Mitochondria as a critical target for toxicity

In Vitro and Molecular Toxicology: Journal of Basic and Applied Research

Volumn 11, Issue 1, 1998, Pages 73-81

  Sweet, Susan ^a   Duivenvoorden, Wilhelmina ^a   Singh, Gurmit ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b JURAVINSKI CANCER CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATION; OXIDIZING AGENT;

APOPTOSIS; BIOENERGY; CALCIUM CELL LEVEL; CELL DEATH; CELL DIVISION; CELL GROWTH; CELL PH; CONFERENCE PAPER; CYTOTOXICITY; GENETIC RECOMBINATION; HOMEOSTASIS; LIPOPHILICITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; OSMOSIS; OXIDATION REDUCTION STATE;

EID: 0031857984     PISSN: 10979336     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (55)

1. ADAMS, K., and SINGH, G. (1998). Photodynamic therapy induces expression of the mitochondrial heat shock protein (Hsp60) in a photofin-induced photodynamic therapy resistant cell variant. Proceedings of the Eighty-ninth Annual Meeting of the American Association for Cancer Research, Vol. 39.
2. ALLEN, J.A., and COOMBS, M.M. (1980). Covalent binding of polycyclic aromatic compounds to mitochondrial and nuclear DNA. Nature 287, 244-245.
3. AGARWAL, R.P., and OLIVERO, O.A. (1997). Genotoxicity and mitochondrial damage in human lymphocytic cells chemically exposed to 3′-azido-2′,3′-dideoxythymidine. Mutation Res 390, 223-231.
4. ANDERSON, S., BANKLER, A.T., and BAREK, B.G. (1981). Sequence and organization of the human mitochndrial genome. Nature 290, 457-465.
5. ANDREWS, P.A., and ALBRIGHT, K.D. (1992). Mitochondrial defects in . cis-diamminedichlorplatinum(II)-resistant human ovarian carcinoma cells. Cancer Res 52, 1895-1901.
6. BALANSKY, R., IZZOTI, A., SCATOLINI, L., D'AGOSTINI, F., and DEFLORA, S. (1996). Induction of carcinogens and chemoprevention by N-Acetyl-cysteine of adducts to mitochondrial DNA in rat organs. Cancer Res. 56, 1642-1647.
7. BEREITER-HAHN, J. (1990). Behaviour of Mitochondria in the Living Cell. Intl. Rev. Cytol. 122, 1-63.
8. BERNS, M.W., DAHLMAN, A., JOHNSON, F.M., BURNS, R., and WILE, A. (1982). In vitro cellular effect of hematoporphyrin derivative. Cancer Res. 42, 2325-2329.
9. BOEGHEIM, J.P.J., LAGERBERG, J.W.M., DUBBELMAN, T.M., TUSSEN, K., and VAN STEVENINCK, J. (1988). Photodynamic effects of hematoporphyrinderivative on the uptake of Rhodamine 123 by mitochondria of intact murine L929 fibroblasts and chinese hamster ovary K1 cells. Photochem. Photobiol. 48, 613-620.
10. BRAGADIN, M., and DELL'ANTONE, P. (1996). Mitochondrial bioenergetics as affected by cationic detergents. Arch. Environ. Contain. Toxicol. 30, 280-284.
11. CHEN, L.B. (1989). Fluorescent labelling of mitochondria. Methods Cell Biol. 29, 103-123.
12. DRIGGERS, W.J., GRISHKO, V.I., LEDOUX, S.P., and WILSON, G.L. (1996). Defective repair of oxidative damage in the mitochondrial DNA of a Xeroderma Pigmentosum Group A cell line. Cancer Res. 56, 1262-1266.
13. GAVISH, M., KATZ, Y., BAR-AMI, S., and WEIZMAN, R. (1992). Biochemical, physiological and pathological aspects of the peripheral benzodiazepine receptor. J. Neurochem. 58, 1589-1601.
14. GERBITZ, K.D. (1992). Does the mitochondrial DNA play a role in the pathogenesis of diabetes? Diabetol. 35, 1181-1186.
