메뉴 건너뛰기




Volumn 9, Issue 6, 1998, Pages 589-600

Malignant glioma: Should chemotherapy be overthrown by experimental treatments?

Author keywords

Brain neoplasms; Chemotherapy; Gene therapy; Gtioma; Immunotherapy; Review literature

Indexed keywords

ANGIOSTAT; CARBOPLATIN; CARMUSTINE; CHLORMETHINE; DACARBAZINE; ETOPOSIDE; FLUOROURACIL; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYDROXYUREA; IFOSFAMIDE; LOMUSTINE; METALLOPROTEINASE INHIBITOR; METHOTREXATE; MITOLACTOL; PACLITAXEL; PREDNISONE; PROCARBAZINE; TEMOZOLOMIDE; THIOTEPA; THROMBOCYTE FACTOR 4; THROMBOSPONDIN 1; TIOGUANINE; VINCRISTINE;

EID: 0031852664     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008267312782     Document Type: Review
Times cited : (73)

References (106)
  • 1
    • 0023835686 scopus 로고
    • The prognostic importance of tumor size in malignant gliomas: A computed tomographic scan study by the brain tumor cooperative group
    • Wood JR, Green SB, Shapiro WR. The prognostic importance of tumor size in malignant gliomas: A computed tomographic scan study by the brain tumor cooperative group. J Clin Oncol 1988; 6: 338-43.
    • (1988) J Clin Oncol , vol.6 , pp. 338-343
    • Wood, J.R.1    Green, S.B.2    Shapiro, W.R.3
  • 2
    • 0003043605 scopus 로고
    • Cancer, Principles and Practice of Oncology
    • De Vita VT Jr. Hellman S. Rosenberg SA (eds): Philadelphia: JB Lippincot
    • Levin VA, Gutin PH, Leibel S, Cancer, Principles and Practice of Oncology. In De Vita VT Jr. Hellman S. Rosenberg SA (eds): Neoplasms of the Central Nervous System. Philadelphia: JB Lippincot 1993; 1679-737.
    • (1993) Neoplasms of the Central Nervous System , pp. 1679-1737
    • Levin, V.A.1    Gutin, P.H.2    Leibel, S.3
  • 3
    • 0018848780 scopus 로고
    • Assumptions in the radiotherapy of glioblastoma
    • Hochberg FH, Pruitt A. Assumptions in the radiotherapy of glioblastoma. Neurology 1980; 30: 907-11.
    • (1980) Neurology , vol.30 , pp. 907-911
    • Hochberg, F.H.1    Pruitt, A.2
  • 4
    • 0018568970 scopus 로고
    • An analysis of dose-effect relationship in the radiotherapy of malignant gliomas
    • Walker MD, Strike TA, Sheline GE. An analysis of dose-effect relationship in the radiotherapy of malignant gliomas. Int J Radial Oncol Biol Phys 1979; 5: 1725-31.
    • (1979) Int J Radial Oncol Biol Phys , vol.5 , pp. 1725-1731
    • Walker, M.D.1    Strike, T.A.2    Sheline, G.E.3
  • 5
    • 0019142613 scopus 로고
    • Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery
    • Walker MD, Green SB., Byar DP. Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 1980; 303: 1323-9.
    • (1980) N Engl J Med , vol.303 , pp. 1323-1329
    • Walker, M.D.1    Green, S.B.2    Byar, D.P.3
  • 6
    • 0028353403 scopus 로고
    • The chemotherapy of high-grade astrocytomas
    • Lesser GJ, Grossman S. The chemotherapy of high-grade astrocytomas. Semin Oncol 1994; 21: 220-35.
    • (1994) Semin Oncol , vol.21 , pp. 220-235
    • Lesser, G.J.1    Grossman, S.2
  • 7
    • 0013682207 scopus 로고    scopus 로고
    • Concepts in Neurosurgery: The molecular basis of neurosurgical disease
    • Raffel C. Harsh IV GR (eds): Baltimore: Williams and Wilkins Chapter 12
    • Petersdorf SH, Berger MS. Concepts in Neurosurgery: The molecular basis of neurosurgical disease. In Raffel C. Harsh IV GR (eds): Molecular Basis of Chemotherapy for Brain Tumors. Baltimore: Williams and Wilkins 1996; Chapter 12 (Vol 8): 198-210.
    • (1996) Molecular Basis of Chemotherapy for Brain Tumors , vol.8 , pp. 198-210
    • Petersdorf, S.H.1    Berger, M.S.2
  • 8
    • 0023108382 scopus 로고
    • Astrocytes induce blood brain barrier properties in endothelial cells
    • Janzer RC, Raff MC. Astrocytes induce blood brain barrier properties in endothelial cells. Nature 1987; 325: 253-7.
    • (1987) Nature , vol.325 , pp. 253-257
    • Janzer, R.C.1    Raff, M.C.2
  • 9
    • 0029582767 scopus 로고
    • Distribution of drugs following controlled delivery to the brain interstitium
    • Mak M, Fung L. Strasser JF et al. Distribution of drugs following controlled delivery to the brain interstitium. J Neurooncol 1995; 26: 91-102.
    • (1995) J Neurooncol , vol.26 , pp. 91-102
    • Mak, M.1    Fung, L.2    Strasser, J.F.3
  • 10
    • 0015623214 scopus 로고
    • Initial clinical trials with merhyl-CCNU 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-I-nitrosourea (MeCCNU)
    • Young RC. Walker MD, Canellos GP. Initial clinical trials with merhyl-CCNU 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-I-nitrosourea (MeCCNU). Cancer 1973; 31: 1164-9.
