메뉴 건너뛰기




Volumn 12, Issue 1, 1998, Pages 1-17

Pathogenesis of Crohn's disease

Author keywords

Cytokines; IBD aetiology; Inflammation; Mucosal immunology

Indexed keywords

ANTIGEN; CELL ADHESION MOLECULE;

EID: 0031866865     PISSN: 09503528     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0950-3528(98)90083-5     Document Type: Article
Times cited : (20)

References (75)
  • 3
    • 0022396421 scopus 로고
    • Circulating human leucocyte elastase in patients with inflammatory bowel disease
    • Adeyemi EO, Neumann S, Chadwick VS et al (1985) Circulating human leucocyte elastase in patients with inflammatory bowel disease. Gut 26: 1306-1311.
    • (1985) Gut , vol.26 , pp. 1306-1311
    • Adeyemi, E.O.1    Neumann, S.2    Chadwick, V.S.3
  • 4
    • 0029913624 scopus 로고    scopus 로고
    • Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease
    • Babyatsky MW, Rossiter G & Podolsky DK (1996) Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. Gastroenterology 110: 975-984.
    • (1996) Gastroenterology , vol.110 , pp. 975-984
    • Babyatsky, M.W.1    Rossiter, G.2    Podolsky, D.K.3
  • 5
    • 0029992279 scopus 로고    scopus 로고
    • Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease
    • Belluzzi A, Brignola C, Campieri M et al (1996) Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease. New England Journal of Medicine 13: 1557-1560.
    • (1996) New England Journal of Medicine , vol.13 , pp. 1557-1560
    • Belluzzi, A.1    Brignola, C.2    Campieri, M.3
  • 6
    • 0028860746 scopus 로고
    • Differences in the intrinsic capacity of peripheral blood mononuclear cells to produce tumour necrosis factor alpha and beta in patients with inflammatory bowel disease and healthy controls
    • Bouma G, Odukerk-Pool M, Scharenberg JG et al (1995) Differences in the intrinsic capacity of peripheral blood mononuclear cells to produce tumour necrosis factor alpha and beta in patients with inflammatory bowel disease and healthy controls. Scandinavian Journal of Gastroenterology 30: 1095-1100.
    • (1995) Scandinavian Journal of Gastroenterology , vol.30 , pp. 1095-1100
    • Bouma, G.1    Odukerk-Pool, M.2    Scharenberg, J.G.3
  • 7
    • 0030016911 scopus 로고    scopus 로고
    • Keratinocyte growth factor is highly over-expressed in inflammatory bowel disease
    • Brachle M, Madlener M, Wagner AD et al (1996) Keratinocyte growth factor is highly over-expressed in inflammatory bowel disease. American Journal of Pathology 149: 521-529.
    • (1996) American Journal of Pathology , vol.149 , pp. 521-529
    • Brachle, M.1    Madlener, M.2    Wagner, A.D.3
  • 9
    • 0028236232 scopus 로고
    • Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease
    • Breese EJ, Michie CA, Nicholls SW et al (1994) Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease. Gastroenterology 106: 1455-1466.
    • (1994) Gastroenterology , vol.106 , pp. 1455-1466
    • Breese, E.J.1    Michie, C.A.2    Nicholls, S.W.3
  • 10
    • 0026342111 scopus 로고
    • Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
    • Butcher EC (1991) Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67: 1033-1036.
    • (1991) Cell , vol.67 , pp. 1033-1036
    • Butcher, E.C.1
  • 11
    • 0031038034 scopus 로고    scopus 로고
    • Oxidative damage and transforming growth factor beta 1 expression in pretumoral and tumoral lesions of human intestine
    • Chiarpotto E, Sacvazza A, Leonarduszzi G et al (1997) Oxidative damage and transforming growth factor beta 1 expression in pretumoral and tumoral lesions of human intestine. Free Radical Biology and Medicine 22: 889-894.
