Multiple mechanisms of N-phosphonacetyl-L-aspartate resistance in human cell lines: Carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase gene amplification is frequent only when chromosome 2 is rearranged

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 5, 1997, Pages 1816-1821

  Smith, Kathleen A ^a   Chernova, Olga B ^b   Groves, Richard P ^c   Stark, Mary B ^b   Martínez, José L ^d   Davidson, Jeffrey N ^e   Trent, Jeffrey M ^f   Patterson, Thomas E ^b   Agarwal, Archana ^b   Duncan, Pamela ^b   Agarwal, Munna L ^b   Stark, George R ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b LERNER RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^e UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^f NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Chromosome rearrangements; Fluorescence in situ hybridization; Genomic stability; Induced amplification; Isochromosome 2

Indexed keywords

ASPARTATE CARBAMOYLTRANSFERASE; CARBAMATE KINASE; DIHYDROOROTASE; SPARFOSIC ACID;

CELL LINE; CHROMOSOME 2; CHROMOSOME REARRANGEMENT; CONFERENCE PAPER; CONTROLLED STUDY; DRUG RESISTANCE; GENE AMPLIFICATION; HUMAN; HUMAN CELL; ISOCHROMOSOME; PRIORITY JOURNAL;

ASPARTATE CARBAMOYLTRANSFERASE; ASPARTIC ACID; CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING); CELL LINE; CENTROMERE; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 2; DIHYDROOROTASE; DNA PROBES; DRUG RESISTANCE; GENE AMPLIFICATION; GENE DOSAGE; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MULTIENZYME COMPLEXES; PHOSPHONOACETIC ACID; TELOMERE; TUMOR CELLS, CULTURED;

RODENTIA;

EID: 0031055329     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.5.1816     Document Type: Article

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