    • (1973) Cancer , vol.31 , pp. 1164-1169
    • Young, R.C.1    Walker, M.D.2    Canellos, G.P.3
  • 11
    • 0345204493 scopus 로고
    • Phase II study of CCNU in the treatment of brain tumors
    • Fewer D.Wilson CB. Boldrey EB. Phase II study of CCNU in the treatment of brain tumors. Cancer Chem Rep 1972; 56: 421-7.
    • (1972) Cancer Chem Rep , vol.56 , pp. 421-427
    • Fewer, D.1    Wilson, C.B.2    Boldrey, E.B.3
  • 12
    • 0015644651 scopus 로고
    • CCNU in the treatment of cancer: A phase II study
    • Hoogstraten B, Gottlieb JA, Caoili A. CCNU in the treatment of cancer: A phase II study. Cancer 1973; 32: 38-43.
    • (1973) Cancer , vol.32 , pp. 38-43
    • Hoogstraten, B.1    Gottlieb, J.A.2    Caoili, A.3
  • 13
    • 0027516695 scopus 로고
    • Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults
    • Fine HA, Dear KBG, Loeffler JS. Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 1993; 71 (8): 2585-97.
    • (1993) Cancer , vol.71 , Issue.8 , pp. 2585-2597
    • Fine, H.A.1    Dear, K.B.G.2    Loeffler, J.S.3
  • 14
    • 0014388644 scopus 로고
    • Clinical experience with vincristine in tumors of the central nervous system and other malignant diseases
    • Smart CR, Ottomoan RE, Rochlin DB. Clinical experience with vincristine in tumors of the central nervous system and other malignant diseases. Cancer Chem Rep 1968; 52: 733-41.
    • (1968) Cancer Chem Rep , vol.52 , pp. 733-741
    • Smart, C.R.1    Ottomoan, R.E.2    Rochlin, D.B.3
  • 16
    • 0030013676 scopus 로고    scopus 로고
    • Chemotherapy for malignant gliomas. In Cerebral Gliomas
    • Forsyth PA, Cairncross JG. Chemotherapy for malignant gliomas. In Cerebral Gliomas. Baillière's Clin Neurol 1996; 5 (2): 371-93.
    • (1996) Baillière's Clin Neurol , vol.5 , Issue.2 , pp. 371-393
    • Forsyth, P.A.1    Cairncross, J.G.2
  • 17
    • 0024818478 scopus 로고
    • Reevaluation of procarbazine for the treatment of recurrent malignant central nervous system tumors
    • Rodriguez LA, Prados M, Silver P. Reevaluation of procarbazine for the treatment of recurrent malignant central nervous system tumors. Cancer 1989; 64: 2420-3.
    • (1989) Cancer , vol.64 , pp. 2420-2423
    • Rodriguez, L.A.1    Prados, M.2    Silver, P.3
  • 18
    • 0025135063 scopus 로고
    • Procarbazine chemotherapy in the treatment of recurrent malignant astrocytomas after radiation and nitrosourea failure
    • Newton HB, Junck L, Bromberg J. Procarbazine chemotherapy in the treatment of recurrent malignant astrocytomas after radiation and nitrosourea failure. Neurology 1990; 40: 1743-6.
    • (1990) Neurology , vol.40 , pp. 1743-1746
    • Newton, H.B.1    Junck, L.2    Bromberg, J.3
  • 19
    • 0003222659 scopus 로고    scopus 로고
    • Modulation of resistance to BCNU by depleting MGMT activity with procarbazine in patients with relapsed high-grade gliomas
    • Abstr 1375
    • Cook J, Robinson B, Levi J. Modulation of resistance to BCNU by depleting MGMT activity with procarbazine in patients with relapsed high-grade gliomas. Proc Am Soc Clin Oncol 1997; 16 (Abstr 1375).
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Cook, J.1    Robinson, B.2    Levi, J.3
  • 20
  • 21
    • 0029166912 scopus 로고
    • Salvage chemotherapy with paclitaxel for recurrent primary brain tumors
    • Chamberlain MC, Kormanik P. Salvage chemotherapy with paclitaxel for recurrent primary brain tumors. J Clin Oncol 1995; 13 (8): 2066-71.
    • (1995) J Clin Oncol , vol.13 , Issue.8 , pp. 2066-2071
    • Chamberlain, M.C.1    Kormanik, P.2
  • 22
    • 9444291844 scopus 로고    scopus 로고
    • Phase II study of paclitaxel in patients with recurrent malignant glioma
    • Prados MD, Schold SC. Spence AM et al. Phase II study of paclitaxel in patients with recurrent malignant glioma. J Clin Oncol 1996: 14(8): 2316-21.
    • (1996) J Clin Oncol , vol.14 , Issue.8 , pp. 2316-2321
    • Prados, M.D.1    Schold, S.C.2    Spence, A.M.3
  • 23
    • 0026513077 scopus 로고
    • Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)
    • Newlands ES, Blackledge GRP, Slack JA et al. Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856). Br J Cancer 1992; 65: 287-91.
    • (1992) Br J Cancer , vol.65 , pp. 287-291
    • Newlands, E.S.1    Blackledge, G.R.P.2    Slack, J.A.3
  • 24
    • 0030449301 scopus 로고    scopus 로고
    • The Charing Cross Hospital experience with Temozolomide in patients with gliomas
    • Newlands ES. O'Reilly SM, Glaser MG. The Charing Cross Hospital experience with Temozolomide in patients with gliomas. Eur J Cancer 1996; 32A (13): 2236-41.
    • (1996) Eur J Cancer , vol.32 A , Issue.13 , pp. 2236-2241
    • Newlands, E.S.1    O'Reilly, S.M.2    Glaser, M.G.3
  • 25
    • 0006189851 scopus 로고    scopus 로고
    • Phase II study of Temodal (temozolomide) at first relapse in anaplastic astrocytoma (AA) patients
    • Abstr 1370
    • Levin V, Yung A, Prados M. Phase II study of Temodal (temozolomide) at first relapse in anaplastic astrocytoma (AA) patients. Proc Am Soc Clin Oncol 1997; 16 (Abstr 1370).