    • (1997) Free Radical Biology and Medicine , vol.22 , pp. 889-894
    • Chiarpotto, E.1    Sacvazza, A.2    Leonarduszzi, G.3
  • 13
    • 0029885179 scopus 로고    scopus 로고
    • Picotamide inhibition of excess in vitro thromboxane B2 release by colorectal mucosa in inflammatory bowel disease
    • Collins CE, Benson MJ, Burnham WR et al (1996) Picotamide inhibition of excess in vitro thromboxane B2 release by colorectal mucosa in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics 10: 315-320.
    • (1996) Alimentary Pharmacology and Therapeutics , vol.10 , pp. 315-320
    • Collins, C.E.1    Benson, M.J.2    Burnham, W.R.3
  • 14
    • 0025167803 scopus 로고
    • Interleukin-1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis
    • Cominelli F, Nast CC, Clarke BD et al (1990) Interleukin-1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis. Journal of Clinical Investigation 86: 972-980.
    • (1990) Journal of Clinical Investigation , vol.86 , pp. 972-980
    • Cominelli, F.1    Nast, C.C.2    Clarke, B.D.3
  • 15
    • 0000897755 scopus 로고
    • Specific mucosal imbalance of IL-1 and IL-1 receptor antagonist (IL-1ra) in IBD: A potential mechanism of chronic inflammation
    • Cominelli F, Kam L, Casini-Raggi V et al (1994) Specific mucosal imbalance of IL-1 and IL-1 receptor antagonist (IL-1ra) in IBD: a potential mechanism of chronic inflammation. Gastroenterology 106: A667.
    • (1994) Gastroenterology , vol.106
    • Cominelli, F.1    Kam, L.2    Casini-Raggi, V.3
  • 16
    • 0025777448 scopus 로고
    • Interleukin-1 and interleukin-1 antagonism
    • Dinarello CA (1991) Interleukin-1 and interleukin-1 antagonism. Blood 8: 1627-1652.
    • (1991) Blood , vol.8 , pp. 1627-1652
    • Dinarello, C.A.1
  • 17
    • 0029931508 scopus 로고    scopus 로고
    • Bacteria-specific T cell clones are selective in their reactivity towards different enterobacteria or H. pylori and increased in inflammatory bowel disease
    • Duchmann R, Marker-Hermann E & Meyer-zum-Buschenfelde KH (1996) Bacteria-specific T cell clones are selective in their reactivity towards different enterobacteria or H. pylori and increased in inflammatory bowel disease. Scandinavian Journal of Immunology 44: 71-79.
    • (1996) Scandinavian Journal of Immunology , vol.44 , pp. 71-79
    • Duchmann, R.1    Marker-Hermann, E.2    Meyer-zum-Buschenfelde, K.H.3
  • 18
    • 0025910090 scopus 로고
    • Neutrophil cytoplasmic antibodies: A link between primary sclerosing cholangitis and ulcerative colitis
    • Duerr RH, Targen SR, Landers CJ et al (1991) Neutrophil cytoplasmic antibodies: a link between primary sclerosing cholangitis and ulcerative colitis. Gastroenterologe 100: 406-413.
    • (1991) Gastroenterologe , vol.100 , pp. 406-413
    • Duerr, R.H.1    Targen, S.R.2    Landers, C.J.3
  • 19
    • 0029050742 scopus 로고
    • Treatment of Crohn's disease with anti-tumour necrosis factor chimeric monoclonal antibody (cA2)
    • van Dulleman HM, van Deventer SJ, Hommes DW et al (1995) Treatment of Crohn's disease with anti-tumour necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 109: 129-135.
    • (1995) Gastroenterology , vol.109 , pp. 129-135
    • Van Dulleman, H.M.1    Van Deventer, S.J.2    Hommes, D.W.3
  • 20
    • 0030600341 scopus 로고    scopus 로고
    • Crohn's disease after in-utero measles virus exposure
    • Ekbom A, Daszak P, Kraaz W et al (1996) Crohn's disease after in-utero measles virus exposure. Lancet 348: 515-517.
    • (1996) Lancet , vol.348 , pp. 515-517
    • Ekbom, A.1    Daszak, P.2    Kraaz, W.3
  • 21
    • 0028143211 scopus 로고
    • Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis
    • Elliott MJ, Maini RN, Feldmann M et al (1994) Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. Lancet 344: 1105-1110.
