Active replication of HIV-1 at the lymphoepithelial surface of the tonsil

American Journal of Pathology

Volumn 151, Issue 1, 1997, Pages 89-96

  Frankel, Sarah S ^a,d   Tenner Racz, Klara ^a   Racz, Paul ^a,b   Wenig, Bruce M ^a   Hansen, Christian H ^c   Heffner, Dennis ^d   Nelson, Ann M ^a   Pope, Melissa ^a   Steinman, Ralph M ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; EPITHELIUM; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN SITU HYBRIDIZATION; LYMPHOID TISSUE; MALE; PRIORITY JOURNAL; TONSIL; VIRUS DETECTION; VIRUS DNA CELL DNA INTERACTION; VIRUS EXPRESSION; VIRUS INFECTIVITY; VIRUS REPLICATION;

ADENOIDS; ADULT; CHILD; EPITHELIUM; FEMALE; GIANT CELLS; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOID TISSUE; MALE; MIDDLE AGED; S100 PROTEINS; TONSIL; VIRUS REPLICATION;

EID: 0030787773     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Frankel SS, Wenig BM, Burke AP, Mannan P, Thompson LDR, Abbondanzo SL, Nelson AM, Pope M, Steinman RM: Replication of HIV-1 in dendritic cell-derived syncytia at the mucosal surface of the adenoid. Science 1996, 272:115-117
2. Owen RL, Nemanic P: Antigen processing structures of the mammalian intestinal tract: an SEM study of lymphoepithelial organs. Scanning Electron Micros 1978, 11:367-378
3. Ruco LP, Uccini S, Stoppacciaro A, Pilozzi E, Morrone S, Gallo A, De Vincentiis M, Santoni A, Baroni CD: The lymphoepithelia organization of the tonsil: an immunohistochemical study in chronic recurrent tonsillitis. J Pathol 1995, 176:391-398
4. Winther B, Innes DJ: The human adenoid: a morphologic study. Arch Otolaryngol Head Neck Surg 1994, 120:144-149
5. Fujiyoshi T, Watanabe T, Ichimiya I, Mogi G: Functional architecture of the nasopharyngeal tonsil. Am J Otolaryngol 1989, 10:124-131
6. Morente M, Piris MA, Orradre JL, Rivas C, Villuendas R: Human tonsil intraepithelial B cells: a marginal zonerelated subpopulation. J Clin Pathol 1992, 45:668-672
7. Bani D, Gallo O, Fini-Storchi O: Intraepithelial lymphocyte subpopulations and dendritic accessory cells in normal and hypertrophie adenoids. Laryngoscope 1994, 104:869-873
8. Pope M, Betjes MGH, Romani N, Hirmand H, Cameron PU, Hoffman L, Gezelter S, Schuler G, Steinman RM: Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell 1994, 78:389-398
9. + T cells. J Exp Med 1995, 182:2045-2056
10. Tenner-Racz K, Bofill M, Schulz-Meyer A, Dietrich M, Weber J, Pinching AJ, Veronese-Dimarzo F, Popovic M, Klatzmann D, Gluckman JC, Janossy G: HTLV-III/LAV viral antigens in lymph nodes of homosexual men with persistent generalized lymphadenopathy and AIDS. Am J Pathol 1986, 123:9-15
11. Takahashi K, Isobe T, Ohtsuki Y, Sonobe H, Takeda I, Akagi T: Immunohistochemical localization and distribution of S-100 proteins in the human lymphoreticular system. Am J Pathol 1984, 116:497-503
12. Amerongen HM, Weltzin R, Farnet CM, Michetti P, Haseltine WA, Neutra MR: Transepithelial transport of HIV-1 by intestinal M cells: a mechanism for transmission of AIDS. J AIDS 1991, 4:760-765-
13. Neutra MR, Pringault E, Kraehenbuhl J-P: Antigen sampling across epithelial barriers and induction of mucosal immune responses. Annu Rev Immunol 1996, 14: 275-300
14. Rinfret A, Latendresse H, Lefebvre R, St Louis G, Jolicoeur P, Lamarre L: Human immunodeficiency virus-infected multinucleated histiocytes in oropharyngeal lymphoid tissues from two asymptomatic patients. Am J Pathol 1991, 138:421-426
15. Koenig S, Gendelman HE, Orenstein JM, Dal Canto MC, Pezeshkpour G, Yungbluth M, Janotta F, Aksamit A, Martin MA, Fauci AS: Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 1986, 233:1089-1093
16. Budka H: Multinucleated giant cells in brain: a hallmark of the acquired immune deficiency syndrome (AIDS). Acta Neuropathol (Berlin) 1986, 69:353-358
17. Jolly J: La bourse de Fabricius et les organes lymphoepitheliaux: compt rend de l'assoc des anatomistes 1911, 164-176
18. Schmincke A: Classics in oncology: on lymphoepithelial tumors. Pathol Anat 1921, 68:161-170
19. Gebert A, Rothkotter H, Pabst R: M Cells in the Peyer's patches of the intestine. Int Rev Cytol 1996, 167:91159
20. Neutra MR, Frey A, Kraehenbuhl J-P: Epithelial M cells: gateways for mucosal infection and immunization. Cell 1996, 86:345-348
21. Wilders MM, Sminia T, Plesch BEC, Drexhage HA, Welte-Vreden EF, Meuwissen SGM: Large mononuclear la-positive veiled cells in Peyer's patches. II. Localization in rat Peyer's patches. Immunology 1983, 48:461-467
22. + T cells. Science 1992, 257:383-387
23. Pinchuk LM. Polacino PS, Agy MB, Klaus SJ, Clark EA: The role of CD40 and CD80 accessory cell molecules in dendritic cell-dependent HIV-1 infection. Immun 1994, 1:317-325
24. + T cells is markedly enhanced in the setting of antigen-specific immune activation. J Exp Med 1996, 183:687-692
25. Pope M, Elmore D, Ho D, Marx P: Dendritic cell-T cell mixtures, isolated from the skin and mucosae of macaques, support the replication of SIV. AIDS Res Hum Retroviruses 1997 (in press)
26. Baba TW, Trichel AM, An L, Liska V, Martin LN, Murphey-Corb M, Ruprecht RM: Infection and AIDS in adult macaques after nontraumatic oral exposure to cell-free SIV. Science 1996, 272:1486-1489
27. SpiraAl, Marx PA, Patterson BK, Mahoney J, Koup RA, Wolinsky SM, Ho DD: Cellular targets of infection and route of viral dissemination following an intravaginal inoculation of SIV into rhesus macaques. J Exp Med 1996, 183:215-225
28. Pantaleo G, Graziosi C. Demarest JF, Butini L, Montroni M, Fox CH, Orenstein JM, Kotler DP, Fauci AS: HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 1993, 362:355-358