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Levin, V.1    Yung, A.2    Prados, M.3
  • 26
    • 0018859770 scopus 로고
    • Modified procarbazine. CCNU and vincristine (PCV3) combination chemotherapy in the treatment of malignant brain tumors
    • Levin VA, Edwards MS, Wright DC. Modified procarbazine. CCNU and vincristine (PCV3) combination chemotherapy in the treatment of malignant brain tumors. Cancer Treat Rep 1980; 64 (2-3): 237-41.
    • (1980) Cancer Treat Rep , vol.64 , Issue.2-3 , pp. 237-241
    • Levin, V.A.1    Edwards, M.S.2    Wright, D.C.3
  • 27
    • 0021368124 scopus 로고
    • Combination chemotherapy with vincristine (NSC 67574). procarbazine (NSC 77213). prednisone (NSC 10023) with or without nitrogen mustard (NSC 762) (MOPP vs OPP) in children with recurrent brain tumors
    • Cangir A, Ragub A, Steuber P. Combination chemotherapy with vincristine (NSC 67574). procarbazine (NSC 77213). prednisone (NSC 10023) with or without nitrogen mustard (NSC 762) (MOPP vs OPP) in children with recurrent brain tumors. Med Pediatr Oncol 1984; 12: 1-3.
    • (1984) Med Pediatr Oncol , vol.12 , pp. 1-3
    • Cangir, A.1    Ragub, A.2    Steuber, P.3
  • 28
    • 0023762658 scopus 로고
    • Salvage chemotherapy fro recurrent primary brain tumors in children
    • Van Eyse J, Baram T, Cangir A et al. Salvage chemotherapy fro recurrent primary brain tumors in children. J Pediatr 1988; 113. 601-6.
    • (1988) J Pediatr , vol.113 , pp. 601-606
    • Van Eyse, J.1    Baram, T.2    Cangir, A.3
  • 29
    • 0025608728 scopus 로고
    • Mechlorethamine, vineristine and procarbazine chemotherapy for recurent high-grade glioma in adults: A phase II study
    • Coyle T, Baptista J, Winfield J. Mechlorethamine, vineristine and procarbazine chemotherapy for recurent high-grade glioma in adults: A phase II study. J Clin Oncol 1990; 8 (12): 2014-8.
    • (1990) J Clin Oncol , vol.8 , Issue.12 , pp. 2014-2018
    • Coyle, T.1    Baptista, J.2    Winfield, J.3
  • 30
    • 0025312332 scopus 로고
    • Treatment of patients with recurrent gliomas with cyclophosphamide and vincristine
    • Longee DC, Friedman HS, Albright RE. Treatment of patients with recurrent gliomas with cyclophosphamide and vincristine. J Neurosurg 1990; 72: 583-8.
    • (1990) J Neurosurg , vol.72 , pp. 583-588
    • Longee, D.C.1    Friedman, H.S.2    Albright, R.E.3
  • 31
    • 0030445597 scopus 로고    scopus 로고
    • Treatment of recurrent malignant supralentorial gliomas with ifosfamide, carboplatin. and etoposide: A phase II study
    • Sanson M, Ameri A, Monjour A et al. Treatment of recurrent malignant supralentorial gliomas with ifosfamide, carboplatin. and etoposide: A phase II study. Eur J Cancer 1996; 32A: 2229-35.
    • (1996) Eur J Cancer , vol.32 A , pp. 2229-2235
    • Sanson, M.1    Ameri, A.2    Monjour, A.3
  • 32
    • 0026695162 scopus 로고
    • Treatment of recurrent gliomas and metastatic brain tumors with a polydrug protocol designed to combat nitrosourea resistance
    • Levin VA, Prados MD. Treatment of recurrent gliomas and metastatic brain tumors with a polydrug protocol designed to combat nitrosourea resistance. J Clin Oncol 1992; 10 (5): 766-71.
    • (1992) J Clin Oncol , vol.10 , Issue.5 , pp. 766-771
    • Levin, V.A.1    Prados, M.D.2
  • 33
    • 0028150911 scopus 로고
    • Survival in patients with recurrent glioma as a mesure of treatment efficacy: Prognostic factors following nitosourea chemotherapy
    • Rujan B, Ross G, Lim CC. Survival in patients with recurrent glioma as a mesure of treatment efficacy: Prognostic factors following nitosourea chemotherapy. Eur J Cancer 1994; 30A: 1809-15.
    • (1994) Eur J Cancer , vol.30 A , pp. 1809-1815
    • Rujan, B.1    Ross, G.2    Lim, C.C.3
  • 34
    • 0028107037 scopus 로고
    • Adjuvant therapy with dibromodulcitol and BCNU increases survival of adults with malignant gliomas
    • Hildebrand J, Sahmoud T, Mignolet F. Adjuvant therapy with dibromodulcitol and BCNU increases survival of adults with malignant gliomas. Neurology 1994; 44: 1479-83.
    • (1994) Neurology , vol.44 , pp. 1479-1483
    • Hildebrand, J.1    Sahmoud, T.2    Mignolet, F.3
  • 35
    • 0025239917 scopus 로고
    • Superiority of post-radiotherapy adjuvant chemotherapy with CCNU. procarbazine and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report
    • Levin VA, Silver PBA, Hannigan JMS. Superiority of post-radiotherapy adjuvant chemotherapy with CCNU. procarbazine and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report. Int J Radiat Oncol Biol Phys 1990: 18: 321-4.
    • (1990) Int J Radiat Oncol Biol Phys , vol.18 , pp. 321-324
    • Levin, V.A.1    Silver, P.B.A.2    Hannigan, J.M.S.3
  • 36
    • 4243969692 scopus 로고
    • Adjuvant chemotherapy for malignant glioma: An analysis of methodology and outcome data from clinical trials
    • Abstr 810S
    • Perry JR. Adjuvant chemotherapy for malignant glioma: An analysis of methodology and outcome data from clinical trials. Neurology 1995: 45 (Suppl 4): 386 (Abstr 810S).