    • (1994) Lancet , vol.344 , pp. 1105-1110
    • Elliott, M.J.1    Maini, R.N.2    Feldmann, M.3
  • 22
    • 84907035967 scopus 로고
    • Phase II trial of copper zinc superoxide dismutase (CuZn SOD) in the treatment of Crohn's disease
    • Emerit J, Pelletier S, Likforman J et al (1991) Phase II trial of copper zinc superoxide dismutase (CuZn SOD) in the treatment of Crohn's disease. Free Radical Research Communications 12: 563-569.
    • (1991) Free Radical Research Communications , vol.12 , pp. 563-569
    • Emerit, J.1    Pelletier, S.2    Likforman, J.3
  • 23
    • 2642618014 scopus 로고    scopus 로고
    • Inducible nitric oxide synthetase (iNOS) and cyclooxygenase (COX-2) expression in ulcerative colitis and Crohn's disease
    • Fu S, Ramanujam KS, Meltzer SJ et al (1996) Inducible nitric oxide synthetase (iNOS) and cyclooxygenase (COX-2) expression in ulcerative colitis and Crohn's disease. Gastroenterology 110: A910.
    • (1996) Gastroenterology , vol.110
    • Fu, S.1    Ramanujam, K.S.2    Meltzer, S.J.3
  • 24
    • 0029120815 scopus 로고
    • Adequacy of mucosal biopsies for evaluation of intestinal cytokine-specific mRNA. Comparative study of RT-PCR in biopsies and isolated cells from normal and inflamed intestine
    • Fukushima K, West G & Fiocchi C (1995) Adequacy of mucosal biopsies for evaluation of intestinal cytokine-specific mRNA. Comparative study of RT-PCR in biopsies and isolated cells from normal and inflamed intestine. Digestive Diseases and Sciences 40: 1498-1505.
    • (1995) Digestive Diseases and Sciences , vol.40 , pp. 1498-1505
    • Fukushima, K.1    West, G.2    Fiocchi, C.3
  • 25
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • Fuss IJ, Neurath M, Boirivant M et al (1996) Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. Journal of Immunology 157: 1261-1270.
    • (1996) Journal of Immunology , vol.157 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3
  • 26
    • 0030057266 scopus 로고    scopus 로고
    • Elevated cell-associated levels of interleukin 1 beta and interleukin 6 in inflamed mucosa of inflammatory bowel disease
    • Grottrup-Wolfers E, Moeller J, Karbach U et al (1996) Elevated cell-associated levels of interleukin 1 beta and interleukin 6 in inflamed mucosa of inflammatory bowel disease. European Journal of Clinical Investigation 26: 115-122.
    • (1996) European Journal of Clinical Investigation , vol.26 , pp. 115-122
    • Grottrup-Wolfers, E.1    Moeller, J.2    Karbach, U.3
  • 27
    • 0030175792 scopus 로고    scopus 로고
    • CD4+ cell oligoclonality in Crohn's disease: Evidence for an antigen-specific response
    • Gulwani-Akolkar B, Akolkar PN, Minassian A et al (1996) CD4+ cell oligoclonality in Crohn's disease: evidence for an antigen-specific response. Human Immunology 48: 114-124.
    • (1996) Human Immunology , vol.48 , pp. 114-124
    • Gulwani-Akolkar, B.1    Akolkar, P.N.2    Minassian, A.3
  • 28
    • 0030059771 scopus 로고    scopus 로고
    • Absence of measles viral genomic sequence in intestinal tissues from Crohn's disease by nested polymerase chain reaction
    • Haga Y, Funakoshi O, Kuroe K et al (1996) Absence of measles viral genomic sequence in intestinal tissues from Crohn's disease by nested polymerase chain reaction. Gut 38: 211-215.
    • (1996) Gut , vol.38 , pp. 211-215
    • Haga, Y.1    Funakoshi, O.2    Kuroe, K.3
  • 29
    • 0027232053 scopus 로고
    • Epithelial deposits of immunoglobulin G1 and activated complement colocalise with the M(r) 40 kD putative autoantigen in ulcerative colitis
    • Halstensen TS, Das KM & Brandtzaeg P (1993) Epithelial deposits of immunoglobulin G1 and activated complement colocalise with the M(r) 40 kD putative autoantigen in ulcerative colitis. Gut 34: 650-657.