15. GETHING, M.J., and SAMBROOK, J. (1992). Protein folding in the cell. Nature, 355, 33-45.
16. GRIVELL, L.A. (1995). Nucleo-mitochondrial interactions in mitochondrial gene expression. Crit. Rev. Biochem. Mol. Biol. 30, 121-164.
17. HAYASHI, J.I., OHTA, S., KIKUCHI, A., TAKEMITSU, M., GOTO, Y., and NONAKA, I. (1991). Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction. Proc. Natl. Acad. Sci. USA 88, 10614-10618.
18. HILF, R. GIBSON, S.L., PENNEY, D.P., CECKLER, T.L., and BRYANT, R.S. (1987). Early biochemical responses to photodynamic therapy monitored by NMR spectroscopy. Photochem. Photobiol. 46, 809-817.
19. HONKOOP, P., SCHOLTE, H.R., DEMAN, R.A., and SCHALM, S.W. (1997). Mitochondrial injury: Lessons from the fialuridine trial. Drug Safety 17, 1-7.
20. ITOH, H., KOBAYASHI, R., WAKUI, H., KOMATSUDA, A., and TASHIMA, Y. (1995). Mammalian 60-kDa stress protein (chaperonin homolog). J. Biol. Chem. 270, 13429-13435.
21. JENUTH, J.P., PETERSON, A.C., FU, K., and SHOUBRIDGE, E.A. (1996). Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA. Nature Genet. 14, 146-151.
22. JOHNSON, L.V., WALSH, M.L., and CHEN, L.B. (1980). Localization of mitochondria in living cells with Rhodamine 123. Proc. Natl. Acad. Sci. USA 77, 990-994.
23. KERR, D.S. (1997). Protean manifestations of mitochondrial diseases: a minireview. J. Ped. Hematol./Oncol. 19, 279-286.
24. KLUCK, K.M., BOSSY-WETZEL, E., GREEN, D.R., and NEWMEYER, D.D. (1997). The release of cytochrome c from mitochondria: A primary site for bcl-2 regulation of apoptosis. Science 275, 1132-1136.
25. KROEMER, G., ZAMZAMI, N., and SUSIN, S.A. (1997). Mitochondrial control of apoptosis. Immunol. Today 18, 44-51.
26. LAMPIDIS, T.J., BERNAL, S.D., SUMMERHAYES, I.C., and CHEN, L.B. (1983). Selective toxicity of Rhodamine 123 in carcinoma cells in vitro. Cancer Res. 43, 716-720.
27. LIU, X., KIM, C.N., YANG, J., JEMMERSON, R., and WANG, X. (1996). Induction of apoptotic program in cell-free extracts: Requirement for dADP and cytochrome c. Cell 86, 147-157.
28. MCENERY, M.W., SNOWMAN, A.M., TRIFILETTI, R.R., and SNYDER, S.H. (1992). Isolation of the mitochondrial benzodiazapine receptor: Association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc. Natl. Acad. Sci. USA 89, 3170-3174.
29. MODICA-NAPOLITANO, J.S., KOYA, K., WEISBERG, E., BRUNELLI, B., YANG, L., and CHEN, L.B. (1996). Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077. Cancer Res. 56, 544-550.
30. MURPHY, M.P. (1997). Selective targeting of bioactive compounds to mitochondria. Trends Biotech. 15, 326-330.
31. PEDERSEN, P.L. (1994). The machine that makes ATP. Current Biology 4, 1138-1141.
32. PETIT, J.M., DENIS-GAY, M., and RATINAUD, M.H. (1993). Assessment of fluorochromes for cellular structure and function studies by flow cytometry. Biol. Cell 78, 1-13.
33. PETIT, P.X., ZAMZAMI, N., VAYSSIERE, J.L., MIGNOTTE, B., KROEMER, G., and CASTEDO, M. (1997). Implication of mitochondria in apoptosis. Mol. Cell. Biochem. 174, 185-188.
34. PETRONILLI, V., SZABO, I., and ZORATTI, M. (1989). The inner mitochondrial membrane contains ion-conducting channels similar to those found in bacteria. FEBS Letters 259, 137-143.