    • (1995) Neurology , vol.45 , Issue.4 SUPPL. , pp. 386
    • Perry, J.R.1
  • 37
    • 0027302507 scopus 로고
    • Oligodendroglioma.The Princess Margaret Hospital experience (1958 1984)
    • NijjarTS, Simpson WJ. Gadalla Tet al. Oligodendroglioma.The Princess Margaret Hospital experience (1958 1984). Cancer 1993; 71 (12): 4002-6.
    • (1993) Cancer , vol.71 , Issue.12 , pp. 4002-4006
    • Nijjar, T.S.1    Simpson, W.J.2    Gadalla, T.3
  • 38
    • 0029397626 scopus 로고
    • Molecular pathways in the formation of gliomas
    • Von Deimling A, Louis DN, Wiestler OD. Molecular pathways in the formation of gliomas. Glia 1995; 15: 328-38.
    • (1995) Glia , vol.15 , pp. 328-338
    • Von Deimling, A.1    Louis, D.N.2    Wiestler, O.D.3
  • 39
    • 0027972896 scopus 로고
    • Chemotherapy for anaplastic oligodendroglioma
    • Cairncross G, Macdonald D, Ludwin S. Chemotherapy for anaplastic oligodendroglioma. J Clin Oncol 1994; 12 (10): 2013-21.
    • (1994) J Clin Oncol , vol.12 , Issue.10 , pp. 2013-2021
    • Cairncross, G.1    Macdonald, D.2    Ludwin, S.3
  • 40
    • 0008319363 scopus 로고    scopus 로고
    • High-dose thiotepa with hematopoietic reconstitution (deferring radiation) for newly diagnosed aggressive oligodendroglioma
    • Abstr 1386
    • Cairncross G, Swinnen L, Stiff P. High-dose thiotepa with hematopoietic reconstitution (deferring radiation) for newly diagnosed aggressive oligodendroglioma. Proc Am Soc Clin Oncol 1997; 16 (Abstr 1386).
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Cairncross, G.1    Swinnen, L.2    Stiff, P.3
  • 41
    • 0027523539 scopus 로고
    • The treatment of anaplastic oligodendrogliomas and mixed gliomas
    • Kyritsis AP, Yung WKA, Bruner J et al. The treatment of anaplastic oligodendrogliomas and mixed gliomas. Neurosurgery 1993; 32:365-71.
    • (1993) Neurosurgery , vol.32 , pp. 365-371
    • Kyritsis, A.P.1    Yung, W.K.A.2    Bruner, J.3
  • 43
    • 0026100939 scopus 로고
    • Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas
    • Brem H, Mahaley Ms, Vick NA. Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas. J Neurosurg 1991; 74: 441-6.
    • (1991) J Neurosurg , vol.74 , pp. 441-446
    • Brem, H.1    Mahaley, Ms.2    Vick, N.A.3
  • 44
    • 0028917333 scopus 로고
    • Placebo controlled trial of safety and efficacy of intraoperative controlled delivery by bio-degradable polymers of chemotherapy for recurrent gliomas
    • Brem H, Piantadosi S, Burger PC. Placebo controlled trial of safety and efficacy of intraoperative controlled delivery by bio-degradable polymers of chemotherapy for recurrent gliomas. Lancet 1995; 345: 1008-12.
    • (1995) Lancet , vol.345 , pp. 1008-1012
    • Brem, H.1    Piantadosi, S.2    Burger, P.C.3
  • 45
    • 0026591763 scopus 로고
    • A randomized comparison of intra-arterial rersus intravenous BCNU. with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant ghioma
    • Shapiro WR, Green SB, Burger PC. A randomized comparison of intra-arterial rersus intravenous BCNU. with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant ghioma. J Neurosurg 1992; 76: 772-81.
    • (1992) J Neurosurg , vol.76 , pp. 772-781
    • Shapiro, W.R.1    Green, S.B.2    Burger, P.C.3
  • 46
    • 0025907744 scopus 로고
    • Intracarotid chemotherapy with etoposide and cisplatin for malignant brain tumors
    • Madajewiez S, Chowhan N, Ilya A. Intracarotid chemotherapy with etoposide and cisplatin for malignant brain tumors. Cancer 1991; 67: 2844-9.
    • (1991) Cancer , vol.67 , pp. 2844-2849
    • Madajewiez, S.1    Chowhan, N.2    Ilya, A.3
  • 47
    • 0027172763 scopus 로고
    • Intra-arterial mannitol infusion in the chemotherapy for malignant brain tumors
    • Iwadate Y, Namba H, Saegusa T. Intra-arterial mannitol infusion in the chemotherapy for malignant brain tumors. J Neuroncol 1993; 15: 185-93.
    • (1993) J Neuroncol , vol.15 , pp. 185-193
    • Iwadate, Y.1    Namba, H.2    Saegusa, T.3
  • 48
    • 0023121609 scopus 로고
    • High-dose carmustine with autologous bone marrow transplantation for the adjuvant treatment of high-grade glionms of the central nervous system
    • Wolff SN, Phillips GL, Herzig GP. High-dose carmustine with autologous bone marrow transplantation for the adjuvant treatment of high-grade glionms of the central nervous system. Cancer Treat Rep 1987; 71 (2): 183-5.
    • (1987) Cancer Treat Rep , vol.71 , Issue.2 , pp. 183-185
    • Wolff, S.N.1    Phillips, G.L.2    Herzig, G.P.3
  • 49
    • 0024213195 scopus 로고
    • High-dose BCNU chemotherapy with autologous bone marrow tranplantation and fulldose radiotherapy for grade IV astrocytoma
    • Mbidde EK, Selby PJ, Perren TJ. High-dose BCNU chemotherapy with autologous bone marrow tranplantation and fulldose radiotherapy for grade IV astrocytoma. Br J Cancer 1988; 58: 779-82.