    • (1993) Gut , vol.34 , pp. 650-657
    • Halstensen, T.S.1    Das, K.M.2    Brandtzaeg, P.3
  • 30
    • 0026649732 scopus 로고
    • Surface epithelium related activation of complement differs in Crohn's disease and ulcerative colitis
    • Halstensen TS, Mollnes TE, Garred P et al (1992) Surface epithelium related activation of complement differs in Crohn's disease and ulcerative colitis. Gut 33: 902-908.
    • (1992) Gut , vol.33 , pp. 902-908
    • Halstensen, T.S.1    Mollnes, T.E.2    Garred, P.3
  • 31
    • 0017743481 scopus 로고
    • Selective IgA deficiency and Crohn's disease: Report of two cases
    • Hodgson HJ & Jewell DP (1977) Selective IgA deficiency and Crohn's disease: report of two cases. Gut 18: 644-646.
    • (1977) Gut , vol.18 , pp. 644-646
    • Hodgson, H.J.1    Jewell, D.P.2
  • 32
    • 0022970442 scopus 로고
    • Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor
    • Hollander D, Vadheim CM, Brettholz E et al (1986) Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor. Annals of Internal Medicine 105: 883-885.
    • (1986) Annals of Internal Medicine , vol.105 , pp. 883-885
    • Hollander, D.1    Vadheim, C.M.2    Brettholz, E.3
  • 33
    • 13344259990 scopus 로고    scopus 로고
    • Mapping of a susceptibility locus for Crohn's disease on chromosome 16
    • Hugot JP, Laurent-Puig P, Gower-Rousseau C et al (1996) Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature 379: 821-823.
    • (1996) Nature , vol.379 , pp. 821-823
    • Hugot, J.P.1    Laurent-Puig, P.2    Gower-Rousseau, C.3
  • 34
    • 0028812021 scopus 로고
    • Absence of measles virus in Crohn's disease
    • Iizuka M, Nakagomi O, Chiba M et al (1995) Absence of measles virus in Crohn's disease. Lancet 345: 199.
    • (1995) Lancet , vol.345 , pp. 199
    • Iizuka, M.1    Nakagomi, O.2    Chiba, M.3
  • 35
    • 0023485712 scopus 로고
    • Mucosal subclass distribution of immunoglobulin G-producing cells is different in ulcerative colitis and Crohn's disease of the colon
    • Kett K, Rognum TO & Brandtzaeg P (1987) Mucosal subclass distribution of immunoglobulin G-producing cells is different in ulcerative colitis and Crohn's disease of the colon. Gastroenterology 93: 919-924.
    • (1987) Gastroenterology , vol.93 , pp. 919-924
    • Kett, K.1    Rognum, T.O.2    Brandtzaeg, P.3
  • 36
    • 0026660635 scopus 로고
    • Expression of vascular adhesion molecules in inflammatory bowel disease
    • Koizumi M, King N, Lobb R et al (1992) Expression of vascular adhesion molecules in inflammatory bowel disease. Gastroenterology 103: 840-847.
    • (1992) Gastroenterology , vol.103 , pp. 840-847
    • Koizumi, M.1    King, N.2    Lobb, R.3
  • 37
    • 0029082950 scopus 로고
    • Antigen specificity of circulating anti-neutrophil cytoplasmic antibodies in inflammatory bowel disease
    • Kossa K, Coulthart A, Ives CT et al (1995) Antigen specificity of circulating anti-neutrophil cytoplasmic antibodies in inflammatory bowel disease. European Journal of Gastroenterology and Hepatology 7: 783-789.
