Modulation of human immunodeficiency virus type 1-induced syncytium formation by the conformational state of LFA-1 determined by a new luciferase-based syncytium quantitative assay

Journal of Virology

Volumn 72, Issue 9, 1998, Pages 7125-7136

  Barbeau, Benoit ^b   Fortin, Jean François ^b   Genois, Nicolas ^b   Tremblay, Michel J ^a  

^a UNIVERSITY OF QUEBEC   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; QUANTITATIVE ASSAY; SYNCYTIUM; T LYMPHOCYTE ACTIVATION;

EID: 0031849748     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.9.7125-7136.1998     Document Type: Article

References (61)

1. Aguilar-Cordova, E., J. Chinen, L. Donehower, D. E. Lewis, and J. W. Belmont. 1994. A sensitive reporter cell line for HIV-1 tat activity, HIV-1 inhibitors, and T cell activation effects. AIDS Res. Hum. Retroviruses 10: 295-301.
2. Alkhatib, G., C. Combadiere, C. C. Broder, Y. Feng, P. E. Kennedey, P. M. Murphy, and E. A. Berger. 1996. CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272: 1955-1959.
3. Allen, A. D., D. N. Hart, M. K. Hechinger, M. J. Slattery, C. V. Chesson, and P. Vidikan. 1995. Leukocyte adhesion molecules as a cofactor in AIDS: basic science and pilot study. Med. Hypotheses 45:164-168.
4. Barbeau, B., R. Bernier, N. Dumais, G. Briand, M. Olivier, R. Faure, B. I. Posner, and M. Tremblay. 1997. Activation of HIV-1 LTR transcription and virus replication via NF-κB-dependent and -independent pathways by potent phosphotyrosine phosphatase inhibitors, the peroxovanadium compounds. J. Biol. Chem. 272:12968-12977.
5. Bazil, V., I. Stefanova, I. Hilgert, H. Kristofova, S. Vanek, and V. Horejsi. 1990. Monoclonal antibodies against leukocytes antigens IV. Antibodies against the LFA-1 (CD11a/CD18) leukocyte-adhesion glycoprotein. Folia Biol. 36:41-50.
6. Berman, P. W., and G. R. Nakamura. 1994. Adhesion mediated by intercellular adhesion molecule 1 attenuates the potency of antibodies that block HIV-1 gp160-dependent syncytium formation. AIDS Res. Hum. Retroviruses 10:585-593.
7. Bernier, R., and M. Tremblay. 1995. Homologous interference resulting from the presence of defective particles of human immunodeficiency virus type 1. J. Virol. 69:291-300.
8. Bieniasz, P. D., R. A. Fridell, I. Aramori, S. S. G. Ferguson, M. G. Caron, and B. R. Cullen. 1997. HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor. EMBO J. 16:2599-2609.
9. Binnerts, M. E., Y. van Kooyk, D. L. Simmons, and C. G. Figdor. 1994. Distinct binding of T lymphocytes to ICAM-1, -2, or -3 upon activation of LFA-1. Eur. J. Immunol. 24:2155-2160.
10. lck. Virology 231:10-19.
11. Butera, S. T., V. L. Perez, B.-Y. Wu, G. J. Nabel, and T. M. Folks. 1991. Oscillation of the human immunodeficiency virus surface receptor is regulated by the state of viral activation in a CD4+ cell model of chronic infection. J. Virol. 65:4645-4653.
12. Butini, L., A. R. De Fougerolles, M. Vaccarezza, D. I. Cohen, M. Montroni, T. A. Springer, G. Pantaleo, and A. S. Fauci. 1994. Intercellular adhesion molecules (ICAM)-1 1CAM-2 and ICAM-3 function as counter-receptors for lymphocyte function-associated molecule 1 in human immunodeficiency virus-mediated syncytia formation. Eur. J. Immunol. 24:2191-2195.
13. Cantin, R., J.-F. Fortin, G. Lamontagne, and M. Tremblay. 1997. The presence of host-derived HLA-DR1 on human immunodeficiency virus type 1 increases viral infectivity. J. Virol. 71:1922-1930.
14. Caputo, A., J. G. Sodroski, and W. A. Haseltine. 1990. Constitutive expression of HIV-1 Tat protein in human Jurkat T cells using a BK virus vector. J. Acquired Immune Defic. Syndr. 3:372-379.
15. Dalgleish, A. G., P. C. L. Beverly, P. R. Clapham, D. H. Crawford, M. F. Greaves, and R. A. Weiss. 1984. The CD4(T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312:763-767.
16. de Fougerolles, A. R., and T. A. Springer. 1992. Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes. J. Exp. Med. 175:185-190.