    • (1988) Br J Cancer , vol.58 , pp. 779-782
    • Mbidde, E.K.1    Selby, P.J.2    Perren, T.J.3
  • 50
    • 0023201746 scopus 로고
    • Prolongation of survival for high-grade malignant gliomas with adjuvant high-dose BCNU and autologous bone marrow transplantation
    • Johnson DB, Thompson JM, Corwin JA. Prolongation of survival for high-grade malignant gliomas with adjuvant high-dose BCNU and autologous bone marrow transplantation. J Clin Oncol 1987; 5 (5): 783-9.
    • (1987) J Clin Oncol , vol.5 , Issue.5 , pp. 783-789
    • Johnson, D.B.1    Thompson, J.M.2    Corwin, J.A.3
  • 51
    • 0021064297 scopus 로고
    • Autologous bone-marrow transplantation: Host effects of high-dose BCNU
    • Takvorian T, Parker LM, Hochberg FH. Autologous bone-marrow transplantation: host effects of high-dose BCNU. J Clin Oncol 1983; 1 (10): 610-20.
    • (1983) J Clin Oncol , vol.1 , Issue.10 , pp. 610-620
    • Takvorian, T.1    Parker, L.M.2    Hochberg, F.H.3
  • 52
    • 0022628253 scopus 로고
    • Intensive 1.3-bis(2-chloroethyl)-1-nitrosourea (BCNU) monochemotherapy and autologous marrow transplantation for malignant glioma
    • Phillips GL, Woltf SN, Fay JW. Intensive 1.3-bis(2-chloroethyl)-1-nitrosourea (BCNU) monochemotherapy and autologous marrow transplantation for malignant glioma. J Clin Oncol 1986; 4 (5): 639-45.
    • (1986) J Clin Oncol , vol.4 , Issue.5 , pp. 639-645
    • Phillips, G.L.1    Woltf, S.N.2    Fay, J.W.3
  • 53
    • 9544237124 scopus 로고    scopus 로고
    • Pilot study of high-dose thiotepa and etoposide with autologous hone marrow rescue in children and young adults with recurrent CNS minors
    • Finlay JL, Goldman S, Wong MC. Pilot study of high-dose thiotepa and etoposide with autologous hone marrow rescue in children and young adults with recurrent CNS minors. J Clin Oncol 1996; 14 (9): 2495-2503.
    • (1996) J Clin Oncol , vol.14 , Issue.9 , pp. 2495-2503
    • Finlay, J.L.1    Goldman, S.2    Wong, M.C.3
  • 54
    • 2042451940 scopus 로고    scopus 로고
    • Time to tumor progression as a measure of efficacy in phase II chemotherapy trials for recurrent malignant gliomas
    • Abstr 277
    • Wong ET, Hess KR, Gleason MJ. Time to tumor progression as a measure of efficacy in phase II chemotherapy trials for recurrent malignant gliomas. Proc Am Soc Clin Oncol 1996; 15 (Abstr 277).
    • (1996) Proc Am Soc Clin Oncol , pp. 15
    • Wong, E.T.1    Hess, K.R.2    Gleason, M.J.3
  • 55
    • 0000165214 scopus 로고    scopus 로고
    • Response to Carmustine (BCNU), tumor control, and survival in recurrent glioblastoma multiforme (GM)
    • Abstr 307
    • Barker FG, Chang SM, Prados MD. Response to Carmustine (BCNU), tumor control, and survival in recurrent glioblastoma multiforme (GM). Proc Am Soc Clin Oncol 1996; 15 (Abstr 307).
    • (1996) Proc Am Soc Clin Oncol , pp. 15
    • Barker, F.G.1    Chang, S.M.2    Prados, M.D.3
  • 56
    • 0025281789 scopus 로고
    • Response criteria for phase II studies of supratentorial malignant glioma
    • Macdonald DR, Cascino TL, Clifford Schold S. Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 1990; 8 (7): 1277-80.
    • (1990) J Clin Oncol , vol.8 , Issue.7 , pp. 1277-1280
    • Macdonald, D.R.1    Cascino, T.L.2    Clifford Schold, S.3
  • 57
    • 0028237507 scopus 로고
    • Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification
    • Ekstrand AJ, Longo N, Hamid ML et al. Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification. Oncogene 1994; 9: 2313-20.
    • (1994) Oncogene , vol.9 , pp. 2313-2320
    • Ekstrand, A.J.1    Longo, N.2    Hamid, M.L.3
  • 58
    • 0028146767 scopus 로고
    • A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity
    • Nishikawa R, Ji XD, Harmon RC et al. A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc Natl Acad Sci USA 1994; 91: 7727-31.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 7727-7731
    • Nishikawa, R.1    Ji, X.D.2    Harmon, R.C.3
  • 59
    • 0029397307 scopus 로고
    • The p53 gene and its role in human brain tumors
    • Bögler O. Huang HJS, Kleihus P et al. The p53 gene and its role in human brain tumors. Glia 1995; 15: 308-27.
    • (1995) Glia , vol.15 , pp. 308-327
    • Bögler, O.1    Huang, H.J.S.2    Kleihus, P.3
  • 60
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y, Maya R. Kazaz A et al. Mdm2 promotes the rapid degradation of p53. Nature 1997; 387: 296-9.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3
  • 61
    • 0028618304 scopus 로고
    • Deletion of p16 and p15 genes in brain tumors
    • Jen J, Harper JW, Bigner SH et al. Deletion of p16 and p15 genes in brain tumors. Cancer Res 1994; 54: 6353-8.