    • (1995) European Journal of Gastroenterology and Hepatology , vol.7 , pp. 783-789
    • Kossa, K.1    Coulthart, A.2    Ives, C.T.3
  • 38
    • 0027521572 scopus 로고
    • IL-10 deficient mice develop chronic enteroclitis
    • Kuhn R, Lohler J, Rennick D et al (1993) IL-10 deficient mice develop chronic enteroclitis. Cell 75: 263-274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3
  • 39
    • 0023948516 scopus 로고
    • In vivo profiles of eicosanoids in ulcerative colitis, Crohn's colitis, and Clostridium difficile colitis
    • Lauritsen K, Laursen LS, Bukhave K et al (1988) In vivo profiles of eicosanoids in ulcerative colitis, Crohn's colitis, and Clostridium difficile colitis. Gastroenterology 95: 11-17.
    • (1988) Gastroenterology , vol.95 , pp. 11-17
    • Lauritsen, K.1    Laursen, L.S.2    Bukhave, K.3
  • 40
    • 0025233897 scopus 로고
    • Immunological study of histologically non-involved jejunum during Crohn's disease: Evidence for reduced in vivo secretion of secretory IgA
    • Marteau P, Colombel JF, Nemeth J et al (1990) Immunological study of histologically non-involved jejunum during Crohn's disease: evidence for reduced in vivo secretion of secretory IgA. Clinical and Experimental Immunology 80: 196-201.
    • (1990) Clinical and Experimental Immunology , vol.80 , pp. 196-201
    • Marteau, P.1    Colombel, J.F.2    Nemeth, J.3
  • 41
    • 0026590363 scopus 로고
    • Peripheral blood monocyte cytokine production and acute phase response in inflammatory bowel disease
    • Mazlam MZ & Hodgson HJF (1992) Peripheral blood monocyte cytokine production and acute phase response in inflammatory bowel disease. Gut 33: 773-778.
    • (1992) Gut , vol.33 , pp. 773-778
    • Mazlam, M.Z.1    Hodgson, H.J.F.2
  • 42
    • 0028275028 scopus 로고
    • Expression of interleukin 8 gene in inflammatory bowel disease is related to the histological grade of active inflammation
    • Mazzucchelli L, Hauser C, Zgraggen K et al (1994) Expression of interleukin 8 gene in inflammatory bowel disease is related to the histological grade of active inflammation. American Journal of Pathology 144: 997-1007.
    • (1994) American Journal of Pathology , vol.144 , pp. 997-1007
    • Mazzucchelli, L.1    Hauser, C.2    Zgraggen, K.3
  • 43
    • 0028103683 scopus 로고
    • Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives
    • Munkholm P, Langholz E, Hollander D et al (1994) Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives. Gut 35: 68-72.
    • (1994) Gut , vol.35 , pp. 68-72
    • Munkholm, P.1    Langholz, E.2    Hollander, D.3
  • 44
    • 0029744262 scopus 로고    scopus 로고
    • Involvement of interleukin 4 and -10 in inflammatory bowel disease
    • Nielsen O, Koppen T, Rudiger N et al (1996) Involvement of interleukin 4 and -10 in inflammatory bowel disease. Digestive Diseases and Science 41: 1786-1793.
    • (1996) Digestive Diseases and Science , vol.41 , pp. 1786-1793
    • Nielsen, O.1    Koppen, T.2    Rudiger, N.3
  • 45
    • 0029130042 scopus 로고
    • Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)
    • Niessner M & Volk BA (1995) Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clinical and Experimental Immunology 101: 428-435.
    • (1995) Clinical and Experimental Immunology , vol.101 , pp. 428-435
    • Niessner, M.1    Volk, B.A.2
  • 46
    • 0026605497 scopus 로고
    • Light and electron microscopic immunolocalization of endothelial leukocyte adhesion molecule-1 in inflammatory bowel disease. Morphological evidence of active synthesis and secretion into vascular endothelium
    • Ohtani H, Nakamura S, Watanabe Y et al (1992) Light and electron microscopic immunolocalization of endothelial leukocyte adhesion molecule-1 in inflammatory bowel disease. Morphological evidence of active synthesis and secretion into vascular endothelium. Virchows Archives A für Pathologie, Anatomie und Histopathologie 420: 403-409.