17. de Fougerolles, A. R., S. A. Stacker, R. Schwarting, and T. A. Springer. 1991. Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1. J. Exp. Med. 174:253-267.
18. Deng, H., R. Liu, W. Ellmeier, S. Choe, D. Unutmaz, M. Burkhart, P. Di Marzio, S. Marmon, R. E. Sutton, C. Mark Hill, C. B. Davis, S. C. Peiper, T. J. Schall, D. R. Littman, and N. R. Landau. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661-666.
19. Diamond, M. S., and T. A. Springer. 1994. The dynamic regulation of integrin adhesiveness. Curr. Biol. 4:506-517.
20. Donaldson, Y. K., J. E. Bell, E. C. Holmes, E. S. Hugues, H. K. Brown, and P. Simmonds. 1994. In vivo distribution and cytopathology or variants of human immunodeficiency virus type 1 showing restricted sequence variability in the V3 loop. J. Virol. 68:5991-6005.
21. Dragic, T., V. Litwin, G. P. Allaway, S. R. Martin, Y. Huang, K. A. Nagashima, C. Cayanan, P. J. Maddon, R. A. Koup, J. P. Moore, and W. A. Paxton. 1996. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667-673.
22. Dransfield, I., C. Cabanas, A. Craig, and N. Hogg. 1992. Divalent cation regulation of the function of the leukocyte integrin LFA-1. J. Cell Biol. 116: 219-226.
23. Dustin, M. L., and T. A. Springer. 1989. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 341:619-624.
24. Feng, Y., C. C. Broder, P. E. Kennedey, and E. A. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G proteincoupled receptor. Science 272:872-877.
25. Figdor, C. G., Y. van Kooyk, and G. D. Keizer. 1990. On the mode of action of LFA-1. Immunol. Today 11:277-280.
26. Fortin, J.-F., R. Cantin, G. Lamontagne, and M. Tremblay. 1997. Hostderived ICAM-1 glycoproteins incorporated on human immunodeficiency virus type 1 are biologically active and enhances viral infectivity. J. Virol. 71: 3588-3596.
27. Fortin, J.-F., R. Cantin, and M. Tremblay. 1998. T cells expressing activated LFA-1 are more susceptible to infection with human immunodeficiency virus type 1 particles bearing host-encoded ICAM-1. J. Virol. 72:2105-2112.
28. Fortin, J.-F., R. Cantin, M. G. Bergeron, and M. J. Tremblay. Unpublished data.
29. Frankel, S. S., K. Tenner-Racz, B. M. Wenig, C. H. Hansen, D. Heffner, A. M. Nelson, M. Pope, and R. M. Steinman. 1997. Active replication of HIV-1 at the lymphoepithelial surface of the tonsil. Am. J. Pathol. 151:89-96.
30. Gottlinger, H. E., J. G. Sodroski, and W. A. Haseltine. 1989. Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of HIV-1. Proc. Natl. Acad. Sci. USA 86:5781-5785.
31. Gruber, M. F., D. S. A. Webb, T. L. Gerrard, H. S. Mostowski, L. Vujcic, and H. Golding. 1991. Re-evaluation of the involvement of the adhesion molecules ICAM/LFA-1 in syncytia formation of HIV-infected subclones of a CEM T-cell leukemic line. AIDS Res. Hum. Retroviruses 7:45-53.
32. Hedman, H., and E. Lundgren. 1992. Regulation of LFA-1 activity in human B cells. J. Immunol. 149:2295-2299.
33. Hildreth, J. E. K., and R. J. Orentas. 1989. Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation. Science 244:1075-1078.
34. Keizer, G. D., W. Visser, M. Vliem, and C. C. Figdor. 1988. A monoclonal antibody (NKI-L16) directed against a unique epitope on the α-chain of human leukocyte function-associated antigen 1 induces homotypic cell-cell interactions. J. Immunol. 140:1393-1400.
35. Kimpton, J., and M. Emerman. 1992. Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated β-galactosidase gene. J. Virol. 66: 2232-2239.
36. Lahm, H. W., and S. Stein. 1985. Characterization of recombinant human 11-2 with micromethods. J. Chromatogr. 326:357-361.
37. Landis, C. R., R. I. Bennett, and N. Hogg. 1993. A novel LFA-1 activation epitope maps to the I domain. J. Cell Biol. 120:1519-1527.
38. Li, X., J. Mak, E. J. Arts, Z. Gu, L. Kleiman, M. A. Wainberg, and M. A. Parniak. 1994. Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replication. J. Virol. 68:6198-6206.
39. Lifson, J. D., M. B. Feinberg, G. R. Reyes, L. Rabin, B. Banapour, S. Chakrabarti, B. Moss, F. Wong-Staal, K. S. Steimer, and E. G. Engleman. 1986. Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein. Nature 323:725-728.