    • (1994) Cancer Res , vol.54 , pp. 6353-6358
    • Jen, J.1    Harper, J.W.2    Bigner, S.H.3
  • 62
    • 0028986612 scopus 로고
    • Loss of p16ink4 expressions is frequent in high-grade gliomas
    • Nishikawa R, Furnari FB. Lin H et al. Loss of p16ink4 expressions is frequent in high-grade gliomas. Cancer Res 1995; 55: 1941-5.
    • (1995) Cancer Res , vol.55 , pp. 1941-1945
    • Nishikawa, R.1    Furnari, F.B.2    Lin, H.3
  • 63
    • 0028061974 scopus 로고
    • CDK4 amplification is an alternative mechanisms to p16 gene homozygous deletion in glioma cell lines
    • He J, Allen JR. Collins VP el al. CDK4 amplification is an alternative mechanisms to p16 gene homozygous deletion in glioma cell lines. Cancer Res 1994; 54: 5804-7.
    • (1994) Cancer Res , vol.54 , pp. 5804-5807
    • He, J.1    Allen, J.R.2    Collins, V.P.3
  • 64
    • 0027943938 scopus 로고
    • The retinoblastoma gene is involved in malignant progression of astrocytomas
    • Henson JW, Schnitker BL. Correa KM et al. The retinoblastoma gene is involved in malignant progression of astrocytomas. Ann Neurol 1994; 36: 714-21.
    • (1994) Ann Neurol , vol.36 , pp. 714-721
    • Henson, J.W.1    Schnitker, B.L.2    Correa, K.M.3
  • 65
    • 0028970955 scopus 로고
    • Lack of p16ink4 or retinoblastoma protein (pRb) or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines
    • He J, Olson JJ, James CD. Lack of p16ink4 or retinoblastoma protein (pRb) or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines. Cancer Res 1995; 55: 4833-6.
    • (1995) Cancer Res , vol.55 , pp. 4833-4836
    • He, J.1    Olson, J.J.2    James, C.D.3
  • 66
    • 0030936323 scopus 로고    scopus 로고
    • PTEN. a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D el al. PTEN. a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997; 275: 1943-7.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3
  • 67
    • 0028855751 scopus 로고
    • Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 allelles to glioblasloma cells
    • Van Meir E, Roemer G. Discrens AC et al. Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 allelles to glioblasloma cells. Proc Nail Acad Sci USA 1995; 92: 1008-12.
    • (1995) Proc Nail Acad Sci USA , vol.92 , pp. 1008-1012
    • Van Meir, E.1    Roemer, G.2    Discrens, A.C.3
  • 68
    • 0030020689 scopus 로고    scopus 로고
    • Adenovirusmediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis
    • Gomez-Manzano C, Fueyo J, Kyritsis AP et al. Adenovirusmediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Res 1996; 56: 694-9.
    • (1996) Cancer Res , vol.56 , pp. 694-699
    • Gomez-Manzano, C.1    Fueyo, J.2    Kyritsis, A.P.3
  • 69
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe SW, Ruley HE, Jacks et al. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993; 74: 957-67.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks3
  • 70
    • 0028231586 scopus 로고
    • Induction of chemosentivity in human lung cancer cells in vivo by adenoviral-mediated transfer of the wild-type p53 gene
    • Fujiwara T, Grimm EA, Mukhopadhyay T et al. Induction of chemosentivity in human lung cancer cells in vivo by adenoviral-mediated transfer of the wild-type p53 gene. Cancer Res 1994; 54: 2287-91.
    • (1994) Cancer Res , vol.54 , pp. 2287-2291
    • Fujiwara, T.1    Grimm, E.A.2    Mukhopadhyay, T.3
  • 71
    • 0031025998 scopus 로고    scopus 로고
    • Gene therapy for cancer: What have we done and where are we going?
    • Roth JA, Cristiano R. Gene therapy for cancer: What have we done and where are we going? J Natl Cancer Inst 1997; 89: 21-39.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 21-39
    • Roth, J.A.1    Cristiano, R.2
  • 72
    • 9544244796 scopus 로고    scopus 로고
    • Retroviral-mediated wildtype p53 gene transfer to tumors of patients with lung cancer
    • Roth JA, Nguyen D, Lawrene DD et al. Retroviral-mediated wildtype p53 gene transfer to tumors of patients with lung cancer. Nature Med 1996; 2: 985-91.
    • (1996) Nature Med , vol.2 , pp. 985-991
    • Roth, J.A.1    Nguyen, D.2    Lawrene, D.D.3
  • 73
    • 0028147863 scopus 로고
    • Hypoxic Stimulation of vascular endothelial growth factor expression in vitro and in vivo
    • Minchencko A, Bauer T. Salceda S et al. Hypoxic Stimulation of vascular endothelial growth factor expression in vitro and in vivo. Lab Invest 1994; 71: 374-9.
    • (1994) Lab Invest , vol.71 , pp. 374-379
    • Minchencko, A.1    Bauer, T.2    Salceda, S.3
  • 74
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivti
    • Kim KJ, Li B. Winer J et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivti. Nature 1993; 362: 841-4.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3
  • 75
    • 0028174337 scopus 로고
    • Glioblastoma growth inhibited in vivo by a dominant-negative FIk-1 mutant
    • Millauer B, Shawer LK, Plate KH et al. Glioblastoma growth inhibited in vivo by a dominant-negative FIk-1 mutant. Nature 1994; 367: 576-9.
    • (1994) Nature , vol.367 , pp. 576-579
    • Millauer, B.1    Shawer, L.K.2    Plate, K.H.3
  • 76
    • 0029863730 scopus 로고    scopus 로고
    • Dominant-negative inhibition of FIk-1 suppresses the growth of many tumor types in vivo
    • Millauer B, Longhi MP, Plate KH et al. Dominant-negative inhibition of FIk-1 suppresses the growth of many tumor types in vivo. Cancer Res 1996; 56 (7): 1615-20.