    • (1992) Virchows Archives A für Pathologie, Anatomie und Histopathologie , vol.420 , pp. 403-409
    • Ohtani, H.1    Nakamura, S.2    Watanabe, Y.3
  • 47
    • 0031057872 scopus 로고    scopus 로고
    • Type 1 T-helper cell predominance and interleukin 12 expression in the gut of patients with Crohn's disease
    • Parronchi P, Romagnani P, Annunziato F et al (1997) Type 1 T-helper cell predominance and interleukin 12 expression in the gut of patients with Crohn's disease. American Journal of Pathology 150: 823-832.
    • (1997) American Journal of Pathology , vol.150 , pp. 823-832
    • Parronchi, P.1    Romagnani, P.2    Annunziato, F.3
  • 48
    • 0025304016 scopus 로고
    • Cytokines and endothelial cell biology
    • Pober JS & Cotran RS (1990) Cytokines and endothelial cell biology. Physiological Reviews 70: 427-451.
    • (1990) Physiological Reviews , vol.70 , pp. 427-451
    • Pober, J.S.1    Cotran, R.S.2
  • 49
    • 0027248939 scopus 로고
    • Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody
    • Podolsky DK, Lobb R, King N et al (1993) Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody. Journal of Clinical Investigation 92: 372-380.
    • (1993) Journal of Clinical Investigation , vol.92 , pp. 372-380
    • Podolsky, D.K.1    Lobb, R.2    King, N.3
  • 50
    • 0027486839 scopus 로고
    • Trefoil peptide gene expression in small intestinal Crohn's disease and dietary adaptation
    • Poulson R, Chinery R, Sarraf C et al (1993) Trefoil peptide gene expression in small intestinal Crohn's disease and dietary adaptation. Journal of Clinical Gastroenterology 17: S78-S91.
    • (1993) Journal of Clinical Gastroenterology , vol.17
    • Poulson, R.1    Chinery, R.2    Sarraf, C.3
  • 51
    • 0028197568 scopus 로고
    • Antimycobacterial therapy in Crohn's disease: Results of a controlled, double-blind trial with a multiple antibiotic regimen
    • Prantera C, Kohn A, Mangiarotti R et al (1994) Antimycobacterial therapy in Crohn's disease: results of a controlled, double-blind trial with a multiple antibiotic regimen. American Journal of Gastroenterology 89: 513-518.
    • (1994) American Journal of Gastroenterology , vol.89 , pp. 513-518
    • Prantera, C.1    Kohn, A.2    Mangiarotti, R.3
  • 52
    • 0028306753 scopus 로고
    • Protective effect of epidermal growth factor in an experimental model of colitis in rats
    • Procaccino F, Reinshagen M, Hoffmann P et al (1994) Protective effect of epidermal growth factor in an experimental model of colitis in rats. Gastroenterology 107: 12-17.
    • (1994) Gastroenterology , vol.107 , pp. 12-17
    • Procaccino, F.1    Reinshagen, M.2    Hoffmann, P.3
  • 53
    • 0027293793 scopus 로고
    • Review article: Thromboxanes in inflammatory bowel disease - Pathogenic and therapeutic implications
    • Rampton DS & Collins CE (1993) Review article: thromboxanes in inflammatory bowel disease - pathogenic and therapeutic implications. Alimentary Pharmacology and Therapeutics 7: 357-367.
    • (1993) Alimentary Pharmacology and Therapeutics , vol.7 , pp. 357-367
    • Rampton, D.S.1    Collins, C.E.2
  • 54
    • 0026551228 scopus 로고
    • 5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease
    • Rask-Madsen J, Bukhave K, Laursen LS et al (1992) 5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease. Agents Actions 35 Special No.: C37-46.
    • (1992) Agents Actions , vol.35 , Issue.SPECIAL NO
    • Rask-Madsen, J.1    Bukhave, K.2    Laursen, L.S.3
  • 55
    • 0029889689 scopus 로고    scopus 로고
    • Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn's disease
    • Reimund JM, Wittersheim C, Dumont S et al (1996) Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn's disease. Journal of Clinical Immunology 16: 144-150.
