HUMAN TISSUE; MESODERM; MOLECULAR CLONING; MOUSE; MULTIGENE FAMILY; MUTANT; NONHUMAN; NOTOCHORD; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SEQUENCE HOMOLOGY; SOMITE; VERTEBRATE;

AMINO ACID SEQUENCE; BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, 6-12 AND X; CLONING, MOLECULAR; DNA-BINDING PROTEINS; EXONS; FETAL PROTEINS; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INTRONS; MOLECULAR SEQUENCE DATA; T-BOX DOMAIN PROTEINS; TRANSCRIPTION FACTORS;

EID: 0029966604     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.6.3.226     Document Type: Article

References (16)

1. Agulnik, S.I., R.J. Bollag, and L.M. Silver. 1995. Conservation of the T-Box gene family from Mus musculus to Caenorhabditis elegans. Genomics 25: 214-219.
2. Amos, D.B., N. Ruderman, N. Mendell, and A.H. Johnson. 1975. Linkage between HLA and spinal development. Transplant. Proc. 7: 93-95.
3. Beddington, R.S.P., P. Rashbass, and V. Wilson. 1992. Brachyury - A gene affecting mouse gastrulation and early organogenesis. Development (Suppl.): 157-165.
4. Blanché, H., L.G. Wright, G. Vergnaud, B. de Gouyon, V. Lauthier, L.M. Silver, J. Dausset, H.M. Cann, and R.S. Spielman. 1992. Genetic mapping of three human homologs of murine t-complex genes localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLG. Genomics 12: 826-828.
5. Bobrow, M., J.G. Bodmer, W.F. Bodmer, H.O. McDevitt, J. Lorber, and P.N. Swift. 1975. The search for a human equivalent of the mouse T-locus. Negative results from a study of HLA types in spina bifida. Tissue Antigens 5: 234-237.
6. Bollag, R.J., Z. Siegfried, J.A. Cebra-Thomas, N. Garvey, E.M. Davison, and L.M. Silver. 1994. An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus. Nature Genet. 7: 383-389.
7. Campbell, C., K. Goodrich, G. Casey, and B. Beatty. 1995. Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene. Genomics 28: 255-260.
8. Chomczynski, P. and N. Sacchi. 1987. Single-step of RNA isolation by acid guanidinium thiocyanate phenol chloroform extract. Anal. Biochem. 162: 156-159.
9. Edwards, Y.H., W. Putt, M. Fox, and J.H. Ives. 1995. A novel human phosphoglucomutase (PGM5), maps to the centromeric region of chromosome 9. Genomics 30: 350-353.
10. Fellous, M., J. Hors, J. Bone, J. Dausset, and F. Jacob. 1979. Are there human analogs of the mouse T-locus in central nervous system malformations? Birth Defects Orig. Art. Ser. XV(3): 93-104.
11. Gaidano, G., R.S. Hauptschein, N.Z. Parsa, K. Offit, P.H. Rao, G. Lenoir, D.M. Knowles, R.S. Chaganti, and R. Dalla-Favera. 1992. Deletions involving two distinct regions of 6q in B-cell non-Hodgkin lymphoma. Blood 80: 1781-1787.
12. Halpern, M.E., R.K. Ho, C. Walker, and C.B. Kimmel. 1993. Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation. Cell 75: 99-111.
13. Wilson, V., P. Rashbass, and R.S.P. Beddington. 1993. Chimeric analysis of T (Brachyury) gene function. Development 117: 1321-1331.
14. Wilson, V., L. Manson, W.C. Skarnes, and R.S.P. Beddington. 1995. The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation. Development 121: 877-886.
15. Yasuo, H. and N. Satoh. 1993. Function of vertebrate T gene. Nature 364: 582-583.
16. Ziegler, A., L.L. Field, and A.Y. Sakaguchi. 1991. Report of the committee on the genetic constitution of chromosome 6. Cytogenet. Cell. Genet. 58: 295-336.