    • (1996) Cancer Res , vol.56 , Issue.7 , pp. 1615-1620
    • Millauer, B.1    Longhi, M.P.2    Plate, K.H.3
  • 77
    • 0030937456 scopus 로고    scopus 로고
    • Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angio-genesis and tumor growth
    • Tanaka T, Manome Y, Wen P et al. Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angio-genesis and tumor growth. Nature Med 1997; 3: 437-42.
    • (1997) Nature Med , vol.3 , pp. 437-442
    • Tanaka, T.1    Manome, Y.2    Wen, P.3
  • 79
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996; 271: 1734-6.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 80
    • 0030685044 scopus 로고    scopus 로고
    • Immunobiology of gliomas: New perspectives for therapy
    • Dietrich PY, Saas P,Walker PR et al. Immunobiology of gliomas: New perspectives for therapy. Ann N Y Acad Sci 1997; 824: 124-40.
    • (1997) Ann N Y Acad Sci , vol.824 , pp. 124-140
    • Dietrich, P.Y.1    Saas, P.2    Walker, P.R.3
  • 81
    • 0026536584 scopus 로고
    • Protease inhibitors interfere with the transforming growth factor-β-dependent but not the trans-forming growth factor-β-independent pathway of tumor cell-mediated immunosuppression
    • Huber D, Philipp J, Fontana A. Protease inhibitors interfere with the transforming growth factor-β-dependent but not the trans-forming growth factor-β-independent pathway of tumor cell-mediated immunosuppression. J Immunol 1992; 148: 277-84.
    • (1992) J Immunol , vol.148 , pp. 277-284
    • Huber, D.1    Philipp, J.2    Fontana, A.3
  • 82
    • 0028807156 scopus 로고
    • Human glioma-derived Interleukin-10 inhibits antitumor immune responses in vitro
    • Hishii M, Nitta T, Ishida H et al. Human glioma-derived Interleukin-10 inhibits antitumor immune responses in vitro. Neurosurgery 1995;37: 1160-7.
    • (1995) Neurosurgery , vol.37 , pp. 1160-1167
    • Hishii, M.1    Nitta, T.2    Ishida, H.3
  • 83
    • 0030895084 scopus 로고    scopus 로고
    • Fas ligand expression by astrocytoma in vivo: Maintaining immune privilege in the brain?
    • Saas P, Walker PR, Hahne M et al. Fas ligand expression by astrocytoma in vivo: Maintaining immune privilege in the brain? J Clin Invest 1997; 99: 1173-8.
    • (1997) J Clin Invest , vol.99 , pp. 1173-1178
    • Saas, P.1    Walker, P.R.2    Hahne, M.3
  • 84
    • 0031570098 scopus 로고    scopus 로고
    • The role of Fas Ligand (CD95L) in immune escape: The tumor cell strikes back
    • Walker PR, Saas P, Dietrich PY. The role of Fas Ligand (CD95L) in immune escape: The tumor cell strikes back. J Immunol 1997; 158: 4521-4.
    • (1997) J Immunol , vol.158 , pp. 4521-4524
    • Walker, P.R.1    Saas, P.2    Dietrich, P.Y.3
  • 85
    • 0028908324 scopus 로고
    • Paracrine cytokine adjuvants in cancer immunotherapy
    • Pardoll DM. Paracrine cytokine adjuvants in cancer immunotherapy. Annu Rev Immunol 1995; 13: 399-415.
    • (1995) Annu Rev Immunol , vol.13 , pp. 399-415
    • Pardoll, D.M.1
  • 86
    • 43949160470 scopus 로고
    • Inflammatory cytokines in the brain: Does the CNS shape immune responses?
    • Owens T, Renno T, Taupin V et al. Inflammatory cytokines in the brain: Does the CNS shape immune responses? Immunol Today 1994; 15: 566-71.
    • (1994) Immunol Today , vol.15 , pp. 566-571
    • Owens, T.1    Renno, T.2    Taupin, V.3
  • 87
    • 0023194190 scopus 로고
    • In vivo labeling of blood T cells: Rapid traffic into cerebrospinal fluid in multiple sclerosis
    • Hafler DA, Weiner HL. In vivo labeling of blood T cells: Rapid traffic into cerebrospinal fluid in multiple sclerosis. Ann Neurol 1987; 22: 89-93.
    • (1987) Ann Neurol , vol.22 , pp. 89-93
    • Hafler, D.A.1    Weiner, H.L.2
  • 88
    • 0026582225 scopus 로고
    • Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo
    • Aoki T, Tashiro K, Miyatake S et al. Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo. Proc Natl Acad Sci USA 1992; 89: 3850-4.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3850-3854
    • Aoki, T.1    Tashiro, K.2    Miyatake, S.3
  • 89
    • 0027507179 scopus 로고
    • Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA
    • Trojan J, JohnsonTR, Rudin SD et al. Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA. Science 1993; 259: 94-7.
    • (1993) Science , vol.259 , pp. 94-97
    • Trojan, J.1    Johnson, T.R.2    Rudin, S.D.3
  • 90
    • 0028271497 scopus 로고
    • Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors
    • Resnicoff M, Sell C, Rubini M et al. Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors. Cancer Res 1994; 54: 2218-22.
    • (1994) Cancer Res , vol.54 , pp. 2218-2222
    • Resnicoff, M.1    Sell, C.2    Rubini, M.3
  • 91
    • 0027945365 scopus 로고
    • Modulation of tumor immunogenicity of rat glioma cells by s-myc expression: Eradication of rat gliomas in vivo
    • Asai A, Miyagi Y, Hashimoto H et al. Modulation of tumor immunogenicity of rat glioma cells by s-myc expression: Eradication of rat gliomas in vivo. Cell Growth Diff 1994; 5: 1153-8.