    • (1996) Journal of Clinical Immunology , vol.16 , pp. 144-150
    • Reimund, J.M.1    Wittersheim, C.2    Dumont, S.3
  • 56
    • 0030002828 scopus 로고    scopus 로고
    • Expanded CD4+CD45RO+ phenotype and defective proliferative response in T lymphocytes from patients with Crohn's disease
    • Roman LI, Manzano L, De-La-Hera A et al (1996) Expanded CD4+CD45RO+ phenotype and defective proliferative response in T lymphocytes from patients with Crohn's disease. Gastroenterology 110: 1008-1019.
    • (1996) Gastroenterology , vol.110 , pp. 1008-1019
    • Roman, L.I.1    Manzano, L.2    De-La-Hera, A.3
  • 57
    • 0028240846 scopus 로고
    • Increased macrophage subset in inflammatory bowel disease: Apparent recruitment from peripheral blood monocytes
    • Rugtveit J, Brandtzaeg P, Halstensen TS et al (1994) Increased macrophage subset in inflammatory bowel disease: apparent recruitment from peripheral blood monocytes. Gut 35: 669-674.
    • (1994) Gut , vol.35 , pp. 669-674
    • Rugtveit, J.1    Brandtzaeg, P.2    Halstensen, T.S.3
  • 58
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack B, Merz H, Schorle H et al (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-261.
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3
  • 59
    • 0026649731 scopus 로고
    • Mycobacterium paratuberculosis DNA in Crohn's disease tissue
    • Sanderson JD, Moss MR, Tizard MLC & Hermon-Taylor J (1992) Mycobacterium paratuberculosis DNA in Crohn's disease tissue. Gut 33: 890-896.
    • (1992) Gut , vol.33 , pp. 890-896
    • Sanderson, J.D.1    Moss, M.R.2    Tizard, M.L.C.3    Hermon-Taylor, J.4
  • 60
    • 0029970133 scopus 로고    scopus 로고
    • Clinical patterns of familial inflammatory bowel disease
    • Satsangi J, Grootscholten C, Holt H et al (1996a) Clinical patterns of familial inflammatory bowel disease. Gut 38: 738-741.
    • (1996) Gut , vol.38 , pp. 738-741
    • Satsangi, J.1    Grootscholten, C.2    Holt, H.3
  • 61
    • 16044373177 scopus 로고    scopus 로고
    • Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12
    • Satsangi J, Parkes M, Louis E et al (1996b) Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nature Genetics 14: 199-202.
    • (1996) Nature Genetics , vol.14 , pp. 199-202
    • Satsangi, J.1    Parkes, M.2    Louis, E.3
  • 62
    • 0030007093 scopus 로고    scopus 로고
    • Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease
    • Satsangi J, Welsh KL, Bunce M et al (1996c) Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease. Lancet 347: 1212-1217.
    • (1996) Lancet , vol.347 , pp. 1212-1217
    • Satsangi, J.1    Welsh, K.L.2    Bunce, M.3
  • 63
    • 0022621499 scopus 로고
    • Indium-111-granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease. A comparison with colonoscopy, histology, and faecal indium 111-granulocyte excretion
    • Saverymuttu SH, Camilleri M, Rees H et al (1986) Indium-111-granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease. A comparison with colonoscopy, histology, and faecal indium 111-granulocyte excretion. Gastroenterology 90: 1121-1128.
    • (1986) Gastroenterology , vol.90 , pp. 1121-1128
    • Saverymuttu, S.H.1    Camilleri, M.2    Rees, H.3
  • 64
    • 0027992920 scopus 로고
    • Platelets in ulcerative colitis and Crohn's disease express functional interleukin-1 and interleukin-8 receptors
    • Schaufelberger HD, Uhr MR, McGuckin C et al (1994) Platelets in ulcerative colitis and Crohn's disease express functional interleukin-1 and interleukin-8 receptors. European Journal of Clinical Investigation 24: 656-663.
    • (1994) European Journal of Clinical Investigation , vol.24 , pp. 656-663
    • Schaufelberger, H.D.1    Uhr, M.R.2    McGuckin, C.3
  • 65
    • 0024562760 scopus 로고
    • Anti-neutrophil nuclear antibody in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis
    • Snook JA, Chapman RW, Fleming K et al (1989) Anti-neutrophil nuclear antibody in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis. Clinical and Experimental Immunology 76: 30-33.