35. POLYAK, K., XIA, Y., ZWELER, J.L., KINZLER, K.W., and VOGELSTEIN, B. (1997). A model for p53-induced apoptosis. Nature 389, 300-305.
36. REED, J.C. (1994). Bcl-2 and the regulation of programmed cell death. J. Cell Biol. 124, 1-6.
37. ROSTOVTSEVA, T., and COLOMBINI, M. (1996). ATP flux is controlled by a voltage-gated channel from the mitochondrial outer membrane. J. Biol. Chem. 271, 28006-28008.
38. SENIOR, A.E. (1988). ATP synthesis by oxidative phosphorylation. Physiol. Rev. 68, 177-231.
39. SHAW, T., and SINGH, G. (1998). Mitochondrial impairment in peripheral benzodiazepine receptor ligand antiproliferative activity (submitted for publication).
40. SINGH, B., PATEL, H.V., RIDLEY, R.G., FREEMAN, K.B., and GUPTA, R.S. (1990). Mitochondrial import of the human chaperonin (hsp60) protein. Biochem. Biophy. Res. Commun. 169, 371-396.
41. SINGH, G., HAUSWIRTH, W.H., ROSS, W.E., and NEIMS, A.H. (1985). A method for assessing damage to mitochondrial DNA caused by radiation and epichlorohydrin. Mol. Pharmacol. 27, 167-170.
42. SINGH, G. (1989). A possible cellular mechanism of cisplatin-induced nephrotoxicity. Toxicol. 58, 71-80.
43. SINGH, G., SHARKEY, S.M., and MOOREHEAD, R. (1992). Mitochondrial DNA damage by anticancer agents. Pharmacol. Therapy 54, 217-230.
44. SINGH, G., and MANICCIA-BOZZO, E. (1990). Evidence for lack of mitochondrial DNA repair following cis-dichlorodiammineplatinum treatement. Cancer Chemother. Pharmacol. 26, 97-100.
45. SINGH, G., and MOOREHEAD, R. (1992). Mitochondria as a target for cancer chemotherapy. Intl. J. Oncol. 1, 825-829.
46. SOLTYS, B.J., and GUPTA, R.S. (1996). Immunoelectron microscopic localization of the 60-kDa heat shock chaperonin protein (hsp60) in mammalian cells. Exp. Cell Res. 222, 16-27.
47. SWEET, S., and SINGH, G. (1995). Accumulation of human promyelocytic (HL-60) cells at two energetic cell cycle checkpoins. Cancer Res. 55, 5164-5167.
48. SWEET, S., and SINGH, G. (1998). Changes in mitochondrial mass, membrane potential and cellular ATP levels during the cell cycle (submitted for publication).
49. WANG, J.K.T., MORGAN, J.I., and SPECTOR, S. (1984). Benzodiazepines that bind at peripheral sites inhibit cell proliferation. Proc. Natl. Acad. Sci. USA 81, 753-756.
50. WEISBERG, E.L., KOYA, K., MODICA-NAPOLITANO, J., LI, Y., and CHEN, L.B. (1996). In vivo administration of MKT-077 causes partial yet reversible impairment of mitochondrial function. Cancer Res. 56, 551-555.
51. YAKES, F.M., and VANHOUTEN, B. (1997). Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc. Natl. Acad. Sci. USA, 94, 514-519.
52. YANG, J., LIU, X., BHALLA, K., et al. (1997). Prevention of apoptosis by bcl-2: Release of cytochrome c from mitochondria blocked. Science 275, 1129-1132.
53. ZAMZAMI, N., MARCHETTI, P., CASTEDO, M., et al. (1995). Reduction in mitochondrial potential constitutes and early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med. 181, 1661-1672.
54. ZINKEWICH-PEOTTI, K., and ANDREWS, P.A. (1992). Loss of cis-diammindichloroplatinum (II) resistance in human ovarian carcinoma cells selected for rhodamine 123 resistance. Cancer Res. 52, 1902-1906.
55. ZORATTI, M., and SZABO, I. (1995). The mitochondrial permeability transition. Biochim. Biophys. Acta. 1241, 139-176.