    • (1994) Cell Growth Diff , vol.5 , pp. 1153-1158
    • Asai, A.1    Miyagi, Y.2    Hashimoto, H.3
  • 92
    • 0029865486 scopus 로고    scopus 로고
    • Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy
    • Fakhrai H, Dorigo O, Shawler DL et al. Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy. Proc Natl Acad Si USA 1996; 93: 2909-14.
    • (1996) Proc Natl Acad Si USA , vol.93 , pp. 2909-2914
    • Fakhrai, H.1    Dorigo, O.2    Shawler, D.L.3
  • 93
    • 0029841918 scopus 로고    scopus 로고
    • Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CDS+ cell mediated immunity against tumors located in the 'immunologically privileged' central nervous system
    • Sampson JH, Archer GE. Ashley DM et al. Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CDS+ cell mediated immunity against tumors located in the 'immunologically privileged' central nervous system. Proc Natl Acad Sci USA 1996; 93: 10399-404.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10399-10404
    • Sampson, J.H.1    Archer, G.E.2    Ashley, D.M.3
  • 94
    • 0030808677 scopus 로고    scopus 로고
    • Bone marrow derived dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors
    • Ashley DM, Faiola B. Nair S et al. Bone marrow derived dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors. J Exp Med 1997; 186; 1177-82.
    • (1997) J Exp Med , vol.186 , pp. 1177-1182
    • Ashley, D.M.1    Faiola, B.2    Nair, S.3
  • 95
    • 0027203715 scopus 로고
    • Treatment of glioma by engineered interleukin 4-secreting cells
    • Yu JS, Wei MX, Chiocca Ea et al. Treatment of glioma by engineered interleukin 4-secreting cells. Cancer Res 1993; 53: 3125-8.
    • (1993) Cancer Res , vol.53 , pp. 3125-3128
    • Yu, J.S.1    Wei, M.X.2    Chiocca, Ea.3
  • 96
    • 16944361879 scopus 로고    scopus 로고
    • Limited efficacy of the HSV-TK/GCV system for gene therapy of malignant gliomas and perspectives for the combined transductiort of the IL-4 gene
    • Benedetti S, DiMeco F, Polio B et al. Limited efficacy of the HSV-TK/GCV system for gene therapy of malignant gliomas and perspectives for the combined transductiort of the IL-4 gene. Hum Gene Ther 1997; 8: 1345-53.
    • (1997) Hum Gene Ther , vol.8 , pp. 1345-1353
    • Benedetti, S.1    DiMeco, F.2    Polio, B.3
  • 97
    • 0026772206 scopus 로고
    • In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
    • Culver KW, Ram Z, Wallbridge S et al. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 1992; 256: 1550-2.
    • (1992) Science , vol.256 , pp. 1550-1552
    • Culver, K.W.1    Ram, Z.2    Wallbridge, S.3
  • 98
    • 0028065106 scopus 로고
    • Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene
    • Wei MX, Tamiya T, Chase M et al. Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene. Hum Gene Ther 1994; 5: 969-78.
    • (1994) Hum Gene Ther , vol.5 , pp. 969-978
    • Wei, M.X.1    Tamiya, T.2    Chase, M.3
  • 99
    • 0027990763 scopus 로고
    • Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines
    • Weller M, Frei K, Groscurth P et al Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines. J Clin Invest 1994; 94: 954-64.
    • (1994) J Clin Invest , vol.94 , pp. 954-964
    • Weller, M.1    Frei, K.2    Groscurth, P.3
  • 100
    • 0029073752 scopus 로고
    • Fas/APO-1 gene transfer for human malignant glioma
    • Weller M, Malipiero U, Rensing-Eh1 A et al. Fas/APO-1 gene transfer for human malignant glioma. Cancer Res 1995; 55: 2936-44.
    • (1995) Cancer Res , vol.55 , pp. 2936-2944
    • Weller, M.1    Malipiero, U.2    Rensing-Ehl, A.3
  • 101
    • 0344188096 scopus 로고    scopus 로고
    • An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
    • Bischoff JR, Kirn DH. Williams A et al. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 1996; 274: 373-6.
    • (1996) Science , vol.274 , pp. 373-376
    • Bischoff, J.R.1    Kirn, D.H.2    Williams, A.3
  • 102
    • 0030917202 scopus 로고    scopus 로고
    • ONYX-015, an EIB gene-attenuated adenovirus. causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
    • Heise C, Sampson-Johannes A, Williams A et al. ONYX-015, an EIB gene-attenuated adenovirus. causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nature Med 1997; 3: 639-45.
    • (1997) Nature Med , vol.3 , pp. 639-645
    • Heise, C.1    Sampson-Johannes, A.2    Williams, A.3
  • 104
    • 0028129836 scopus 로고
    • Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblasloma cells
    • Van Meir EG, Polverini PJ, Chazin VR el al. Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblasloma cells. Nature Genet 1994; 8: 171-6.
    • (1994) Nature Genet , vol.8 , pp. 171-176
    • Van Meir, E.G.1    Polverini, P.J.2    Chazin, V.R.3
  • 105
    • 0029842830 scopus 로고    scopus 로고
    • Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells
    • Gabrilovich DI, Chen HL, Girgis KR et al. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nature Med 1996; 2: 1096-103.
    • (1996) Nature Med , vol.2 , pp. 1096-1103
    • Gabrilovich, D.I.1    Chen, H.L.2    Girgis, K.R.3
  • 106
    • 0028897739 scopus 로고
    • Inhibition of angiogenesis in vivo by interleukin-12
    • Voest EE, Kenyon BM. O'Reilly MS et al. Inhibition of angiogenesis in vivo by interleukin-12. J Natl Cancer Inst 1995; 87: 581-6.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 581-586
    • Voest, E.E.1    Kenyon, B.M.2    O'Reilly, M.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.