40. Lifson, J. D., G. R. Reyes, M. S. McGrath, B. S. Stein, and E. G. Engleman. 1986. AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen. Science 232:1123-1127.
41. Lub, M., Y. van Kooyk, and C. G. Figdor. 1995. Ins and out of LFA-1. Immunol. Today 16:479-483.
42. Lusso, P., F. Cocchi, C. Balotta, P. D. Markham, A. Louie, P. Farci, R. Pal, R. C. Gallo, and M. S. Reitz, Jr. 1995. Growth of macrophage-tropic and primary human immunodeficiency virus type 1 (HIV-1) isolates in a unique CD4+ T-cell clone (PM1): failure to downregulate CD4 and to interfere with cell-line-tropic HIV-1. J. Virol. 69:3712-3720.
43. + cell line H9. AIDS Res. Hum. Retroviruses 5:253-255.
44. McCallus, D. E., K. E. Ugen, A. I. Sato, W. V. Williams, and D. B. Weiner. 1992. Construction of a recombinant bacterial human CD4 expression system producing a bioactive CD4 molecule. Viral Immunol. 5:163-172.
45. + cells by a complex of the 11OK viral protein and the T4 molecule. Science 231:382-385.
46. Moir, S., and L. Poulin. 1996. Expression of HIV env gene in a human T cell line for a rapid and quantifiable cell fusion assay. AIDS Res. Hum. Retroviruses 12:811-820.
47. Pantaleo, G., L. Butini, C. Graziosi, G. Poli, S. M. Schnittman, J. J. Greenhouse, J. I. Gallin, and A. S. Fauci. 1991. Human immunodeficiency virus (HIV) infection in CD4+ T lymphocytes genetically deficient in LFA-1: LFA-1 is required for HIV-mediated cell fusion but not for viral transmission. J. Exp. Med. 173:511-514.
48. Parrot, D. M., and P. C. Wilkinson. 1981. Lymphocyte locomotion and migration. Prog. Allergy 28:193-284.
49. 2+ mobilization after CD3 stimulation. J. Immunol. 147:3145-3148.
50. Petito, C. K., B. A. Navia, E.-S. Cho, B. D. Jordan, D. C. George, and R. W. Price. 1985. Vacuolar myelopathy pathologically resembling subacute combined degeneration in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med. 312:874-879.
51. Rizzuto, C. D., and J. G. Sodroski. 1997. Contribution of virion ICAM-1 to human immunodeficiency virus infectivity and sensitivity to neutralization. J. Virol. 71:4847-4851.
52. Rothlein, R., M. L. Dustin, S. D. Marlin, and T. A. Springer. 1986. A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J. Immunol. 137:1270-1274.
53. Schwartz, O., J.-L. Virelizier, L. Montagnier, and U. Hazan. 1990. A microtransfection method using the luciferase-encoding reporter gene for the assay of human immunodeficiency virus LTR promoter activity. Gene 88: 197-205.
54. Smith, S. D., Shatsky, M. P. S. Cohen, R. Warnke, M. P. Link, and B. E. Glader. 1984. Monoclonal antibody and enzymatic profiles of human malignant T lymphoid cells and derived cell lines. Cancer Res. 44:5657-5660.
55. Sodroski, J., W. C. Goh, C. Rosen, K. Campbell, and W. A. Haseltine. 1986. Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity. Nature 322:470-474.
56. Springer, T. A. 1990. Adhesion receptors of the immune system. Nature 346: 425-434.
57. Starcich, B., L. Ratner, S. F. Josephs, T. Okamoto, R. C. Gallo, and F. Wong-Staal. 1985. Characterization of long terminal repeat sequences of HTLV-III. Science 227:538-540.
58. Staunton, D. E., M. L. Dustin, and T. A. Springer. 1989. Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1. Nature 339:61-64.
59. Valentin, A., K. Lundin, M. Pararroyo, and B. Asjö. 1990. The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced syncytia formation in monocytoid and T cells. J. Immunol. 144:934-937.
60. Weiss, A., J. Imboden, D. Shohack, and J. Strobo. 1984. Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium. Proc. Natl. Acad. Sci. USA 81:4169-4173.
61. Willard-Gallo, K. E., F. Van de Keere, and R. Kettmann. 1990. A specific defect in CD3 gamma-chain gene transcription results in loss of T-cell receptor/CD3 expression late after human immunodeficiency virus infection of a CD4+ T-cell line. Proc. Natl. Acad. Sci. USA 87:6713-6717.