    • (1989) Clinical and Experimental Immunology , vol.76 , pp. 30-33
    • Snook, J.A.1    Chapman, R.W.2    Fleming, K.3
  • 66
    • 0026663420 scopus 로고
    • Lysozyme gene expression in inflammatory bowel disease
    • Stamp GW, Poulsom R, Chung LP et al (1992) Lysozyme gene expression in inflammatory bowel disease. Gastroenterology 103: 532-538.
    • (1992) Gastroenterology , vol.103 , pp. 532-538
    • Stamp, G.W.1    Poulsom, R.2    Chung, L.P.3
  • 67
    • 0027422089 scopus 로고
    • Chronic intestinal inflammation: An unexpected outcome in cytokine or T cell receptor mutant mice
    • Strober W & Erhardt RD (1993) Chronic intestinal inflammation: an unexpected outcome in cytokine or T cell receptor mutant mice. Cell 75: 230-235.
    • (1993) Cell , vol.75 , pp. 230-235
    • Strober, W.1    Erhardt, R.D.2
  • 68
    • 0031080948 scopus 로고    scopus 로고
    • Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation
    • Strober W, Kelsall B, Fuss I et al (1997) Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation. Immunology Today 18: 61-64.
    • (1997) Immunology Today , vol.18 , pp. 61-64
    • Strober, W.1    Kelsall, B.2    Fuss, I.3
  • 69
    • 0023713859 scopus 로고
    • Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking
    • Tysk C, Lindberg E, Jarnerot G et al (1988) Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 29: 990-996.
    • (1988) Gut , vol.29 , pp. 990-996
    • Tysk, C.1    Lindberg, E.2    Jarnerot, G.3
  • 70
    • 0023839955 scopus 로고
    • Diminished neutrophil function in Crohn's disease and ulcerative colitis identified by decreased oxidative metabolism and low superoxide dismutase content
    • Verspaget HW, Pena AS, Weterman IT et al (1988) Diminished neutrophil function in Crohn's disease and ulcerative colitis identified by decreased oxidative metabolism and low superoxide dismutase content. Gut 29: 223-228.
    • (1988) Gut , vol.29 , pp. 223-228
    • Verspaget, H.W.1    Pena, A.S.2    Weterman, I.T.3
  • 72
    • 0028968488 scopus 로고
    • Crohn's disease: Pathogenesis and persistent measles virus infection
    • Wakefield AJ, Ekbom A, Dhillon AP et al (1995) Crohn's disease: pathogenesis and persistent measles virus infection. Gastroenterology 108: 911-916.
    • (1995) Gastroenterology , vol.108 , pp. 911-916
    • Wakefield, A.J.1    Ekbom, A.2    Dhillon, A.P.3
  • 73
    • 0031048321 scopus 로고    scopus 로고
    • In situ immune responses in Crohn's disease: A comparison with acute and persistent measles virus infection
    • Wakefield AJ, Sim R, Akbar AN et al (1997) In situ immune responses in Crohn's disease: a comparison with acute and persistent measles virus infection. Journal of Medical Virology 41: 90-100.
    • (1997) Journal of Medical Virology , vol.41 , pp. 90-100
    • Wakefield, A.J.1    Sim, R.2    Akbar, A.N.3
  • 74
    • 0343504560 scopus 로고
    • Interleukin 10 inhibits inflammatory mediator production in ulcerative colitis
    • Wardle TD (1994) Interleukin 10 inhibits inflammatory mediator production in ulcerative colitis. Gut 35: S48.
    • (1994) Gut , vol.35
    • Wardle, T.D.1
  • 75
    • 0027409322 scopus 로고
    • Localisation of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells
    • Youngman KR, Simon PL, West GA et al (1993) Localisation of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells. Gastroenterology 104: 749-758.
    • (1993) Gastroenterology , vol.104 , pp. 749-758
    • Youngman, K.R.1    Simon, P.L.2    West, G.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.